S-particles at their naturalness limits

We draw attention on a particular configuration of supersymmetric particle masses, motivated by naturalness and flavour considerations. All its relevant phenomenological properties for the LHC are described in terms of a few physical parameters, irrespective of the underlying theoretical model. This allows a simple characterization of its main features, useful to define a strategy for its discovery.Comment: 13 pages, 8 figures, added reference

Convolutional architectures for virtual screening

Background: A Virtual Screening algorithm has to adapt to the different stages of this process. Early screening needs to ensure that all bioactive compounds are ranked in the first positions despite of the number of false positives, while a second screening round is aimed at increasing the prediction accuracy. Results: A novel CNN architecture is presented to this aim, which predicts bioactivity of candidate compounds on CDK1 using a combination of molecular fingerprints as their vector representation, and has been trained suitably to achieve good results as regards both enrichment factor and accuracy in different screening modes (98.55% accuracy in active-only selection, and 98.88% in high precision discrimination). Conclusion: The proposed architecture outperforms state-of-the-art ML approaches, and some interesting insights on molecular fingerprints are devised

Anomalous Couplings in Double Higgs Production

The process of gluon-initiated double Higgs production is sensitive to non-linear interactions of the Higgs boson. In the context of the Standard Model, studies of this process focused on the extraction of the Higgs trilinear coupling. In a general parametrization of New Physics effects, however, an even more interesting interaction that can be tested through this channel is the (ttbar hh) coupling. This interaction vanishes in the Standard Model and is a genuine signature of theories in which the Higgs boson emerges from a strongly-interacting sector. In this paper we perform a model-independent estimate of the LHC potential to detect anomalous Higgs couplings in gluon-fusion double Higgs production. We find that while the sensitivity to the trilinear is poor, the perspectives of measuring the new (ttbar hh) coupling are rather promising.Comment: 22 pages, 9 figures. v2: plots of Figs.8 and 9 redone to include experimental uncertainty on the Higgs couplings, references adde

Higgs Low-Energy Theorem (and its corrections) in Composite Models

The Higgs low-energy theorem gives a simple and elegant way to estimate the couplings of the Higgs boson to massless gluons and photons induced by loops of heavy particles. We extend this theorem to take into account possible nonlinear Higgs interactions resulting from a strong dynamics at the origin of the breaking of the electroweak symmetry. We show that, while it approximates with an accuracy of order a few percents single Higgs production, it receives corrections of order 50% for double Higgs production. A full one-loop computation of the gg->hh cross section is explicitly performed in MCHM5, the minimal composite Higgs model based on the SO(5)/SO(4) coset with the Standard Model fermions embedded into the fundamental representation of SO(5). In particular we take into account the contributions of all fermionic resonances, which give sizeable (negative) corrections to the result obtained considering only the Higgs nonlinearities. Constraints from electroweak precision and flavor data on the top partners are analyzed in detail, as well as direct searches at the LHC for these new fermions called to play a crucial role in the electroweak symmetry breaking dynamics.Comment: 30 pages + appendices and references, 12 figures. v2: discussion of flavor constraints improved; references added; electroweak fit updated, results unchanged. Matches published versio

Nontrival Cosmological Constant in Brane Worlds with Unorthodox Lagrangians

In self-tuning brane-world models with extra dimensions, large contributions to the cosmological constant are absorbed into the curvature of extra dimensions and consistent with flat 4d geometry. In models with conventional Lagrangians fine-tuning is needed nevertheless to ensure a finite effective Planck mass. Here, we consider a class of models with non conventional Lagrangian in which known problems can be avoided. Unfortunately these models are found to suffer from tachyonic instabilities. An attempt to cure these instabilities leads to the prediction of a positive cosmological constant, which in turn needs a fine-tuning to be consistent with observations.Comment: 17 pages, 1 figur

The Electric Dipole Moment of the Nucleons in Holographic QCD

We introduce the strong CP-violation in the framework of AdS/QCD model and calculate the electric dipole moments of nucleons as well as the CP-violating pion-nucleon coupling. Our holographic estimate of the electric dipole moments gives for the neutron d_n=1.08 X 10^{-16} theta (e cm), which is comparable with previous estimates. We also predict that the electric dipole moment of the proton should be precisely the minus of the neutron electric dipole moment, thus leading to a new sum rule on the electric dipole moments of baryons.Comment: 22 pages, no figures. v2: A reference and an acknowledgment added. v3: One more reference, to appear in JHE

Probing the minimal length scale by precision tests of the muon g-2

Modifications of the gyromagnetic moment of electrons and muons due to a minimal length scale combined with a modified fundamental scale M_f are explored. Deviations from the theoretical Standard Model value for g-2 are derived. Constraints for the fundamental scale M_f are given.Comment: 4 page

Potential agnostic role of BRCA alterations in patients with several solid tumors: One for all, all for one?

Germline BRCA1/2 alterations in the Homologous Recombination (HR) pathway are considered as main susceptibility biomarkers to Hereditary Breast and Ovarian Cancers (HBOC). The modern molecular biology technologies allowed to characterize germline and somatic BRCA1/2 alterations in several malignancies, broadening the landscape of BRCA1/2-alterated tumors. In the last years, BRCA genetic testing, beyond the preventive value, also assumed a predictive and prognostic significance for patient management. The approval of molecules with agnostic indication is leading to a new clinical model, defined "mutational". Among these drugs, the Poly (ADP)-Ribose Polymerase inhibitors (PARPi) for BRCA1/2-deficient tumors were widely studied leading to increasing therapeutic implications. In this Review we provided an overview of the main clinical studies describing the association between BRCA-mutated tumors and PARPi response, focusing on the controversial evidence about the potential agnostic indication based on BRCA1/2 alterations in several solid tumors

Unification in 5D SO(10)

Gauge unification in a five dimensional supersymmetric SO(10) model compactified on an orbifold $S^1/(Z_2 \times Z_2^{\prime})$ is studied. One orbifolding reduces N=2 supersymmetry to N=1, and the other breaks SO(10) to the Pati-Salam gauge group \ps. Further breaking to the standard model gauge group is made through the Higgs mechanism on one of the branes. The differences of the three gauge couplings run logarithmically even in five dimensions and we can keep the predictability for unification as in four dimensional gauge theories. We obtain an excellent prediction for gauge coupling unification with a cutoff scale $M_* \sim 3 \times 10^{17}$ GeV and a compactification scale $M_c \sim 1.5 \times 10^{14}$ GeV. Finally, although proton decay due to dimension 5 operators may be completely eliminated, the proton decay rate in these models is sensitive to the placement of matter multiplets in the 5th dimension, as well as to the unknown physics above the cutoff scale.Comment: 33 pages, one reference added and fig. 3 caption correcte

Holographic models for undoped Weyl semimetals

We continue our recently proposed holographic description of single-particle correlation functions for four-dimensional chiral fermions with Lifshitz scaling at zero chemical potential, paying particular attention to the dynamical exponent z = 2. We present new results for the spectral densities and dispersion relations at non-zero momenta and temperature. In contrast to the relativistic case with z = 1, we find the existence of a quantum phase transition from a non-Fermi liquid into a Fermi liquid in which two Fermi surfaces spontaneously form, even at zero chemical potential. Our findings show that the boundary system behaves like an undoped Weyl semimetal.Comment: 64 pages, 19 figure