Conocimiento y poder: Ciencia en la corte y utilidad política en la obra de Roger Bacon.

In his major works for the pope, as well as several other works from his maturity, Bacon focused on the utility of natural knowledge, both in terms of human know-how and what that know-how could produce. He looked to the courtly sciences (such as medicine, astral science, optics, and material science), which privilege application and knowledge gained through the sensorium, as sources of natural knowledge and as exemplars for the potential of natural knowledge. This essay argues that Roger Bacon’s work ought to be understood within the context of the court. Bacon’s emphasis on devices in the pursuit of knowledge and utility demonstrates the extent to which the courtly sciences (such as engineering, navigation, alchemy, and divination) were valued alongside traditional natural philosophical frameworks, and need to be understood in that context. Both the courtly sciences and Bacon’s theory of scientia experimentalis focus on materials, sensory knowledge, and knowledge of particulars in pursuit of applied ends. Bacon drew inspiration from the courtly sciences in theorizing how natural knowledge could serve ruling power. By examining Bacon’s major works on scientia experimentalis and analyzing his reliance on examples from the history of Alexander the Great, this essay demonstrates the interrelation of political power and erudite knowledge, and how they intersected through the cultivation and application of experimentum and technology. Finally, Bacon’s interest in the utility of knowledge suggests that courtly settings in this period are significant locations for the development and applications of natural knowledge.En sus principales trabajos para el Papa, así como en ciertas obras de madurez, Bacon se centró en la utilidad del conocimiento natural, tanto en términos de saber práctico humano como de lo que ese saber podía producir. Miró a las ciencias practicadas en la corte (como la medicina, la ciencia astral, la óptica y la ciencia de la materia), que privilegian la aplicación y el conocimiento obtenido a través de los sentidos, como fuentes de conocimiento natural y como ejemplos del potencial del conocimiento de la naturaleza. Este ensayo sostiene que la obra de Roger Bacon debe entenderse en el contexto de la corte. El énfasis de Bacon en los dispositivos para la búsqueda del conocimiento y la utilidad demuestra hasta qué punto las ciencias desarrolladas en la corte (la ingeniería, la navegación, la alquimia y la adivinación) se valoraban junto a distintos ámbitos filosóficos tradicionales sobre la naturaleza, y es en este contexto en el que deben ser entendidos. Tanto las ciencias desarrolladas en la corte como la teoría de Bacon sobre la scientia experimentalis se centran en los materiales, el conocimiento sensorial y el conocimiento que persigue fines aplicados de hechos concretos. Bacon se inspiró en las ciencias desarrolladas en la corte para teorizar cómo el conocimiento natural podía servir al poder gobernante. Examinando las principales obras de Bacon sobre la scientia experimentalis y analizando cómo recurre a ejemplos de la historia de Alejandro Magno, este ensayo demuestra la interrelación entre el poder político y el conocimiento erudito, y cómo se entrecruzan practicando y aplicando el experimentum y la tecnología. Por último, el interés de Bacon por la utilidad del conocimiento sugiere que los escenarios cortesanos de este periodo

Fictions of life and death: Tomb automata in medieval romance

While automata appear in medieval European textual sources in many different settings, they frequently cluster around tombs, memorials and other places associated with the dead. In several different literary examples, automata expose the unstable definitions of ‘life’ and ‘death’ and reveal contemporary ideas about the complexity and permeability of these categories

Influence of Introduced Peregrine Falcons on the Distribution of Red Knots within a Spring Staging Site

Predator recovery driven by single-species management approaches may lead to conservation conflicts between recovered predators and prey species of conservation concern. As part of an aggressive recovery plan, the Eastern Peregrine Falcon Recovery Team released (1975–1985) 307 captive-reared peregrine falcons (Falco peregrinus) and successfully established a breeding population within the mid-Atlantic Coastal Plain, a physiographic region with no historic breeding population and a critical spring staging area for migratory shorebirds. We examined the influence of resident falcons on the distribution of foraging red knots during spring migration. We conducted weekly aerial surveys (2006–2009) along the Virginia barrier islands during the spring staging period (25 April– 6 June) to map foraging red knots (Calidris canutus) and evaluated the influence of proximity (0–3, 3–6, \u3e6 km) of beaches to active peregrine falcon nests on knot density (birds/km). Accumulated use of beaches throughout the season by red knots was significantly influenced by proximity of beaches to active falcon nests such that mean density was more than 6 fold higher on beaches that were \u3e6 km compared to beaches that were only 0–3 km from active eyries. Whether or not an eyrie was used in a given year had a significant influence on the use of associated close (0–3 km) beaches. From 6.5 to 64 fold more knots used beaches when associated eyries were not active compared to when they were active depending on the specific site. Historically, red knots and other migratory shorebirds would have enjoyed a peregrine-free zone within this critical staging site. The establishment of a dense breeding population of falcons within the area represents a new hazard for the knot population

Sample Return Systems for Extreme Environments (SaRSEE)

Sample return missions offer a greater science yield when compared to missions that only employ in situ experiments or remote sensing observations, since they allow the application of more complex technological and analytical methodologies in controlled terrestrial laboratories,that are both repeatable and can be independently verified. The successful return of extraterrestrial materials over the last four decades has contributed to our understanding of the solar system, but retrieval techniques have largely depended on the use of either soft-landing, or touch-and-go procedures that result in high V requirements, larger spacecraft mass ratios, and return yields typically limited to a few grams of surface materials that have experienced varying degrees of alteration from space weathering. Hard-landing methods using planetary penetrators offer an alternative for sample return that significantly reduce a mission's V and mass ratios,increase sample yields, and allow for the collection of subsurface materials, and lessons can be drawn from previous sample return missions. The following details progress in the design,development, and testing of penetrator/sampler technology capable of surviving subsonic and low, supersonic impact velocities (<700 m/s) that would enable the collection of geologic materials using tether technology to return the sample to a passing spacecraft. The testing of energy absorbing material for protecting the sample, design evolution and field testing of the penetrator, and dynamic modeling of tether behavior during sampling are discussed. It is shown through both modeling and field testing that penetrators at speeds between 300-600 m/s (~Mach 1-2) can penetrator into the ground to depths of 1-2 m with overall structural integrity attained.The first flight tests demonstrated the potential for survivability at these speeds. The second flight series demonstrated core sample collection with partial ejection of the sample return canister. The 3rd flight series demonstrated self-ejection of the sample return system fully intact and with the core retaining the full stratigraphy of the rock bed. The tether analysis shows that the forces on the tether during release and return of the sample to the main spacecraft are all at levels that can easily be handled by existing tether materials. The mass analysis of the requirements indicates that sample return form the asteroids could be handled with Discovery or New Frontier range of missions dependent on the number of samples to be returned to the Earth

Positively Correlated miRNA-miRNA Regulatory Networks in Mouse Frontal Cortex During Early Stages of Alcohol Dependence

Although the study of gene regulation via the action of specific microRNAs (miRNAs) has experienced a boom in recent years, the analysis of genome-wide interaction networks among miRNAs and respective targeted mRNAs has lagged behind. MicroRNAs simultaneously target many transcripts and fine-tune the expression of genes through cooperative/combinatorial targeting. Therefore, they have a large regulatory potential that could widely impact development and progression of diseases, as well as contribute unpredicted collateral effects due to their natural, pathophysiological, or treatment-induced modulation. We support the viewpoint that whole mirnome-transcriptome interaction analysis is required to better understand the mechanisms and potential consequences of miRNA regulation and/or deregulation in relevant biological models. In this study, we tested the hypotheses that ethanol consumption induces changes in miRNA-mRNA interaction networks in the mouse frontal cortex and that some of the changes observed in the mouse are equivalent to changes in similar brain regions from human alcoholics. Results: miRNA-mRNA interaction networks responding to ethanol insult were identified by differential expression analysis and weighted gene coexpression network analysis (WGCNA). Important pathways (coexpressed modular networks detected by WGCNA) and hub genes central to the neuronal response to ethanol are highlighted, as well as key miRNAs that regulate these processes and therefore represent potential therapeutic targets for treating alcohol addiction. Importantly, we discovered a conserved signature of changing miRNAs between ethanol-treated mice and human alcoholics, which provides a valuable tool for future biomarker/diagnostic studies in humans. We report positively correlated miRNA-mRNA expression networks that suggest an adaptive, targeted miRNA response due to binge ethanol drinking. Conclusions: This study provides new evidence for the role of miRNA regulation in brain homeostasis and sheds new light on current understanding of the development of alcohol dependence. To our knowledge this is the first report that activated expression of miRNAs correlates with activated expression of mRNAs rather than with mRNA downregulation in an in vivo model. We speculate that early activation of miRNAs designed to limit the effects of alcohol-induced genes may be an essential adaptive response during disease progression.NIAAA 5R01AA012404, 5P20AA017838, 5U01AA013520, P01AA020683, 5T32AA007471-24/25Waggoner Center for Alcohol and Addiction Researc

The Oyster and the Oyster Industry of Maryland

Information n the life-history and management of the Oyster and Oyster Industry. Dr. Truitt has traveled and researched almost every important oyster producing Area in America. Includes semidiagramatic sketches of anatomy, information on food and feeding, respiration and circulation,valves, reproduction. Oyster production - natural beds or rocks, oyster farming, tongs and tonging, dredge. Marketing - canned, raw, shell stock. Includes bibliography. (PDF contains 47 pages