163 research outputs found
A Self Consistent Study of the Phase Transition in the Scalar Electroweak Theory at Finite Temperature
We propose the study of the phase transition in the scalar electroweak theory
at finite temperature by a two - step method. It combines i) dimensional
reduction to a 3-dimensional {\it lattice\/} theory via perturbative blockspin
transformation, and ii) either further real space renormalization group
transformations, or solution of gap equations, for the 3d lattice theory. A gap
equation can be obtained by using the Peierls inequality to find the best
quadratic approximation to the 3d action. % This method avoids the lack of self
consistency of the usual treatments which do not separate infrared and
UV-problems by introduction of a lattice cutoff. The effective 3d lattice
action could also be used in computer simulations.Comment: 3 pages, LaTeX file, contribution to Lattice 9
Data-based modeling of drug penetration relates human skin barrier function to the interplay of diffusivity and free-energy profiles
Based on experimental concentration depth profiles of the antiinflammatory drug dexamethasone in human skin, we model the time-dependent drug penetration by the 1D general diffusion equation that accounts for spatial variations in the diffusivity and free energy. For this, we numerically invert the diffusion equation and thereby obtain the diffusivity and the free-energy profiles of the drug as a function of skin depth without further model assumptions. As the only input, drug concentration profiles derived from X-ray microscopy at three consecutive times are used. For dexamethasone, skin barrier function is shown to rely on the combination of a substantially reduced drug diffusivity in the stratum corneum (the outermost epidermal layer), dominant at short times, and a pronounced free-energy barrier at the transition from the epidermis to the dermis underneath, which determines the drug distribution in the long-time limit. Our modeling approach, which is generally applicable to all kinds of barriers and diffusors, allows us to disentangle diffusivity from free-energetic effects. Thereby we can predict short-time drug penetration, where experimental measurements are not feasible, as well as long-time permeation, where ex vivo samples deteriorate, and thus span the entire timescales of biological barrier functioning
The cross section minima in elastic Nd scattering: a ``smoking gun'' for three nucleon force effects
Neutron-deuteron elastic scattering cross sections are calculated at
different energies using modern nucleon-nucleon interactions and the
Tucson-Melbourne three-nucleon force adjusted to the triton binding energy.
Predictions based on NN forces only underestimate nucleon-deuteron data in the
minima at higher energies starting around 60 MeV. Adding the three-nucleon
forces fills up those minima and reduces the discrepancies significantly.Comment: 11 pages, 6 figure
Quantum Calogero-Moser Models: Integrability for all Root Systems
The issues related to the integrability of quantum Calogero-Moser models
based on any root systems are addressed. For the models with degenerate
potentials, i.e. the rational with/without the harmonic confining force, the
hyperbolic and the trigonometric, we demonstrate the following for all the root
systems: (i) Construction of a complete set of quantum conserved quantities in
terms of a total sum of the Lax matrix (L), i.e. (\sum_{\mu,\nu\in{\cal
R}}(L^n)_{\mu\nu}), in which ({\cal R}) is a representation space of the
Coxeter group. (ii) Proof of Liouville integrability. (iii) Triangularity of
the quantum Hamiltonian and the entire discrete spectrum. Generalised Jack
polynomials are defined for all root systems as unique eigenfunctions of the
Hamiltonian. (iv) Equivalence of the Lax operator and the Dunkl operator. (v)
Algebraic construction of all excited states in terms of creation operators.
These are mainly generalisations of the results known for the models based on
the (A) series, i.e. (su(N)) type, root systems.Comment: 45 pages, LaTeX2e, no figure
Nucleon-deuteron elastic scattering as a tool to probe properties of three-nucleon forces
Faddeev equations for elastic Nd scattering have been solved using modern NN
forces combined with the Tucson-Melbourne two-pion exchange three-nucleon
force, with a modification thereof closer to chiral symmetry and the Urbana IX
three-nucleon force. Theoretical predictions for the differential cross section
and several spin observables using NN forces only and NN forces combined with
three-nucleon force models are compared to each other and to the existing data.
A wide range of energies from 3 to 200 MeV is covered. Especially at the higher
energies striking three-nucleon force effects are found, some of which are
supported by the still rare set of data, some are in conflict with data and
thus very likely point to defects in those three-nucleon force models.Comment: 30 pages, 14 Postscript figures; now minor changes in figures and
reference
Thermal variational principle and gauge fields
A Feynman-Jensen version of the thermal variational principle is applied to
hot gauge fields, Abelian as well as non-Abelian: scalar electrodynamics
(without scalar self-coupling) and the gluon plasma. The perturbatively known
self-energies are shown to derive by variation from a free quadratic
(''Gaussian'') trial Lagrangian. Independence of the covariant gauge fixing
parameter is reached (within the order studied) after a reformulation of
the partition function such that it depends on only even powers of the gauge
field. Also static properties (Debye screening) are reproduced this way. But
because of the present need to expand the variational functional, the method
falls short of its potential nonperturbative power.Comment: 36 pages, LaTeX, no figures. Updated version: new title, section on
static properties and some references adde
Chemotherapy followed by low dose radiotherapy in childhood Hodgkin's disease: retrospective analysis of results and prognostic factors
PURPOSE: To report the treatment results and prognostic factors of childhood patients with Hodgkin's disease treated with chemotherapy (CT) followed by low dose radiotherapy (RT). PATIENTS AND METHODS: This retrospective series analyzed 166 patients under 18 years old, treated from January 1985 to December 2003. Median age was 10 years (range 2–18). The male to female ratio was 2,3 : 1. Lymphonode enlargement was the most frequent clinical manifestation (68%), and the time of symptom duration was less than 6 months in 55% of the patients. In histological analysis Nodular Sclerosis was the most prevalent type (48%) followed by Mixed Celularity (34.6%). The staging group according Ann Arbor classification was: I (11.7%), II (36.4%), III (32.1%) and IV (19.8%). The standard treatment consisted of chemotherapy multiple drug combination according the period of treatment protocols vigent: ABVD in 39% (n-65) of the cases, by VEEP in 13 %(n-22), MOPP in 13 %(n-22), OPPA-13 %(n-22) and ABVD/OPPA in 22 %(n-33). Radiotherapy was device to all areas of initial presentation of disease. Dose less or equal than 21 Gy was used in 90.2% of patients with most part of them (90%) by involved field (IFRT) or mantle field. RESULTS: The OS and EFS in 10 years were 89% and 87%. Survival according to clinical stage as 94.7%, 91.3%, 82.3% and 71% for stages I to IV(p = 0,005). The OS was in 91.3% of patients who received RT and in 72.6% of patients who did not (p = 0,003). Multivariate analysis showed presence of B symptoms, no radiotherapy and advanced clinical stage to be associated with a worse prognosis. CONCLUSION: This data demonstrating the importance of RT consolidation with low dose and reduced volume, in all clinical stage of childhood HD, producing satisfactory ten years OS and EFS. As the disease is highly curable, any data of long term follow-up should be presented in order to better direct therapy, and to identify groups of patients who would not benefit from radiation treatment
Phospholipids and protein adaptation of Pseudomonas sp. to the xenoestrogen tributyltin chloride (TBT)
Pilot evaluation of the Frankfurt Social Skills Training for children and adolescents with autism spectrum disorder
Freiburg Questionnaire of linguistic pragmatics (FQLP): psychometric properties based on a psychiatric sample
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