How the equitable sharing of benefits from genetic resources can contribute to fairness and innovation

The Sustainable Development Goals (SDGs) take a holistic approach, recognising that human and environmental wellbeing are inextricably linked. SDG 1 – No poverty – expands the vision of poverty reduction to go beyond economic resources and include also the na- tural resources on which the poor depend. Agricultural biodiversity is one natural resource pool that poor farmers have always relied on in fact farmers are the people who developed the thousands of crop varieties we know today, which provide nutritious diets and support low-input farming systems. Even though farmers developed these genetic resources, and depend upon them, their rights over them and the traditional knowledge associated with them are not always recognised and the ensuing benefits are not always shared fairly and equitably. Two SDG targets directly address fair and equitable sharing of benefits from genetic resources and traditional knowledge: 2.5 Zero hunger, and 15.6 Life on land. Additionally, several international treaties govern the use of agricultural genetic resources: The Interna- tional Treaty on Plant Genetic Resources for Food and Agriculture, the Nagoya Protocol of the Convention on Biological Diversity, and the International Union for the Protection of New Varieties of Plaunts (UPOV) Convention. National governments also have their own laws. Into this mix, farmers and private sector companies bring their own perspectives and interests of what is fair, what is equitable and what is necessary to spur agricultural innova- tion. In some cases, different views about what fair and equitable treatment means divide actors who should be working together. But there are also examples of where heightened emphasis on promoting equity and fairness has contributed to successful outcomes. My remarks will discuss how to bring successful local practices to national and international levels; how to bring international legal commitments on access and benefit sharing to local levels; and how to engage the private sector at the local, national and international level

SEEKING AGRICULTURAL COMPETITIVENESS THROUGH TRADE NEGOTIATIONS: WANTING DOESN'T MAKE IT SO

International Relations/Trade,

Market Access

The negotiation of improved market access in agriculture is crucial to the success of the Doha Round. The depth of tariff cuts will be the main indication of the level of ambition of the agricultural talks and hence the Round as a whole. Agricultural tariffs remain five times higher than tariffs in industrial goods, and account for the bulk of the distortions in agricultural trade. Recent analysis indicates that 92 percent of the global gains from trade liberalization in agriculture result from removing market access barriers. The July Framework reaffirmed the objective of substantial improvements in market access. This is to be accomplished by a single approach, a tiered (or banded) formula for tariff cuts, with the higher tariff rates being subject to the highest cuts. Negotiations have centered on how many bands to select, where to place the thresholds, and how progressive to make the band-specific reductions. The issue of whether to impose a tariff cap was left undecided in the Framework Agreement. Tariff caps have the advantage of reducing tariffs that are so high that they are little different from an import ban. If the cap is set at a low enough level, real trade improvements may follow. The Framework Agreement specifies that each Member may identify in the schedule a number of products as "Sensitive Products." However, analysis has shown that even exempting as little as two percent of tariff lines from formula based cuts would substantially reduce the expected gains from market access improvements. This points up the need for significant increases in TRQs for Sensitive Products to achieve significant improvements in market access. All tariff lines subject to TRQs, whether or not they are classified as Sensitive Products, should be subject to quota volume expansion. Improving the administration of TRQs and reducing in-quota tariffs are both important objectives for the Doha Round. There is considerable scope to improve the efficiency and transparency of quota regimes. The continued availability of the Special Safeguard for Agriculture by WTO members "remains under negotiation." But abuse of such a safeguard in order to protect domestic producers thwarts the objective of improved market access. Some limitations will need to be introduced if the safeguard is to be continued under the new agreement. The Framework Agreement emphasizes that Special and Differential Treatment is to be an integral part of the market access outcome. This can be ensured by several provisions. Developing countries can specify a number of products as Special Products, based on criteria of food security, livelihood security and rural development needs. The difficulty is in devising concrete criteria for selecting these products. The Framework Agreement also endorses the creation of a Special Safeguard Mechanism for developing countries. Tariff cuts in the Doha Round can erode the value of preferences and can have important consequences for some countries. Preference-granting countries could offset the declining value of those preferences either through financial transfers or additional market access for all products from the current preferred exporters. Least Developed Countries (LDCs) should not be required to undertake any reduction commitments, though they might wish to do so for their own economic advantage. Developed countries should provide duty- and quota-free access to LDCs to encourage full integration into the trade system.International Relations/Trade,

Implicit Theories of Ability and Self-Efficacy: Testing Alternative Social Cognitive Models to Science Motivation

Our overall goal was to empirically test what we called the “growth mindset as inoculation” hypothesis using a series of latent profile analytical approaches. This inoculation hypothesis, which is consistent with the way in which Dweck and Leggett (1988) described their social cognitive approach, states that believing in the malleability of intelligence serves a protective role against negative motivational and achievement outcomes. Participants were Grade 6 students (n = 504) from a middle school and Grade 10 students (n = 354) from two high schools in the Southeastern part of the United States. Two distinct patterns emerged, which corresponded to a growth mindset profile, and an all moderate profile. Our findings did not completely confirm or disconfirm the inoculation hypothesis – rather, a more nuanced conclusion should be drawn. Although there was evidence that the growth mindset profile evinced more adaptive outcomes compared to the all moderate alternative, which reinforced Dweck and Leggett’s claims, there was no evidence of any profiles with a distinct fixed theory of ability. This was true even when we forced our data to conform to such a model. Results refine Dweck and Leggett’s social cognitive approach to motivation

Poly-Pattern Compressive Segmentation of ASTER Data for GIS

Pattern-based segmentation of multi-band image data, such as ASTER, produces one-byte and two-byte approximate compressions. This is a dual segmentation consisting of nested coarser and finer level pattern mappings called poly-patterns. The coarser A-level version is structured for direct incorporation into geographic information systems in the manner of a raster map. GIs renderings of this A-level approximation are called pattern pictures which have the appearance of color enhanced images. The two-byte version consisting of thousands of B-level segments provides a capability for approximate restoration of the multi-band data in selected areas or entire scenes. Poly-patterns are especially useful for purposes of change detection and landscape analysis at multiple scales. The primary author has implemented the segmentation methodology in a public domain software suite

RGS10 shapes the hemostatic response to injury through its differential effects on intracellular signaling by platelet agonists.

Platelets express ≥2 members of the regulators of G protein signaling (RGS) family. Here, we have focused on the most abundant, RGS10, examining its impact on the hemostatic response in vivo and the mechanisms involved. We have previously shown that the hemostatic thrombi formed in response to penetrating injuries consist of a core of fully activated densely packed platelets overlaid by a shell of less-activated platelets responding to adenosine 5\u27-diphosphate (ADP) and thromboxane A2 (TxA2). Hemostatic thrombi formed in RGS10-/- mice were larger than in controls, with the increase due to expansion of the shell but not the core. Clot retraction was slower, and average packing density was reduced. Deleting RGS10 had agonist-specific effects on signaling. There was a leftward shift in the dose/response curve for the thrombin receptor (PAR4) agonist peptide AYPGKF but no increase in the maximum response. This contrasted with ADP and TxA2, both of which evoked considerably greater maximum responses in RGS10-/- platelets with enhanced Gq- and Gi-mediated signaling. Shape change, which is G13-mediated, was unaffected. Finally, we found that free RGS10 levels in platelets are actively regulated. In resting platelets, RGS10 was bound to 2 scaffold proteins: spinophilin and 14-3-3γ. Platelet activation caused an increase in free RGS10, as did the endothelium-derived platelet antagonist prostacyclin. Collectively, these observations show that RGS10 serves as an actively regulated node on the platelet signaling network, helping to produce smaller and more densely packed hemostatic thrombi with a greater proportion of fully activated platelets

Diabetogenic polypeptide from human pituitaries similar to that excreted by proteinuric diabetic patients

A polypeptide exhibiting diabetogenic and antiinsulin properties has been isolated from human pituitary glands by a procedure slightly modified from that with which a similar polypeptide was previously isolated from the adenohypophysis of cattle, sheep and pigs. The isoelectric point of the compound is approximately pH 4.1 which is the same as that of the compound isolated from the adenohypophysis of the other three species and from urine of patients with lipoatrophic diabetes and proteinuric diabetics without lipoatrophy. Administration of 1 mg polypeptide per kilogram of body weight to dogs resulted in significant intolerance to glucose and resistance to exogenous insulin 10 and 34 hours after injection. Comparison of glucose tolerance tests in the same animals discloses that the diabetogenic potency of the substance from human pituitaries is much greater than that of human growth hormone or ovine prolactin. The molecular weight of the substance as determined by the dodecyl sulfate-polyacrylamide gel electrophoresis method is 20,600. A modified procedure for the isolation and purification of the polypeptide has been outlined.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/34180/1/0000469.pd

Motivation and Beliefs about the Nature of Scientific Knowledge Within an Immersive Virtual Ecosystems Environment

We explored Grade 6 students‘ (n = 202) self-efficacy, epistemic beliefs, and science interest over a 10-day virtual ecology curriculum. Pre- and post-surveys were administered, and analyses revealed that (1) students became more self-efficacious about inquiring scientifically after participating in the activity; (2) students on average evinced a shift toward more constructivist views about the role of authority in justifying scientific claims; (3) students who identified more strongly with being a science person evinced greater gains in self efficacy, developed a less constructivist view about the role of authority in justifying claims, and became more interested in science overall; and (4) students who held an incremental theory of ability evinced greater gains in self-efficacy. We discuss the implications of these findings for science educators and instructional designers in the design and use of immersive virtual worlds for middle school science students

Trends in the Salience of Data Collected in a Multi User Virtual Environment: an Exploratory Study

In this study, by exploring patterns in the degree of physical salience of the data the students collected, I investigated the relationship between the level of students’ tendency to frame explanations in terms of complex patterns and evidence of how they attend to and select data in support of their developing understandings of causal relationships. I accomplished this by analyzing longitudinal data collected as part of a larger study of 143 7th grade students (clustered within 36 teams, 5 teachers, and 2 schools in the same Northeastern school district) as they navigated and collected data in an ecosystems-based multi-user virtual environment curriculum known as the EcoMUVE Pond module (Metcalf, Kamarainen, Tutwiler, Grotzer, Dede, 2011) . Using individual growth modeling (Singer & Willett, 2003) I found no direct link between student pre-intervention tendency to offer explanations containing complex causal components and patterns of physical salience-driven data collection (average physical salience level, number of low physical salience data points collected, and proportion of low physical salience data points collected), though prior science content knowledge did affect the initial status and rate of change of outcomes in the average physical salience level and proportion of low physical salience data collected over time. The findings of this study suggest two issues for consideration about the use of MUVEs to study student data collection behaviors in complex spaces. Firstly, the structure of the curriculum in which the MUVE is embedded might have a direct effect on what types of data students choose to collect. This undercuts our ability to make inferences about student-driven decisions to collect specific types of data, and suggests that a more open-ended curricular model might be better suited to this type of inquiry. Secondly, differences between teachers’ choices in how to facilitate the units likely contribute to the variance in student data collection behaviors between students with different teachers. This foreshadows external validity issues in studies that use behaviors of students within a single class to develop “detectors” of student latent traits (e.g., Baker, Corbett, Roll, Koedinger, 2008)