Effects of chemical equilibrium on turbine engine performance for various fuels and combustor temperatures

A study was performed to quantify the differences in turbine engine performance with and without the chemical dissociation effects for various fuel types over a range of combustor temperatures. Both turbojet and turbofan engines were studied with hydrocarbon fuels and cryogenic, nonhydrocarbon fuels. Results of the study indicate that accuracy of engine performance decreases when nonhydrocarbon fuels are used, especially at high temperatures where chemical dissociation becomes more significant. For instance, the deviation in net thrust for liquid hydrogen fuel can become as high as 20 percent at 4160 R. This study reveals that computer central processing unit (CPU) time increases significantly when dissociation effects are included in the cycle analysis

Avionics Box Cold Plate Damage Prevention

Over the years there have been several occurrences of damage to Space Shuttle Orbiter cold plates during removal and replacement of avionics boxes. Thus a process improvement team was put together to determine ways to prevent these kinds of damage. From this effort there were many solutions including, protective covers, training, and improved operations instructions. The focus of this paper is to explain the cold plate damage problem and the corrective actions for preventing future damage to aerospace avionics cold plate designs

Bio-optical profile data report: Southern California Bight Study (SCB2-29) R/V Robert G. Sproul, 20-25 August 1988

Time series measurements of the incident surface downwelling irradiance and vertical profiles of the bio-optical properties of the ocean were studied during the 29th cruise of the Southern California Bight Study (SCBS) during the period of August 20-25, 1988. A summary of these data is presented to permit investigators an overview of the data collected. The data are available in digital form for scientific investigators

Human Modeling For Ground Processing Human Factors Engineering Analysis

There have been many advancements and accomplishments over that last few years using human modeling for human factors engineering analysis for design of spacecraft and launch vehicles. The key methods used for this are motion capture and computer generated human models. The focus of this paper is to explain the different types of human modeling used currently and in the past at Kennedy Space Center (KSC) currently, and to explain the future plans for human modeling for future spacecraft designs

Emerging trend in second messenger communication and myoendothelial feedback

Over the past decade, second messenger communication has emerged as one of the intriguing topics in the field of vasomotor control. Of particular interest has been the idea of second messenger flux from smooth muscle to endothelium initiating a feedback response that attenuates constriction. Mechanistic details of the precise signaling cascade have until recently remained elusive. In this perspective, we introduce readers to how myoendothelial gaps junctions could enable sufficient inositol trisphosphate flux to initiate endothelial Ca2+ events that activate Ca2+ sensitive K+ channels. The resulting hyperpolarizing current would in turn spreads back through the same myoendothelial gap junctions to moderate smooth muscle depolarization and constriction. In discussing this defined feedback mechanism, this brief manuscript will stress the importance of microdomains and of discrete cellular signaling

Bio-optical profile data report: Joint Global Ocean Flux Study, Hawaii Ocean Time-Series, HOT-3, R/V Moana Wave, 6-10 January 1989

Time-series measurements of the incident surface downwelling irradiance and vertical profiles of the Bio-optical properties of the ocean have been measured during the third cruise of the Hawaii Ocean Time-Series to the ALOHA site, 22 degrees 56.4 minutes N, 157 degrees 54.6 minutes W, north of the island of Oahu, Hawaii, during the period January 6 to 10, 1989. A summary of these data is presented to permit investigators an overview of the data collected. The data are available in digital form for scientific investigators

Domain Adaptation for Enterprise Email Search

In the enterprise email search setting, the same search engine often powers multiple enterprises from various industries: technology, education, manufacturing, etc. However, using the same global ranking model across different enterprises may result in suboptimal search quality, due to the corpora differences and distinct information needs. On the other hand, training an individual ranking model for each enterprise may be infeasible, especially for smaller institutions with limited data. To address this data challenge, in this paper we propose a domain adaptation approach that fine-tunes the global model to each individual enterprise. In particular, we propose a novel application of the Maximum Mean Discrepancy (MMD) approach to information retrieval, which attempts to bridge the gap between the global data distribution and the data distribution for a given individual enterprise. We conduct a comprehensive set of experiments on a large-scale email search engine, and demonstrate that the MMD approach consistently improves the search quality for multiple individual domains, both in comparison to the global ranking model, as well as several competitive domain adaptation baselines including adversarial learning methods.Comment: Proceedings of the 42nd International ACM SIGIR Conference on Research and Development in Information Retrieva

OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability.

BackgroundMitochondrial fusion protein mutations are a cause of inherited neuropathies such as Charcot-Marie-Tooth disease and dominant optic atrophy. Previously we reported that the fusion protein optic atrophy 1 (OPA1) is decreased in heart failure.Methods and resultsWe investigated cardiac function, mitochondrial function, and mtDNA stability in a mouse model of the disease with OPA1 mutation. The homozygous mutation is embryonic lethal. Heterozygous OPA(+/-) mice exhibit reduced mtDNA copy number and decreased expression of nuclear antioxidant genes at 3 to 4 months. Although initial cardiac function was normal, at 12 months the OPA1(+/-) mouse hearts had decreased fractional shortening, cardiac output, and myocyte contraction. This coincided with the onset of blindness. In addition to small fragmented mitochondria, aged OPA1(+/-) mice had impaired cardiac mitochondrial function compared with wild-type littermates.ConclusionsOPA1 mutation leads to deficiency in antioxidant transcripts, increased reactive oxygen species, mitochondrial dysfunction, and late-onset cardiomyopathy

Relationships of diversity, disparity, and their evolutionary rates in squirrels (Sciuridae)

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111786/1/evo12642.pd