Federal Home Loan Bank Advances and Small Business Lending

Adequate credit availability for small businesses is an important public policy issue because small businesses are essential for employment and economic growth for the economy. The Gramm-Leach-Bliley Act of 1999 includes a provision that could potentially support financial institutions in the provision of credit to small businesses through the use of advances from the Federal Home Loan Bank (FHLB) system that are secured with small business loans. We explore the relation between FHLB advances to financial institutions and the provision of loans to small businesses. We find a positive link between the change in FHLB advances and the change in small business loans and the level of FHLB advances and the level of small business loans. This relation holds for large and small banks and pre- and post-2007 recession. However, we find that the change in the proportion of small business loans to assets is only positively related to the change in the advances to assets ratio prior to the recessionary period. This suggests that banks substitute small business loans for other types of assets during relatively normal economic periods, but FHLB advances are a source of wholesale funds that will be invested in the most attractive financial assets available with no preference for any particular asset during periods of contracting credit

Topology of the Spin-polarized Charge Density in bcc and fcc Iron

We investigate the topology of the spin-polarized charge density in bcc and fcc iron. While the total spin-density is found to possess the topology of the non-magnetic prototypical structures, in some cases the spin-polarized densities are characterized by unique topologies; for example, the spin-polarized charge densities of bcc and high-spin fcc iron are atypical of any known for non-magnetic materials. In these cases, the two spin-densities are correlated: the spin-minority electrons have directional bond paths with deep minima in the minority density, while the spin-majority electrons fill these holes, reducing bond directionality. The presence of two distinct spin topologies suggests that a well-known magnetic phase transition in iron can be fruitfully reexamined in light of these topological changes. We show that the two phase changes seen in fcc iron (paramagnetic to low-spin and low-spin to high-spin) are different. The former follows the Landau symmetry-breaking paradigm and proceeds without a topological transformation, while the latter also involves a topological catastrophe.Comment: 5 pages, 3 figures. Phys. Rev. Lett. (in press

Electronic Selection Rules Controlling Dislocation Glide in bcc Metals

The validity of the structure-property relationships governing the deformation behavior of bcc metals was brought into question with recent {\it ab initio} density functional studies of isolated screw dislocations in Mo and Ta. These existing relationships were semiclassical in nature, having grown from atomistic investigations of the deformation properties of the groups V and VI transition metals. We find that the correct form for these structure-property relationships is fully quantum mechanical, involving the coupling of electronic states with the strain field at the core of long $a/2$ screw dislocations.Comment: 4 pages, 2 figure

Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy

Cellular FLICE-like inhibitory protein (c-FLIP) has been identified as a protease-dead, procaspase-8-like regulator of death ligand-induced apoptosis, based on observations that c-FLIP impedes tumor necrosis factor-alpha (TNF-alpha), Fas-L, and TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by binding to FADD and/or caspase-8 or -10 in a ligand-dependent fashion, which in turn prevents death-inducing signaling complex (DISC) formation and subsequent activation of the caspase cascade. c-FLIP is a family of alternatively spliced variants, and primarily exists as long (c-FLIP(L)) and short (c-FLIP(S)) splice variants in human cells. Although c-FLIP has apoptogenic activity in some cell contexts, which is currently attributed to heterodimerization with caspase-8 at the DISC, accumulating evidence indicates an anti-apoptotic role for c-FLIP in various types of human cancers. For example, small interfering RNAs (siRNAs) that specifically knocked down expression of c-FLIP(L) in diverse human cancer cell lines, e.g., lung and cervical cancer cells, augmented TRAIL-induced DISC recruitment, and thereby enhanced effector caspase stimulation and apoptosis. Therefore, the outlook for the therapeutic index of c-FLIP-targeted drugs appears excellent, not only from the efficacy observed in experimental models of cancer therapy, but also because the current understanding of dual c-FLIP action in normal tissues supports the notion that c-FLIP-targeted cancer therapy will be well tolerated. Interestingly, Taxol, TRAIL, as well as several classes of small molecules induce c-FLIP downregulation in neoplastic cells. Efforts are underway to develop small-molecule drugs that induce c-FLIP downregulation and other c-FLIP-targeted cancer therapies. In this review, we assess the outlook for improving cancer therapy through c-FLIP-targeted therapeutics

Isolating the enhanced memory of a glassy system

Studies of glassy systems have shown how cyclic driving forms memories of amplitude. We explore how choice of driving protocol reveals dramatically different features of this memory. We model rearranging soft spots in sheared amorphous solids as hysterons. Cyclic shear with positive and negative shear strain reveals a return-point memory of multiple strains known from experiments and molecular dynamics simulations, while asymmetric driving (e.g. only positive shear strains) suppresses multiple memories. However, when we introduce frustrated interactions between hysterons, we identify a different mechanism that restores multiple memories for asymmetric driving and can be used for design. Our work suggests that this enhanced memory is a signature of frustration.Comment: 5 pages, 5 figure

Identification of Extra Neutral Gauge Bosons at the LHC Using b- and t-Quarks

New Neutral Gauge Bosons, Z' 's, are predicted by many models of physics beyond the Standard Electroweak Theory. It is possible that a Z' would be discovered early in the Large Hadron Collider program. The next step would be to measure its properties to identify the underlying theory that gave rise to the Z'. Heavy quarks have the unique property that they can be identified in the final states. In this letter we demonstrate that measuring Z' decays to b- and t-quark final states can act as an effective means of discriminating between models with extra gauge bosons.Comment: 5 pages, 4 figures, references added and minor clarification

Grain Physics and Rosseland Mean Opacities

Tables of mean opacities are often used to compute the transfer of radiation in a variety of astrophysical simulations from stellar evolution models to proto-planetary disks. Often tables, such as Ferguson et al. (2005), are computed with a predetermined set of physical assumptions that may or may not be valid for a specific application. This paper explores the effects of several assumptions of grain physics on the Rosseland mean opacity in an oxygen rich environment. We find that changing the distribution of grain sizes, either the power-law exponent or the shape of the distribution, has a marginal effect on the total mean opacity. We also explore the difference in the mean opacity between solid homogenous grains and grains that are porous or conglomorations of several species. Changing the amount of grain opacity included in the mean by assuming a grain-to-gas ratio significantly affects the mean opacity, but in a predictable way.Comment: 19 pages, 6 figures, accepted for publication in Ap

Human β-galactoside α-2,3-sialyltransferase (ST3Gal III) attenuated Taxol-induced apoptosis in ovarian cancer cells by downregulating caspase-8 activity

Taxol triggers apoptosis in a variety of cancer cells, but it also upregulates cytoprotective proteins and/or pathways that compromise its therapeutic efficacy. In this report, we found that Taxol treatment resulted in caspase-8-dependent apoptosis in SKOV3 human ovarian cancer cells. Moreover, Taxol-induced apoptosis was associated with caspase-3 activation. Interestingly, Taxol treatment upregulated α-2,3-sialyltransferase (ST3Gal III) expression and forced expression of ST3Gal III attenuated Taxol-induced apoptosis. Furthermore, ST3Gal III overexpression inhibited Taxol-ttiggered caspase-8 activation, indicating that ST3Gal III upregulation produces cellular resistance to Taxol and hence reduces the efficacy of Taxol therapy

Configurational temperature control for atomic and molecular systems

A new configurational temperature thermostat suitable for molecules with holonomic constraints is derived. This thermostat has a simple set of motion equations, can generate the canonical ensemble in both position and momentum space, acts homogeneously through the spatial coordinates, and does not intrinsically violate the constraints. Our new configurational thermostat is closely related to the kinetic temperature Nosé-Hoover thermostat with feedback coupled to the position variables via a term proportional to the net molecular force. We validate the thermostat by comparing equilibrium static and dynamic quantities for a fluid of n-decane molecules under configurational and kinetic temperature control. Practical aspects concerning the implementation of the new thermostat in a molecular dynamics code and the potential applications are discussed