Thin Ice Target for 16^{16}O(p,p') experiment

A windowless and self-supporting ice target is described. An ice sheet with a thickness of 29.7 mg/cm$^2$ cooled by liquid nitrogen was placed at the target position of a magnetic spectrometer and worked stably in the $^{16}$O$(p,p')$ experiment at $E_{p}=392$ MeV. Background-free spectra were obtained.Comment: 14 pages, 4 figures, Nucl. Instr. & Meth. A (in press

Identification of a novel human memory T cell population with the characteristics of stem-like chemo-resistance

我々は新しいヒトCD8+免疫記憶T幹細胞であるYoung memory T（TYM）細胞を同定した。TYM細胞は高い増殖能，多分化能，抗がん剤耐性を持ちウイルス免疫および癌免疫に関わっている。TYM細胞の制御が今後の免疫療法の効果の増強に重要と考える

Immunohistological analysis of pancreatic carcinoma after vaccination with survivin 2B peptide: Analysis of an autopsy series.

当教室では本学消化器・総合，乳腺・内分泌外科および東京大学医科学研究所，神奈川県立がんセンターと共同で有効な治療法のない進行膵臓がん患者にサバイビン2Bペプチドワクチンを用いた無作為化二重盲検群間比較試験を行った．本研究では上記の臨床試験参加者に対して施行された病理解剖組織検体を用いて腫瘍微小環境における免疫学的効果の判定を目的として，対照群を含む13例（うち7例がワクチン投与群）の病理解剖検体組織を用いて腫瘍組織局所における各種の免疫細胞浸潤の評価した

The role of the RACK1 ortholog Cpc2p in modulating pheromone-induced cell cycle arrest in fission yeast

The detection and amplification of extracellular signals requires the involvement of multiple protein components. In mammalian cells the receptor of activated C kinase (RACK1) is an important scaffolding protein for signal transduction networks. Further, it also performs a critical function in regulating the cell cycle by modulating the G1/S transition. Many eukaryotic cells express RACK1 orthologs, with one example being Cpc2p in the fission yeast Schizosaccharomyces pombe. In contrast to RACK1, Cpc2p has been described to positively regulate, at the ribosomal level, cells entry into M phase. In addition, Cpc2p controls the stress response pathways through an interaction with Msa2p, and sexual development by modulating Ran1p/Pat1p. Here we describe investigations into the role, which Cpc2p performs in controlling the G protein-mediated mating response pathway. Despite structural similarity to Gβ-like subunits, Cpc2p appears not to function at the G protein level. However, upon pheromone stimulation, cells overexpressing Cpc2p display substantial cell morphology defects, disorientation of septum formation and a significantly protracted G1 arrest. Cpc2p has the potential to function at multiple positions within the pheromone response pathway. We provide a mechanistic interpretation of this novel data by linking Cpc2p function, during the mating response, with its previous described interactions with Ran1p/Pat1p. We suggest that overexpressing Cpc2p prolongs the stimulated state of pheromone-induced cells by increasing ste11 gene expression. These data indicate that Cpc2p regulates the pheromone-induced cell cycle arrest in fission yeast by delaying cells entry into S phase

The RNA Binding Protein Csx1 Promotes Sexual Differentiation in Schizosaccharomyces pombe

Sexual differentiation is a highly regulated process in the fission yeast Schizosaccharomyces pombe and is triggered by nutrient depletion, mainly nitrogen source

The Antigen ASB4 on Cancer Stem Cells Serves as a Target for CTL Immunotherapy of Colorectal Cancer

網羅的なHLAリガンドーム解析により，がん幹細胞（cancer stem cell，CSC）に特異的なASB4由来のペプチドIV9を同定し，CSCを特異的に傷害可能なCTL免疫療法となることを示した．更にCSCを標的としたCTL免疫療法が再発予防として有用であることを明らかにした

Compressional-mode giant resonances in deformed nuclei

AbstractBackground-free inelastic scattering spectra have been obtained for the Sm isotopes with 400 MeV α particles at forward angles (including 0°) to investigate the effect of deformation on the compressional-mode giant resonances. The strength distributions for the isoscalar giant resonances (L⩽3) have been extracted for the spherical nucleus 144Sm and the deformed nucleus 154Sm. We have observed that the effects of deformation are different for the low- and high-excitation-energy components of the isoscalar giant dipole resonance in 154Sm. Evidence for the theoretically predicted coupling between the isoscalar dipole resonance and the high-energy octupole resonance is reported