108 research outputs found
Atmosphere-Ionosphere Response to the M9 Tohoku Earthquake Revealed by Joined Satellite and Ground Observations. Preliminary results
The recent M9 Tohoku Japan earthquake of March 11, 2011 was the largest
recorded earthquake ever to hit this nation. We retrospectively analyzed the
temporal and spatial variations of four different physical parameters -
outgoing long wave radiation (OLR), GPS/TEC, Low-Earth orbit tomography and
critical frequency foF2. These changes characterize the state of the atmosphere
and ionosphere several days before the onset of this earthquake. Our first
results show that on March 8th a rapid increase of emitted infrared radiation
was observed from the satellite data and an anomaly developed near the
epicenter. The GPS/TEC data indicate an increase and variation in electron
density reaching a maximum value on March 8. Starting on this day in the lower
ionospheric there was also confirmed an abnormal TEC variation over the
epicenter. From March 3-11 a large increase in electron concentration was
recorded at all four Japanese ground based ionosondes, which return to normal
after the main earthquake. We found a positive correlation between the
atmospheric and ionospheric anomalies and the Tohoku earthquake. This study may
lead to a better understanding of the response of the atmosphere /ionosphere to
the Great Tohoku earthquakeComment: Preliminary results reported at EGU 2011 in Vienna, Austri
In situ study of the temperature stability of TiO1.05 titanium monooxide using synchrotron radiation
The temperature stability of cubic TiO1.05 titanium monooxide is investigated. An in situ X-ray structural analysis is performed using synchrotron radiation in a high temperature vacuum chamber. It is found that under poor vacuum and at high heating rates of up to 1250 C, the structural transformations in TiO1.05 occur at 630 C. In particular, there is a phase transition from TiO1.05 (space group Fm-3m) to rhombohedraic Ti2O3 (space group R-3c) via Ti2.5O3 (space group Immm). Β© 2013 Allerton Press, Inc
Synthesis of octahydro-2H-chromen-4-ol from vanillin and isopulegol over acid modified montmorillonite clays: Effect of acidity on the Prins cyclization
Two calcium-rich natural layered aluminosilicates containing 90β95 wt.% montmorillonite were chemically activated using 0.125β3.0 M HCl solutions. Structural and textural properties were characterized by X-ray diffraction, elemental analysis and N2-adsorption/desorption analyses. According to infrared spectroscopy using pyridine as probe molecule, the amount of BrΓΈnsted acid sites increased when increasing HCl concentration. The catalytic performance of these materials was investigated in the Prins cyclization of (β)-isopulegol with vanillin to form octahydro-2H-chromen-4-ol, carried out in toluene at 35 Β°C. It was found that the amount of BrΓΈnsted acid sites and the microporosity of the catalysts are key factors for the control of the reaction rate and the selectivity towards octahydro-2H-chromen-4-o
Determination of Debye Temperatures and Lamb-MΓΆssbauer Factors for LnFeO3 Orthoferrite Perovskites (Ln = La, Nd, Sm, Eu, Gd)
Lanthanide orthoferrites have wide-ranging industrial uses including solar, catalytic and electronic applications. Here a series of lanthanide orthoferrite perovskites, LnFeO3 (Ln = La; Nd; Sm; Eu; Gd), prepared through a standard stoichiometric wet ball milling route using oxide precursors, has been studied. Characterisation through X-ray diffraction and X-ray fluorescence confirmed the synthesis of phase-pure or near-pure LnFeO3 compounds. 57Fe MΓΆssbauer spectroscopy was performed over a temperature range of 10 K to 293 K to observe hyperfine structure and to enable calculation of the recoil-free fraction and Debye temperature (ΞΈD) of each orthoferrite. Debye temperatures (Ln = La 474 K; Nd 459 K; Sm 457 K; Eu 452 K; Gd 473 K) and recoil-free fractions (Ln = La 0.827; Nd 0.817; Sm 0.816; Eu 0.812; Gd 0.826) were approximated through minimising the difference in the temperature dependent experimental Centre Shift (CS) and theoretical Isomer Shift (IS), by allowing the Debye temperature and Isomer Shift values to vary. This method of minimising the difference between theoretical and actual values yields Debye temperatures consistent with results from other studies determined through thermal analysis methods. This displays the ability of variable-temperature MΓΆssbauer spectroscopy to approximate Debye temperatures and recoil-free fractions, whilst observing temperature induced transitions over the temperature range observed. X-ray diffraction and Rietveld refinement show an inverse relationship between FeO6 octahedral volume and approximated Debye temperatures. Raman spectroscopy show an increase in the band positions attributed to soft modes of Ag symmetry, Ag(3) and Ag(5) from La to GdFeO3 corresponding to octahedral rotations and tilts in the [010] and [101] planes respectively
Choice of the optimal treatment strategy for patient with multifocal bladder cancer: clinical case
Transurethral resection of bladder is the standard surgical procedure for management of bladder cancer when it is suspected. Accurate clinical staging of the disease based on the histologic findings followed by further assessment of recurrence risks and risks of disease progression are vital for defining an optimal individualized treatment strategy. Early radical cystectomy (RC) is recommended for patients suffering from superficial bladder cancer at high risk for tumor recurrence.Patients diagnosed with bladder tumors with multifocal lesions as well as with tumor size > 3 Ρm are related to a group of high risk for cancer progression. In this case in order to take a decision about the benefits of radical surgery, itβs essential to remember that RC is considered to be a major surgical procedure with a broad range of both intraoperative and postoperative complications. The vast majority of patients experience a lower quality of life based on the development of different types of metabolic alterations as well as the necessity for using urinals or inability to have adequate urination control. Organ-preserving therapy with active follow-up is thereby preferably to conduct on young patients with active life position.In our clinical case we confirmed that such treatment strategy allows to establish adequate control over neoplastic process with less negative impact on patientsβ quality of life
POLYPOID CYSTITIS: A FINDING AND DIFFERENTIAL DIAGNOSIS
Background. Polypoid cystitis may simulate urothelial neoplasias cystoscopically and histologically. The frequency of polypoid cystitis is 0.38%; that among patients undergoing bladder catheterization is 6 %.Subjects and methods. The authors estimated the frequency of polypoid cystitis among chronic cystitis patients admitted to City Clinical Hospital Fifty, a base of the Clinic of Urology, Moscow State University of Medicine and Dentistry, in the period from February 2008 to February 2010. Out of 819 patients followed up, 3 who had diagnosed as having polypoid cystitis complained of pollakiuria, imperative micturate urges, and macrohematuria. They underwent ultrasonography, computed tomography, and cystoscopy; bladder masses measured 1.0, 7.0, and 11.5 cm, respectively; extensive growth was verified in 2 cases. Endoscopic studies identified procumbent rough-villous masses without well-defined outlines with the signs of bullous edema, decay, hemorrhages, and urinary salt encrustations. By taking into account the clinical picture and laboratory and instrumental findings, the authors suspected stage T3bNΡ
MΡ
bladder tumor in 2 patients and T1NΡ
MΡ
stage in 1. According to the European Association of Urology guidelines for management of bladder cancer, the patients underwent transurethral bladder resection. The patients were diagnosed as having polypoid cystitis on the basis of postmortem evidence.Results. In this study the frequency of polypoid cystitis was 37 %. Polypoid cystitis, a benign mass without a risk for malignancy, had signs of invasive transitional cell carcinoma.Conclusion. Such cases that rarely occur in practice are of clinical value and interest to urologists, pathologists, and oncologists.</p
ΠΠΎΠ²ΠΎΠ΅ Π² ΡΡΠ°Π΄ΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ ΠΌΠΎΡΠ΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ·ΡΡΡ
Β Introduction. Histological grading system is an important prognostic factor of bladder cancer. Grading of urothelial carcinoma has been a matter of debate since the three-grade system was introduced in 1973.Objective. Optimization of the grading system for urothelial carcinoma.Materials and methods. An analysis of literature devoted to evaluation of diagnostic significance, variability and interobserver reproducibility of the existing classifications of urothelial cancer of the bladder proposed in 1973, 1998, 1999 and 2004.Results. The classification proposed in 1973 is the most popular and time honored method of grading bladder tumors. In 1998 it was modified by the International Society of Urological Pathology. In 1999 the World Health Organization (WHO) approved a new classification which preserved the three-grade system but differed from the previous ones. According to this new classification, tumors could fall into the following categories: papilloma, papillary urothelial neoplasm of low malignant potential, urothelial carcinoma of I, II, and III malignancy grade. The definition of papilloma was identical in all of these classifications. In 2004 a new WHO classification was introduced in which non-invasive urothelial tumors were subdivided into papilloma, papillary urothelial neoplasm of low malignant potential and low and high grade carcinoma. All of the proposed grading systems had a certain level of subjectivity and interobserver reproducibility, but reproducibility between unfamiliar pathologists was considerably higher than in groups of pathologists who had studied or worked together. Importantly, the 2004 WHO classification aimed to provide a detailed explanation of histological criteria for each diagnostic category and therefore improve reproducibility between different pathologists. However, no improvement of reproducibility in comparison with the 1973 WHO classification was observed. Moreover, among the pathologists better reproducibility of the 1973 WHO classification was registered compared to the 1999 and 2004 classifications. Reproducibility of the papillary urothelial neoplasm of low malignant potential diagnosis was only 48 %. At the same time, reproducibility of the 1973 WHO classification too has its problems. The biggest criticism is ambiguity in the diagnostic criteria of the 3 grades of urothelial carcinoma.Conclusions. Standardization of the grading system of superficial bladder cancer allows to validate comparison between treatment outcomes in different centers. Introduction of the 2004 classification is the first step to treatment and monitoring standardization, but all of the classifications proposed by the WHO have shortcomings caused by considerable heterogeneity of papillary urothelial neoplasms. Significant interobserver reproducibility between papillary urothelial neoplasm of low malignant potential and low grade papillary urothelial carcinoma shows inadvisability of creating a separate diagnostic category for papillary urothelial neoplasm of low malignant potential.Β ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅. ΠΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠΈΡΡΠ΅ΠΌΠ° ΡΡΠ°Π΄ΠΈΡΠΎΠ²Π°Π½ΠΈΡ β Π²Π°ΠΆΠ½ΡΠΉ ΠΏΡΠΎΠ³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠ°ΠΊΡΠΎΡ ΡΠ°ΠΊΠ° ΠΌΠΎΡΠ΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ·ΡΡΡ. Π‘ΡΠ°Π΄ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ ΠΌΠΎΡΠ΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ·ΡΡΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΡΠ΅Π΄ΠΌΠ΅ΡΠΎΠΌ Π΄ΠΈΡΠΊΡΡΡΠΈΠΉ Ρ ΠΌΠΎΠΌΠ΅Π½ΡΠ° Π²Π½Π΅Π΄ΡΠ΅Π½ΠΈΡ Π² 1973 Π³. ΡΡΠ΅Ρ
ΡΡΡΠΏΠ΅Π½ΡΠ°ΡΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΎΠΏΡΠΈΠΌΠΈΠ·ΠΈΡΠΎΠ²Π°ΡΡ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΡΡ ΡΠΈΡΡΠ΅ΠΌΡ ΡΡΠ°Π΄ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ, ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π½ΡΠΉ ΠΎΡΠ΅Π½ΠΊΠ΅ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΠΈ, Π²Π°ΡΠΈΠ°Π±Π΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΈ ΠΌΠ΅ΠΆ- Π½Π°Π±Π»ΡΠ΄Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ Π²ΠΎΡΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΠΌΠΎΡΡΠΈ ΠΈΠΌΠ΅ΡΡΠΈΡ
ΡΡ Π½Π° ΡΠ΅Π³ΠΎΠ΄Π½ΡΡΠ½ΠΈΠΉ Π΄Π΅Π½Ρ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΉ ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° ΠΌΠΎΡΠ΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ·ΡΡΡ: 1973, 1998, 1999 ΠΈ 2004 Π³Π³.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½Π°Ρ Π² 1973 Π³. ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ β Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΡΠΉ ΠΈ ΠΏΡΠΎΠ²Π΅ΡΠ΅Π½Π½ΡΠΉ Π²ΡΠ΅ΠΌΠ΅Π½Π΅ΠΌ ΠΌΠ΅ΡΠΎΠ΄ ΡΡΠ°Π΄ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ ΠΌΠΎΡΠ΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ·ΡΡΡ. Π 1998 Π³. ΠΎΠ½Π° Π±ΡΠ»Π° ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π° ΠΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΡΠΌ ΠΎΠ±ΡΠ΅ΡΡΠ²ΠΎΠΌ ΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ. Π 1999 Π³. ΠΡΠ΅ΠΌΠΈΡΠ½Π°Ρ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΡ Π·Π΄ΡΠ°Π²ΠΎΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΡ (ΠΠΠ) ΡΡΠ²Π΅ΡΠ΄ΠΈΠ»Π° Π½ΠΎΠ²ΡΡ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ, ΠΊΠΎΡΠΎΡΠ°Ρ ΠΎΡΡΠ°Π»Π°ΡΡ ΡΡΠ΅Ρ
ΡΡΡΠΏΠ΅Π½ΡΠ°ΡΠΎΠΉ, Π½ΠΎ ΠΎΡΠ»ΠΈΡΠ°Π»Π°ΡΡ ΠΎΡ ΡΠ°Π½Π΅Π΅ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½ΡΡ
ΡΠ΅ΠΌ, ΡΡΠΎ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ ΠΏΠΎΠ΄ΡΠ°Π·Π΄Π΅Π»ΡΠ»ΠΈΡΡ Π½Π° ΠΏΠ°ΠΏΠΈΠ»Π»ΠΎΠΌΡ, ΠΏΠ°ΠΏΠΈΠ»Π»ΡΡΠ½ΡΡ ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΡΡ ΠΎΠΏΡΡ
ΠΎΠ»Ρ Ρ Π½ΠΈΠ·ΠΊΠΈΠΌ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠΌ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΡΡΠΈ, ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΡΡ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ I, II ΠΈ III ΡΡΠ΅ΠΏΠ΅Π½Π΅ΠΉ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΡΡΠΈ. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΏΠ°ΠΏΠΈΠ»Π»ΠΎΠΌΡ Π±ΡΠ»ΠΎ ΠΎΠ΄ΠΈΠ½Π°ΠΊΠΎΠ²ΡΠΌ Π²ΠΎ Π²ΡΠ΅Ρ
ΡΡΠΈΡ
ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΡΡ
. Π 2004 Π³. ΡΡΠ²Π΅ΡΠΆΠ΄Π΅Π½Π° Π½ΠΎΠ²Π°Ρ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΠΠ, Π² ΠΊΠΎΡΠΎΡΠΎΠΉ Π½Π΅ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΡΠ΅ ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»Ρ- Π½ΡΠ΅ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ ΠΏΠΎΠ΄ΡΠ°Π·Π΄Π΅Π»ΡΡΡΡΡ Π½Π° ΠΏΠ°ΠΏΠΈΠ»Π»ΠΎΠΌΡ, ΠΏΠ°ΠΏΠΈΠ»Π»ΡΡΠ½ΡΡ ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΡΡ ΠΎΠΏΡΡ
ΠΎΠ»Ρ Ρ Π½ΠΈΠ·ΠΊΠΈΠΌ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠΌ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΡΡΠΈ, ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ Π½ΠΈΠ·ΠΊΠΎΠΉ ΠΈ Π²ΡΡΠΎΠΊΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½Π΅ΠΉ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΡΡΠΈ. ΠΡΠ΅ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½ΡΠ΅ ΡΠΈΡΡΠ΅ΠΌΡ Π³ΡΠ°Π΄Π°ΡΠΈΠΈ ΠΈΠΌΠ΅Π»ΠΈ ΡΡ ΠΈΠ»ΠΈ ΠΈΠ½ΡΡ ΡΡΠ΅ΠΏΠ΅Π½Ρ ΡΡΠ±ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈ ΠΌΠ΅ΠΆΠ½Π°Π±Π»ΡΠ΄Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ Π²ΠΎΡΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΠΌΠΎΡΡΠΈ, ΠΎΠ΄Π½Π°ΠΊΠΎ Π²ΠΎΡΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΠΌΠ΅ΠΆΠ΄Ρ Π½Π΅Π·Π½Π°ΠΊΠΎΠΌΡΠΌΠΈ Π΄ΡΡΠ³ Ρ Π΄ΡΡΠ³ΠΎΠΌ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³Π°ΠΌΠΈ Π±ΡΠ»Π° Π½Π°ΠΌΠ½ΠΎΠ³ΠΎ Π±ΠΎΠ»ΡΡΠ΅, ΡΠ΅ΠΌ Π² Π³ΡΡΠΏΠΏΠ°Ρ
ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΎΠ², ΠΊΠΎΡΠΎΡΡΠ΅ ΡΡΠΈΠ»ΠΈΡΡ ΠΈΠ»ΠΈ ΡΠ°Π±ΠΎΡΠ°Π»ΠΈ Π²ΠΌΠ΅ΡΡΠ΅. ΠΠ°ΠΆΠ½ΠΎΠΉ Π·Π°Π΄Π°ΡΠ΅ΠΉ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΠΠ 2004 Π³. Π±ΡΠ»ΠΎ ΠΏΡΠ΅Π΄ΠΎΡΡΠ°Π²ΠΈΡΡ Π΄Π΅ΡΠ°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ΅ ΠΎΠ±ΡΡΡΠ½Π΅Π½ΠΈΠ΅ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΊΡΠΈΡΠ΅ΡΠΈΠ΅Π² Π΄Π»Ρ ΠΊΠ°ΠΆΠ΄ΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠ°ΡΠ΅Π³ΠΎΡΠΈΠΈ ΠΈ, ΡΠ°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, ΡΠ»ΡΡΡΠΈΡΡ Π²ΠΎΡΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠ°Π·Π½ΡΠΌΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³Π°ΠΌΠΈ. ΠΠ΄Π½Π°ΠΊΠΎ ΡΠ»ΡΡΡΠ΅Π½ΠΈΡ Π²ΠΎΡΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΠΌΠΎΡΡΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³Π°ΠΌΠΈ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠ΅ΠΉ ΠΠΠ 1973 Π³. Π½Π΅ Π·Π°ΡΠΈΠΊΡΠΈΡΠΎΠ²Π°Π½ΠΎ. ΠΠΎΠ»Π΅Π΅ ΡΠΎΠ³ΠΎ, ΡΡΠ΅Π΄ΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΎΠ² ΠΎΡΠΌΠ΅ΡΠ΅Π½Π° Π»ΡΡΡΠ°Ρ Π²ΠΎΡΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΠΠ 1973 Π³. ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΡΠΌΠΈ 1999 ΠΈ 2004 Π³Π³. ΠΠΎΡΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ Ρ Π΄ΠΈΠ°Π³Π½ΠΎΠ·ΠΎΠΌ ΠΏΠ°ΠΏΠΈΠ»Π»ΡΡΠ½ΠΎΠΉ ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ Ρ Π½ΠΈΠ·ΠΊΠΈΠΌ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠΌ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΡΡΠΈ ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° Π²ΡΠ΅Π³ΠΎ 48 %. Π ΡΠΎ ΠΆΠ΅ Π²ΡΠ΅ΠΌΡ Π²ΠΎΡΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΠΠ 1973 Π³. ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΡΡ
ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ ΡΠ°ΠΊΠΆΠ΅ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ°ΡΠΈΡΠ½Π°. ΠΠ°ΠΈΠ±ΠΎΠ»ΡΡΡΡ ΠΊΡΠΈΡΠΈΠΊΡ ΡΡΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ Π²ΡΠ·ΡΠ²Π°Π΅Ρ Π½Π΅ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΠΎΡΡΡ ΠΊΡΠΈΡΠ΅ΡΠΈΠ΅Π² Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ Π² ΡΠ°Π·Π΄Π΅Π»Π΅Π½ΠΈΠΈ 3 ΡΡΠ΅ΠΏΠ΅Π½Π΅ΠΉ ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ.ΠΡΠ²ΠΎΠ΄Ρ. Π‘ΡΠ°Π½Π΄Π°ΡΡΠΈΠ·Π°ΡΠΈΡ ΡΠΈΡΡΠ΅ΠΌΡ ΡΡΠ°Π΄ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° ΠΌΠΎΡΠ΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ·ΡΡΡ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Π²Π°Π»ΠΈΠ΄ΠΈΠ·ΠΈΡΠΎΠ²Π°ΡΡ ΡΡΠ°Π²Π½Π΅Π½ΠΈΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² Π»Π΅ΡΠ΅Π½ΠΈΡ Π² ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΠ΅Π½ΡΡΠ°Ρ
. ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ 2004 Π³. ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΠ΅ΡΠ²ΡΠΌ ΡΠ°Π³ΠΎΠΌ Π² ΡΡΠ°Π½Π΄Π°ΡΡΠΈΠ·Π°ΡΠΈΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΈ ΡΠ΅ΠΆΠΈΠΌΠΎΠ² Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ, ΠΎΠ΄Π½Π°ΠΊΠΎ Π²ΡΠ΅ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½ΡΠ΅ ΠΠΠ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΈΠΌΠ΅ΡΡ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΊΠΈ, ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π½ΡΠ΅ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ Π³Π΅ΡΠ΅ΡΠΎΠ³Π΅Π½Π½ΠΎΡΡΡΡ ΡΡΠ΅Π΄ΠΈ ΠΏΠ°ΠΏΠΈΠ»Π»ΡΡΠ½ΡΡ
ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΡΡ
ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ. ΠΠ½Π°ΡΠΈΡΠ΅Π»ΡΠ½Π°Ρ ΠΌΠ΅ΠΆΠ½Π°Π±Π»ΡΠ΄Π°ΡΠ΅Π»ΡΠ½Π°Ρ Π²ΠΎΡΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΠΌΠ΅ΠΆΠ΄Ρ ΠΏΠ°ΠΏΠΈΠ»Π»ΡΡΠ½ΠΎΠΉ ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΠΎΠΏΡΡ
ΠΎΠ»ΡΡ Ρ Π½ΠΈΠ·ΠΊΠΈΠΌ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠΌ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΡΡΠΈ ΠΈ ΠΏΠ°ΠΏΠΈΠ»Π»ΡΡΠ½ΠΎΠΉ ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΠΎΠΉ Π½ΠΈΠ·ΠΊΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΡΡΠΈ ΡΠΊΠ°Π·ΡΠ²Π°Π΅Ρ Π½Π° Π½Π΅ΡΠ΅Π»Π΅ΡΠΎΠΎΠ±ΡΠ°Π·Π½ΠΎΡΡΡ Π²ΡΠ΄Π΅Π»Π΅Π½ΠΈΡ ΠΎΡΠ΄Π΅Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠ°ΡΠ΅Π³ΠΎΡΠΈΠΈ ΠΏΠ°ΠΏΠΈΠ»Π»ΡΡΠ½ΠΎΠΉ ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ Ρ Π½ΠΈΠ·ΠΊΠΈΠΌ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠΌ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΡΡΠΈ
ΠΠΊΡΠΏΡΠ΅ΡΡΠΈΡ Ρ53 Π² ΠΏΠΎΠ²Π΅ΡΡ Π½ΠΎΡΡΠ½ΡΡ ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΡΡ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΠ°Ρ ΠΌΠΎΡΠ΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ·ΡΡΡ β Π½Π΅Π·Π°Π²ΠΈΡΠΈΠΌΡΠΉ ΡΠ°ΠΊΡΠΎΡ ΠΏΡΠΎΠ³Π½ΠΎΠ·Π°
Purpose. Determination the role of the p53 expression as a prognostic factor in the development of superficial urothelial bladder carcinoma.Materials and methods. Medical histories of 72 patients (11 women and 61 men) with diagnosed primary superficial urothelial carcinomaΒ of the bladder I and II grade were retrospectively analyzed. All patients were undergone a repeated transurethral resection was performedΒ in 6 weeks after the first operation. In the case of the absence of residual tumor, cystoscopy was performed every 3 months during the first yearΒ then every 3β6 months during next 5 years. The average time of follow-up was 43.2 months. According to the standard protocol an immunohistochemicalΒ study with detection of p53 was carried out on 72 sections of formalin-fixed and paraffin-embedded tumor fragments. p53 expressionΒ was also determined in 10 histologically unchanged fragments of the bladder mucosa.Results. Depending on the percent of nuclei with p53 expression, two groups were identified. The first group included 40 tumor samples (55.5 %)Β with p53 expression less than 20 % and 17 tumor samples (23.6 %) without p53 expression. The second group included 15 tumor samplesΒ (20.9 %) with p53 expression more than 20 % (4 patients β 20β40 %, 8 patients β 40β60 %, 3 patients β 60β80 %). Ρ53 expression wasΒ not determined in the all 10 samples of normal bladder tissue. During follow-up period 1 of 57 patients of the first group has a disease progressionΒ comparing with 13 of 15 patients in the second group. Patients of the both group were similar in respect with clinical characteristics.Β The mean time to disease progression was 17.3 months.Conclusion. Results of the current study shows that p53 immunohistochemical marker is a prognostic factor in the development of superficialΒ urothelial bladder carcinoma.ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅. ΠΡΠΈΠΌΠ΅ΡΠ½ΠΎ 80 % ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΡΠ΅ΠΌΡΡ
ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΡΡ
ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌ ΠΌΠΎΡΠ΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ·ΡΡΡ ΡΠ²Π»ΡΡΡΡΡ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠ½ΡΠΌΠΈ. ΠΡΠΈΒ ΡΡΠΎΠΌ Ρ 10β20 % ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎ Π²ΡΡΠ²Π»ΡΠ΅ΠΌΡΠΌ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠ½ΡΠΌ ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΡΠΌ ΡΠ°ΠΊΠΎΠΌ Π²ΠΏΠΎΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠΈ ΡΠ°Π·Π²ΠΈΠ²Π°Π΅ΡΡΡ ΠΌΡΡΠ΅ΡΠ½ΠΎ-ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΠΎΠ΅ ΠΈ ΠΌΠ΅ΡΠ°ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅. Π ΡΠ²ΡΠ·ΠΈ Ρ ΡΡΠΈΠΌ Π²Π°ΠΆΠ½ΠΎΠΉ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΏΡΠΎΠ³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ², ΠΊΠΎΡΠΎΡΡΠ΅ ΠΌΠΎΠ³Π»ΠΈ Π±Ρ Π²ΡΠ΄Π΅Π»ΠΈΡΡ Π³ΡΡΠΏΠΏΡ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠ½ΡΡ
ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ Ρ Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠΎΠΊΠΈΠΌ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠΌ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΡΡΠΈ.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠΎΠ»ΠΈ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Ρ53 ΠΊΠ°ΠΊ ΡΠ°ΠΊΡΠΎΡΠ° ΠΏΡΠΎΠ³Π½ΠΎΠ·Π° Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠ½ΡΡ
ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΡΡ
ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΒ ΠΌΠΎΡΠ΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ·ΡΡΡ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. Π Π΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎ ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ 72 ΠΈΡΡΠΎΡΠΈΠΈ Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² (11 ΠΆΠ΅Π½ΡΠΈΠ½ ΠΈ 61 ΠΌΡΠΆΡΠΈΠ½Ρ) Ρ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎΒ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠ½ΡΠΌ ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΡΠΌ ΡΠ°ΠΊΠΎΠΌ ΠΌΠΎΡΠ΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ·ΡΡΡ I ΠΈ II ΡΡΠ΅ΠΏΠ΅Π½Π΅ΠΉ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΡΡΠΈ. ΠΡΠ΅ΠΌ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌ Π±ΡΠ»Π°Β ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π° ΠΏΠΎΠ²ΡΠΎΡΠ½Π°Ρ ΡΡΠ°Π½ΡΡΡΠ΅ΡΡΠ°Π»ΡΠ½Π°Ρ ΡΠ΅Π·Π΅ΠΊΡΠΈΡ ΡΠ΅ΡΠ΅Π· 6 Π½Π΅Π΄ ΠΏΠΎΡΠ»Π΅ 1-ΠΉ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ. ΠΡΠΈ ΠΎΡΡΡΡΡΡΠ²ΠΈΠΈ ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΠΉ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌΒ Π²ΡΠΏΠΎΠ»Π½ΡΠ»ΠΈ ΡΠΈΡΡΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠ°ΠΆΠ΄ΡΠ΅ 3 ΠΌΠ΅Ρ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 1-Π³ΠΎ Π³ΠΎΠ΄Π° ΠΏΠΎΡΠ»Π΅ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π° ΠΈ ΠΊΠ°ΠΆΠ΄ΡΠ΅ 3β6 ΠΌΠ΅Ρ Π² ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠ΅ΠΌ.Β Π‘ΡΠ΅Π΄Π½Π΅Π΅ Π²ΡΠ΅ΠΌΡ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΎ 43,2 ΠΌΠ΅Ρ. ΠΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Ρ ΠΎΠ½ΠΊΠΎΠΏΡΠΎΡΠ΅ΠΈΠ½ΠΎΠΌ Ρ53 Π±ΡΠ»ΠΎ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΏΠΎ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΠΎΠΌΡ ΠΏΡΠΎΡΠΎΠΊΠΎΠ»Ρ Π½Π° 72 ΡΡΠ΅Π·Π°Ρ
ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠ½ΡΡ
Π·Π°ΡΠΈΠΊΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΠΎΡΠΌΠ°Π»ΠΈΠ½ΠΎΠΌ ΠΈ Π·Π°Π»ΠΈΡΡΡ
Π² ΠΏΠ°ΡΠ°ΡΠΈΠ½ ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠΎΠ² ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ. ΠΠΊΡΠΏΡΠ΅ΡΡΠΈΡ Ρ53 ΡΠ°ΠΊΠΆΠ΅ Π±ΡΠ»Π° ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π° Π² 10 Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ Π½Π΅ΠΈΠ·ΠΌΠ΅Π½Π΅Π½Π½ΡΡ
ΡΡΠ°Π³ΠΌΠ΅Π½ΡΠ°Ρ
ΡΠ»ΠΈΠ·ΠΈΡΡΠΎΠΉ ΠΎΠ±ΠΎΠ»ΠΎΡΠΊΠΈ ΠΌΠΎΡΠ΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ·ΡΡΡ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΠΏΡΠΎΡΠ΅Π½ΡΠ° ΡΠ΄Π΅Ρ Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠ΅ΠΉ Ρ53 Π±ΡΠ»ΠΈ Π²ΡΠ΄Π΅Π»Π΅Π½Ρ 2 Π³ΡΡΠΏΠΏΡ: 1-Ρ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ 40 (55,5 %) ΠΎΠ±ΡΠ°Π·ΡΠΎΠ²Β ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠ΅ΠΉ Ρ53 < 20 % ΠΈ 17 (23,6 %) ΠΎΠ±ΡΠ°Π·ΡΠΎΠ² Π±Π΅Π· ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Ρ53; 2-Ρ β 15 (20,9 %) ΠΎΠ±ΡΠ°Π·ΡΠΎΠ² Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠ΅ΠΉ Ρ53 > 20 %Β (4 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ° β 20β40 %, 8 β 40β60 %, 3 β 60β80 %). Π Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΠΌΠΎΡΠ΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ·ΡΡΡ Π²ΠΎ Π²ΡΠ΅Ρ
10 ΠΎΠ±ΡΠ°Π·ΡΠ°Ρ
ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ Ρ53Β Π½Π΅ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»Π°ΡΡ. ΠΠ° Π²ΡΠ΅ΠΌΡ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ Ρ 1 ΠΈΠ· 57 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² 1-ΠΉ Π³ΡΡΠΏΠΏΡ Π±ΡΠ»ΠΎ ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, Π²ΠΎ 2-ΠΉ Π³ΡΡΠΏΠΏΠ΅Β ΠΈΡ
ΡΠΈΡΠ»ΠΎ Π΄ΠΎΡΡΠΈΠ³Π°Π»ΠΎ 13 ΠΈΠ· 15. ΠΠ°ΡΠΈΠ΅Π½ΡΡ Π³ΡΡΠΏΠΏ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΠΎΠ΄ΠΈΠ½Π°ΠΊΠΎΠ²Ρ ΠΏΠΎ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ°ΠΌ. Π‘ΡΠ΅Π΄Π½Π΅Π΅ Π²ΡΠ΅ΠΌΡ Π΄ΠΎ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΎ 17,3 ΠΌΠ΅Ρ.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ Π½Π°ΡΡΠΎΡΡΠ΅Π³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π΄ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡ, ΡΡΠΎ ΠΎΠ½ΠΊΠΎΠΌΠ°ΡΠΊΠ΅Ρ p53 ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ°ΠΊΡΠΎΡΠΎΠΌ ΠΏΡΠΎΠ³Π½ΠΎΠ·Π° Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈΒ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠ½ΡΡ
ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΡΡ
ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌ ΠΌΠΎΡΠ΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ·ΡΡΡ
ΠΠΈΡΡΠΎΠ·Π½ΡΠΉ ΠΈ ΠΆΠ΅Π»Π΅Π·ΠΈΡΡΡΠΉ ΡΠΈΡΡΠΈΡ, ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΡ Ρ ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΡΠΌ ΡΠ°ΠΊΠΎΠΌ ΠΌΠΎΡΠ΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ·ΡΡΡ
Background. Cystic-glandular cysititis is defined as cystic formation of the urothelial nests which may be associated with inflammatory conditions as well as neoplastic processes.Objective β to establish a relationship between cystic-glandular cysititis and bladder cancer.Materials and methods. We conducted a retrospective study using data of 52 patients whoβd been diagnosed with cystic-glandular cysititis of common or intestinal type in the period between 2006 and 2014. The patientsβ information regarding age, gender, type of histological material (biopsy or transurethral resection of bladder), urological anamnesis has been analyzed. Follow-up duration included cystoscopy performance with bladder biopsy and varied from 1 to 8 years.Results. Patients suffering from diagnosed cystic-glandular cystitis were between the ages of 27 and 89 years old, with a higher prevalence rate, 2:1, in men to women. Intestinal metaplasia was revealed in 7 (14 %) out of 52 patients. Thorough study of the urological anamnesis revealed 50 (96 %) cases of chronic bladder inflammation. Concurrent cancer was diagnosed in 6 (12 %) cases: 4 patients with urothelial carcinoma and 2 β with intestinal type adenocarcinoma. Follow-up of the remained 46 patients revealed the development of urothelial carcinoma in 1 patient which happened 6 months after his primary biopsy. By the way, this patient has already had upper urinary tract urothelial carcinoma in his anamnesis.Conclusions. Study results show that there is a relatively frequent coexistence of cystic-glandular cystitis and bladder cancer. However, longterm follow-up of patients with cystic-glandular cystitis donβt allow us to consider this pathology as a preneoplastic.ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅. ΠΠΈΡΡΠΎΠ·Π½ΠΎ-ΠΆΠ΅Π»Π΅Π·ΠΈΡΡΡΠΉ ΡΠΈΡΡΠΈΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅Ρ ΡΠΎΠ±ΠΎΠΉ ΠΊΠΈΡΡΠΎΠ·Π½ΠΎ ΡΠ°ΡΡΠΈΡΠ΅Π½Π½ΡΠ΅ Β«Π³Π½Π΅Π·Π΄Π°Β» ΡΡΠΎΡΠ΅Π»ΠΈΡ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΌΠΎΠ³ΡΡ Π²ΡΡΡΠ΅ΡΠ°ΡΡΡΡ ΠΊΠ°ΠΊ ΠΏΡΠΈ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΡΠΎΡΡΠΎΡΠ½ΠΈΡΡ
, ΡΠ°ΠΊ ΠΈ ΠΏΡΠΈ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠ°Ρ
.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ Π½Π°Π»ΠΈΡΠΈΠ΅ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·ΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΠΊΠΈΡΡΠΎΠ·Π½ΠΎ-ΠΆΠ΅Π»Π΅Π·ΠΈΡΡΡΠΌ ΡΠΈΡΡΠΈΡΠΎΠΌ ΠΈ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΠΎΠΉ ΠΌΠΎΡΠ΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ·ΡΡΡ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΡΠ΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ 52 ΠΈΡΡΠΎΡΠΈΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², Ρ ΠΊΠΎΡΠΎΡΡΡ
Π² ΠΏΠ΅ΡΠΈΠΎΠ΄ Ρ 2006 ΠΏΠΎ 2014 Π³. Π±ΡΠ» Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠΎΠ²Π°Π½ ΠΊΠΈΡΡΠΎΠ·Π½ΠΎ-ΠΆΠ΅Π»Π΅Π·ΠΈΡΡΡΠΉ ΡΠΈΡΡΠΈΡ Ρ ΠΊΠΈΡΠ΅ΡΠ½ΠΎΠΉ ΠΌΠ΅ΡΠ°ΠΏΠ»Π°Π·ΠΈΠ΅ΠΉ ΠΈΠ»ΠΈ Π±Π΅Π· ΡΠ°ΠΊΠΎΠ²ΠΎΠΉ. ΠΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΡΠ»Π΅Π΄ΡΡΡΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ: Π²ΠΎΠ·ΡΠ°ΡΡ, ΠΏΠΎΠ» ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°, ΡΠΈΠΏ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° (Π±ΠΈΠΎΠΏΡΠΈΡ ΠΈΠ»ΠΈ ΡΡΠ°Π½ΡΡΡΠ΅ΡΡΠ°Π»ΡΠ½Π°Ρ ΡΠ΅Π·Π΅ΠΊΡΠΈΡ ΠΌΠΎΡΠ΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ·ΡΡΡ), ΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°ΠΌΠ½Π΅Π· ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ². ΠΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ Π²ΠΊΠ»ΡΡΠ°Π»ΠΎ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΠ΅ ΡΠΈΡΡΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Ρ Π±ΠΈΠΎΠΏΡΠΈΠ΅ΠΉ ΠΌΠΎΡΠ΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ·ΡΡΡ ΠΈ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΎ ΠΎΡ 1 Π΄ΠΎ 8 Π»Π΅Ρ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠΎΠ·ΡΠ°ΡΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ ΠΊΠΈΡΡΠΎΠ·Π½ΠΎ-ΠΆΠ΅Π»Π΅Π·ΠΈΡΡΡΠΌ ΡΠΈΡΡΠΈΡΠΎΠΌ Π²Π°ΡΡΠΈΡΠΎΠ²Π°Π» ΠΎΡ 27 Π΄ΠΎ 89 Π»Π΅Ρ, ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠ΅ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΌΡΠΆΡΠΊΠΎΠ³ΠΎ ΠΈ ΠΆΠ΅Π½ΡΠΊΠΎΠ³ΠΎ ΠΏΠΎΠ»Π° ΡΠΎΡΡΠ°Π²Π»ΡΠ»ΠΎ 2:1. ΠΠ· 52 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΊΠΈΡΠ΅ΡΠ½Π°Ρ ΠΌΠ΅ΡΠ°ΠΏΠ»Π°Π·ΠΈΡ Π±ΡΠ»Π° Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠΎΠ²Π°Π½Π° Ρ 7 (14 %), Ρ 50 (96 %) Π² Π°Π½Π°ΠΌΠ½Π΅Π·Π΅ ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΠ΅ ΠΌΠΎΡΠ΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ·ΡΡΡ. ΠΠ°Π»ΠΈΡΠΈΠ΅ ΡΠΎΠΏΡΡΡΡΠ²ΡΡΡΠ΅ΠΉ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠΎΠ²Π°Π½ΠΎ Π² 6 (12 %) ΡΠ»ΡΡΠ°ΡΡ
: Π² 4 β ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½Π°Ρ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΠ° ΠΈ Π² 2 β ΠΆΠ΅Π»Π΅Π·ΠΈΡΡΠ°Ρ Π°Π΄Π΅Π½ΠΎΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΠ° ΠΊΠΈΡΠ΅ΡΠ½ΠΎΠ³ΠΎ ΡΠΈΠΏΠ°. ΠΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ ΠΎΡΡΠ°Π²ΡΠΈΡ
ΡΡ 46 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ ΡΠΎΠ»ΡΠΊΠΎ Ρ 1 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ° ΡΠ΅ΡΠ΅Π· 6 ΠΌΠ΅Ρ ΠΏΠΎΡΠ»Π΅ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎΠΉ Π±ΠΈΠΎΠΏΡΠΈΠΈ, ΠΏΡΠΈ ΡΡΠΎΠΌ Π² Π°Π½Π°ΠΌΠ½Π΅Π·Π΅ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ° Π±ΡΠ»Π° ΡΡΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½Π°Ρ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΠ° Π²Π΅ΡΡ
Π½ΠΈΡ
ΠΌΠΎΡΠ΅Π²ΡΡ
ΠΏΡΡΠ΅ΠΉ.ΠΡΠ²ΠΎΠ΄Ρ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡ Π΄ΠΎΠ²ΠΎΠ»ΡΠ½ΠΎ ΡΠ°ΡΡΠΎΠ΅ ΡΠΎΡΡΡΠ΅ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠΈΡΡΠΎΠ·Π½ΠΎ-ΠΆΠ΅Π»Π΅Π·ΠΈΡΡΠΎΠ³ΠΎ ΡΠΈΡΡΠΈΡΠ° ΠΈ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ ΠΌΠΎΡΠ΅Π²ΠΎΠ³ΠΎ ΠΏΡΠ·ΡΡΡ, ΡΠ΅ΠΌ Π½Π΅ ΠΌΠ΅Π½Π΅Π΅ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ Π·Π° ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌΠΈ Ρ ΠΊΠΈΡΡΠΎΠ·Π½ΠΎ-ΠΆΠ΅Π»Π΅Π·ΠΈΡΡΡΠΌ ΡΠΈΡΡΠΈΡΠΎΠΌ Π½Π΅ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡ ΡΡΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΠΊΠ°ΠΊ ΠΏΡΠ΅Π΄ΡΠ°ΠΊΠΎΠ²ΠΎΠ΅
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