Familial Mediterranean fever, from pathogenesis to treatment: a contemporary review

Familial Mediterranean fever (FMF) (OMIM #249100) is the most common hereditary autoinflammatory disease in the world. FMF is caused by gain of function mutations of MEFV gene which encodes an immune regulatory protein, pyrin. Over the last few years, we have witnessed several new developments in the pathogenesis, genetic testing, diagnosis, comorbidities, disease related damage and treatment approaches to FMF. Elucidation of some of the pathogenic mechanisms has led to the discovery of pathways involved in inflammatory, metabolic, cardiovascular and degenerative diseases. The use of next generation sequencing in FMF has revealed many new gene variants whose clinical significance may be clarified by developing functional assays and biomarkers. Clinically, although FMF is considered an episodic disease characterized by brief attacks, recent systematic studies have defined several associated chronic inflammatory conditions. Colchicine is the mainstay of FMF treatment, and interleukin (IL)-1 antagonists are the treatment of choice in refractory or intolerant cases. Experience of IL-1 antagonists, anakinra and canakinumab, is now available in thousands of colchicine resistant or intolerant FMF patients. In this contemporary review, we surveyed current FMF knowledge in the light of these recent advances

Stopping Power Calculations of Compounds by Using Thomas-Fermi-Dirac-Weizsäcker Density Functional

Electronic stopping power of compounds was calculated by using the Thomas-Fermi-Dirac-Weizsäcker density functional. Bragg's rule was employed to determine stopping power of compounds from the elemental stopping power results. Calculations were done for Be, B, O, and Si ions in Al 2 O 3 , SiO 2 , and CO 2 targets by using the Thomas-Fermi-Dirac-Weizsäcker density functional. The obtained results were compared with other ThomasFermi based theoretical calculations and show that using Thomas-FermiDirac-Weizsäcker density functional in stopping power calculations yields reasonably accurate results in especially light systems (with respect to the number of electrons in the system)

Use of a Global Positioning System (GPS) to Manage Extensive Sheep Farming and Pasture Land

The terrestrial climate is not sufficient to produce enough food to meet the roughage needs of the animals benefiting from the pasture lands because of excessive and early grazing of those areas. Plant growth is adversely affected in pastures that are not uniformly grazed. Tracking animals using the Global Positioning System (GPS) is a very important factor in determining the uniform distribution of grazing animals in a pasture, increasing the utilization rate of the pasture, and saving costs and time. With GPS tracking systems, establishing more effective pasture-use systems by monitoring the feeding regimes of small animals, the status of feed in the pasture, and the grazing behavior of the animals would be possible. The present study aimed to investigate the use of GPS for pasture and herd management in Turkey in addition to using the traditional techniques.In the present study conducted in the village of Köseyusuflu in Yozgat Province in May 2017, 2018, and 2019, grazing benefits that were determined from the pasture containing two Akkaraman sheep herds were recorded using GPS tracking devices. The results suggested that the area covered with vegetation along the sheep’s spring grazing routes varied between 43.6 and 62.9%, the ratio of legumes in the pasture grass in the low grazing areas was between 0.50 and 4.10%, and the grass species were between 12.75 and 44.50%. We determined that the sheep in herd A traveled between 7.6 and 9.9 km, while the sheep in herd B traveled between 4.7 and 5.7 km daily, and the two herds grazed an average of between 122 and 254 daa

Subclinical immune reactions to viral infections may correlate with child and adolescent diagnosis of attention-deficit/hyperactivity disorder: A preliminary study from Turkey

Background: Attention-Deficit/Hyperactivity Disorder (ADHD) is one of the most common neuro-developmental disorders of childhood and  adolescence. Studies focusing on the relationship of infectious agents and ADHD are scarce. It is also known that cerebellar injury may lead to  hyperactive behavior. This study aimed to evaluate the relationship  between viral agents of cerebellitis and the diagnosis of ADHD.Methods: The study group was formed of 60 consecutive ADHD patients and 30 healthy children. IgG levels for VZV; HSV-1, CMV, Measles, Mumps, Rubella and EBV were evaluated.Results: Males were significantly higher among patients with ADHD (65% vs. 40%, p=0.025). Patients with ADHD displayed significantly higher positivity for measles IgG (80% vs. 60%, p=0.044). When patients with ADHD were classified according to their pubertal status, adolescents with ADHD displayed higher positivity for mumps (100% vs. 74.4%, p=0.043). Most of the patients were diagnosed with ADHD-Combined or  Hyperactive/Impulsive Subtypes (56.6%) while 43.3% were diagnosed with ADHD-predominantly inattentive type. When patients with subtypes of ADHD were compared in terms of seropositivity, it was found that patients with ADHD-Combined/ Hyperactive-Impulsive subtypes had significantly elevated reactions for Rubella (100% vs. 88.5%, p=0.044).Conclusion: Although limited to a single center and may be prone to sampling biases, our results may support the notion that immune reactions may be related with ADHD among children and adolescents. Further,  prospective studies from multiple centers are needed to support our  findings and establish causality.Key words: ADHD, infection, immunology, measles, rubella, mumps, Ig

State of the Knowledge for Gender in Breeding: Case Studies for Practitioners

Debates around gender-responsive agricultural research, particularly plant and animal breeding, invariably circulate around similar topics: the recognition that considering gender is important to developing varieties that lead to equitable benefits, coupled with questions around an evidence base that proves this point. Without convincing evidence—exemplified by case studies across commodities and countries—our arguments for gender-responsive research fall on deaf ears. This synthesis seeks to compile available cases from two workshops organized by the CGIAR Gender and Agriculture Research Network: “Gender, Breeding and Genomics” (18–21 October 2016) and “Innovation in Gender-Responsive Breeding” (5–7 October 2017). While by no means comprehensive, with these 10 cases we hope to emphasize the point that considering gender in breeding program design, working with women in the breeding process, and acting on these findings can have dramatic consequences on breeding programs. We begin the synthesis by setting the scene with a chapter reflecting on how taking gender into account matters for the success of plant or animal breeding programs with welfare or development goals and a focus on smallholders. This chapter illustrates how the use of a conceptual framework for gender analysis can help breeding programs make sense of gender-differentiated traits and tease out the likely impact of taking gender into account in program-level policies and strategies. The following case studies are structured around steps of a plant breeding cycle (see Figure 1.1), examining cases that consider gender in setting breeding priorities, selection, testing experimental varieties, and seed production and distribution. The cases cover a wide range of commodities: beans, cassava, forage grasses, poultry, maize, sorghum, matooke, barley, and groundnuts. Although cases mostly focus on sub-Saharan Africa (Nigeria, Mali, Tanzania, Uganda, Ethiopia, Malawi), we also present cases from China and Syria. What is particularly compelling about these cases is that they not only provide evidence that men and women have different trait preferences; access to resources; or opportunities to engage in production, processing, and marketing of diverse commodities. They also illustrate steps taken by breeding programs to address these issues. These steps range from incorporating “cooking time” as a must-have trait in bean breeding to creating opportunities for maize seed production and sale for women; from changing the structure of matooke breeding programs to add participatory processing for food quality, new breeding targets for adaptation, to nutrient poor soils in sorghum. These are powerful illustrations and positive examples that documenting differences is a means to an end—the real focus should be on change. The synthesis ends with a chapter drawing lessons from the case studies for future action aiming to integrate gender and gender analysis in breeding. We hope that these cases, together with the companion publications from the GBI on design principles1, gender and social targeting2, breeding decisions3, and uptake pathways4, compel and challenge breeding programs to become truly gender responsive

Effects of Vitamin D levels on asthma control and severity in pre-school children

OBJECTIVE: Prevalence of asthma and Vitamin D deficiency has been increasing and leading to significant morbidities. This study aimed to compare the Vitamin D levels in the pre-school children with asthma and in healthy controls and to assess the relationship between Vitamin D levels and asthma clinical parameters and control. PATIENTS AND METHODS: Vi tamin D [25(OH)D3] levels were measured in 102 preschool children, aged 1-4 years with asthma and 102 healthy controls in winter. The patients with asthma were grouped according to serum Vitamin D levels as sufficient, insufficient and deficient. Asthma control was classified according to the Global Initiative for Asthma (GINA) guidelines and the Test for Respiratory and Asthma Control in Kids (TRACK) in 1-4 years-old children. RESULTS: Serum Vitamin D levels were 22.64 (9.96) ng/ml in the asthma group and 32.11 (14.74) ng/ml in the control group (p = 0.001). Total number of exacerbations during the previous year were significantly lower in the Vitamin D sufficient group, compared to the deficient and insufficient groups (p = 0.03). Frequency of patients with controlled asthma was higher in the sufficient group compared to the deficient and insufficient groups (p = 0.001 and p = 0.001, respectively). There was a positive correlation between serum Vitamin D levels and asthma control. CONCLUSIONS: The frequency of Vitamin D deficiency and insufficiency was higher in children with asthma, compared to the controls. Therefore, we suggest that lower levels of Vitamin D are associated with poor asthma control and increased asthma severity

Potential of cottonseed oil as fish oil replacer in European Sea Bass feed formulation

Triplicate groups of 20 European sea bass (35 g) were fed five diets in which the added lipid was 100% fish oil (FO), 40% (CSO40), 60% (CSO60), 80% (CSO80) and 100% (CSO100) refined cottonseed oil (CSO), for a period of 120 days. Overall fish growth, feed conversion ratio and protein utilization were unaffected by dietary treatment, but hepatosomatic and visceral fat indexes increased with increasing dietary CSO. Fillet fatty acid composition of total lipids reflected the fatty acids in the test diets. The monounsaturated fatty acids were significantly higher in fillet of fish fed diet FO, CSO40 and CSO60 compared to other treatments while saturated and polyunsaturated fatty acids (PUFA) were not affected by the dietary treatment. Some fatty acids (18:0, 18:1n-9, 20:5n-3 and 22:6n-3) were present in higher concentration in fillet lipid than in the CSO100 dietary lipid indicating accumulation in fillet relative to test diets. Retention of n-3 LC-PUFA within the fillet was increasingly inefficient among fish fed increasing levels of FO. Thus, this study suggests that CSO can be considered as a relatively effective substitute for fish oil in European sea bass (35 g) in terms of growth performances and feed efficiency as far as fish meal is present in the diet

From traits to typologies: Piloting new approaches to profiling trait preferences along the cassava value chain in Nigeria

Breeding programs are increasing efforts towards demand-led breeding approaches to ensure that cultivars released meet the needs of end users including processors, traders, and consumers, and that they are adopted by farmers. To effectively deploy these approaches, new tools are required to better understand and quantify the degree of preference differences among alternative trait changes competing for measurement and selection effort. The purpose of this study was to present a method of quantifying preferences and developing typologies according to breeding priorities by applying an online trait preference survey approach to cassava (Manihot esculenta Crantz). This paper presents a conjoint analysis based on Potentially All Pairwise RanKings of all possible Alternatives (PAPRIKA) to help guide breeding programs in understanding trait preferences across value chain roles and social contexts and set breeding priorities that represent diverse interests. Trait preferences were assessed using a comprehensive survey and analysis package incorporating a core adaptive conjoint method (1000minds, 2020). Trait selection was based on a trade-off of 11 cassava traits carried out with 792 cassava value chain actors in four geopolitical regions in Nigeria. Principal component and cluster analyses revealed three clusters (typologies) of respondents according to their trait preferences. The results demonstrate the usefulness of this methodology that innovates on previous trait preference approaches to address the expanding needs of plant breeding programs within smallholder contexts. © 2021 The Authors. Crop Science © 2021 Crop Science Society of Americ

Giant cervicothoracic extradural arachnoid cyst: case report

The pathogenesis, etiology, and treatment of the spinal arachnoid cyst have not been well established because of its rarity. A 57-year-old male was presented with spastic quadriparesis predominantly on the left side. His radiological examination showed widening of the cervical spinal canal and left neural foramina due to a cerebrospinal fluid - filled extradural cyst that extended from C2 to T2 level. The cyst was located left anterolaterally, compressing the spinal cord. Through a C4–T2 laminotomy, the cyst was excised totally and the dural defect was repaired. Several features of the reported case, such as cyst size, location, and clinical features make it extremely unusual. The case is discussed in light of the relevant literature