Status of Chiral-Scale Perturbation Theory

Chiral-scale perturbation theory $\chi$PT$_\sigma$ has been proposed as an alternative to chiral $SU(3)_L\times SU(3)_R$ perturbation theory which explains the $\Delta I = 1/2$ rule for kaon decays. It is based on a low-energy expansion about an infrared fixed point in three-flavor QCD. In $\chi$PT$_\sigma$, quark condensation $\langle\bar q q \rangle_\mathrm{vac} \neq 0$ induces nine Nambu-Goldstone bosons: $\pi, K, \eta$ and a QCD dilaton $\sigma$ which we identify with the $f_0(500)$ resonance. Partial conservation of the dilatation and chiral currents constrains low-energy constants which enter the effective Lagrangian of $\chi$PT$_\sigma$. These constraints allow us to obtain new phenomenological bounds on the dilaton decay constant via the coupling of $\sigma/f_0$ to pions, whose value is known precisely from dispersive analyses of $\pi\pi$ scattering. Improved predictions for $\sigma \to \gamma \gamma$ and the $\sigma NN$ coupling are also noted. To test $\chi$PT$_\sigma$ for kaon decays, we revive a 1985 proposal for lattice methods to be applied to $K \to \pi$ on-shell.Comment: 10 pages, 1 figure. Presented at the 8th International Workshop on Chiral Dynamics, 29 June 2015 - 03 July 2015, Pisa, Italy. Revision: references and comment adde

The Aesthetic Uncanny: Staging Dorian Gray

This article discusses my theatrical adaptation of Oscar Wilde's The Picture of Dorian Gray (1891) for the Edinburgh Festival Fringe (2008). Freud's concept of the uncanny (1919) was treated as a purely aesthetic phenomenon and related to late nineteenth century social and literary preoccupations such as Christianity, the supernatural and glamorous, criminal homosexuality. These considerations led to a conceptual ground plan that allowed for experiments during rehearsal in a form of theatrical shorthand

ΔI=1/2\Delta I=1/2 rule for kaon decays derived from QCD infrared fixed point

This article gives details of our proposal to replace ordinary chiral $SU(3)_L\times SU(3)_R$ perturbation theory $\chi$PT$_3$ by 3-flavor chiral-scale perturbation theory $\chi$PT$_\sigma$. In $\chi$PT$_\sigma$, amplitudes are expanded at low energies and small $u,d,s$ quark masses about an infrared fixed point $\alpha^{}_\mathrm{IR}$ of 3-flavor QCD. At $\alpha^{}_\mathrm{IR}$, the quark condensate $\langle \bar{q}q\rangle_{\mathrm{vac}} \not= 0$ induces nine Nambu-Goldstone bosons: $\pi, K, \eta$ and a $0^{++}$ QCD dilaton $\sigma$. Physically, $\sigma$ appears as the $f_{0}(500)$ resonance, a pole at a complex mass with real part $\lesssim m_K$. The $\Delta I=1/2$ rule for nonleptonic $K$-decays is then a consequence of $\chi$PT$_\sigma$, with a $K_S\sigma$ coupling fixed by data for $\gamma\gamma\rightarrow\pi\pi$ and $K_{S} \to \gamma\gamma$. We estimate $R_\mathrm{IR} \approx 5$ for the nonperturbative Drell-Yan ratio $R = \sigma(e^{+}e^{-}\rightarrow\mathrm{hadrons})/ \sigma(e^{+}e^{-}\rightarrow\mu^{+}\mu^{-})$ at $\alpha^{}_\mathrm{IR}$, and show that, in the many-color limit, $\sigma/f_0$ becomes a narrow $q\bar{q}$ state with planar-gluon corrections. Rules for the order of terms in $\chi$PT$_\sigma$ loop expansions are derived in Appendix A, and extended in Appendix B to include inverse-power Li-Pagels singularities due to external operators. This relates to an observation that, for $\gamma\gamma$ channels, partial conservation of the dilatation current is not equivalent to $\sigma$-pole dominance.Comment: 20 pages, 11 figures. This article is an expanded version of the letter arXiv:1203.1321 (2012). v4: Fig. 1 moved to second page to match PRD formatting, minor changes to text and reference

Nasal Lipopolysaccharide Challenge and Cytokine Measurement Reflects Innate Mucosal Immune Responsiveness

<div><p>Background</p><p><b>P</b>ractical methods of monitoring innate immune mucosal responsiveness are lacking. Lipopolysaccharide (LPS) is a component of the cell wall of Gram negative bacteria and a potent activator of Toll-like receptor (TLR)-4. To measure LPS responsiveness of the nasal mucosa, we administered LPS as a nasal spray and quantified chemokine and cytokine levels in mucosal lining fluid (MLF).</p><p>Methods</p><p>We performed a 5-way cross-over, single blind, placebo-controlled study in 15 healthy non-atopic subjects (n = 14 <i>per protocol</i>). Doses of ultrapure LPS (1, 10, 30 or 100μg/100μl) or placebo were administered by a single nasal spray to each nostril. Using the recently developed method of nasosorption with synthetic adsorptive matrices (SAM), a series of samples were taken. A panel of seven cytokines/chemokines were measured by multiplex immunoassay in MLF. mRNA for intercellular cell adhesion molecule-1 (ICAM-1) was quantified from nasal epithelial curettage samples taken before and after challenge.</p><p>Results</p><p>Topical nasal LPS was well tolerated, causing no symptoms and no visible changes to the nasal mucosa. LPS induced dose-related increases in MLF levels of IL-1β, IL-6, CXCL8 (IL-8) and CCL3 (MIP-1α) (AUC at 0.5 to 10h, compared to placebo, p<0.05 at 30 and 100μg LPS). At 100μg LPS, IL-10, IFN-α and TNF-α were also increased (p<0.05). Dose-related changes in mucosal ICAM-1 mRNA were also seen after challenge, and neutrophils appeared to peak in MLF at 8h. However, 2 subjects with high baseline cytokine levels showed prominent cytokine and chemokine responses to relatively low LPS doses (10μg and 30μg LPS).</p><p>Conclusions</p><p>Topical nasal LPS causes dose-dependent increases in cytokines, chemokines, mRNA and cells. However, responsiveness can show unpredictable variations, possibly because baseline innate tone is affected by environmental factors. We believe that this new technique will have wide application in the study of the innate immune responses of the respiratory mucosa.</p><p>Key Messages</p><p>Ultrapure LPS was used as innate immune stimulus in a human nasal challenge model, with serial sampling of nasal mucosal lining fluid (MLF) by nasosorption using a synthetic absorptive matrix (SAM), and nasal curettage of mucosal cells. A dose response could be demonstrated in terms of levels of IL-1β, IL-6, CXCL8 and CCL3 in MLF, as well as ICAM-1 mRNA in nasal curettage specimens, and levels of neutrophils in nasal lavage. Depending on higher baseline levels of inflammation, there were occasional magnified innate inflammatory responses to LPS.</p><p>Trial Registration</p><p>Clinical Trials.gov <a href="https://clinicaltrials.gov/ct2/show/NCT02284074?term=nasal+lipopolysaccharide&rank=1" target="_blank">NCT02284074</a></p></div

An enhanced compressor sub-idle map generation method

Several techniques have come about for the mathematical extrapolation of compressor maps from the idle region down to zero speed. Relatively little work has been done on methods which attempt to extract compressor sub - idle performance from physical grounds. This paper focuses on the design of an axial compressor rig to obtain sub - idle data in the form of locked rotor and windmill characteristics. The rig design is presented and the results obtained discussed. The data gathered is used to generate physics - based sub - idle compressor maps which are then compared to existing method s for sub - idle map generation. Interpolation from the locked rotor characteristic is shown to improve map generation over extrapolation methodologies, while the windmilling characteristic is shown to be an important addition to the interpolation process

Media outlets and their moguls: why concentrated individual or family ownership is bad for editorial independence

This article investigates the levels of owner influence in 211 different print and broadcast outlets in 32 different European media markets. Drawing on the literature from industrial organisation, it sets out reasons why we should expect greater levels of influence where ownership of individual outlets is concentrated; where it is concentrated in the hands of individuals or families; and where ownership groups own multiple outlets in the same media market. Conversely, we should expect lower levels of influence where ownership is dispersed between transnational companies. The articles uses original data on the ownership structures of these outlets, and combines it with reliable expert judgments as to the level of owner influence in each of the outlets. These hypotheses are tested and confirmed in a multilevel regression model of owner influence. The findings are relevant for policy on ownership limits in the media, and for the debate over transnational versus local control of media

Metallization of Fluid Hydrogen

The electrical resistivity of liquid hydrogen has been measured at the high dynamic pressures, densities and temperatures that can be achieved with a reverberating shock wave. The resulting data are most naturally interpreted in terms of a continuous transition from a semiconducting to a metallic, largely diatomic fluid, the latter at 140 GPa, (ninefold compression) and 3000 K. While the fluid at these conditions resembles common liquid metals by the scale of its resistivity of 500 micro-ohm-cm, it differs by retaining a strong pairing character, and the precise mechanism by which a metallic state might be attained is still a matter of debate. Some evident possibilities include (i) physics of a largely one-body character, such as a band-overlap transition, (ii) physics of a strong-coupling or many-body character,such as a Mott-Hubbard transition, and (iii) processes in which structural changes are paramount.Comment: 12 pages, RevTeX format. Figures available on request; send mail to: [email protected] To appear: Philosophical Transaction of the Royal Society

Comparison of Howland and General Impedance Converter (GIC) circuit based current sources for bio-impedance measurements

The current source is a key component in bio-impedance measurement systems. The accuracy of the current source can be measured in terms of its output impedance together with other parameters, with certain applications demanding extremely high output impedance. This paper presents an investigation and comparison of different current source designs based on the Enhanced Howland circuit combined with a General Impedance Converter (GIC) circuit using both ideal and non-ideal operational amplifiers. Under differing load conditions two different settings of the GIC are evaluated and the results are compared to show its performance settings. Whilst the study has shown that over a wide bandwidth (i.e. 100Hz-100MHz) the output impedance is limited, operation over a more limited range offers output impedance in the Giga-ohm range, which can be considered as being infinite