Enhancing high-intensity actions during a basketball game after a strength training program with random recovery times between sets

To examine the effects of a strength training program with random recovery times between sets in consideration of several physical parameters, high-intensity actions (HIA), and spatial exploration index during a simulated basketball game. Twenty male basketball players (age: 19.45 ± 4.36 years) were assigned randomly, either to strength training group (n = 10), or a control group (n = 10). The strength training included: parallel back squat and bench press exercises, twice a week for the duration of 10 weeks, with two blocks of 5 sets × 5 repetitions interspersed with variable passive recovery (range = 15–35 sec.) between sets, and constant passive recovery (3-min) between blocks with the load that maximized propulsive power output. The pre- and post-test assessments included jumping (bilateral and unilateral), change-of-direction, straight sprinting, and a 5-on-5 full-court situation. The external training load was assessed using the local positioning system, and the internal load was recorded with the use of individual heart rate monitors. A significant interaction effect (group x time) was observed on countermovement jump (CMJ), unilateral right hops, high-intensity accelerations and decelerations, and peak accelerations and decelerations in the 5-on-5 full-court situation. Relative improvements observed and recorded in the training group on unilateral right hops, accelerations, and decelerations were correlated. Similar results were observed on 0–25m sprints, high-intensity decelerations, peak accelerations, and decelerations. Strength training paired with random recovery times enhanced physical and game-related aspects in the observed basketball players

A comparison of 3 different unilateral strength training strategies to enhance jumping performance and decrease interlimb asymmetries in soccer players

Purpose: This study compared the effects of performing different unilateral strength training interventions on unilateral and bilateral jumping performance and their related asymmetries in young soccer players. Methods: Forty-five male young (U-17) soccer players were randomly assigned to three eccentric overload training programs: The first group executed the same volume with both legs starting with the weaker leg (SVW, n=15), the second group carried out the double volume with the weaker leg and also starting with the weaker leg (DVW, n=15), and the third group performed the same volume with both legs starting with the stronger leg (SVS, n=15). Jumping performance assessment included a single-leg horizontal jump test, a triple single-leg horizontal jump test, a bilateral countermovement (CMJ) jump test and unilateral countermovement jump test. Asymmetries were also analyzed in the unilateral jumping tests. Results: CMJ was improved (effect size [ES]: 0.27-0.48) and CMJ asymmetry was possibly reduced (ES: 0.08-0.24) in all groups. Substantial improvements were found in triple hop (ES: 0.52-0.71) in SVW and DVW, and triple hop asymmetry was substantially decreased (ES: 0.88) in DVW. Between-group analysis showed a substantial better performance in triple hop and horizontal hop with right leg in SVW and DVW compared to SVS. Conclusions: Unilateral strength training programs were shown to substantially improve bilateral jumping performance, while unilateral jumping was substantially enhanced in those groups that started the training session with the weaker leg. Finally, between-limbs asymmetries in the triple hop were mainly reduced through performing the double volume with the weaker leg

Effects of direction-specific training interventions on physical performance and inter-limb asymmetries

This study analyzed the effects of two different training programs on functional performance and inter-limb asymmetries in basketball players. Twenty-four elite youth basketball players were randomly assigned to a training program including variable unilateral horizontal movements (VUH, n = 12) or unilateral lateral movements (VUL, n = 12). Eccentric-overload training (EOT) was performed twice a week for a six-week period. Functional performance assessment included a countermovement jump test, unilateral multidirectional jumping tests (i.e., lateral, horizontal, and vertical), a rebound jump test, a limb symmetry index, a 25 m linear sprint test, and several change of direction (COD) tests. Within-group analysis showed substantial improvements in almost all functional tests in both groups (ES = 0.35−0.89). Furthermore, almost all jumping asymmetries were improved in both groups (ES = 0.38−0.69) except for vertical jumping asymmetry in VUL (ES = −0.04). Between-group analyses showed a substantial and possibly better performance in vertical jumping asymmetry and 5 m in VUH compared to that of VUL, respectively. In contrast, lateral jumping with left (ES = 1.22) and right leg (ES = 0.49) were substantially greater in VUL than in VUH. Specific force-vector training programs induced substantial improvements in both functional performance tests and inter-limb asymmetries, although greater improvements of lateral and horizontal variables may depend on the specific force vector targeted

Intrinsic and observed dual AGN fractions from major mergers

A suite of 432 collisionless simulations of bound pairs of spiral galaxies with mass ratios 1:1 and 3:1, and global properties consistent with the $\Lambda$CDM paradigm, is used to test the conjecture that major mergers fuel the dual AGN (DAGN) of the local volume. Our analysis is based on the premise that the essential aspects of this scenario can be captured by replacing the physics of the central BH with restrictions on their relative separation in phase space. We introduce several estimates of the DAGN fraction and infer predictions for the activity levels and resolution limits usually involved in surveys of these systems, assessing their dependence on the parameters controlling the length of both mergers and nuclear activity. Given a set of constraints, we find that the values adopted for some of the latter factors often condition the outcomes from individual experiments. Still, the results do not reveal, in general, very tight correlations, being the tendency of the frequencies normalized to the merger time to anticorrelate with the orbital circularity the clearest effect. In agreement with other theoretical studies, our simulations predict intrinsic abundances of these systems that range from $\sim$few to $15\%$ depending on the maximum level of nuclear activity achieved. At the same time, we show that these probabilities are reduced by about an order of magnitude when they are filtered with the typical constraints applied by observational studies of the DAGN fraction at low redshift. As a whole, the results of the present work prove that the consideration of the most common limitations involved in the detection of close active pairs at optical wavelengths is sufficient by itself to reconcile the intrinsic frequencies envisaged in a hierarchical universe with the small fractions of double-peaked narrow-line systems which are often reported at kpc-scales.Comment: 24 pages, 11 figures, 3 Tables, accepted by A&

Distinct Roles of Mus81, Yen1, Slx1-Slx4, and Rad1 Nucleases in the Repair of Replication-Born Double-Strand Breaks by Sister Chromatid Exchange

Most spontaneous DNA double-strand breaks (DSBs) arise during replication and are repaired by homologous recombination (HR) with the sister chromatid. Many proteins participate in HR, but it is often difficult to determine their in vivo functions due to the existence of alternative pathways. Here we take advantage of an in vivo assay to assess repair of a specific replication-born DSB by sister chromatid recombination (SCR). We analyzed the functional relevance of four structure-selective endonucleases (SSEs), Yen1, Mus81-Mms4, Slx1-Slx4, and Rad1, on SCR in Saccharomyces cerevisiae. Physical and genetic analyses showed that ablation of any of these SSEs leads to a specific SCR decrease that is not observed in general HR. Our work suggests that Yen1, Mus81-Mms4, Slx4, and Rad1, but not Slx1, function independently in the cleavage of intercrossed DNA structures to reconsti-tute broken replication forks via HR with the sister chromatid. These unique effects, which have not been detected in other stud-ies unless double mutant combinations were used, indicate the formation of distinct alternatives for the repair of replication- born DSBs that require specific SSEs.Ministerio de Ciencia e Innovación FU2010-16372, CSD2007-015Junta de Andalucía BIO102 and CVI4567National Institutes of Health GM5801

Optimization of Rear Point Contact Geometry by Means of 3-D Numerical Simulation

Abstract In this work three-dimensional (3-D) numerical simulations, validated by the experimental measurements of a reference cell, have been performed to optimize the rear contact geometry of a PERC-type solar cell, featuring a high sheet resistance (140 Ω/sq) phosphorus-doped emitter and a front-side metallization with narrow and highly-conductive electro-plated copper lines (40 μm wide) on lowly resistive Ti contacts. The simulation results show that an optimization of the rear point contact design potentially leads to an efficiency improvement of 0.68%abs compared to the reference cell

Comparación entre dos tipos de gastrostomías quirúrgicas, abierta y laparoscópica, en nutrición enteral domiciliaria

Objetivo: Exponer las complicaciones de las gastrostomías quirúrgicas utilizadas como vía de soporte nutricional enteral domiciliario (SNED) y detectar si existen diferencias entre las dos técnicas usadas en nuestro medio: Cirugía abierta vs laparoscópica. Material y métodos: Estudio observacional descriptivo de carácter retrospectivo de las gastrostomías quirúrgicas realizadas entre los años 1994 y 2009 seguidas por nuestra unidad. Se han analizado las complicaciones detectadas en consulta durante el seguimiento de pacientes con SNED a través de gastrostomía quirúrgica realizada con técnica laparotómica abierta vs laparoscópica, valorando: fuga del contenido gástrico al exterior, irritación de la pared abdominal, presencia de exudado, presencia de exudado con cultivo positivo que requirió tratamiento antibiótico, quemadura o pérdida de sustancia de la zona periostomía, rotura de balón, úlcera de decúbito por la sonda y formación de granuloma. Resultados: Durante los años 1994-2009 se realizaron 57 gastrostomías quirúrgicas: 47 por técnica laparótomica (abierta) convencional y 10 por vía laparoscópica. La edad media de los pacientes fue de 57,51 ± 17,29 años. La causa más frecuente que motivó la realización de la gastrostomía quirúrgica fue el cáncer de esófago (38,6%) seguido de alteraciones neurológicas (26,3%) y tumores de cabeza y cuello (26,3%). El 97,9% de los pacientes a los que se realizó una gastrostomía quirúrgica abierta presentaron al menos una complicación, es decir que solo el 2,1% estuvieron libres de complicaciones; mientras que el 50% de los que se sometieron a una gastrostomía laparoscópica no tuvo ninguna. Las complicaciones más frecuentes fueron la presencia de fuga del contenido gástrico y la irritación de la pared abdominal que se presentaron en el 89,4% y 83% respectivamente de las gastrostomías laparotómicas frente a la aparición de solo el 30% de ambas complicaciones en las gastrostomías laparoscópicas siendo la diferencia estadísticamente significativa (p Aim: Exposing the complications of surgical gastrostomies used as way of home enteral nutritional support (HEN) and detecting the differences between the two techniques used in our environment: Open Surgery vs Laparoscopic Surgery. Material and methods: Retrospective descriptive observational study of the surgical gastrostomies performed between 1994 and 2009 followed up by our unit. Have been analyzed the complications detected in our practice during the follow-up of patients with HEN performed via open laparotomy vs. laparoscopic tecniques, assessing: leaks of gastric fluid to the exterior, abdominal wall irritation, presence of exudate, presence of exudate with positive culture that required antibiotical treatment, burning or loss of substance of the periostomic zone, breach of balloon, decubitus ulcer caused by the tube and formation of granuloma. Results: Between 1994 and 2009, 57 surgical gastrostomies were performed: 47 using the conventional laparotomic (open) tecnique and 10 laparoscopies. The average age of the patients was 57.51 ± 17.29 years old. The most common cause for the performance of surgical gastrostomy was esophageal cancer (38.6%) followed by neurologic alterations (26.3%) and head and neck tumors (26.3%). 97.9% of the patients who underwent to surgical gastrostomy presented at least one complication, meaning that only 2.1% were free of complications; meanwhile, 50% of the patients were laparoscopic gastrostomy was performed had none of these complications. The most common complications were the presence of leaks of gastric fluid and abdominal wall irritation that appeared on 89.4% and 83% respectively of the laparotomic gastrostomies versus the presence of only 30% of both complications in laparoscopic gastrostomies being the difference statistically significant (p < 0.01). Conclusions: After the introduction of the laparoscopic technique in the performance of surgical gastrostomies has been observed a decrease of the complications occured during the home enteral nutritional support related to surgical gastrostomies

Postpandemia y el acceso abierto a las publicaciones científicas

La actual pandemia afectó a más de 180 países en menos de seis meses, perjudicando a gran parte del sistema hospitalario mundial, al igual que la economía, impactada esta por el cierre del tráfico aéreo y marítimo en los cinco continentes. Estos acontecimientos, ocasionaron el cierre de la producción industrial y por consiguiente las cadenas de suministros, generando una pobreza a niveles insospechados (1), sin dejar de lado la desinformación de lo ocurrido, lo que también originó colateralmente una infodemia (epidemia informativa colectiva)

t(6;20)(q13;q12) LMBRD1/CHD6

Short communication on t t(6;20)(q13;q12) LMBRD1/CHD6, with data on clinics, and the genes implicated