45 research outputs found
Template-directed synthesis of macrocyclic aminopyridines: azacalix[n](2,6)pyridines (n = 3, 4)
Template-induced synthetic routes for azacalix[n](2,6)pyridines (n = 3, 4) have been elaborated. The proton and nickel ion served as the efficient template for the cyclization reactions, and the presence of the templates preferentially afforded the cyclic trimers and tetramers in moderate to good yields, respectively. The compatibility of the cyclic tetramer with nickel ion was also confirmed by X-ray crystallography
PBLによるプログラミング入門科目の提案:一般情報教育における入門カリキュラムの構築
現代社会において,プログラミングは義務教育の1つとなり,誰もが学ぶべきものとなったが,高等教育においては,プログラミングの内容を含む必須カリキュラムの実施には至っていない.新しいカリキュラムでは,言語を学びコードが書けるようになることを目的とするのではなく,プログラミングの概念を学び,その原理を理解することに加え,プログラムを活用するために,ソフトウェア開発プロジェクトの知識を含める必要があると考えた.著者らは,1科目のみで構成する,誰もが学ぶべき入門レベルのカリキュラムと位置づけ,プログラミング入門にPBL(Project-based Learning)を組み合わせた方法を提案し,この提案に基づき2単位90分15回のカリキュラムを構築した.本論文では,プログラミング入門にPBLを組み合わせたカリキュラムを設計・構築し,実践授業から得られたデータ(コンピテンシー評価,履修者の課題や最終レポートなどの提出物)をもとにカリキュラムの妥当性を検証した.In modern society, programming has become a part of basic education and should be learned by everyone. However, there is still no mandatory, universal, higher-education curriculum that includes programming content. The authors consider that a practical, new curriculum requires not so much having students being able to code, as having them learn concepts, understand principles, and gain knowledge of software development projects in order to build a foundation in programming. We propose a curriculum that includes content required of all people in contemporary society. It is a single-subject, introductory-level curriculum implemented with PBL for a two-credit, ninety-minute, fifteen-class, university-level course. In this paper, we introduce the curriculum that we designed and analyze its validity based on data (competency evaluations, student assignments, final reports, etc.) obtained from the recent practical implementation of the course at a women\u27s university in Japan
Molecular Design of Organic Superbases, Azacalix[3](2,6)pyridines: Catalysts for 1,2- and 1,4-Additions
The molecular design, characteristics, and catalytic
activity of
macrocyclic amino compounds, azacalix[3](2,6)pyridine derivatives,
were studied. The introduction of an electron-donating group on the
pyridine moiety and bridging amino phenyl group enabled the enhancement
of the basicity of azacalix[3](2,6)pyridine up to p<i>K</i><sub>BH<sup>+</sup></sub> = 29.5 in CD<sub>3</sub>CN. These derivatives
were shown to be efficient catalysts for 1,4-addition reactions of
nitroalkanes or primary alcohols to α,β-unsaturated carbonyl
compounds and 1,2-addition reactions of nitroalkanes to aromatic aldehydes