Circulating adhesion molecules and arterial stiffness

Aim: VCAM-1 and ICAM-1 are two important members of the immunoglobulin gene superfamily of adhesion molecules, and their potential role as biomarkers of diagnosis, severity and prognosis of cardiovascular disease has been investigated in a number of clinical studies. The aim of the present study was to determine the relationship between circulating ICAM-1 and VCAM-1 levels and aortic stiffness in patients referred for echocardiographic examination. Methods: Aortic distensibility was determined by echocardiography using systolic and diastolic aortic diameters in 63 consecutive patients referred for echocardiography. Venous samples were collected in the morning after a 12-hour overnight fast, and serum concentrations of ICAM-1 and VCAM-1 were measured using commercial enzyme immunoassay kits. Results: Data of a total of 63 participants (mean age 55.6 ± 10.5 years, 31 male) were included in the study. Circulating levels of adhesion molecules were VCAM-1: 12.604 ± 3.904 ng/ml and ICAM-1: 45.417 ± 31.429 ng/ml. We were unable to demonstrate any correlation between indices of aortic stiffness and VCAM-1 and ICAM-1 levels. Conclusion: The role of soluble adhesion molecules in cardiovascular disease has not been fully established and clinical studies show inconsistent results. Our results indicate that levels of circulating adhesion molecules cannot be used as markers of aortic stiffness in patients

Synthesis of Carboxymethyl Starch for increasing drilling mud quality in drilling oil and gas wells

This paper describes the impact of carboxymethyl starch preparation conditions on physicochemical properties of polysaccharide reagent, widely used as fluid loss reducing agent in drilling mud. Variation of the main parameters of carboxymethylation is researched in the experiment. The following conditions such as temperature and reaction time, amount of water, as well as ratio of NaOH to monochloracetic acid define the characteristics of carboxymethyl starch. The degree of substitution is defined for polysaccharides, as well as the characteristics of samples have been studied by infrared spectroscopy. Rheological characteristics and fluid loss indicator have been investigated to study the impact of the reagents on drilling mud quality

Evaluation of the morphological characteristic and sex differences of sternum by multi-detector computed tomography

Background: Sternum is one of the skeleton parts which have frequently congenital anomalies and variations are commonly used by researchers in determining sex. We evaluated the morphological characteristics and sex-related changes of the sternum in adult individuals using multidetector computed tomography inour study.Materials and methods: Two hundred adults (103 female and 97 male) aged between 18 and 87 years were evaluated. Utilising the morphological characteristics of the sternum based on the multislice images; length, width and the thickness of manubrium, length, width and the thickness of corpus sterni, total length of sternum, sternal angle, sternal index (SI), length of the xiphoid process, the thickness of xiphoid process, the number of indents of xiphoid process were measured and a total of 20 parameters were evaluated by adding age, heightand weight to these variables.Results: The mean length of the manubrium, the length of corpus sterni, the length of total sternum, SI, sternal angle were found in females 46.7 ± 5.1, 86.6 ± 9.7, 133.1 ± 1.1, 54.47 ± 10.0 and 163.75 ± 5.79; in males 51.2 ± 6,102.4 ± 13.3, 154.1 ± 13.1, 50.11 ± 10.02 and 162.21 ± 6.17, respectively. We found that Hyrtl’s Law and SI did not provide adequate accuracy for sex determination in our patients. It has been detected that the length of the manubrium alone is not helpful for individual samples. Total length of the sternum was found to bemore reliable than the length of the manubrium and the length of corpus sterni. We determined sternal cleft and sternal foramen as 0.5% and 3.5%, respectively.Conclusions: We suggest that the morphometric standards cannot be universally applied and can demonstrate individual differences. The standard rules must be implemented for every population

PAPILLARY THYROID CARCINOMA FOLLOWING ADALIMUMAB TREATMENT IN ANKYLOSING SPONDYLITIS: A CAUSAL OR COINCIDENTAL ASSOCIATION?

The introduction of tumor necrosis factor-alpha (TNF-?) targeting drugs has given new opportunities in the treatment of various inflammatory rheumatic diseases and has been the most important development in the treatment of ankylosing spondylitis (AS). However, the increasing use and longer follow-up periods of treatment also pose risks of developing various adverse effects, ranging from common ones, including infections, to uncommon thyroid neoplasms. Adalimumab (ADA), a fully human monoclonal antibody targeted against TNF-?, is indicated for AS. We describe the case of a patient with AS who developed a papillary thyroid carcinoma (PTC) while on therapy with ADA. Cervical lymphadenopathy and a heterogeneous nodule in the right thyroid lobe were detected in the 48-year-old female patient who had been using ADA (40 mg subcutaneously every 2 weeks) for 2 years with the diagnosis of AS. Fine-needle aspiration cytology confirmed PTC. ADA treatment was discontinued, and a total thyroidectomy surgery was performed. We believe that the thyroid gland should also be taken into consideration while screening for malignancy before and during TNF inhibitors (TNFi). has been approved for use in the treatment of AS. However, the use of these agents has been shown to be associated with multiple potential adverse effects (2). TNF inhibitors (TNFi) are known to have rare side effects, including autoimmune conditions that resemble lupus, vasculitis, inflammatory pulmonary disease, sarcoidosis, psoriasis, uveitis, demyelinating neurological conditions, and autoimmune hepatitis. These side effects may also include infections and lymphoma. Rarely, TNFi medications may be linked to thyroid neoplasms (3). We aimed to discuss a case of papillary thyroid carcinoma (PTC) presenting with clinically asymptomatic cervical swelling after 24 months of ADA treatment. © 2023, Acta Endocrinologica Foundation. All rights reserved

Reactive Extraction of Propionic Acid Using Aliquat-336 in 2-Octanol: Linear Solvation Energy Relationship (LSER) Modeling and Kinetics Study

Reactive extraction is an important recovery method for extraction of propionic acid from dilute streams, providing numerous advantages like high selectivity and recovery. Equilibrium and kinetic study of reactive extraction is essential to choose a proper extractant-diluent for acid recovery and ascertain the kinetic parameters essential for design of the process. In this paper, the linear solvation energy relationship (LSER) modeling of reactive extraction of propionic acid using Aliquat 336 in 2-octanol as diluent was presented to obtain the model parameters. Also, the kinetics of extraction in stirred cell was presented to explain the progress of reactive extraction of propionic acid using Aliquat 336 in the diluent. The reaction was found to be fast pseudo first order. To design the reactor to carry out reactive extraction, the kinetic parameters evaluated are essential. Modeling using LSER model predict a close resemblance of experimental data

The densities of fiber follicles in the Karakas, Norduz, and Zom sheep and a comparative analysis

This study aimed to determine the densities of fiber follicles in the skin of the Karakas, Norduz, and Zom sheep breeds and to carry out a comparative analysis between them. The study included a total of 36 animals aged 1-2 years and 3-4 years. Skin samples were obtained through biopsies taken from the right sides of the animals to determine the densities and ratios of the fleece follicles. Examination of these samples revealed that the primary follicle densities of the three sheep breeds (Karakas, Norduz and Zom) were 3.11 ± 0.42, 3.14 ± 0.49 and 3.34 ± 0.59, while the secondary follicle densities were 8.42 ± 1.48, 8.51 ± 1.54 and 6.36 ± 1.44. The secondary to primary (S/P) follicle ratios of the sheep were 2.71 ± 0.70, 2.79 ± 0.69 and 1.85 ± 0.36, respectively. The primary follicle densities of the Karakas, Norduz and Zom sheep were statistically similar for both age groups. The density of secondary follicles and S/P ratio decreased with age in both age groups. The similarity of the S/P ratios to those from other local sheep breeds suggest that Karakas, Norduz, Zom sheep can be included in the sheep group that has coarse fleece

Association between mean platelet volume levels and inflammation in SLE patients presented with arthritis

Background: Systemic lupus erythematosus (SLE) may be characterized by periods of remissions and chronic or acute relapses. The complexity of clinical presentation of the SLE patients leads to incorrect evaluation of disease activity. Mean platelet volume (MPV) has been studied as a simple inflammatory marker in several diseases. There is no study in the literature about MPV levels in adult SLE patients with arthritis.Objectives: We aimed to investigate the MPV levels in the SLE population with arthritis during and between activations.Methods: The study consisted of 44 SLE patients with arthritis in activation period (Group 1), the same 44 SLE patients with arthritis in remission period (Group 2) and 44 healthy controls (Group 3). Erythrocyte sedimentation rate (ESR), creactive protein (CRP), white blood cell count, platelet count, and mean platelet volume (MPV) levels were retrospectively recorded from patient files.Results: The mean ages of the SLE subjects were 42 ± 16 years, while the mean ages of controls was 41 ± 17 years. MPV was significantly lower in Group 1(7.66±0.89fL) than in Group 2 (8.61±1.06 fL) and Group 3(8.62±1.11fL) (p<0.0001). The differences between groups reached statistical significance.Conclusions: We suggest that MPV levels decrease in patients with arthritis of SLE activation when compared to the same patients in remission and healthy controls.Key words: Systemic lupus erythematosus, Arthritis, Mean platelet volum