Optical properties of a light-emitting polymer directly patterned by soft lithography

Copyright © 2002 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Applied Physics Letters 81 (2002) and may be found at http://link.aip.org/link/?APPLAB/81/1955/1We present the optical properties of a directly patterned light-emitting polymer. The patterned poly(2-methoxy-5-(3',7'-dimethyloctyloxy)-paraphenylenevinylene film is fabricated using hot embossing lithography. The effect of the embossed microstructure on the light emitted from the polymer is examined by measuring the angle-dependent photoluminescence and its photonic band structure. The imposed grating modifies the emitted light by Bragg scattering into free space light that would otherwise be trapped as waveguide modes. This simple patterning technique may find application in improving the performance of light-emitting polymer devices

Single cell induced optical confinement in biological lasers

We acknowledge financial support from the European Research Council (ERC StG ABLASE, 640012), the Scottish Funding Council (via SUPA) and the European Union Marie Curie Career Integration Grant (PCIG12-GA-2012-334407). M.K. acknowledges funding from the EPSRC DTG (EP/M506631/1). M.S. acknowledges funding from the European Commission for a Marie Sklodowska-Curie Individual Fellowship (659213). I.D.W.S. acknowledges funding from a Royal Society Wolfson research merit award.Biological single cell lasers have shown great potential for fundamental research and next generation sensing applications. In this study, the potential of fluorescent biological cells as refractive index landscapes and active optical elements is investigated using a combined Fourier- and hyperspectral imaging technique. We show that the refractive index contrast between cell and surrounding leads to three dimensional confinement of photons inside living cells. The Fourier- and real-space emission characteristics of these biological lasers are closely related and can be predicted from one another. Investigations of the lasing threshold for different energy and momentum position in Fourier-space give insight into the fundamental creation of longitudinal and transverse lasing modes within the cell. These findings corroborate the potential of living biological materials for precision engineering of photonic structures and may pave the way towards low threshold polariton lasing from single cells.Publisher PDFPeer reviewe

Phase diagrams of correlated electrons: systematic corrections to the mean field theory

Perturbative corrections to the mean field theory for particle-hole instabilities of interacting electron systems are computed within a scheme which is equivalent to the recently developed variational approach to the Kohn-Luttinger superconductivity. This enables an unbiased comparison of particle-particle and particle-hole instabilities within the same approximation scheme. A spin-rotation invariant formulation for the particle-hole instabilities in the triplet channel is developed. The method is applied to the phase diagram of the t-t' Hubbard model on the square lattice. At the Van Hove density, antiferromagnetic and d-wave Pomeranchuk phases are found to be stable close to half filling. However, the latter phase is confined to an extremely narrow interval of densities and away from the singular filling, d-wave superconducting instability dominates

Micromegas TPC studies at high magnetic fields using the charge dispersion signal

The International Linear Collider (ILC) Time Projection Chamber (TPC) transverse space-point resolution goal is 100 microns for all tracks including stiff 90 degree tracks with the full 2 meter drift. A Micro Pattern Gas Detector (MPGD) readout TPC can achieve the target resolution with existing techniques using 1 mm or narrower pads at the expense of increased detector cost and complexity. The new MPGD readout technique of charge dispersion can achieve good resolution without resorting to narrow pads. This has been demonstrated previously for 2 mm x 6 mm pads with GEMs and Micromegas in cosmic ray tests and in a KEK beam test in a 1 Tesla magnet. We have recently tested a Micromegas-TPC using the charge dispersion readout concept in a high field super-conducting magnet at DESY. The measured Micromegas gain was found to be constant within 0.5% for magnetic fields up to 5 Tesla. With the strong suppression of transverse diffusion at high magnetic fields, we measure a flat 50 micron resolution at 5 Tesla over the full 15 cm drift length of our prototype TPC.Comment: 7 pages, 3 figure

Pricing and hedging of Asian options: Quasi-explicit solutions via Malliavin calculus

We use Malliavin calculus and the Clark-Ocone formula to derive the hedging strategy of an arithmetic Asian Call option in general terms. Furthermore we derive an expression for the density of the integral over time of a geometric Brownian motion, which allows us to express hedging strategy and price of the Asian option as an analytic expression. Numerical computations which are based on this expression are provided

Partitioning the components of Relative Growth Rate: how important is plant size variation?

Plant growth plays a key role in the functioning of the terrestrial biosphere, and there have been substantial efforts to understand why growth varies among species. To this end, a large number of experimental analyses have been undertaken; however, the emergent patterns between growth rate and its components are often contradictory. We believe that these conflicting results are a consequence of the way growth is measured. Growth is typically characterized by relative growth rate (RGR); however, RGR often declines as organisms get larger, making it difficult to compare species of different sizes. To overcome this problem, we advocate using nonlinear mixed-effects models so that RGR can be calculated at a standard size, and we present easily implemented methods for doing this. We then present new methods for analyzing the traditional components of RGR that explicitly allow for the fact that log (RGR) is the sum of its components. These methods provide an exact decomposition of the variance in log (RGR). Finally, we use simple analytical and simulation approaches to explore the effect of size variation on growth and its components and show that the relative importance of the components of RGR is influenced by the extent to which analyses standardize for plant size

Searching for Earth analogues around the nearest stars: the disk age-metallicity relation and the age distribution in the Solar Neighbourhood

The chemical composition of Earth's atmosphere has undergone substantial evolution over the course of its history. It is possible, even likely, that terrestrial planets in other planetary systems have undergone similar changes; consequently, the age distribution of nearby stars is an important consideration in designing surveys for Earth-analogues. Valenti & Fischer (2005) provide age and metallicity estimates for 1039 FGK dwarfs in the Solar Neighbourhood. Using the Hipparcos catalogue as a reference to calibrate potential biases, we have extracted volume-limited samples of nearby stars from the Valenti-Fischer dataset. Unlike other recent investigations, our analysis shows clear evidence for an age-metallicity relation in the local disk, albeit with substantial dispersion at any epoch. The mean metallicity increases from -0.3 dex at a lookback time of ~10 Gyrs to +0.15 dex at the present day. Supplementing the Valenti-Fischer measurements with literature data to give a complete volume-limited sample, the age distribution of nearby FGK dwarfs is broadly consistent with a uniform star-formation rate over the history of the Galactic disk. In striking contrast, most stars known to have planetary companions are younger than 5 Gyrs; however, stars with planetary companions within 0.4 AU have a significantly flatter age distribution, indicating that those systems are stable on timescales of many Gyrs. Several of the older, lower metallicity host stars have enhanced [alpha/Fe] ratios, implying membership of the thick disk. If the frequency of terrestrial planets is also correlated with stellar metallicity, then the median age of such planetary system is likely to be ~3 Gyrs. We discuss the implications of this hypothesis in designing searches for Earth analogues among the nearby stars.Comment: Accepted for publication in Ap

Mycoplasma hyopneumoniae resides intracellularly within porcine epithelial cells

© 2018, The Author(s). Enzootic pneumonia incurs major economic losses to pork production globally. The primary pathogen and causative agent, Mycoplasma hyopneumoniae, colonises ciliated epithelium and disrupts mucociliary function predisposing the upper respiratory tract to secondary pathogens. Alleviation of disease is reliant on antibiotics, vaccination, and sound animal husbandry, but none are effective at eliminating M. hyopneumoniae from large production systems. Sustainable pork production systems strive to lower reliance on antibiotics but lack of a detailed understanding of the pathobiology of M. hyopneumoniae has curtailed efforts to develop effective mitigation strategies. M. hyopneumoniae is considered an extracellular pathogen. Here we show that M. hyopneumoniae associates with integrin β1 on the surface of epithelial cells via interactions with surface-bound fibronectin and initiates signalling events that stimulate pathogen uptake into clathrin-coated vesicles (CCVs) and caveosomes. These early events allow M. hyopneumoniae to exploit an intracellular lifestyle by commandeering the endosomal pathway. Specifically, we show: (i) using a modified gentamicin protection assay that approximately 8% of M. hyopneumoniae cells reside intracellularly; (ii) integrin β1 expression specifically co-localises with the deposition of fibronectin precisely where M. hyopneumoniae cells assemble extracellularly; (iii) anti-integrin β1 antibodies block entry of M. hyopneumoniae into porcine cells; and (iv) M. hyopneumoniae survives phagolysosomal fusion, and resides within recycling endosomes that are trafficked to the cell membrane. Our data creates a paradigm shift by challenging the long-held view that M. hyopneumoniae is a strict extracellular pathogen and calls for in vivo studies to determine if M. hyopneumoniae can traffic to extrapulmonary sites in commercially-reared pigs