Chromosome 9: linkage for borderline personality disorder features.

Objective A large-scale twin study implicated genetic influences on borderline personality disorder (BPO) features, with a heritability estimate of 42%. To date, no genome-wide linkage study has been conducted to identify the genomic region(s) containing the quantitative trait loci that influence the manifestation of BPD features. Methods We conducted a family-based linkage study using Merlin regress. The participating families were drawn from the community-based Netherlands Twin Register. The sample consisted of 711 sibling pairs with phenotype and genotype data, and 561 additional parents with genotype data. BPD features were assessed on a quantitative scale. Results Evidence for linkage was found on chromosomes 1, 4, 9, and 18. The highest linkage peak was found on chromosome 9p at marker D9S286 with a logarithm of odds score of 3.548 (empirical P= 0.0001). Conclusion To our knowledge, this is the first linkage study on BPD features and shows that chromosome 9 is the richest candidate for genes influencing BPD. The results of this study will move the field closer to determining the genetic etiology of BPD and may have important implications for treatment programs in the future. Association studies in this region are, however, warranted to detect the actual genes. © 2008 Wolters Kluwer Health|Lippincott Williams & Wilkins

The association of genetic predisposition to depressive symptoms with non-suicidal and suicidal self-Injuries

Non-suicidal and suicidal self-injury are very destructive, yet surprisingly common behaviours. Depressed mood is a major risk factor for non-suicidal self-injury (NSSI), suicidal ideation and suicide attempts. We conducted a genetic risk prediction study to examine the polygenic overlap of depressive symptoms with lifetime NSSI, suicidal ideation, and suicide attempts in a sample of 6237 Australian adult twins and their family members (3740 females, mean age\ua0=\ua042.4\ua0years). Polygenic risk scores for depressive symptoms significantly predicted suicidal ideation, and some predictive ability was found for suicide attempts; the polygenic risk scores explained a significant amount of variance in suicidal ideation (lowest p\ua0=\ua00.008, explained variance ranging from 0.10 to 0.16\ua0%) and, less consistently, in suicide attempts (lowest p\ua0=\ua00.04, explained variance ranging from 0.12 to 0.23\ua0%). Polygenic risk scores did not significantly predict NSSI. Results highlight that individuals genetically predisposed to depression are also more likely to experience suicidal ideation/behaviour, whereas we found no evidence that this is also the case for NSSI

KSU Chamber Singers, A Litany for Courage and the Seasons

Kennesaw State University Chamber Singers present David Maslanka\u27s A Litany for Courage and the Seasons, six songs for chorus, clarinet and vibraphone on poems of Richard Beale at the 2013 National Collegiate Choral Organization 5th National Conference in Charleston, South Carolina, October 31 - November 2.https://digitalcommons.kennesaw.edu/musicprograms/1268/thumbnail.jp

KSU Chamber Singers and Men\u27s Ensemble

KSU School of Music presents KSU Chamber Singers and Men\u27s Ensemble.https://digitalcommons.kennesaw.edu/musicprograms/1294/thumbnail.jp

Holiday Concert, Home for the Holidays

Kennesaw State University School of Music presents Holiday Concert, Home for the Holidays.https://digitalcommons.kennesaw.edu/musicprograms/1433/thumbnail.jp