8 research outputs found
LBS4 - Erfahrungen der UB Weimar
Workshop der Mitarbeiter der EDV-Abteilungen der wissenschaftlichen Bibliotheken in Thüringen am 13. Mai 2009, Erfur
Synthesis of Bicyclo[1.1.0]butanes from Iodo-Bicyclo[1.1.1]pentanes
We describe a two step process for the synthesis of substituted bicyclo[1.1.0]butanes. A photo-Hunsdiecker reaction generates iodo-bicyclo[1.1.1]pentanes under metal-free conditions at room temperature. These intermediates react with nitrogen and sulfur nucleophiles to afford substituted bicyclo[1.1.0]butane products
Discovery of Potent Heterodimeric Antagonists of Inhibitor of Apoptosis Proteins (IAPs) with Sustained Antitumor Activity
The
prominent role of IAPs in controlling cell death and their
overexpression in a variety of cancers has prompted the development
of IAP antagonists as potential antitumor therapies. We describe the
identification of a series of heterodimeric antagonists with highly
potent antiproliferative activities in cIAP- and XIAP-dependent cell
lines. Compounds <b>15</b> and <b>17</b> further demonstrate
curative efficacy in human melanoma and lung cancer xenograft models
and are promising candidates for advanced studies
Discovery of Potent Heterodimeric Antagonists of Inhibitor of Apoptosis Proteins (IAPs) with Sustained Antitumor Activity
The
prominent role of IAPs in controlling cell death and their
overexpression in a variety of cancers has prompted the development
of IAP antagonists as potential antitumor therapies. We describe the
identification of a series of heterodimeric antagonists with highly
potent antiproliferative activities in cIAP- and XIAP-dependent cell
lines. Compounds <b>15</b> and <b>17</b> further demonstrate
curative efficacy in human melanoma and lung cancer xenograft models
and are promising candidates for advanced studies