The Swift X-ray Telescope Cluster Survey III: Cluster Catalog from 2005-2012 Archival Data

We present the Swift X-ray Cluster Survey (SWXCS) catalog obtained using archival data from the X-ray telescope (XRT) on board the Swift satellite acquired from 2005 to 2012, extending the first release of the SWXCS. The catalog provides positions, soft fluxes, and, when possible, optical counterparts for a flux-limited sample of X-ray group and cluster candidates. We consider the fields with Galactic latitude |b| > 20 degree to avoid high HI column densities. We discard all of the observations targeted at groups or clusters of galaxies, as well as particular extragalactic fields not suitable to search for faint extended sources. We finally select ~3000 useful fields covering a total solid angle of ~400 degree^2. We identify extended source candidates in the soft-band (0.5-2keV) images of these fields using the software EXSdetect, which is specifically calibrated for the XRT data. Extensive simulations are used to evaluate contamination and completeness as a function of the source signal, allowing us to minimize the number of spurious detections and to robustly assess the selection function. Our catalog includes 263 candidate galaxy clusters and groups down to a flux limit of 7E-15 erg/cm^2/s in the soft band, and the logN-logS is in very good agreement with previous deep X-ray surveys. The final list of sources is cross-correlated with published optical, X-ray, and SZ catalogs of clusters. We find that 137 sources have been previously identified as clusters, while 126 are new detections. Currently, we have collected redshift information for 158 sources (60% of the entire sample). Once the optical follow-up and the X-ray spectral analysis of the sources are complete, the SWXCS will provide a large and well-defined catalog of groups and clusters of galaxies to perform statistical studies of cluster properties and tests of cosmological models.Comment: 41 pages, 16 figures, 3 tables, published on ApJS in Jan 201

Traumi oculari al pronto soccorso oculistico. Ricerca condotta presso la Clinica Oculistica del Policlinico Umberto I di Roma su 81.825 casi in 10 anni. La prevenzione è sempre fondamentale per evitare danni oculari.

Abstract Obiettivo Determinare gli esiti funzionali a distanza dei traumi oculari gravi contusivi e perforanti che hanno necessitato di intervento chirurgico. Metodi Studio retrospettivo, effettuato tra gennaio 2003 e marzo 2013, di 672 pazienti con macrotraumi oculari, giunti al Pronto Soccorso (PS) della Clinica Oculistica, Dipartimento di Oftalmologia del Policlinico Umberto I di Roma. In particolare abbiamo focalizzato l’attenzione sui pazienti con traumi oculari contusivi o “a bulbo chiuso” e perforanti (ferite, corpo estraneo intraoculare – CEIO –, scoppio del bulbo) o “a bulbo aperto”. Risultati Il numero degli accessi per trauma è stato di 81.825 in 10 anni, di cui 672 (0,82%) con un macrotrauma che ha necessitato di intervento medico e chirurgico. Più frequenti (445; 66,18%) i traumi contusivi rispetto ai perforanti (227; 33,82%). Dei perforanti, 105 (46,3%) hanno avuto uno scoppio del bulbo che, assieme ai CEIO (67; 29,7%), sono le principali cause di prognosi infausta per l’occhio traumatizzato. Tra le complicanze più frequenti ci sono state, in ordine, quelle corneali (abrasioni ecc.) (94,2%), l’ipoema (86,3%) e la commotio retinae (edema di Berlin, 85,8%). Gli esiti funzionali a 6 mesi sono variati da visus normale (≤10/10 e >6/10) in 441 pazienti (65,7%), fino a cecità assoluta (MM, PL, NPL) in 57 pazienti (8,3%). L’OTS (ocular trauma score) e la tempestività d’intervento sono risultati essere un indice prognostico importante. Conclusioni Gli esiti funzionali (acuità visiva finale)dei traumi oculari contusivi e perforanti sono incrementabili con l’adeguatezza e la tempestività dell’intervento chirurgico del trauma in sé e delle complicanze che possono presentarsi contemporaneamente o successivamente. I traumi costituiscono una delle principali cause di ipovisione o cecità monoculare nei soggetti giovani adulti

Rest-Frame UV-Optical Selected Galaxies at 2.3 ≾ z ≾ 3.5: Searching for Dusty Star-forming and Passively Evolving Galaxies

A new set of color selection criteria (VJL) analogous with the BzK method is designed to select both star-forming galaxies (SFGs) and passively evolving galaxies (PEGs) at 2.3 ≾ z ≾ 3.5 by using rest-frame UV-optical (V – J versus J – L) colors. The criteria are thoroughly tested with theoretical stellar population synthesis models and real galaxies with spectroscopic redshifts to evaluate their efficiency and contamination. We apply the well-tested VJL criteria to the HST/WFC3 Early Release Science field and study the physical properties of selected galaxies. The redshift distribution of selected SFGs peaks at z ~ 2.7, slightly lower than that of Lyman break galaxies at z ~ 3. Comparing the observed mid-infrared fluxes of selected galaxies with the prediction of pure stellar emission, we find that our VJL method is effective at selecting massive dusty SFGs that are missed by the Lyman break technique. About half of the star formation in massive (M_(star) > 10^(10) M_☉) galaxies at 2.3 ≾ z ≾ 3.5 is contributed by dusty (extinction E(B – V) > 0.4) SFGs, which, however, only account for ~20% of the number density of massive SFGs. We also use the mid-infrared fluxes to clean our PEG sample and find that galaxy size can be used as a secondary criterion to effectively eliminate the contamination of dusty SFGs. The redshift distribution of the cleaned PEG sample peaks at z ~ 2.5. We find six PEG candidates at z > 3 and discuss possible methods to distinguish them from dusty contamination. We conclude that at least part of our candidates are real PEGs at z ~ 3, implying that these types of galaxies began to form their stars at z ≳ 5. We measure the integrated stellar mass density (ISMD) of PEGs at z ~ 2.5 and set constraints on it at z > 3. We find that the ISMD grows by at least about a factor of 10 in 1 Gyr at 3 < z <5 and by another factor of 10 in the next 3.5 Gyr (1 < z < 3)

The Progenitors of the Compact Early-Type Galaxies at High-Redshift

We use GOODS and CANDELS images to identify progenitors of massive (log M > 10 Msun) compact "early-type" galaxies (ETGs) at z~1.6. Since merging and accretion increase the size of the stellar component of galaxies, if the progenitors are among known star-forming galaxies, these must be compact themselves. We select candidate progenitors among compact Lyman-break galaxies at z~3 based on their mass, SFR and central stellar density and find that these account for a large fraction of, and possibly all, compact ETGs at z~1.6. We find that the average far-UV SED of the candidates is redder than that of the non-candidates, but the optical and mid-IR SED are the same, implying that the redder UV of the candidates is inconsistent with larger dust obscuration, and consistent with more evolved (aging) star-formation. This is in line with other evidence that compactness is a sensitive predictor of passivity among high-redshift massive galaxies. We also find that the light distribution of both the compact ETGs and their candidate progenitors does not show any extended "halos" surrounding the compact "core", both in individual images and in stacks. We argue that this is generally inconsistent with the morphology of merger remnants, even if gas-rich, as predicted by N-body simulations. This suggests that the compact ETGs formed via highly dissipative, mostly gaseous accretion of units whose stellar components are very small and undetected in the HST images, with their stellar mass assembling in-situ, and that they have not experienced any major merging until the epoch of observations at z~1.6.Comment: 25 pages, 20 figures; Accepted for publication in Ap

The interstellar medium and feedback in the progenitors of the compact passive galaxies at z~2

Quenched galaxies at z>2 are nearly all very compact relative to z~0, suggesting a physical connection between high stellar density and efficient, rapid cessation of star-formation. We present restframe UV spectra of Lyman-break galaxies (LBGs) at z~3 selected to be candidate progenitors of quenched galaxies at z~2 based on their compact restframe optical sizes and high surface density of star-formation. We compare their UV properties to those of more extended LBGs of similar mass and star formation rate (non-candidates). We find that candidate progenitors have faster ISM gas velocities and higher equivalent widths of interstellar absorption lines, implying larger velocity spread among absorbing clouds. Candidates deviate from the relationship between equivalent widths of Lyman-alpha and interstellar absorption lines in that their Lyman-alpha emission remains strong despite high interstellar absorption, possibly indicating that the neutral HI fraction is patchy such that Lyman-alpha photons can escape. We detect stronger CIV P-Cygni features (emission and absorption) and HeII emission in candidates, indicative of larger populations of metal rich Wolf-Rayet stars compared to non-candidates. The faster bulk motions, broader spread of gas velocity, and Lyman-alpha properties of candidates are consistent with their ISM being subject to more energetic feedback than non-candidates. Together with their larger metallicity (implying more evolved star-formation activity) this leads us to propose, if speculatively, that they are likely to quench sooner than non-candidates, supporting the validity of selection criteria used to identify them as progenitors of z~2 passive galaxies. We propose that massive, compact galaxies undergo more rapid growth of stellar mass content, perhaps because the gas accretion mechanisms are different, and quench sooner than normally-sized LBGs at these early epochs.Comment: Accepted for publication in the Astrophysical Journa

VizieR Online Data Catalog: SWXCS III. Cluster catalog from 2005-2012 Swift data (Liu+, 2015)

From the entire Swift XRT archive in the period 2005 February-2012 November, we select all the fields that can be used to build an unbiased, serendipitous X-ray cluster catalog

Apulian infectious diseases network: survey on the prevalence of delta infection among chronic HBV carriers in Apulia

BackgroundThe current prevalence and clinical burden of Hepatitis Delta Virus (HDV) infection in Apulia are unknown. This study aimed to define the current epidemiological scenario of delta infection and to detect difficulties in the diagnosis and clinical management of HDV patients in Apulia.MethodsFrom May to September 2022, a fact-finding survey was conducted at eight Infectious Diseases Units of the Apulian region; each Unit was asked to complete a questionnaire on screening and diagnosis of HDV infection and demographic, virological, and clinical characteristics of HDV patients.ResultsA total of 1,461 HBsAg-positive subjects were followed up on an outpatient basis. Screening for HDV ranged from 30 to 90% of HBsAg + carriers in a single center. Overall, 952 HBsAg ± subjects (65%) were tested for HDV, and 80/952 (8.4%) were anti-HDV positive. Serum HDV RNA was detected only in 15/80 (19%) anti-HDV-positive subjects, and 12/15 patients (80%) were viremic. Sixty-five anti-HDV-positive subjects (81%) were from Italy; risk factors for HDV acquisition included the presence of HDV infection in the family (29/80 = 36%), drug addiction (12/80 = 15%), and co-infection with HCV or HIV (7/80 = 9%). Liver cirrhosis and hepatocellular carcinoma were diagnosed in 41 (51%) and 4 (5%) patients, respectively. Fifty-seven patients (71%) received nucleos(t)ide analog treatment.ConclusionsThe results of this survey show that HDV screening is variable and insufficient, thus real prevalence data on delta infection are lacking in Apulia. Moreover, the HDV RNA test is not available in most laboratories and is not provided by the national health system. These results underline the need for an organizational model to optimize the management of HDV patients throughout the Apulian region

Defective proteasome biogenesis into skin fibroblasts isolated from Rett syndrome subjects with {MeCP}2 non-sense mutations

Rett Syndrome (RTT) is a rare X-linked neurodevelopmental disorder which affects about 1: 10000 live births. In &gt;95% of subjects RTT is caused by a mutation in Methyl-CpG binding protein-2 (MECP2) gene, which encodes for a transcription regulator with pleiotropic genetic/epigenetic activities. The molecular mechanisms underscoring the phenotypic alteration of RTT are largely unknown and this has impaired the development of therapeutic approaches to alleviate signs and symptoms during disease progression. A defective proteasome biogenesis into two skin primary fibroblasts isolated from RTT subjects harbouring non-sense (early-truncating) MeCP2 mutations (i.e., R190fs and R255X) is herewith reported. Proteasome is the proteolytic machinery of Ubiquitin Proteasome System (UPS), a pathway of overwhelming relevance for post-mitotic cells metabolism. Molecular, transcription and proteomic analyses indicate that MeCP2 mutations down-regulate the expression of one proteasome subunit, α7, and of two chaperones, PAC1 and PAC2, which bind each other in the earliest step of proteasome biogenesis. Furthermore, this molecular alteration recapitulates in neuron-like SH-SY5Y cells upon silencing of MeCP2 expression, envisaging a general significance of this transcription regulator in proteasome biogenesis

Impact of safety-related dose reductions or discontinuations on sustained virologic response in HCV-infected patients: Results from the GUARD-C Cohort

BACKGROUND: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. METHODS: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA <50 IU/mL) were conducted in 951 Caucasian, noncirrhotic genotype (G)1 patients assigned to peginterferon alfa-2a/ribavirin for 48 weeks. The probability of SVR24 was identified by a baseline scoring system (range: 0-9 points) on which scores of 5 to 9 and <5 represent high and low probability of SVR24, respectively. RESULTS: SVR24 rates were 46.1% (754/1634), 77.1% (279/362), 68.0% (514/756), and 51.3% (203/396), respectively, in G1, 2, 3, and 4 patients. Overall, 16.9% and 21.8% patients experienced 651 sr-RD for peginterferon alfa and ribavirin, respectively. Among Caucasian noncirrhotic G1 patients: female sex, lower body mass index, pre-existing cardiovascular/pulmonary disease, and low hematological indices were prognostic factors of sr-RD; SVR24 was lower in patients with 651 vs. no sr-RD by Week 4 (37.9% vs. 54.4%; P = 0.0046) and Week 12 (41.7% vs. 55.3%; P = 0.0016); sr-RD by Week 4/12 significantly reduced SVR24 in patients with scores <5 but not 655. CONCLUSIONS: In conclusion, sr-RD to peginterferon alfa-2a/ribavirin significantly impacts on SVR24 rates in treatment-naive G1 noncirrhotic Caucasian patients. Baseline characteristics can help select patients with a high probability of SVR24 and a low probability of sr-RD with peginterferon alfa-2a/ribavirin

Color and Stellar Population Gradients in Passively Evolving Galaxies at z~2 from HST/WFC3 Deep Imaging in the Hubble Ultra Deep Field

We report the detection of color gradients in six massive (stellar mass > 10^{10} M_{sun}) and passively evolving (specific SFR < 10^{-11}/yr) galaxies at redshift 1.3<z<2.5 identified in the HUDF using HST ACS and WFC3/IR images. After matching different PSFs, we obtain color maps and multi-band optical/near-IR photometry (BVizYJH) in concentric annuli, from the smallest resolved radial (~1.7 kpc) up to several times the H-band effective radius. We find that the inner regions of these galaxies have redder rest-frame UV--optical colors than the outer parts. The slopes of the color gradients mildly depend on the overall dust obscuration and rest-frame (U-V) color, with more obscured or redder galaxies having steeper color gradients. The z~2 color gradients are also steeper than those of local early-types. The gradient of a single parameter (age, extinction or metallicity) cannot fully explain the observed color gradients. Fitting spatially resolved HST seven-band photometry to stellar population synthesis models, we find that, regardless of assumptions for metallicity gradient, the redder inner regions of the galaxies have slightly higher dust obscuration than the bluer outer regions, although the magnitude depends on the assumed extinction law. The derived age gradient depends on the assumptions for metallicity gradient. We discuss the implications of a number of assumptions for metallicity gradient on the formation and evolution of these galaxies. We find that the evolution of the mass--size relationship from z~2 to z~0 cannot be driven by in--situ extended star formation, implying that accretion or merger is mostly responsible for the evolution. The lack of a correlation between color gradient and stellar mass argues against the metallicity gradient predicted by the monolithic collapse, which would require significant major mergers to evolve into the one observed at z~0. (Abridged)Comment: Minor changes to address referee's comments, accepted by Ap