Tree growth response along an elevational gradient: climate or genetics?

Environment and genetics combine to influence tree growth and should therefore be jointly considered when evaluating forest responses in a warming climate. Here, we combine dendroclimatology and population genetic approaches with the aim of attributing climatic influences on growth of European larch (Larix decidua) and Norway spruce (Picea abies). Increment cores and genomic DNA samples were collected from populations along a ~900-m elevational transect where the air temperature gradient encompasses a ~4 °C temperature difference. We found that low genetic differentiation among populations indicates gene flow is high, suggesting that migration rate is high enough to counteract the selective pressures of local environmental variation. We observed lower growth rates towards higher elevations and a transition from negative to positive correlations with growing season temperature upward along the elevational transect. With increasing elevation there was also a clear increase in the explained variance of growth due to summer temperatures. Comparisons between climate sensitivity patterns observed along this elevational transect with those from Larix and Picea sites distributed across the Alps reveal good agreement, and suggest that tree-ring width (TRW) variations are more climate-driven than genetics-driven at regional and larger scales. We conclude that elevational transects are an extremely valuable platform for understanding climatic-driven changes over time and can be especially powerful when working within an assessed genetic framework

Silver clusters of five atoms as highly selective antitumoral agents through irreversible oxidation of thiols

Low atomicity clusters present properties dependent on the size, due to the quantum confinement, with well-defined electronic structures and high stability. Here it is shown that Ag5 clusters catalyze the complete oxidation of sulfur to S+6. Ag5 catalytic activity increases with different oxidant species in the order O2 ≪ H2O2 < OH•. Selective oxidation of thiols on the cysteine residues of glutathione and thioredoxin is the primary mechanism human cells have to maintain redox homeostasis. Contingent upon oxidant concentration, Ag5 catalyzes the irreversible oxidation of glutathione and thioredoxin, triggering apoptosis. Modification of the intracellular environment to a more oxidized state to mimic conditions within cancer cells through the expression of an activated oncogene (HRASG12V) or through ARID1A mutation, sensitizes cells to Ag5 mediated apoptosis. While cancers evolve to evade treatments designed to target pathways or genetic mutations that drive them, they cannot evade a treatment that takes advantage of aberrant redox homeostasis, which is essential for tumor progression and metastasis. Ag5 has antitumor activity in mice with orthotopic lung tumors reducing primary tumor size, and the burden of affected lymphatic nodes. The findings suggest the unique intracellular redox chemistry of Ag5 may lead to new redox-based approaches to cancer therapyThis research was partially supported by 1) “la Caixa” Foundation, Ref. LCF/PR/PR12/11070003 to F.D. and M.A.L.Q.; 2) Ministerio de Ciencia, Innovación y Universidades (MAT2017-89678-R, AEI/FEDER, UE) to F.D. and A.V.; 3) the Consellería de Educación (Xunta de Galicia), Grants No. Grupos Ref. Comp. ED431C 2017/22, ED431C 2019/13 and AEMAT-ED431E2018/08 to M.A.L.Q.; and ED431C 2019/13 to A.V. This project has received funding from the European Union's Horizon 2020 Research and Innovation Programme (Bac-To-Fuel) under Grant Agreement No. 825999 (M.A.L.Q.). J.C.H. acknowledge financial support from European Union's Horizon 2020 research and innovation programme under grant agreement no. 823717-ESTEEM3, and the MICIIN (projects PID2019-107578GA-100 and PID-110018GA-100). J.M.D, L.J.G., and F.G.R. thank to the ANPCyT (PICT 2015-2285 and 2017-3944), UNLP (Project 11/X790) and the partial support by the Laboratório Nacional de Luz Síncrotron (LNLS, Brazil) under proposal SXS-20180280. G.B. acknowledges the CINECA Award N. IsC51, year 2017, under the ISCRA initiative, for the availability of high-performance computing resources and support. D.B. expresses gratitude for a postdoctoral grant from Xunta de Galicia, Spain (POS-A/2013/018). B.D. expresses gratitude for a predoctoral grant from MICINN, Spain (BES-2016-076765). F.D. and A.V. also acknowledged Xunta de Galicia (Centro singular de investigación de Galicia accreditation 2019-2022 ref ED431G 2019/02) and the European Union (European Regional Development Fund – ERDF). Work in M.P.M.'s lab was supported by the Medical Research Council UK (MC_U105663142). T.G.C. gratefully acknowledges the technical assistance of María José Otero-Fraga (FIDIS)S

Puesta en marcha del Doble Grado Internacional en Derecho UCM - Sorbona en el marco de la alianza europea de universidades UNA EUROPA

Implementación de mejoras que potencien el Doble Grado Internacional en Derecho impartido conjuntamente entre la UCM y la Universidad de la Sorbona y que esta doble titulación internacional refuerce el papel de la UCM en la alianza europea UNA EUROP

Detention and removal of foreigners

El contenido del libro coincide con el del curso “Protección de los derechos humanos y control judicial de la inmigración”, impartido en el marco del programa de formación continua del Consejo General del Poder Judicial. Las ponencias del curso están publicadas en (Los artículos que integran este libro fueron publicadas por el Consejo General del Poder Judicial en Cuadernos Digitales de Formación, 10, 2015. El CGPJ es EPO (Ente Promotor Observador) del Proyecto I+D+i Iusmigrante (DER 2011-26449)en cuyo marco se ha realizado esta edición digital.La expulsión de personas extranjeras sin permiso de residencia es uno de los pilares en los que se asienta la política española y europea de gestión de la inmigración irregular. Además de su gran contenido aflictivo, en la mayoría de las ocasiones, la expulsión va precedida de un “ciclo” de restricción de derechos y de privación de libertad de los ciudadanos extranjeros: actuaciones policiales dirigidas a la localización de ciudadanos en situación irregular, detenciones en comisaría, las denominadas “expulsiones exprés”, privación de libertad en los centros de internamiento, etc... Los artículos que integran este libro colectivo ―cuyos autores proceden de la universidad, la judicatura, la fiscalía, la abogacía o el activismo en la defensa de los derechos humanos―, nos muestran una realidad humana y jurídica sin duda necesitada de mayor atención.The removal of foreigners without a residence permit is one of the pillars on which the Spanish and the European policies against illegal immigration sits. Besides the human suffering it causes, in most cases removal is preceded by a "cycle" of rights's restrictions and by the detention of foreign citizens: police actions aimed at locating people in an irregular situation, detention at the police station, the so called "express evictions", deprivation of liberty in detention centers, etc. The items that make up this collective book -whose authors come from the university, the judiciary, the prosecutor, advocacy or activism in the defense of human rights- , show us a human and legal reality which definitely needed more attention.Depto. de Derecho Procesal y Derecho PenalFac. de DerechoFALSEMinisterio de Economía y Competitividad (MINECO)pu

Implementación y ordenación de las relaciones internacionales e institucionales y de las medidas de aseguramiento de la calidad del Doble Grado en Derecho y Estudios Jurídico Militares

DecanatoFac. de DerechoFALSEsubmitte

Asma : proceso asistencial integrado

Este Proceso (2012) integra los dos publicados anteriormente de Asma en la edad pediátrica (2003) y Asma en la edad adulta (2004). Fichero en formato pdf, publicado en la página web de la Consejería de Salud y Bienestar Social: www.juntadeandalucia.es/salud (Consejería de Salud y Bienestar Social / Profesionales / Nuestro Compromiso por la Calidad / Procesos Asistenciales Integrados)YesConjunto de actuaciones por las que se le presta atención a personas que consultan por síntomas sugestivos de asma, donde se establecen los mecanismos para la detección precoz, diagnóstico, clasificación de gravedad, tratamiento ajustado a gravedad y edad, actividades educativas dirigidas a la prevención y estrategias de automanejo y seguimiento; todo ello, encaminado a asegurar una calidad de vida óptima, garantizando la continuidad asistencial, la coordinación entre los diferentes profesionales y la corresponsabilidad de los profesionales y el paciente