Una nuova critica dell’antica pittura italiana.Giovanni Morelli, Emilio Visconti Venosta e l’archeologia del discorso nazionale

A partire dalla celebre recensione di Emilio Visconti Venosta al primo volume di saggi di Giovanni Morelli, il saggio intende dimostrare come, all'indomani dell'unificazione nazionale, la definizione della storia dell'arte come disciplina autonoma partecipi a pieno titolo del discorso nazionalizzante a cui il nuovo stato affida la fabbricazione della sua identità. Il saggio presenta una versione ampliata della relazione al Convegno nazionale della SISCA, Bologna 7,8,9 novembre 2012

Scene per un mondo nuovo. Vanessa Bell, Duncan Grant e il Famous Women Dinner Service

In 1933-34, the Bloomsbury Group painters Duncan Grant and Vanessa Bell honored twelve actresses and dancers from XVIIto XXcentury in The Famous Women Dinner Service, the Wedgewood dinner set which was one of Bell and Grant’s most spectacular joint commissions, the evidence of their dedication to different genres and media and the impressive testament of their close working partnership. Having onlyjust come to light, and first publicly exhibited in 2017 with the whole set, the portraits offer exciting new material for research and discussion: this essay try to unravel the many connections that tie Bell and Grant to the dramatic stage and to explorethe approach of Bloomsbury Group members to theatre as a space of freedom and of experiments of living and working to (try to) change the world

Una experiencia de formación de promotoras contra la violencia de género en los barrios de La Plata y Gran La Plata

En este trabajo presentamos unas primeras reflexiones sobre una experiencia pedagógica realizada en el año 2015 en el marco del Proyecto de Extensión Universitaria: Redescubriendo los lazos sociales del Affidamento. Promotoras para el reposicionamiento subjetivo contra la violencia de género con base en redes cooperativo- comunitarias de la Facultad de Humanidades y Ciencias de la Educación de la UNLP. En el mismo confluimos docentes, graduadas, investigadoras y alumnas de las siguientes Facultades: de Humanidades y Ciencias de la Educación, de Psicología, de Ciencias Jurídicas y Sociales, de Periodismo y Comunicación Social, de Ciencias Naturales y Museo.Eje 4: Prácticas socio-comunitarias en la formación y compromiso social de la universidad. Políticas y estrategias de extensión universitaria: reflexiones y debates.Secretaría de Asuntos Académico

Intrinsically disordered amphiphilic peptides as potential targets in drug delivery vehicles

Intrinsically disordered proteins/peptides play a crucial role in many physiological and pathological events and may assume a precise conformation upon binding to a specific target. Recently, we have described the conformational and functional properties of two linear ester peptides provided with the following sequences: Y-G-E-C-P-C-K-OAllyl (PepK) and Y-G-E-C-P-C-E-OAllyl (PepE). Both peptides are characterized by the presence of the ‘‘CPC’’ motif together with a few amino acids able to promote disorder. The CPC sequence is a binding motif for the CXCR4 receptor that represents a well-known target for cancer therapies. In this paper, we report on synthetic amphiphilic peptides that consist of lipophilic derivatives of PepE and PepK bearing two stearic alkyl chains and/or an ethoxylic spacer. These peptide amphiphiles form stable supramolecular aggregates; they present conformational features that are typical of intrinsically disordered molecules as shown by CD spectroscopy. Solution fluorescence and DLS studies have been performed to evaluate Critical Micellar Concentrations and the dimension of supramolecular aggregates. Moreover, preliminary in vitro cell-based assays have been conducted to investigate the molecular recognition processes involving the CXCR4 receptor. In the end, the results obtained have been compared with the previous data generated by the corresponding non-amphiphilic peptides (PepE and PepK)

En Affidamento: construyendo redes sociales contra la violencia de género

En este trabajo, compartiremos algunas reflexiones sobre nuestra participación en un Proyecto de Extensión Universitaria realizado en el año 2015, titulado: Redescubriendo los lazos sociales del Affidamento. Promotoras para el reposicionamiento subjetivo contra la violencia de género con base en redes cooperativo- comunitaria con continuidad en el año 2016, en la Facultad de Humanidades y Ciencias de la Educación de la UNLP. En el mismo confluimos docentes, graduadas, investigadoras y alumnas de las siguientes Facultades: de Humanidades y Ciencias de la Educación, de Psicología, de Ciencias Jurídicas y Sociales, de Periodismo y Comunicación Social, de Ciencias Naturales y Museo.Mesa 35: ¿Podremos vivir juntos? Ciudadanía, género y culturas urbanas. La perspectiva de género en la producción de conocimiento sociológicoFacultad de Humanidades y Ciencias de la Educació

Conformational Ensembles Explored Dynamically from Disordered Peptides Targeting Chemokine Receptor CXCR4

This work reports on the design and the synthesis of two short linear peptides both containing a few amino acids with disorder propensity and an allylic ester group at the C-terminal end. Their structural properties were firstly analyzed by means of experimental techniques in solution such as CD and NMR methods that highlighted peptide flexibility. These results were further confirmed by MD simulations that demonstrated the ability of the peptides to assume conformational ensembles. They revealed a network of transient and dynamic H-bonds and interactions with water molecules. Binding assays with a well-known drug-target, i.e., the CXCR4 receptor, were also carried out in an attempt to verify their biological function and the possibility to use the assays to develop new specific targets for CXCR4. Moreover, our data indicate that these peptides represent useful tools for molecular recognition processes in which a flexible conformation is required in order to obtain an interaction with a specific target

En Affidamento: construyendo redes sociales contra la violencia de género

En este trabajo, compartiremos algunas reflexiones sobre nuestra participación en un Proyecto de Extensión Universitaria realizado en el año 2015, titulado: Redescubriendo los lazos sociales del Affidamento. Promotoras para el reposicionamiento subjetivo contra la violencia de género con base en redes cooperativo- comunitaria con continuidad en el año 2016, en la Facultad de Humanidades y Ciencias de la Educación de la UNLP. En el mismo confluimos docentes, graduadas, investigadoras y alumnas de las siguientes Facultades: de Humanidades y Ciencias de la Educación, de Psicología, de Ciencias Jurídicas y Sociales, de Periodismo y Comunicación Social, de Ciencias Naturales y Museo.Mesa 35: ¿Podremos vivir juntos? Ciudadanía, género y culturas urbanas. La perspectiva de género en la producción de conocimiento sociológicoFacultad de Humanidades y Ciencias de la Educació

Associations between childhood victimization, inflammatory biomarkers and psychotic phenomena in adolescence: A longitudinal cohort study.

Exposure to victimization in childhood has been linked to the development of psychosis. However, little is known about how childhood victimization is translated into biological risk for psychosis. One possibility is via increased inflammation. This study aimed to investigate the association between childhood victimization, psychotic experiences (PEs) in adolescence and inflammatory markers using data from a general population cohort. Participants were 1,419 British-born children followed from birth to age 18 years as part of the Environmental Risk Longitudinal Twin Study. Childhood victimization was measured prospectively using multiple sources from birth to age 12 years. PEs were assessed during private interviews with participants at age 18 years for the period since age 12. Plasma C-reactive protein (CRP), interleukin-6 (IL-6), and soluble urokinase plasminogen activator receptor (suPAR) levels were measured from plasma samples collected from participants at 18 years. Young people with both PEs and childhood victimization were more likely to belong to a group with elevated suPAR, CRP and IL-6 levels at 18 years of age (OR = 3.34, 95% CI 1.69-6.59, p = 0.001) than those with no childhood victimization and without PEs. However, this association was attenuated when adjusted for other risk factors for elevated inflammation at age 18 (OR = 1.94, 95% CI 0.94-4.04, p = 0.075). In contrast, presence of PEs without childhood victimization was not significantly associated with age-18 inflammatory markers and neither was childhood victimization without PEs (all p's greater than 0.05). The current study highlights that inflammatory dysregulation is mostly present in adolescents reporting PEs who also experienced childhood victimization, though this seemed to be largely due to concurrent inflammation-related risk factors

Construyendo affidamento contra la violencia de género: de un nos-otras a nosotras.

En este trabajo compartiremos algunas reflexiones sobre la experiencia de cinco años de trabajo interdisciplinario en el proyecto de extensión universitaria: "Multiplicando affidamento: promotoras comunitarias en acción. Prácticas en red y estrategias situadas frente a la violencia de género" en coparticipación con el Movimiento Justicia y Libertad. Este proyecto se configuró a partir del surgimiento de una demanda específica en el marco de las acciones llevadas adelante por el grupo de género del Movimiento Justicia y Libertad en su búsqueda por tender redes, affidamentar y potenciar el trabajo contra la violencia de género.Fil: Soza Rossi, Paula Viviana. Universidad Nacional de La Plata; ArgentinaFil: Trotta, Lucía. Universidad Nacional de La Plata; ArgentinaFil: Rodríguez Durán, Adriana. Universidad Nacional de La Plata; ArgentinaFil: Duarte, Yamila. Universidad Nacional de La Plata; ArgentinaFil: Giordano, Antonella. Universidad Nacional de La Plata; ArgentinaFil: Muro, María Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Centro de Estudios Urbanos y Regionales; ArgentinaFil: Lofeudo, Graciela. Universidad Nacional de La Plata; Argentin

Different types of childhood adversity and 5-year outcomes in a longitudinal cohort of first-episode psychosis patients

Little is known about the impact of different forms of childhood adversity on outcomes in first-episode psychosis (FEP) patients beyond the first year of treatment. We investigated associations between different types of childhood adversity and outcomes of FEP patients over the 5 years following their first contact with mental health services for psychosis. 237 FEP cases aged 18–65 years were followed on average for 5 years after first presentation to psychiatric services in South London, UK. Childhood adversity prior to 17 years of age was assessed at baseline using the Childhood Experience of Care and Abuse Questionnaire (CECA.Q). The results showed that exposure to at least one type of childhood adversity was significantly associated with a lower likelihood of achieving symptomatic remission, longer inpatient stays, and compulsory admission over the 5-year follow-up. There was no evidence though of a dose-response effect. Some specificity was evident. Childhood parental separation was associated with significantly greater likelihood of non-compliance with antipsychotic medications, compulsory admission, and substance dependence. Institutional care was significantly associated with longer total length of inpatient stays; and parental death was significantly associated with compulsory admissions. Clinicians should screen FEP patients for childhood adversity and tailor interventions accordingly to improve outcomes