Letter, 1975 August 19, from Bill Treml to Eva Jessye

1 page, Treml was a reporter for The Ann Arbor News

Foreign Market Entry of Company D.E.E.D. Ltd. into Ukraine

Diplomová práce se zabývá analýzou forem vstupu na zahraniční trh v odvětví dřevostaveb zaměřenou na konkrétní firmu D.E.E.D. a.s., a její případný vstup na Ukrajinský trh. Využití metodologie forem vstupu na zahraniční trh pro střední firmu by měla následně ukázat, zda na trh vstoupit či ne, a jakou formu zvolit. Výsledky budou dále také srovnávány s podobným trhem, kde firma již působí. Na tomto základě bude navrženo efektivní využití a postup do budoucna.The master’s thesis deals with an analysis of foreign market entry into Ukraine. The thesis is focused on specific company D.E.E.D. Ltd. and segment of wooden houses. The thesis contains theoretical knowledge about methods of foreign market entry for company of medium size which should subsequently show, if entry the market or not and which method to choose. Results will be compared with similar market, where the company has already worked. On this basis will be proposed effective usage and future process.

KU Biotechnology Undergraduate Research

Undergraduate Researc

Pim Kinases are Required for Short Lived Plasma Cell Responses by Murine B Cells

Humoral immunity is characterized by an early primary response of short lived plasma cells (SLPCs) secreting low affinity antibody followed by the formation of germinal center (GC) reactions and subsequent production of high affinity, class switched antibodies by long lived plasma cells (LLPCs). The lineage relationship between these two processes is not well established. We report that the SLPC element of the humoral response is Pim-dependent. Pim-deficient animals have decreased numbers of PreB cells in the bone marrow, but other subsets remain comparable to control animals. In the periphery, only peritoneal B1a B cell numbers are deficient, contributing to low serum Immunoglobulin (Ig) and a lack of natural antibody. Other aspects of the primary B cell pool and splenic architecture reflect normal development. Following immunization, Pim1-/-Pim2-/- animals mount humoral immune responses deficient in the production of SLPCs. T-independent type II responses, comprised entirely of SLPCs, are virtually absent. T-dependent responses are similarly compromised in their production of SLPCs, but do generate germinal center reactions leading to LLPC production. These deficiencies evince two distinct humoral immune responses: the Pim1/2-dependent early production of SLPCs, and the later, Pim1/2-independent, GC / LLPC response. The upstream mediators of these pathways correlate with the expression of TACI on SLPCs and BR3 on GCs / LLPCs, two receptors for the BLyS family of survival factors, known to be vital to B cell survival

Undergraduate Bioinformatics Conceptualizing Form and Function on a Molecular Scale

Over the past 64 years, since the first actual, three-dimensional structure of a protein was determined by X-Ray diffraction in 1958,1 the library of solved structures has grown to more than 170,000 (as of 2020).2 With the expansion of our knowledge of structures and the advent of applications to visualize them, the tools to aid in our understanding of these as physical objects have greatly improved. Incorporating these ideas, the following is a walkthrough of a project designed to overcome the lack of sense for proteins as real objects