Intravitreal Bevacizumab for Photodynamic Therapy-Induced Massive Macular Detachment in Acute Central Serous Chorioretinopathy

We present a long followed up case of acute central serous chorioretinopathy (CSC) complicated by a severe visual loss due to massive pigment epithelium detachment of the macula after a full-dose photodynamic therapy (PDT). Rapid anatomical and functional improvement was observed after a single intravitreal injection of bevacizumab. To our knowledge, we report the first case of PDT-treated CSC complicated by severe visual loss. We can only speculate that the serous detachment of the posterior pole might have been caused by PDT-induced VEGF overexpression, explaining such an impressive response to Avastin treatment

Detecting hate speech on twitter using a convolution-GRU based deep neural network

In recent years, the increasing propagation of hate speech on social media and the urgent need for effective counter-measures have drawn significant investment from governments, companies, as well as empirical research. Despite a large number of emerging scientific studies to address the problem, existing methods are limited in several ways, such as the lack of comparative evaluations which makes it difficult to assess the contribution of individual works. This paper introduces a new method based on a deep neural network combining convolutional and long short term memory networks, and conducts an extensive evaluation of the method against several baselines and state of the art on the largest collection of publicly available datasets to date. We show that our proposed method outperforms state of the art on 6 out of 7 datasets by between 0.2 and 13.8 points in F1. We also carry out further analysis using automatic feature selection to understand the impact of the conventional manual feature engineering process that distinguishes most methods in this field. Our findings challenge the existing perception of the importance of feature engineering, as we show that: the automatic feature selection algorithm drastically reduces the original feature space by over 90% and selects predominantly generic features from datasets; nevertheless, machine learning algorithms perform better using automatically selected features than the original features

European ST80 community-associated methicillin-resistant Staphylococcus aureus orbital cellulitis in a neonate

<p>Abstract</p> <p>Background</p> <p>Methicillin-resistant <it>Staphylococcus aureus</it> is a serious cause of morbidity and mortality in hospital environment, but also, lately, in the community. This case report is, to our knowledge, the first detailed description of a community-associated methicillin-resistant <it>S. aureus</it> ST80 orbital cellulitis in a previously healthy neonate. Possible predisposing factors of microbial acquisition and treatment selection are also discussed.</p> <p>Case presentation</p> <p>A 28-day-old Caucasian boy was referred to our hospital with the diagnosis of right orbital cellulitis. His symptoms included right eye proptosis, periocular edema and redness. Empirical therapy of intravenous daptomycin, rifampin and ceftriaxone was initiated. The culture of pus yielded a methicillin-resistant <it>S. aureus</it> isolate and the molecular analysis revealed that it was a Panton-Valentine leukocidine-positive ST80 strain. The combination antimicrobial therapy was continued for 42days and the infection was successfully controlled.</p> <p>Conclusions</p> <p>Clinicians should be aware that young infants, even without any predisposing condition, are susceptible to orbital cellulitis caused by community-associated methicillin-resistant <it>S. aureus.</it> Prompt initiation of the appropriate empirical therapy, according to the local epidemiology, should successfully address the infection, preventing ocular and systemic complications.</p

Evaluation of MMP1 and MMP3 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma

Purpose: To investigate possible genetic associations of matrix metalloproteinase-1 (MMP1) and MMP3 gene polymorphisms with exfoliation syndrome (XFS) with (XFS/+G) and without (XFS/-G) glaucoma in a cohort of Greek patients. Methods: A total of 182 unrelated Greek patients with XFS, including 92 patients with XFS/+G, and 214 unrelated age- and gender-matched controls were enrolled in the study. MMP1-1607 1G/2G (rs1799750) and MMP3-1171 5A/6A (rs3025058) polymorphisms were determined using standard PCR/restriction fragment length polymorphism methods. Differences in allele and genotype distributions were analyzed using logistic regression. Results: The distribution of genotypes and alleles in MMP1 and MMP3 polymorphisms was not significantly different between cases with exfoliation syndrome, with or without glaucoma, and controls. However, the allele contrast for the MMP1 variant showed a trend for a significant association with XFS/-G (Odds Ratio=1.47 [1.03-2.10]), since after correction for multiple comparisons, this association was no longer statistically significant. Conclusions: Our study provided some evidence of a possible role of the MMP1 variant in the development of exfoliation syndrome in Greek patients

Domino-style earthquakes along blind normal faults in Northern Thessaly (Greece): kinematic evidence from field observations, seismology, SAR interferometry and GNSS

Here we present a joint analysis of the geodetic, seismological and geological data of the March 2021 Northern Thessaly seismic sequence, that were gathered and processed as of April 30, 2021. First, we relocated seismicity data from regional and local networks and inferred the dip-direction (NE) and dip-angle (38°) of the March 3, 2021 rupture plane. Furthermore, we used ascending and descending SAR images acquired by the Sentinel-1 satellites to map the co-seismic displacement field. Our results indicate that the March 3, 2021 Mw=6.3 rupture occurred on a NE-dipping, 39° normal fault located between the villages Zarko (Trikala) and Damasi (Larissa). The event of March 4, 2021 occurred northwest of Damasi, along a fault oriented WNW-ESE and produced less deformation than the event of the previous day. The third event occurred on March 12, 2021 along a south-dipping normal fault. We computed 22 focal mechanisms of aftershocks with M≥4.0 using P-wave first motion polarities. Nearly all focal mechanisms exhibit normal kinematics or have a dominant normal dip-slip component. The use of InSAR was crucial to differentiate the ground deformation between the ruptures. The majority of deformation occurs in the vertical component, with a maximum of 0.39 m of subsidence over the Mw=6.3 rupture plane, south and west of Damasi. A total amount of 0.3 m horizontal displacement (E-W) was measured. We also used GNSS data (at 30-s sampling interval) from twelve permanent stations near the epicentres to obtain 3D seismic offsets of station positions. Only the first event produces significant displacement at the GNSS stations (as predicted by the fault models, themselves very well constrained by InSAR). We calculated several post-seismic interferograms, yet we have observed that there is almost no post-seismic deformation, except in the footwall area (Zarkos mountain). This post-seismic deformation is below the 7 mm level (quarter of a fringe) in the near field and below the 1 mm level at the GNSS sites. The cascading activation of the three events in a SE to NW direction points to a pattern of domino-style earthquakes, along neighbouring fault segments. The kinematics of the ruptures point to a counter-clockwise change in the extension direction of the upper crust (from NE-SW near Damasi to N-S towards northwest, near Verdikoussa)

Race and Inflammatory Bowel Disease in an Urban Healthcare System

Inflammatory bowel disease (IBD) is increasingly common among non-Caucasian populations, but interracial differences in disease characteristics and management are not well-characterized. We tested the hypothesis that disease characteristics and management vary by race among IBD patients in an ethnically diverse healthcare system. A retrospective study of the safety net healthcare system of San Francisco, CA, from 1996 to 2009 was undertaken. Patient records with International Classification of Diseases, 9th Revision (ICD9) codes 555.xx, 556.xx, and 558.xx were reviewed. Adult patients with confirmed IBD diagnoses were included. Interracial variations in disease characteristics and management were assessed broadly; focused between-race comparisons identified specific differences. The 228 subjects included 77 (33.4%) with Crohn’s disease (CD), 150 (65.8%) with ulcerative colitis, and 1 (0.4%) with IBD, type unclassified. The race distribution included 105 (46.1%) white, 34 (14.9%) black, 35 (15.4%) Hispanic, and 51 (22.4%) Asian subjects. Asians and Hispanics were diagnosed at older ages (41.0 and 37.1 years, respectively) and had shorter disease durations (5.4 and 5.2 years, respectively) than whites (30.5 years at diagnosis and 8.6 years duration, P &lt; 0.05) and blacks (31.7 years at diagnosis and 12.1 years duration, P &lt; 0.05). CD was more common among blacks (50% of subjects) than Asians (25.5% of subjects, P = 0.015). The Montreal classification of IBD was similar among races. Hispanics were less likely than others to be treated with 5-aminosalicylates (5-ASA), immunomodulators, and steroids. Medical and surgical management was otherwise similar among races. Modest race-based differences in IBD characteristics exist in this racially diverse healthcare system, but the management of IBD is similar among race groups

Unusual cardiovascular complications of brucellosis presenting in two men: two case reports and a review of the literature

Introduction: Brucellosis is a zoonosis with worldwide distribution, which is particularly endemic in many countries of the Mediterranean basin. Cardiovascular complications of this disease, such as endocarditis, myocarditis and pericarditis, are very rare, with even fewer cases of myocarditis or asymptomatic pericardial effusion in the absence of concomitant endocarditis being reported. Case presentation: We report two cases of brucellosis in two Caucasian men, aged 17 and 34 years old, with myocarditis and asymptomatic pericardial effusion, respectively. Of note, neither patient had concomitant endocarditis. The disease was confirmed serologically and by blood cultures. Both patients recovered completely after receiving appropriate antibiotic treatment without any sign of relapse during a follow-up of 12 months. Conclusion: These two cases emphasize that in endemic areas Brucella can be considered as a potentially causative agent of idiopathic pericardial effusion or myocarditis, even in the absence of concomitant endocarditis. This possibility could be taken into account particularly in cases where contraction of brucellosis is possible, such as occupational exposure or consumption of unpasteurized dairy products. © 2011 Gatselis et al; licensee BioMed Central Ltd

The efficacy of iron chelator regimes in reducing cardiac and hepatic iron in patients with thalassaemia major: a clinical observational study

<p>Abstract</p> <p>Background</p> <p>Available iron chelation regimes in thalassaemia may achieve different changes in cardiac and hepatic iron as assessed by MR. The aim of this study was to assess the efficacy of four available iron chelator regimes in 232 thalassaemia major patients by assessing the rate of change in repeated measurements of cardiac and hepatic MR.</p> <p>Results</p> <p>For the heart, deferiprone and the combination of deferiprone and deferoxamine significantly reduced cardiac iron at all levels of iron loading. As patients were on deferasirox for a shorter time, a second analysis ("Initial interval analysis") assessing the change between the first two recorded MR results for both cardiac and hepatic iron (minimum interval 12 months) was made. Combination therapy achieved the most rapid fall in cardiac iron load at all levels and deferiprone alone was significantly effective with moderate and mild iron load. In the liver, deferasirox effected significant falls in iron load and combination therapy resulted in the most rapid decline.</p> <p>Conclusion</p> <p>With the knowledge of the efficacy of the different available regimes and the specific iron load in the heart and the liver, appropriate tailoring of chelation therapy should allow clearance of iron. Combination therapy is best in reducing both cardiac and hepatic iron, while monotherapy with deferiprone or deferasirox are effective in the heart and liver respectively. The outcomes of this study may be useful to physicians as to the chelation they should prescribe according to the levels of iron load found in the heart and liver by MR.</p