Jaw biodynamic data for 24 patients with chronic unilateral temporomandibular disorder

This study assessed 24 adult patients, suffering from severe chronic unilateral pain diagnosed as temporomandibular joint (TMJ) disorder (TMD). The full dentate patients had normal occlusion and had never received an occlusal therapy, i.e., were with natural dental evolution/maturation. The following functional and dynamic factors were assessed: (1) chewing function; (2) TMJ remodeling or the condylar path (CP); and (3) lateral jaw motion or lateral guidance (LG). CPs were assessed using conventional axiography, and LG was assessed by K7 jaw tracking. Seventeen (71%) of the 24 (100%) patients consistently showed a habitual chewing side. The mean (standard deviation [SD]) of the CP angles was 47.90 (9.24) degrees. The mean (SD) of the LG angles was 42.95 (11.78) degrees. Data collection emerged from the conception of a new TMD paradigm where the affected side could be the habitual chewing side, the side with flatter lateral jaw motion or the side with an increased CP angle. These data may lead to improved diagnosis, therapy plans and evolution in TMD patients

Improving integrability via absolute summability: a general version of Diestel s Theorem

[EN] A classical result by J. Diestel establishes that the composition of a summing operator with a (strongly measurable) Pettis integrable function gives a Bochner integrable function. In this paper we show that a much more general result is possible regarding the improvement of the integrability of vector valued functions by the summability of the operator. After proving a general result, we center our attention in the particular case given by the -absolutely continuous operators, that allows to prove a lot of special results on integration improvement for selected cases of classical Banach spaces-including C(K), and Hilbert spaces-and operators-p-summing, (q, p)-summing and p-approximable operators.D. Pellegrino acknowledges with thanks the support of CNPq Grant 401735/2013-3 (Brazil). P. Rueda acknowledges with thanks the support of the Ministerio de Economia y Competitividad (Spain) MTM2011-22417. E.A. Sanchez Perez acknowledges with thanks the support of the Ministerio de Economia y Competitividad (Spain) MTM2012-36740-C02-02.Pellegrino, D.; Rueda, P.; Sánchez Pérez, EA. (2016). Improving integrability via absolute summability: a general version of Diestel s Theorem. Positivity. 20(2):369-383. https://doi.org/10.1007/s11117-015-0361-5S369383202Botelho, G., Pellegrino, D., Rueda, P.: A unified Pietsch domination theorem. J. Math. Anal. Appl. 365(1), 269–276 (2010)Defant, A., Floret, K.: Tensor norms and operator ideals. North-Holland, Amsterdam (1992)Diestel, J.: An elementary characterization of absolutely summing operators. Math. Ann. 196, 101–105 (1972)Diestel, J., Jarchow, H., Tonge, A.: Absolutely summing operators. Cambridge University Press, Cambridge (1995)Farmer, J., Johnson, W.B.: Lipschitz p-summing operators. Proc. Amer. Math. Soc. 137, 2989–2995 (2009)Jarchow, H.: Localy convex, spaces. Teubner, Stuttgart (1981)López Molina, J.A., Sánchez Pérez, E.A.: Ideales de operadores absolutamente continuos, Ciencias Exactas, Físicas y Naturales, Madrid. Rev. Real Acad. 87, 349–378 (1993)López Molina, J.A., Sánchez Pérez, E.A.: The associated tensor norm to $$(q, p)$$ ( q , p ) -absolutely summing operators on $$C(K)$$ C ( K ) -spaces. Czec. Math. J. 47(4), 627–631 (1997)López, J.A., Molina, Sánchez-Pérez, E.A.: On operator ideals related to $$(p,\sigma )$$ ( p , σ ) -absolutely continuous operator. Studia Math. 131(8), 25–40 (2000)Matter, U.: Absolute continuous operators and super-reflexivity. Math. Nachr. 130, 193–216 (1987)Pellegrino, D., Santos, J.: A general Pietsch domination theorem. J. Math. Anal. Appl. 375(1), 371–374 (2011)Pellegrino, D., Santos, J., Seoane-Sepúlveda, J.B.: Some techniques on nonlinear analysis and applications. Adv. Math. 229, 1235–1265 (2012)Pietsch, A.: Operator Ideals. Deutsch. Verlag Wiss., Berlin, 1978; North-Holland, Amsterdam-London-New York-Tokyo (1980)Pisier, G.: Factorization of operators through $$L_{p\infty }$$ L p ∞ or $$L_{p1}$$ L p 1 and noncommutative generalizations. Math. Ann. 276(1), 105–136 (1986)Rodríguez, J.: Absolutely summing operators and integration of vector-valued functions. J. Math. Anal. Appl. 316(2), 579–600 (2006

Proinflammatory and Anabolic Gene Expression Effects of Platelet-Rich Gel Supernatants on Equine Synovial Membrane Explants Challenged with Lipopolysaccharide

Platelet-rich plasma (PRP) preparations are used in horses with osteoarthritis (OA). However, some controversies remain regarding the ideal concentration of platelets and leukocytes to produce an adequate anti-inflammatory and anabolic response in the synovial membrane. The aims of this study were to study the influence of leukoconcentrated platelet-rich gel (Lc-PRG) and leukoreduced platelet-rich gel (Lr-PRG) supernatants on the quantitative expression of some proinflammatory and anabolic genes in equine synovial membrane explants (SMEs) challenged with lipopolysaccharide (LPS). SMEs from six horses were cultured over 96 h. Then, SMEs were harvested for RNA extraction and quantitative gene expression analysis by RT-qPCR for nuclear factor kappa B (NFκB), matrix metalloproteinase 13 (MMP-13), a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4), collagen type I alpha 1 (COL1A1), collagen type II alpha 1 (COL2A1), and cartilage oligomeric matrix protein (COMP). The 25% and 50% Lc-PRG supernatants led to downregulation of NFκB, MMP-13, ADAMTS-4, COL1A1, COL2A1, and COMP in SMEs. Lr-PRG supernatants (particularly at the 50% concentration) induced downregulation of NFκB, MMP-13, ADAMTS-4, and COL1A1 and upregulation of COL2A1 and COMP. Lr-PRG supernatants should be used for the treatment of inflammatory arthropathies in horses because they have anti-inflammatory and anabolic effects in the synovial membrane

Presenting signs and patient co-variables in Gaucher disease : outcome of the Gaucher Earlier Diagnosis Consensus (GED-C) Delphi initiative

© 2018 The Authors. Internal Medicine Journal by Wiley Publishing Asia Pty Ltd on behalf of Royal Australasian College of Physicians.Background: Gaucher disease (GD) presents with a range of signs and symptoms. Physicians can fail to recognise the early stages of GD owing to a lack of disease awareness, which can lead to significant diagnostic delays and sometimes irreversible but avoidable morbidities. Aim: The Gaucher Earlier Diagnosis Consensus (GED-C) initiative aimed to identify signs and co-variables considered most indicative of early type 1 and type 3 GD, to help non-specialists identify ‘at-risk’ patients who may benefit from diagnostic testing. Methods: An anonymous, three-round Delphi consensus process was deployed among a global panel of 22 specialists in GD (median experience 17.5 years, collectively managing almost 3000 patients). The rounds entailed data gathering, then importance ranking and establishment of consensus, using 5-point Likert scales and scoring thresholds defined a priori. Results: For type 1 disease, seven major signs (splenomegaly, thrombocytopenia, bone-related manifestations, anaemia, hyperferritinaemia, hepatomegaly and gammopathy) and two major co-variables (family history of GD and Ashkenazi-Jewish ancestry) were identified. For type 3 disease, nine major signs (splenomegaly, oculomotor disturbances, thrombocytopenia, epilepsy, anaemia, hepatomegaly, bone pain, motor disturbances and kyphosis) and one major co-variable (family history of GD) were identified. Lack of disease awareness, overlooking mild early signs and failure to consider GD as a diagnostic differential were considered major barriers to early diagnosis. Conclusion: The signs and co-variables identified in the GED-C initiative as potentially indicative of early GD will help to guide non-specialists and raise their index of suspicion in identifying patients potentially suitable for diagnostic testing for GD.Peer reviewedFinal Published versio

Leptin determination and serum levels in adult alpacas with different body condition

El presente estudio tuvo como objetivo determinar la presencia de la hormona leptina en alpacas adultas, cuantificar sus valores y relacionarlos con la condición corporal. Se utilizaron 36 alpacas hembras adultas, vacías y sin cría, las cuales fueron divididas en dos grupos, según su condición corporal (CC): G1: CC 3.0, de acuerdo a una escala 1 - 5 (1: emaciada, 5: obesa). Se tomaron muestras de sangre por punción de la vena yugular y el suero resultante fue mantenido en congelación a –20 ºC hasta su análisis. La determinación de leptina fue realizada mediante la técnica de radioinmunoensayo (RIA). La media general de la concentración de leptina fue de 17.23 +- 0.81 ng/ml. Los valores encontrados para G1 fueron de 18.14 +- 1.12 ng/ml y para G2: 16.32 +- 1.15 ng/ml, sin diferencias estadísticas entre grupos. Los resultados obtenidos permiten evidenciar la presencia de leptina en alpacas

Hepatocyte Growth Factor Reduces Free Cholesterol-Mediated Lipotoxicity in Primary Hepatocytes by Countering Oxidative Stress

Cholesterol overload in the liver has shown toxic effects by inducing the aggravation of nonalcoholic fatty liver disease to steatohepatitis and sensitizing to damage. Although the mechanism of damage is complex, it has been demonstrated that oxidative stress plays a prominent role in the process. In addition, we have proved that hepatocyte growth factor induces an antioxidant response in hepatic cells; in the present work we aimed to figure out the protective effect of this growth factor in hepatocytes overloaded with free cholesterol. Hepatocytes from mice fed with a high-cholesterol diet were treated or not with HGF, reactive oxygen species present in cholesterol overloaded hepatocytes significantly decreased, and this effect was particularly associated with the increase in glutathione and related enzymes, such as γ-gamma glutamyl cysteine synthetase, GSH peroxidase, and GSH-S-transferase. Our data clearly indicate that HGF displays an antioxidant response by inducing the glutathione-related protection system

Microbial catabolic activities are naturally selected by metabolic energy harvest rate

The fundamental trade-off between yield and rate of energy harvest per unit of substrate has been largely discussed as a main characteristic for microbial established cooperation or competition. In this study, this point is addressed by developing a generalized model that simulates competition between existing and not experimentally reported microbial catabolic activities defined only based on well-known biochemical pathways. No specific microbial physiological adaptations are considered, growth yield is calculated coupled to catabolism energetics and a common maximum biomass-specific catabolism rate (expressed as electron transfer rate) is assumed for all microbial groups. Under this approach, successful microbial metabolisms are predicted in line with experimental observations under the hypothesis of maximum energy harvest rate. Two microbial ecosystems, typically found in wastewater treatment plants, are simulated, namely: (i) the anaerobic fermentation of glucose and (ii) the oxidation and reduction of nitrogen under aerobic autotrophic (nitrification) and anoxic heterotrophic and autotrophic (denitrification) conditions. The experimentally observed cross feeding in glucose fermentation, through multiple intermediate fermentation pathways, towards ultimately methane and carbon dioxide is predicted. Analogously, two-stage nitrification (by ammonium and nitrite oxidizers) is predicted as prevailing over nitrification in one stage. Conversely, denitrification is predicted in one stage (by denitrifiers) as well as anammox (anaerobic ammonium oxidation). The model results suggest that these observations are a direct consequence of the different energy yields per electron transferred at the different steps of the pathways. Overall, our results theoretically support the hypothesis that successful microbial catabolic activities are selected by an overall maximum energy harvest rate

CO-CAVITY pilot survey:Molecular gas and star formation in void galaxies

We present the first molecular gas mass survey of void galaxies. We compare these new data together with data for the atomic gas mass and star formation rate ($\rm SFR$) from the literature to those of galaxies in filaments and walls in order to better understand how molecular gas and star formation are related to the large-scale environment. We observed at the IRAM 30 m telescope the CO(1-0) and CO(2-1) emission of 20 void galaxies selected from the Void Galaxy Survey (VGS), with a stellar mass range from $\rm 10^{8.5}$ to $\rm 10^{10.3}M_{\odot}$. We detected 15 objects in at least one CO line. We compared the molecular gas mass ($M_{\rm H_2}$), the star formation efficiency ($\rm SFE =SFR/M_{\rm H_2}$), the atomic gas mass, the molecular-to-atomic gas mass ratio, and the specific star formation rate (sSFR) of the void galaxies with two control samples of galaxies in filaments and walls, selected from xCOLD GASS and EDGE-CALIFA, for different stellar mass bins and taking the star formation activity into account. The results for the molecular gas mass for a sample of 20 voids galaxies allowed us to make a statistical comparison to galaxies in filaments and walls for the first time.Comment: 24 pages, 15 figures, accepted in A&A, language corrected versio