Supersensitive PSA-Monitored neoadjuvant hormone treatment of clinically localized prostate cancer: Effects on positive margins, tumor detection and epithelial cells in bone marrow

Objective: The present study was done to investigate the effects of supersensitive PSA-controlled inductive treatment on positive margins, detection of tumor and epithelial cells in bone marrow of 101 patients with untreated and clinically localized prostatic carcinoma (cT1-3N0M0). Methods: Hormonal treatment was given until PSA (DPD Immulite(R) third-generation assay) reached 0.3 ng/ml in only 1 case. Of the 101 patients, 82 had a measurable hypoic lesion on initial transrectal ultrasound. 84% of these became smaller, 7.5% remained unchanged and 8.5% increased. Of the 101 prostatectomy specimens, 20 (20%) were margin-positive. The incidence of affected margins was relatively high (35% from 55 patients) with cT3 tumors, but almost negligible (2% from 46 patients) in cT1-2 tumor. Our pathologists, despite their great experience in evaluating hormonally treated prostates (>500 cases) and using immunohistochemical staining, were unable to detect carcinoma in 15 (15%) specimens. Whereas only 2 (4%) of the 55 cT3 specimens were without detectable tumor, this incidence rised to 28% (13 of 46 prostates) in patients with cT1-2 tumors. Of the initial 29 patients with epithelial cells in bone marrow, only 4 (14%) remained positive after controlled induction and all of them had fewer cells than before. Conclusion: Endocrine induction controlled by a supersensitive PSA assay and continued until reaching PSA nadir is highly effective in clearing surgical margins and eliminating tumor cells from bone marrow. It seems to be clearly superior to the conventional 3 months of pretreatment at least in cT1-2 tumors in respect to surgical margins and detectability of tumor in the resected prostate. A definitive statement about the value of endocrine induction can only be given by prospective randomized studies, with optimal drugs, doses and treatment time. But the conventional 3 months of pretreatment are far from exploiting the possibilities of this therapeutic option

The Breathing Mode in Extended Skyrme Model

We study an extended Skyrme model which includes fourth and sixth-order terms. We explore some static properties like the $\Delta$-nucleon mass splitting and investigate the Skyrmion breathing mode in the framework of the linear response theory. We find that the monopole response function has a pronounced peak located at $\sim$ 400 MeV, which we identify to the Roper resonance $N(1440)$. As compared to the standard one, the extended Skyrme model provides a more accurate description of baryon properties.Comment: 12 pages of plain Latex and 3 figures (available from the authors), preprint IPNO/TH 93-0

Renormalization of Hamiltonian Field Theory; a non-perturbative and non-unitarity approach

Renormalization of Hamiltonian field theory is usually a rather painful algebraic or numerical exercise. By combining a method based on the coupled cluster method, analysed in detail by Suzuki and Okamoto, with a Wilsonian approach to renormalization, we show that a powerful and elegant method exist to solve such problems. The method is in principle non-perturbative, and is not necessarily unitary.Comment: 16 pages, version shortened and improved, references added. To appear in JHE

Long-term evolution of an Oligocene/Miocene maar lake from Otago, New Zealand

Foulden Maar is a highly resolved maar lake deposit from the South Island of New Zealand comprising laminated diatomite punctuated by numerous diatomaceous turbidites. Basaltic clasts found in debris flow deposits near the base of the cored sedimentary sequence yielded two new ⁴⁰Ar/³⁹Ar dates of 24.51 ± 0.24 and 23.38 ± 0.24 Ma (2σ). The younger date agrees within error with a previously published ⁴⁰Ar/³⁹Ar date of 23.17 ± 0.19 Ma from a basaltic dyke adjacent to the maar crater. The diatomite is inferred to have been deposited over several tens of thousands of years in the latest Oligocene/earliest Miocene, and may have been coeval with the period of rapid glaciation and subsequent deglaciation of Antarctica known as the Mi-1 event. Sediment magnetic properties and SEM measurements indicate that the magnetic signal is dominated by pseudo-single domain pyrrhotite. The most likely source of detrital pyrrhotite is schist country rock fragments from the inferred tephra ring created by the phreatomagmatic eruption that formed the maar. Variations in magnetic mineral concentration indicate a decrease in erosional input throughout the depositional period, suggesting long-term (tens of thousands of years) environmental change in New Zealand in the latest Oligocene/earliest Miocene

An early Miocene ant (subfam. Amblyoponinae) from Foulden Maar: the first fossil Hymenoptera from New Zealand

The ant subfamily Amblyoponinae is presently represented in New Zealand by one endemic species in the cosmopolitan genus Stigmatomma and an introduced Australian species of Amblyopone. The fossil record of the group is restricted to two species of Stigmatomma from late Eocene Baltic Amber. Here, we describe the third fossil record, an Amblyopone-like specimen from the early Miocene of Otago, southern New Zealand, based on a winged male that resembles the extant A. australis Erichson in size, general habitus and characters of wing venation, but also shares features with the African amblyoponine genus Zymmer. This represents the first fossil record of Amblyoponinae from the Southern Hemisphere and the first example of Hymenoptera among the few pre-Quaternary insect fossils known from New Zealand. It suggests a long history of Amblyoponinae in New Zealand and Australia.Uwe Kaulfuss, Anthony C. Harris, John G. Conran & Daphne E. Le

Davallia (Polypodiales: Davalliaceae) macrofossils from Early Miocene Otago (New Zealand) with in situ spores

Fossil fern fronds referable to the extant fern genus Davallia (Polypodiales: Davalliaceae) bearing sporangia with in situ spores are described from the Early Miocene Foulden Maar diatomite deposit, Otago, New Zealand. The fronds are the first published Southern Hemisphere macrofossil record for the family and provide valuable palaeoclimate data supporting warm conditions in Early Miocene New Zealand. The matching of Davallia fronds to the form spore taxon Polypodiisporites radiatus shows that the genus has had a long, apparently continuous history throughout late Cenozoic New Zealand. © 2010 Elsevier B.V.John G. Conran, Uwe Kaulfuss, Jennifer M. Bannister, Dallas C. Mildenhall and Daphne E. Leehttp://www.elsevier.com/wps/find/journaldescription.cws_home/503359/description#descriptio

A new Miocene fern (Palaeosorum: Polypodiaceae) from New Zealand bearing in situ spores of Polypodiisporites

A new species of fossil fern with in situ spores, Palaeosorum waipiata (Polypodiaceae), is described and figured for a microsoroid fern frond from earliest Miocene sediments in Otago, New Zealand. The fertile frond from the Foulden Maar fossil Lagerstätte is pinnatifid with deep narrow lobes with entire margins and bears circular sori without indusia in rows on either side of the lobe midrib. Monolete spores associated with the frond are differentiated from similar, widespread dispersed spores of Polypodiisporites radiatus in possessing very small proximal verrucae/granulae around the laesurae and more rounded verrucae and the description of Palaeosorum is expanded to include information about sori and spores. This is the first confident Southern Hemisphere record for a microsoroid fern macrofossil, as well as the first with in situ spores. It is probable that this fern was epiphytic on trees or lithophytic on rocks adjacent to the Miocene maar lake.Uwe Kaulfuss, John G. Conran, Jennifer M. Bannister, Dallas C. Mildenhall and Daphne E. Le

Reproductive niche conservatism in the isolated New Zealand flora over 23 million years

Published 15 October 2014The temporal stability of plant reproductive features on islands has rarely been tested. Using flowers, fruits/cones and seeds from a well-dated (23 Ma) Miocene Lagerstätte in New Zealand, we show that across 23 families and 30 genera of forest angiosperms and conifers, reproductive features have remained constant for more than 20 Myr. Insect-, wind- and bird-pollinated flowers and wind- and bird-dispersed diaspores all indicate remarkable reproductive niche conservatism, despite widespread environmental and biotic change. In the past 10 Myr, declining temperatures and the absence of low-latitude refugia caused regional extinction of thermophiles, while orogenic processes steepened temperature, precipitation and nutrient gradients, limiting forest niches. Despite these changes, the palaeontological record provides empirical support for evidence from phylogeographical studies of strong niche conservatism within lineages and biomes.John G. Conran, William G. Lee, Daphne E. Lee, Jennifer M. Bannister and Uwe Kaulfus