On the constitutive modeling of dual-phase steels at finite strains: a generalized plasticity based approach

In this work we propose a general theoretic framework for the derivation of constitutive equations for dual-phase steels, undergoing continuum finite deformation. The proposed framework is based on the generalized plasticity theory and comprises the following three basic characteristics: 1.A multiplicative decomposition of the deformation gradient into elastic and plastic parts. 2.A hyperelastic constitutive equation 3.A general formulation of the theory which prescribes only the number and the nature of the internal variables, while it leaves their evolution laws unspecified. Due to this generality several different loading functions, flow rules and hardening laws can be analyzed within the proposed framework by leaving its basic structure essentially unaltered. As an application, a rather simple material model, which comprises a von-Mises loading function, an associative flow rule and a non-linear kinematic hardening law, is proposed. The ability of the model in simulating simplified representation of the experimentally observed behaviour is tested by two representative numerical examples

A digital platform for the design of patient-centric supply chains

Chimeric Antigen Receptor (CAR) T cell therapies have received increasing attention, showing promising results in the treatment of acute lymphoblastic leukaemia and aggressive B cell lymphoma. Unlike typical cancer treatments, autologous CAR T cell therapies are patient-specific; this makes them a unique therapeutic to manufacture and distribute. In this work, we focus on the development of a computer modelling tool to assist the design and assessment of supply chain structures that can reliably and cost-efficiently deliver autologous CAR T cell therapies. We focus on four demand scales (200, 500, 1000 and 2000 patients annually) and we assess the tool’s capabilities with respect to the design of responsive supply chain candidate solutions while minimising cost

On the constitutive modeling of dual-phase steels at finite strains: a generalized plasticity based approach

In this work we propose a general theoretic framework for the derivation of constitutive equations for dual-phase steels, undergoing continuum finite deformation. The proposed framework is based on the generalized plasticity theory and comprises the following three basic characteristics: 1.A multiplicative decomposition of the deformation gradient into elastic and plastic parts. 2.A hyperelastic constitutive equation 3.A general formulation of the theory which prescribes only the number and the nature of the internal variables, while it leaves their evolution laws unspecified. Due to this generality several different loading functions, flow rules and hardening laws can be analyzed within the proposed framework by leaving its basic structure essentially unaltered. As an application, a rather simple material model, which comprises a von-Mises loading function, an associative flow rule and a non-linear kinematic hardening law, is proposed. The ability of the model in simulating simplified representation of the experimentally observed behaviour is tested by two representative numerical examples

Two-to-one resonant multi-modal dynamics of horizontal/inclined cables. Part II : internal resonance activation, reduced-order models and nonlinear normal modes

Resonant multi-modal dynamics due to planar 2:1 internal resonances in the nonlinear, finite-amplitude, free vibrations of horizontal/inclined cables are parametrically investigated based on the second-order multiple scales solution in Part I [1]. The already validated kinematically non-condensed cable model accounts for the effects of both non-linear dynamic extensibility and system asymmetry due to inclined sagged configurations. Actual activation of 2:1 resonances is discussed, enlightening on a remarkable qualitative difference of horizontal/inclined cables as regards non-linear orthogonality properties of normal modes. Based on the analysis of modal contribution and solution convergence of various resonant cables, hints are obtained on proper reduced-order model selections from the asymptotic solution accounting for higher-order effects of quadratic nonlinearities. The dependence of resonant dynamics on coupled vibration amplitudes, and the significant effects of cable sag, inclination and extensibility on system non-linear behavior are highlighted, along with meaningful contributions of longitudinal dynamics. The spatio-temporal variation of non-linear dynamic configurations and dynamic tensions associated with 2:1 resonant non-linear normal modes is illustrated. Overall, the analytical predictions are validated by finite difference-based numerical investigations of the original partial-differential equations of motion

The scaled boundary finite element method for the efficient modeling of linear elastic fracture

In this work, a study of computational and implementational efficiency is presented, on the treatment of Linear Elastic Fracture Mechanics (LEFM) problems. To this end, the Scaled Boundary Finite Element Method (SBFEM), is compared against the popular eXtended Finite Element Method (XFEM) and the standard FEM approach for efficient calculation of Stress Intensity Factors (SIFs). The aim is to examine SBFEM’s potential for inclusion within a multiscale fracture mechanics framework. The above features will be exploited to solve a series of benchmarks in LEFM comparing XFEM, SBFEM and commercial FEM software to analytical solutions. The extent to which the SBFEM lends itself for inclusion within a multiscale framework will further be assessed

Laparoscopic Cholecystectomy for Severe Acute Cholecystitis in a Patient with Situs Inversus Totalis and Posterior Cystic Artery

Situs inversus totalis is an inherited condition characterized by a mirror-image transposition of thoracic and abdominal organs. It often coexists with other anatomical variations. Transposition of the organs imposes special demands on the diagnostic and surgical skills of the surgeon. We report a case of a 34-year-old female patient presented with left upper quadrant pain, signs of acute abdomen, and unknown situs inversus totalis. Severe acute cholecystitis was diagnosed, and an uneventful laparoscopic cholecystectomy was performed. A posterior cystic artery was identified and ligated. Laparoscopic cholecystectomy is feasible in patients with severe acute calculus cholecystitis and situs inversus totalis; however, the surgeon should be alert of possible anatomic variations

Towards a multiscale scheme for nonlinear dynamic analysis of masonry structures with damage

In this work, a three dimensional multiscale formulation is presented for the analysis of masonry structures based on the multiscale finite element formulation. The method is developed within the framework of the Enhanced Multiscale Finite Element Method. Through this approach, two discretization schemes are considered, namely a fine mesh that accounts for the micro-structure and a coarse mesh that encapsulates the former. Through a numerically derived mapping, the fine scale information is propagated to the coarse mesh where the numerical solution of the governing equations is performed. Inelasticity is introduced at the fine mesh by considering a set of internal variables corresponding to the plastic deformation accumulating at the Gauss points of each fine-scale element. These additional quantities evolve according to properly defined smooth evolution equations. The proposed formalism results in a nonlinear dynamic analysis method where the micro-level state matrices need only be evaluated once at the beginning of the analysis procedure. The accuracy and computational efficiency of the proposed scheme is verified through an illustrative example

Searching for determinism in observed data: a review of the issues involved

International audienceIn this paper we present a review of advances made and problems still existing in the application of the theory of chaos and dynamical systems to time series. In particular we discuss issues pertaining the estimation of dimensions, Lyapunov exponents and nonlinear prediction from an observable. We analyze the problems and discuss proper ways to deal with them

Brainstem phaeohyphomycosis due to Curvularia lunata (Cochliobolus lunatus) in a cat

A 13-year-old female neutered domestic short-hair cat was presented with chronic progressive vestibular ataxia, lethargy and anorexia. Clinical examination revealed bilateral mucopurulent nasal discharge. Neurological examination revealed obtundation, a right head tilt, ambulatory tetraparesis, generalised vestibular ataxia, decreased postural reactions in all limbs, right Horner's syndrome, spontaneous conjugate jerk rotatory nystagmus and right positional ventral strabismus. Neuroanatomical localisation was observed in the right central vestibular system. Computed tomography revealed a solitary ill-defined contrast-enhancing mass lesion at the level of the right cerebellopontine angle. Cerebrospinal fluid (CSF) analysis revealed mild mononuclear pleocytosis and fungal elements. CSF culture was positive for Curvularia spp. Further tests for underlying diseases were all negative. The cat was treated with antibiotic and antifungal treatment, but it deteriorated rapidly and was euthanased. Necropsy of the brainstem mass lesion revealed pyogranulomatous inflammation. Panfungal polymerase chain reaction (PCR) targeting the internal transcribed spacer (ITS) region and subsequent sequencing identified Curvularia lunata in the formalin fixed brain tissue. This is the first report of brainstem phaeohyphomycosis by Curvularia lunata (Pleosporales) in a cat. In addition, this is the first report among animal and humans where fungal elements of Curvularia lunata were found in the CSF cytology. Opportunistic fungal pathogens should be always considered within the differential diagnoses list in cats with neurological signs and advanced imaging findings compatible with solitary mass lesions in the brain. In feline patients with pyogranulomatous meningoencephalitis and a suspicion of a fungal aetiology, panfungal PCR for the ITS region and sequencing should be performed regardless of the absence of fungal elements in histopathology