Validation and comparison of two methods to Assess Human Energy Expenditure during Free-Living Activities

Background: The measurement of activity energy expenditure (AEE) via accelerometry is the most commonly used objective method for assessing human daily physical activity and has gained increasing importance in the medical, sports and psychological science research in recent years. Objective: The purpose of this study was to determine which of the following procedures is more accurate to determine the energy cost during the most common everyday life activities; a single regression or an activity based approach. For this we used a device that utilizes single regression models (GT3X, ActiGraph Manufacturing Technology Inc., FL., USA) and a device using activity-dependent calculation models (move II, movisens GmbH, Karlsruhe, Germany). Material and Methods: Nineteen adults (11 male, 8 female; 30.469.0 years) wore the activity monitors attached to the waist and a portable indirect calorimeter (IC) as reference measure for AEE while performing several typical daily activities. The accuracy of the two devices for estimating AEE was assessed as the mean differences between their output and the reference and evaluated using Bland-Altman analysis. Results: The GT3X overestimated the AEE of walking (GT3X minus reference, 1.26 kcal/min), walking fast (1.72 kcal/min), walking up2/downhill (1.45 kcal/min) and walking upstairs (1.92 kcal/min) and underestimated the AEE of jogging (2 1.30 kcal/min) and walking upstairs (22.46 kcal/min). The errors for move II were smaller than those for GT3X for all activities. The move II overestimated AEE of walking (move II minus reference, 0.21 kcal/min), walking up2/downhill (0.06 kcal/min) and stair walking (upstairs: 0.13 kcal/min; downstairs: 0.29 kcal/min) and underestimated AEE of walking fast (20.11 kcal/min) and jogging (20.93 kcal/min). Conclusions: Our data suggest that the activity monitor using activity-dependent calculation models is more appropriate for predicting AEE in daily life than the activity monitor using a single regression model

The Role of Psychological Factors in Judo: A Systematic Review

(1) Background: Psychological parameters are relevant in the practice of judo. Previous studies have shown that parameters such as anxiety or motivation can have a negative or positive impact on the athlete\u2019s performance and general well-being, depending on the athlete\u2019s perception. This systematic review aimed to summarize the studies examining the influence of various psychological parameters on well-being and performance in judo athletes; (2) Methods: We followed preferred reporting elements for systematic reviews and meta-analyses. We searched the Web of Science database for studies that explained the role of these parameters in elite athletes. Of the 286 articles initially identified, 17 met our eligibility criteria and were included in the review. In total, we analyzed data from 721 judo athletes; (3) Results: The studies found have demonstrated the impact of various psychological parameters during high-level performance and how these parameters can influence and lead an athlete to win or lose a competition. The feelings of tension, anger, anxiety, and nervousness were significantly increased in athletes who were facing defeat, while a decrease in the same segments and an increase in motivation among athletes who were experiencing better performance was observed. Further research under standardized conditions is needed to better understand the effects of these parameters on judo athletes; (4) Conclusions: Considering the athlete\u2019s psychological state can affect performance, and it is therefore important to monitor and train these factors

Psychological Distress in Elite Sambo and Recreational Athletes

Background: Previous studies suggest that engagement in any type of physical activity can be protective against mental health issues, whereas elite-level athletes can endure various mental health challenges. The aim of this study was to determine variations in the prevalence of psychological distress among elite sambo athletes and their recreational counterparts. Methods: A sample consisting of 245 athletes (127 males and 118 females) was chosen. Out of the total sample, 105 were elite-level athletes while 140 were recreational athletes. Participants were accessed via the Depression Anxiety Stress Scales-21 to determine their stress in various domains at a given time. Results: Data indicated that all tested differences between elite sambo athletes and recreational athletes were statistically significant; recreational athletes had a higher score on the depression scale, anxiety and stress, and a general distress score than sambo athletes. Although there are no gender differences in psychological distress in the total sample of athletes, elite sambo athletes achieve significantly lower scores in all tested variants than recreational ones. Women who engage in recreational activities have stood out as a vulnerable subsample in psychological stress. Conclusion: Future epidemiological and interventional studies should explore optimal strategies to identify mental health needs based on specific sport activity, especially in terms of gender. There is a need to place special emphasis on psychological distress in the context of combat sports

Automated Non-Sterile Pharmacy Compounding: A Multi-Site Study in European Hospital and Community Pharmacies with Pediatric Immediate Release Propranolol Hydrochloride Tablets.

Pharmacy compounding, the art and science of preparing customized medications to meet individual patient needs, is on the verge of transformation. Traditional methods of compounding often involve manual and time-consuming processes, presenting challenges in terms of consistency, dosage accuracy, quality control, contamination, and scalability. However, the emergence of cutting-edge technologies has paved a way for a new era for pharmacy compounding, promising to redefine the way medications are prepared and delivered as pharmacy-tailored personalized medicines. In this multi-site study, more than 30 hospitals and community pharmacies from eight countries in Europe utilized a novel automated dosing approach inspired by 3D printing for the compounding of non-sterile propranolol hydrochloride tablets. CuraBlend <sup>®</sup> excipient base, a GMP-manufactured excipient base (pharma-ink) intended for automated compounding applications, was used. A standardized study protocol to test the automated dosing of tablets with variable weights was performed in all participating pharmacies in four different iterative phases. Integrated quality control was performed with an in-process scale and NIR spectroscopy supported by HPLC content uniformity measurements. In total, 6088 propranolol tablets were produced at different locations during this study. It was shown that the dosing accuracy of the process increased from about 90% to 100% from Phase 1 to Phase 4 by making improvements to the formulation and the hardware solutions. The results indicate that through this automated and quality controlled compounding approach, extemporaneous pharmacy manufacturing can take a giant leap forward towards automation and digital manufacture of dosage forms in hospital pharmacies and compounding pharmacies

Drug Absorption Modeling as a Tool to Define the Strategy in Clinical Formulation Development

The purpose of this mini review is to discuss the use of physiologically-based drug absorption modeling to guide the formulation development. Following an introduction to drug absorption modeling, this article focuses on the preclinical formulation development. Case studies are presented, where the emphasis is not only the prediction of absolute exposure values, but also their change with altered input values. Sensitivity analysis of technologically relevant parameters, like the drug’s particle size, dose and solubility, is presented as the basis to define the clinical formulation strategy. Taking the concept even one step further, the article shows how the entire design space for drug absorption can be constructed. This most accurate prediction level is mainly foreseen once clinical data is available and an example is provided using mefenamic acid as a model drug. Physiologically-based modeling is expected to be more often used by formulators in the future. It has the potential to become an indispensable tool to guide the formulation development of challenging drugs, which will help minimize both risks and costs of formulation development

Loneliness in sports active and non-active school-age children: Can sport protect children against loneliness?

Introduction: This study aims to examine can sport protect children against loneliness and, if yes, whether this relationship depends on gender and/or sports-related variables. Methods: The sample includes 762 10-year-old children (414 boys). The total score of The Children's Loneliness Scale is a dependent variable in the study, while sports participation (sports active—individual or team sports, or non-active) and level/duration of sports participation are independent variables. Results: Obtained results indicate that the degree of loneliness differs depending on gender and whether the children are in sports activities or not. Unlike the level of sports participation, the duration of sports participation is relevant to the loneliness degree in both boys and girls. Discussion: This research results could represent the right direction for educators and/or parents in their endeavor to preserve and develop school-age children's mental health

Efficiency of Coagulation/Flocculation for the Removal of Complex Mixture of Textile Fibers from Water

Synthetic fibers enter wastewater treatment plants together with natural fibers, which may affect treatment efficiency, a fact not considered in previous studies. Therefore, the aim of the present study was to evaluate the efficiency of the coagulation/flocculation process for the removal of a mixture of textile fibers from different water matrices. Natural and synthetic fibers (100 mg/L; cotton, polyacrylonitrile, and polyamide) were added to a synthetic matrix, surface water and laundry wastewater and subjected to coagulation/flocculation experiments with ferric chloride (FeCl3) and polyaluminum chloride (PACl) under laboratory conditions. In the synthetic matrix, both coagulants were found to be effective, with FeCl3 having a lesser advantage, removing textile fibers almost completely from the water (up to 99% at a concentration of 3.94 mM). In surface water, all dosages had approximately similar high values, with the coagulant resulting in complete removal. In laundry effluent, the presence of surfactants is thought to affect coagulation efficiency. PACl was found to be effective in removing textile fibers from laundry wastewater, with the lowest removal efficiency being 89% and all dosages having similar removal efficiencies. Natural organic matter and bicarbonates showed a positive effect on the efficiency of FeCl3 in removing textile fibers from surface water. PACl showed better performance in coagulating laundry wastewater while surfactants had a negative effect on FeCl3 coagulation efficiency

Rapid weight loss and mood states in judo athletes: A systematic review

Objective: Rapid weight loss (RWL) has been traditionally practiced in judo. While the effects of it on performance and health have been extensively studied, less attention is dedicated to psychological ramifications of RWL. We sought to investigate the effects of RWL on mood states in judo athletes. Method: PubMed and Web of Science were systematically searched for the relevant literature. Only original studies investigating the magnitude of RWL in judo athletes while jointly using Profile of Mood States questionnaire were eligible. Results: Six studies met the inclusion criteria and were included in the analysis. Studies varied vastly in their design (time allocated to RWL and the degree of RWL), but the common trait in virtually all studies was a significant increase in tension and significant drop in vigor following RWL. It appears that when ≥ 5% RWL per week is prompted, mood states greatly exacerbate in judo athletes. Conclusion: Overall, data showed that mood states in judo athletes are aggravated after ≥ 5% RWL with no significant difference between males and females. Future studies should explore the long-term effects of weight cycling on the mental health of judo athletes and other athletes participating in weight-classified sports