The effective evidence-based high school librarian: a journey to decision.

This thesis aims to establish how high school librarians in Scotland and America can become effective evidence-based decision-makers. Initial data collection consisted of written questionnaires to elicit background data from librarians on the extent of their evidence-based practice. Three main themes emerged: collaboration; interprofessional relationships and roles; and decision-making. These themes are discussed in more detail. A range of qualitative methodologies was designed and implemented to gain more in-depth information on practice and viewpoints, involving librarians and stakeholders. A draft model was created of the effective evidence-based practitioner in a high school library, based on an interpretation of findings and readings from the literature. After member-checking and validating by stakeholders, a final model was produced. This emergent model focuses not on the role of the school librarian in isolation, but stresses the importance of interrelationships involving the librarian. The study makes an original contribution to knowledge by giving a better understanding of the effective evidence-based high school librarian in the wider context of education. There is also a contribution to knowledge by adding to the general theory of workplace decision-making and evidence-based practice which is applicable outwith the school sector, and the pragmatic solution-driven model of decision-making is introduced. Key findings give an insight into the complexity of the school library situation, and highlights that ideally there will be positive relationships between school management, school librarian and collaboration. When these come together, it can mean an increase in student achievement, and more effective evidence-based decisions can be made. Findings also demonstrate links between these elements with evidence, national bodies and skills and qualities needed to be an effective evidence-based high school librarian, and identify how the new and complex expectations made of school librarians can be met. Recommendations are made to help stakeholders improve practice

Use of prenatal testing, emotional attachment to the fetus and fetal health locus of control

This study examines the relationship between maternal emotional attachment to the fetus, beliefs about fetal health locus of control, and use of prenatal testing (i.e., amniocentesis and maternal serum screening). To date, no research has directly addressed the link between these psychosocial variables and prenatal testing uptake. Ninety-one pregnant women at risk for fetal abnormalities (i.e., 35 years of age or older) participated in the study, of whom 35 had no testing, 27 had serum screening, and 29 had amniocentesis in their current pregnancy. Results of a hierarchical multiple regression partially supported the hypothesis that internal and powerful others Fetal Health Locus of Control (Labs & Wurtele, 1986) and prenatal testing status would be predictive of attachment (Prenatal Attachment Inventory; Muller, 1993) over and above the effects of gestational age, maternal age and attitude toward abortion. Fetal Health Locus of Control beliefs regarding one’s own role (FHLC-I) in determining the health of one’s fetus were found to be predictive of prenatal attachment. Results failed to support the hypothesis that the role of health professionals (FHLC-P) would be predictive of prenatal attachment. As predicted, women who had not used prenatal testing or who underwent amniocentesis tended to have stronger prenatal attachment than those who underwent serum screening only. Results supported the hypotheses that stronger attachment to the fetus would be positively correlated with both FHLC-I and FHLC-P scores. Women who had no testing were found to hold less favourable attitudes toward abortion and rate their religious as stronger than those who had amniocentesis. Emotional attachment to the fetus was stronger among women who had previous miscarriages than those who had not, but did not differ between women who had a previous abortion and those who had not

The Importance of Being Earnestly Independent

Article published in the Michigan State Law Review

CaRMS at 50: Making the match for medical education

Entry into postgraduate medical training in Canada is facilitated through a national application and matching system which establishes matches between applicants and training programs based on each party’s stated preferences. Health human resource planning in Canada involves many factors, influences, and decisions. The complexity of the system is due, in part, to the fact that much of the decision making is dispersed among provincial, territorial, regional, and federal jurisdictions, making a collaborative national approach a challenge. The national postgraduate application and matching system is one of the few aspects of the health human resources continuum that is truly pan-Canadian. This article examines the evolution of the application and matching system over the past half century, the values that underpin it, and CaRMS' role in the process

Early Buddhists and urban centers : narrative representations of Pataliputra, Rajagrha and Kusavati in the Pali Canon

While it is often said that Buddhism is an "urban religion" or a "product of an urban revolution", the actual relationship between Buddhists and the urban space of ancient India remains somewhat vague. This is in part due to a lack of evidence. In order to understand the connection of early Buddhism to the urban environment in which it seems to have arisen we need to carefully examine what source are available, including archaeological evidence and textual sources like the Pali Canon. By looking at the narratives concerning the cities of Pâtaliputra, Râjagrha and Kusâvati in the Buddhist texts of the Pali Canon, I will provide a clearer view of how the Buddhist religious community imagined its relationship to urban space. Three elements will provide the focus of this endeavour: firstly, the narratives of the physical urban space in the texts; secondly, the comparison of that description with available archaeological evidence relating to that physical space; and thirdly, the analysis of what the textual evidence indicates about the authors perceived relationship with that physical space

Process Kinetics of Transient Liquid Phase

The problem of inadequate measurement techniques for quantifying the isothermal solidification process during transient liquid phase sintering (TLPS) in binary isomorphous systems such as Ni-Cu, and the resulting uncertainty regarding the solidification mechanism and its sensitivity to important process parameters, has been investigated. A unique combination of differential scanning calorimetry (DSC), neutron diffraction (ND), and metallographic techniques has enabled the quantitative characterization of important TLPS stages (i.e., solid-state sintering, melting and dissolution, isothermal solidification, and homogenization) as well as verifying the re-melt behaviour of post-sintered specimens and measuring variable melting point (VMP) properties. This has resulted in the advancement of the fundamental understanding of liquid formation and its removal mechanism during isothermal, or diffusional, solidification. The Ni-Cu system was chosen for experimentation due to its commercial relevance as a braze filler material and also because it is an ideal model system (due to its isomorphous character) that is not well understood on a quantitative or phenomenological basis. Samples consisted of elemental Ni and Cu powder mixtures of varying particle size and composition. In DSC experiments, the progress of isothermal solidification was determined by measuring the enthalpy of melting and solidification after isothermal hold periods of varying length and comparing these to the measured enthalpy of pure Cu. The low melting enthalpies measured for all Ni/Cu mixtures heated just past the Cu melting point (1090°C) indicate that solid-state sintering and interdiffusion during heat-up significantly suppress initial liquid formation and densification from the wetting liquid. For samples heated well past the Cu melting point (1140°C), Ni dissolution causes increased initial liquid fractions and densification. It was found that significantly more time was required for complete liquid removal at 1140°C vs. 1090°C. This is attributed to the observed increase in initial liquid fractions formed at higher processing temperatures due to the dissolution of Ni. This effectively counteracts the increased diffusivities at these temperatures, and thus more time is required to completely remove the increased liquid content. TLP mixtures sintered at 1140°C using three different particle sizes revealed that fine base metal Ni particles cause high degrees of solid-state interdiffusion during heat-up, small initial liquid fractions, and accelerated liquid removal rates due to high surface area/volume ratios. A diffusion-based analytical model was developed to account for these effects (i.e., particle size, temperature, solid-state sintering, and dissolution). Comparison with experimental DSC results reveals that this model can accurately predict liquid removal given accurate diffusivities. Metallographic analysis of post-sintered DSC specimens via SEM and EDS indicates that isothermal liquid solidification leaves behind Ni-rich cores surrounded by Cu-rich matrix regions having compositions given by the Ni-Cu phase diagram solidus (CS) at a selected isothermal processing temperature (TP). ND experiments were used to investigate the melting event and interdiffusion during the isothermal hold segment by analyzing the evolution of the {200} FCC peaks of Ni and Cu. ND patterns were collected in situ at 1 minute intervals during prolonged sintering cycles for larger powder specimens. The Cu melting event was characterized by an abrupt decrease in Cu peak intensity at 1085°C as well as a shift towards higher 2 angles corresponding to lower Cu contents. This shifted residual peak (hereafter referred to as the CS peak) originates from regions of the specimen having compositions near solidus at TP. Immediately following the melting event, the evolution of ND patterns shows that these CS peaks grow rapidly, indicating the isothermal growth of a Cu-rich phase. These in situ findings confirmed the metallographic and DSC data and indicated that isothermal solidification of the liquid phase proceeds via the growth of a solute-rich solid solution layer surrounding the Ni particles. This occurs by the transient progression of the solid/liquid interface at compositions given by the liquidus and solidus (CS/CL). During sintering, diffraction intensities gradually increased at intermediate 2 angles between previous Ni and Cu peaks. ND patterns gradually evolved from initially having a broad double-peak profile to a sharper single-peak profile due to increased Ni-Cu interdiffusion. The 2position and width of the post-sintered peaks indicated very homogeneous sintered alloys. Metallographic analysis of post-sintered specimens having undergone prolonged sintering and homogenization revealed extensive Kirkendall pore formation from unequal diffusivities (DCu > DNi). In this study, the unique combination of diffusion-based modelling as well as DSC, ND, and supporting metallographic analysis has enabled the identification of characteristic sintering behaviour, important process parameters, and processing windows for TLPS in Ni-Cu systems. Quantitative and in situ information of this nature is absent in the previous TLPS literature

Expanding the genotypic spectrum of Jalili syndrome: Novel CNNM4 variants and uniparental isodisomy in a north American patient cohort

Jalili syndrome is a rare multisystem disorder with the most prominent features consisting of cone‐rod dystrophy and amelogenesis imperfecta. Few cases have been reported in the Americas. Here we describe a case series of patients with Jalili syndrome examined at the National Eye Institute’s Ophthalmic Genetics clinic between 2016 and 2018. Three unrelated sporadic cases were systematically evaluated for ocular phenotype and determined to have cone‐rod dystrophy with bull’s eye maculopathy, photophobia, and nystagmus. All patients had amelogenesis imperfecta. Two of these patients had Guatemalan ancestry and the same novel homozygous CNNM4 variant (p.Arg236Trp c.706C > T) without evidence of consanguinity. This variant met likely pathogenic criteria by the American College of Medical Genetics guidelines. An additional patient had a homozygous deleterious variant in CNNM4 (c.279delC p.Phe93Leufs*31), which resulted from paternal uniparental isodisomy for chromosome 2p22‐2q37. This individual had additional syndromic features including developmental delay and spastic diplegia, likely related to mutations at other loci. Our work highlights the genotypic variability of Jalili syndrome and expands the genotypic spectrum of this condition by describing the first series of patients seen in the United States.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154406/1/ajmga61484_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154406/2/ajmga61484.pd

Development and validation of the Psychological Adaptation Scale (PAS): Use in six studies of adaptation to a health condition or risk

We introduce The Psychological Adaptation Scale (PAS) for assessing adaptation to a chronic condition or risk and present validity data from six studies of genetic conditions

The Relevance of Marine Chemical Ecology to Plankton and Ecosystem Function: An Emerging Field

Marine chemical ecology comprises the study of the production and interaction of bioactive molecules affecting organism behavior and function. Here we focus on bioactive compounds and interactions associated with phytoplankton, particularly bloom-forming diatoms, prymnesiophytes and dinoflagellates. Planktonic bioactive metabolites are structurally and functionally diverse and some may have multiple simultaneous functions including roles in chemical defense (antipredator, allelopathic and antibacterial compounds), and/or cell-to-cell signaling (e.g., polyunsaturated aldehydes (PUAs) of diatoms). Among inducible chemical defenses in response to grazing, there is high species-specific variability in the effects on grazers, ranging from severe physical incapacitation and/or death to no apparent physiological response, depending on predator susceptibility and detoxification capability. Most bioactive compounds are present in very low concentrations, in both the producing organism and the surrounding aqueous medium. Furthermore, bioactivity may be subject to synergistic interactions with other natural and anthropogenic environmental toxicants. Most, if not all phycotoxins are classic secondary metabolites, but many other bioactive metabolites are simple molecules derived from primary metabolism (e.g., PUAs in diatoms, dimethylsulfoniopropionate (DMSP) in prymnesiophytes). Producing cells do not seem to suffer physiological impact due to their synthesis. Functional genome sequence data and gene expression analysis will provide insights into regulatory and metabolic pathways in producer organisms, as well as identification of mechanisms of action in target organisms. Understanding chemical ecological responses to environmental triggers and chemically-mediated species interactions will help define crucial chemical and molecular processes that help maintain biodiversity and ecosystem functionality