Five-dimensional N=4, SU(2) X U(1) Gauged Supergravity from Type IIB

We construct the complete and explicit non-linear Kaluza-Klein ansatz for deriving the bosonic sector of N=4 SU(2)\times U(1) gauged five-dimensional supergravity from the reduction of type IIB supergravity on S^5. This provides the first complete example of such an S^5 reduction that includes non-abelian gauge fields, and it allows any bosonic solution of the five-dimensional N=4 gauged theory to be embedded in D=10.Comment: latex, 12 page

Consistent SO(6) Reduction Of Type IIB Supergravity on S^5

Type IIB supergravity can be consistently truncated to the metric and the self-dual 5-form. We obtain the complete non-linear Kaluza-Klein S^5 reduction Ansatz for this theory, giving rise to gravity coupled to the fifteen Yang-Mills gauge fields of SO(6) and the twenty scalars of the coset SL(6,R)/SO(6). This provides a consistent embedding of this subsector of N=8, D=5 gauged supergravity in type IIB in D=10. We demonstrate that the self-duality of the 5-form plays a crucial role in the consistency of the reduction. We also discuss certain necessary conditions for a theory of gravity and an antisymmetric tensor in an arbitrary dimension D to admit a consistent sphere reduction, keeping all the massless fields. We find that it is only possible for D=11, with a 4-form field, and D=10, with a 5-form. Furthermore, in D=11 the full bosonic structure of eleven-dimensional supergravity is required, while in D=10 the 5-form must be self-dual. It is remarkable that just from the consistency requirement alone one would discover D=11 and type IIB supergravities, and that D=11 is an upper bound on the dimension.Comment: Latex, 14 pages, typos corrected and comments adde

Spatial assessment of pollutant loads for surface water quality management: a case study in Lai Chau city, Vietnam

The aim of this study is to present a method for estimating the pollutant load from different sources in an effort to provide improved information regarding water pollution and help control the surface water pollution, using Lai Chau city as a case study. The pollutant load was calculated in accordance with the Vietnam Environment Administration Decree No.154/2019 on the guidance for calculating the total pollutant load of river water. The pollutant sources include point sources (domestic wastewater, animal husbandry, industrial complexes and economic services) and surface sources (run-off from agricultural land uses) that generate wastes that potentially contaminate water bodies. The source locations were mapped and spatially joined with the drainage-basin map delineated from a Digital Elevation Model (DEM) to calculate the loads for the sub-basin units. Multivariate analysis then showed that the farming and domestic sources had the strongest positive loading factors for the sub-basins located in the city center and its fringe areas. Of these waste from animal husbandry account for up to 75.1% of total pollutant load. The main conclusion from the study's results is that the management approach should be changed from the total controlling mode, which is currently applied in the city, to a source specific approach based on the pollutant discharge loads and the allocated capacities

Glueballs, symmetry breaking and axionic strings in non-supersymmetric deformations of the Klebanov-Strassler background

We obtain an analytic solution for an axionic non-supersymmetric deformation of the warped deformed conifold. This allows us to study D-strings in the infrared limit of non-supersymmetric deformations of the Klebanov-Strassler background. They are interpreted as axionic strings in the dual field theory. Following the arguments of [hep-th/0405282], the axion is a massless pseudo-scalar glueball which is present in the supergravity fluctuation spectrum and it is interpreted as the Goldstone boson of the spontaneously broken U(1) baryon number symmetry, being the gauge theory on the baryonic branch. Besides, we briefly discuss about the Pando Zayas-Tseytlin solution where the SU(2) \times SU(2) global symmetry is spontaneously broken. This background has been conjectured to be on the mesonic branch of the gauge theory.Comment: 30 pages; V2: minor corrections; V3: section 3 corrected and misprints corrected to match version published in JHE

Classification of p-branes, NUTs, Waves and Intersections

We give a full classification of the multi-charge supersymmetric $p$-brane solutions in the massless and massive maximal supergravities in dimensions $D\ge2$ obtained from the toroidal reduction of eleven-dimensional supergravity. We derive simple universal rules for determining the fractions of supersymmetry that they preserve. By reversing the steps of dimensional reduction, the $p$-brane solutions become intersections of $p$-branes, NUTs and waves in D=10 or D=11. Having classified the lower-dimensional $p$-branes, this provides a classification of all the intersections in D=10 and D=11 where the harmonic functions depend on the space transverse to all the individual objects. We also discuss the structure of U-duality multiplets of $p$-brane solutions, and show how these translate into multiplets of harmonic and non-harmonic intersections.Comment: Latex, 67 pages, minor correction

Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification

SummaryObjective/MethodAggrecanase activity, most notably ADAMTS-5, is implicated in pathogenic cartilage degradation. Selective monoclonal antibodies (mAbs) to both ADAMTS-5 and ADAMTS-4 were generated and in vitro, ex vivo and in vivo systems were utilized to assess target engagement, aggrecanase inhibition and modulation of disease-related endpoints with the intent of selecting a candidate for clinical development in osteoarthritis (OA).ResultsStructural mapping predicts the most potent mAbs employ a unique mode of inhibition by cross-linking the catalytic and disintegrin domains. In a surgical mouse model of OA, both ADAMTS-5 and ADAMTS-4-specific mAbs penetrate cartilage following systemic administration, demonstrating access to the anticipated site of action. Structural disease modification and associated alleviation of pain-related behavior were observed with ADAMTS-5 mAb treatment. Treatment of human OA cartilage demonstrated a preferential role for ADAMTS-5 inhibition over ADAMTS-4, as measured by ARGS neoepitope release in explant cultures. ADAMTS-5 mAb activity was most evident in a subset of patient-derived tissues and suppression of ARGS neoepitope release was sustained for weeks after a single treatment in human explants and in cynomolgus monkeys, consistent with high affinity target engagement and slow ADAMTS-5 turnover.ConclusionThis data supports a hypothesis set forth from knockout mouse studies that ADAMTS-5 is the major aggrecanase involved in cartilage degradation and provides a link between a biological pathway and pharmacology which translates to human tissues, non-human primate models and points to a target OA patient population. Therefore, a humanized ADAMTS-5-selective monoclonal antibody (GSK2394002) was progressed as a potential OA disease modifying therapeutic

Super Yang-Mills Operators from the D3-brane Action in a Curved Background

A consistent truncation of IIB on S^5 has been obtained in the sector of the metric and the 4-form potential. The ansatz contains 20 scalars and all 15 gauge fields of ${\cal N}=8$ gauged supergravity in five dimensions. With this fully non-linear ansatz, the calculations for n-point correlators of super Yang-Mills (SYM) theory via AdS/CFT are simpler than those in the literature that use {\em linear} ansatz followed by non-linear field redefinitions. We work out the SYM operators that couple to the scalars by expanding the Dirac-Born-Infeld (DBI) action plus Wess-Zumino (WZ) terms around an AdS_5\timesS^5 background with the metric fluctuations. The resulting operators agree with those based on a superconformal symmetry argument. We discuss the significance of our results.Comment: one author's name correcte

RG flows from Spin(7), CY 4-fold and HK manifolds to AdS, Penrose limits and pp waves

We obtain explicit realizations of holographic renormalization group (RG) flows from M-theory, from E^{2,1} \times Spin(7) at UV to AdS_4 \times \tilde{S^7} (squashed S^7) at IR, from E^{2,1} \times CY4 at UV to AdS_4 \times Q^{1,1,1} at IR, and from E^{2,1} \times HK (hyperKahler) at UV to AdS_4 \times N^{0,1,0} at IR. The dual type IIA string theory configurations correspond to D2-D6 brane systems where D6 branes wrap supersymmetric four-cycles. We also study the Penrose limits and obtain the pp-wave backgrounds for the above configurations. Besides, we study some examples of non-supersymmetric and supersymmetric flows in five-dimensional gauge theories.Comment: 42 pages, 6 eps figures, typos and misprints correcte