Tables of Hyperonic Matter Equation of State for Core-Collapse Supernovae

We present sets of equation of state (EOS) of nuclear matter including hyperons using an SU_f(3) extended relativistic mean field (RMF) model with a wide coverage of density, temperature, and charge fraction for numerical simulations of core collapse supernovae. Coupling constants of Sigma and Xi hyperons with the sigma meson are determined to fit the hyperon potential depths in nuclear matter, U_Sigma(rho_0) ~ +30 MeV and U_Xi(rho_0) ~ -15 MeV, which are suggested from recent analyses of hyperon production reactions. At low densities, the EOS of uniform matter is connected with the EOS by Shen et al., in which formation of finite nuclei is included in the Thomas-Fermi approximation. In the present EOS, the maximum mass of neutron stars decreases from 2.17 M_sun (Ne mu) to 1.63 M_sun (NYe mu) when hyperons are included. In a spherical, adiabatic collapse of a 15$M_\odot$ star by the hydrodynamics without neutrino transfer, hyperon effects are found to be small, since the temperature and density do not reach the region of hyperon mixture, where the hyperon fraction is above 1 % (T > 40 MeV or rho_B > 0.4 fm^{-3}).Comment: 23 pages, 6 figures (Fig.3 and related comments on pion potential are corrected in v3.

EOS of hyperonic matter for core-collapse supernovae

Abstract We discuss the properties of supernova matter equation of state (EOS) including hyperons, and the emergence of hyperons in dynamical core-collapse processes. The recently tabulated EOS including hyperons is based on an SU f (3) extended relativistic mean field (RMF) model, in which the coupling constants of hyperons with scalar mesons are determined to fit the hyperon potential depths in nuclear matter, (U Σ , U Ξ ) = (+30MeV, −15 MeV), which are suggested from recent analyses of hyperon production reactions. Hyperon effects are found to be small in the core-collapse and bounce stages, but abundant hyperons appear when the temperature becomes high during the black hole formation and promote earlier collapse of the accreting proto-neutron star. The maximum mass of hot proto-neutron star is discussed, and it gives a rough estimate of the critical mass of the accreting proto-neutron star, at which the proto-neutron star re-collapses to a black hole

Microscopic global optical potential for nucleon-nucleus systems in the energy range 50-400 MeV

We provide a microscopic global optical potential (MGOP) for nucleon-nucleus (NA) systems in a wide range of nuclear mass numbers (A = 10-276) and incident energies (E = 50-400 MeV). The potential is microscopically constructed based on a single-folding (SF) model with the complex G-matrix interaction. The nuclear densities used in the SF model are generated, in a non-empirical way, from two kinds of microscopic mean-field models: the relativistic-mean-field (RMF) and Skyrme-Hartree-Fock BCS (HF-PBCS) models. We calculate the NA potentials for more than 1000 even-even nuclei with atomic number Z = 6-92, involving proton- and neutron-rich unstable nuclei. We confirm that both the MGOP models well reproduce the available experimental data of the total reaction cross sections, the total neutron cross sections, the elastic-scattering cross sections, the analyzing power, and the spin-rotation function Q. We also calculate the proton scattering cross sections of O-22, O-24, and Ni-56 targets to compare the experimental data and then the cross sections for unknown S-48, Zr-100, and Zr-110 are presented for future measurements. For the sake of convenience, the real and imaginary parts of the central and spin-orbit components of the NA potentials are respectively represented in a linear combination of 12-range Gaussians. They are provided on the website [http://www2.yukawa.kyoto-u.ac.jp/similar to takenori.furumoto/] with a program source file for reconstructing the MGOP

Supplementary Material for: Carpal Tunnel Surgery as Proxy for Dialysis-Related Amyloidosis: Results from the Japanese Society for Dialysis Therapy

<b><i>Background/Aims:</i></b> This study aims to identify current risk factors for developing dialysis-related amyloidosis using carpal tunnel syndrome (CTS) as proxy for general amyloidosis. <b><i>Methods:</i></b> The cohort consisted of 166,237 patients on dialysis (mean age 66.1 ± 12.4 years; mean dialysis vintage 7.2 ± 6.4 years) who could be followed for a year between 2010 and 2011. Of these, 2,157 (1.30%) needed first-time CTS surgery during the study period. Odds ratios (ORs) for CTS were calculated at a 95% confidence interval (95% CI) after adjusting for age, gender, primary kidney disease, history of smoking, history of hypertension vintage, dialysis modality, use of high-flux membrane, body mass index, serum albumin, Kt/V, normalized protein catabolic rate, C-reactive protein, pretreatment β₂-microglobulin (β₂MG), and β₂MG clearance. <b><i>Results:</i></b> Adjusted ORs of first-time CTS for vintages 10-15, 15-20, 20-25 (referent), 25-30, and >30 years were, respectively, 0.18 (0.12-0.26), 0.43 (0.31-0.62), 1.00, 2.37 (1.64-3.40), and 3.87 (2.52-5.93). Adjusted ORs for ages 40-50, 50-60 (referent), 60-70, 70-80, and >80 were 0.53 (0.30-0.94), 1.00, 1.89 (1.41-2.52), 1.52 (1.08-2.14), and 1.04 (0.60-1.80). Female gender, low serum albumin, and diabetic nephropathy were also associated with CTS. Pretreatment serum β₂MG and β₂MG clearance <80% were not significant, although β₂MG clearance >80% was negatively associated with CTS [OR 0.34 (0.13-0.90)]. <b><i>Conclusion:</i></b> ORs of first-time CTS almost doubled with every 5-year increase in dialysis vintage. ORs of CTS were highest for patients aged 60-70. Other factors associated with CTS were gender, serum albumin, and diabetic nephropathy. β₂MG clearance >80% may decrease the incidence of CTS

TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition

Transforming growth factor beta (TGF(beta) induces epithelial-mesenchymal transition (EMT), which correlates with sternness and invasiveness. Mesenchymal-epithelial transition (MET) is induced by TGF beta withdrawal and correlates with metastatic colonization. Whether TGF beta promotes sternness and invasiveness simultaneously via EMT remains unclear. We established a breast cancer cell model expressing red fluorescent protein (RFP) under the E-cadherin promoter. In 2D cultures, TGF beta induced EMT, generating RFPlow cells with a mesenchymal transcriptome, and regained RFP, with an epithelial transcriptome, after MET induced by TGF beta withdrawal. RFPlow cells generated robust mammospheres, with epithelio-mesenchymal cell surface features. Mammospheres that were forced to adhere generated migratory cells, devoid of RFP, a phenotype which was inhibited by a TGF beta receptor kinase inhibitor. Further stimulation of RFPlow mammospheres with TGF beta suppressed the generation of motile cells, but enhanced mammosphere growth. Accordingly, mammary fat-pad-transplanted mammospheres, in the absence of exogenous TGF beta treatment, established lung metastases with evident MET (RFPhigh cells). In contrast, TGF beta-treated mammospheres revealed high tumour-initiating capacity, but limited metastatic potential. Thus, the biological context of partial EMT and MET allows TGF beta to differentiate between pro-sternness and pro-invasive phenotypes.Cancer Signaling networks and Molecular Therapeutic