Optimal Control of Industrial Assembly Lines

This paper discusses the problem of assembly line control and introduces an optimal control formulation that can be used to improve the performance of the assembly line, in terms of cycle time minimization, resources' utilization, etc. A deterministic formulation of the problem is introduced, based on mixed-integer linear programming. A simple numerical simulation provides a first proof of the proposed concept

Reproduction of the azooxanthellate coral Caryophyllia inornata is not affected by temperature along an 850 km gradient on the Western Italian coast

The Intergovernmental Panel on Climate Change (IPCC) predicted that ocean surface temperature will rise of 0.6–2.0◦C by 2100. Ocean warming is expected to produce strong impacts on marine ecosystems such as coral reefs, affecting their physiological events including reproductive processes. To date, relatively few studies have examined the effects of climate change on the reproductive success of temperate corals and even less in the azooxanthellate ones. This study examined the reproductive output of the azooxanthellate Mediterranean coral Caryophyllia inornata along a wide latitudinal gradient of seawater temperature and solar radiation. A total of 260 samples, collected from five populations along the Western Italian coast, have been analyzed through histological techniques. The intriguing aspects characterizing all populations of C. inornata along the latitudinal gradient are a strong male-biased sex ratio and the presence of embryos in all stages of development throughout the year in females, males, and sexually inactive individuals. This peculiarity could suggest a mixed strategy of sexual and asexual reproduction in this species as has been observed for some anemones of the genus Actinia. Fecundity and spermary abundance (i.e., the number of reproductive elements per body volume unit), gonadal index (i.e., the percentage of body volume occupied by the germ cells) and fertility (i.e., the number of embryos per body volume unit) in females, males and sexually inactive individuals were unrelated to solar radiation and temperature along the latitudinal gradient. These results suggest that the reproduction in C. inornata is not affected by increasing solar radiation and temperature. The lack of zooxanthellae could make this species less dependent on these environmental parameters, as previously hypothesized for another azooxanthellate species, Leptopsammia pruvoti, investigated along the same gradient

Taste intensity and hedonic responses to simple beverages in gastrointestinal cancer patients

Changes in the taste of food have been implicated as a potential cause of reduced dietary intake among cancer patients. However, data on intensity and hedonic responses to the four basic tastes in cancer are scanty and contradictory. The present study aimed at evaluating taste intensity and hedonic responses to simple beverages in 47 anorectic patients affected by gastrointestinal cancer and in 55 healthy subjects. Five suprathreshold concentrations of each of the four test substances (sucrose in black current drinks, citric acid in lemonade, NaCl in unsalted tomato juice, and urea in tonic water) were used. Patients were invited to express a judgment of intensity and pleasantness ranging from 0 to 10. Mean intensity scores directly correlated with concentrations of sour, salty, bitter, and sweet stimuli, in both normals and those with cancer. Intensity judgments were higher in cancer patients with respect to sweet (for median and high concentrations, P < 0.05), salty (for all concentrations, P < 0.05), and bitter tastes (for median concentration, P < 0.01). Hedonic function increased with the increase of the stimuli only for the sweet taste. A negative linear correlation was found between sour, bitter, and salty concentrations and hedonic score. Both in cancer patients and in healthy subjects, hedonic judgments increased with the increase of the stimulus for the sweet taste (r 1/4 0.978 and r 1/4 0.985, P 1/4 0.004 and P 1/4 0.002, respectively), and decreased for the salty (r 1/4 ??0.827 and r 1/4 ??0.884, P 1/4 0.084 and P 1/4 0.047, respectively) and bitter tastes (r 1/4 ??0.990 and r 1/4 ??0.962, P 1/4 0.009 and P 1/4 0.001, respectively). For the sour taste, the hedonic scores remained stable with the increase of the stimulus in noncancer controls (r 1/4 ??0.785, P 1/4 0.115) and decreased in cancer patients (r 1/4 ??0.996, P 1/4 0.0001). The hedonic scores for the sweet taste and the bitter taste were similar in cancer patients and healthy subjects, and these scores were significantly higher in cancer patients than in healthy subjects for most of the concentrations of the salty taste and all the concentrations of the sour taste. The present study suggests that cancer patients, compared to healthy individuals, have a normal sensitivity, a normal likingfor pleasant stimuli, and a decreased dislike for unpleasant stimuli. Moreover, when compared to controls, they show higher hedonic scores for middle and high concentrations of the salty taste and for all concentrations of the sour taste. Further studies are needed to evaluate whether these changes observed in cancer patients translate into any alteration in dietary behavior and/or food preferences

Lipopolysaccharide modulates astrocytic S100B secretion: a study in cerebrospinal fluid and astrocyte cultures from rats

<p>Abstract</p> <p>Background</p> <p>Inflammatory responses in brain are primarily mediated by microglia, but growing evidence suggests a crucial importance of astrocytes. S100B, a calcium-binding protein secreted by astrocytes, has properties of a neurotrophic or an inflammatory cytokine. However, it is not known whether primary signals occurring during induction of an inflammatory response (e.g. lipopolysaccharide, LPS) directly modulate S100B.</p> <p>Methods</p> <p>In this work, we evaluated whether S100B levels in cerebrospinal fluid (CSF) and serum of Wistar rats are affected by LPS administered by intraperitoneal (IP) or intracerebroventricular (ICV) injection, as well as whether primary astrocyte cultures respond directly to lipopolysaccharide.</p> <p>Results</p> <p>Our data suggest that S100B secretion in brain tissue is stimulated rapidly and persistently (for at least 24 h) by ICV LPS administration. This increase in CSF S100B was transient when LPS was IP administered. In contrast to these S100B results, we observed an increase in in TNFα levels in serum, but not in CSF, after IP administration of LPS. In isolated astrocytes and in acute hippocampal slices, we observed a direct stimulation of S100B secretion by LPS at a concentration of 10 μg/mL. An involvement of TLR4 was confirmed by use of specific inhibitors. However, lower levels of LPS in astrocyte cultures were able to induce a decrease in S100B secretion after 24 h, without significant change in intracellular content of S100B. In addition, after 24 h exposure to LPS, we observed a decrease in astrocytic glutathione and an increase in astrocytic glial fibrillary acidic protein.</p> <p>Conclusions</p> <p>Together, these data contribute to the understanding of the effects of LPS on astrocytes, particularly on S100B secretion, and help us to interpret cerebrospinal fluid and serum changes for this protein in neuroinflammatory diseases. Moreover, non-brain S100B-expressing tissues may be differentially regulated, since LPS administration did not lead to increased serum levels of S100B.</p

Development of Improved Iron-Aluminide Filter Tubes and Elements

The purpose of this Cooperative Research and Development Agreement (CRADA) was to explore and develop advanced manufacturing techniques to fabricate sintered iron-aluminide intermetallic porous bodies used for gas filtration so as to reduce production costs while maintaining or improving performance in advanced coal gasification and combustion systems. The use of a power turbine fired with coal-derived synthesis gas requires some form of gas cleaning in order to protect turbine and downstream components from degradation by erosion, corrosion, and/or deposition. Hot-gas filtration is one form of cleaning that offers the ability to remove particles from the gases produced by gasification processes without having to substantially cool and, possibly, reheat them before their introduction into the turbine. This technology depends critically on materials durability and reliability, which have been the subject of study for a number of years

The Kormendy relation of early-type galaxies as a function of wavelength in Abell S1063, MACS J0416.1-2403 and MACS J1149.5+2223

The wavelength dependence of the Kormendy relation (KR) is well characterised at low-redshift, but poorly studied at intermediate redshifts. The KR provides information on the evolution of the population of early-type galaxies (ETGs), therefore, by studying it, we may shed light on the assembly processes of these objects and their size evolution. Since studies at different redshifts are generally conducted in different rest-frame wavebands, investigating whether there is a wavelength dependence of the KR is fundamental to interpret the conclusions we might draw from it. We analyse the KRs of the three Hubble Frontier Fields clusters, Abell S1063 (z = 0.348), MACS J0416.1-2403 (z = 0.396), and MACS J1149.5+2223 (z = 0.542), as a function of wavelength. This is the first time the KR of ETGs has been explored consistently in such a large range of wavelength at intermediate redshifts. We exploit very deep HST photometry, ranging from the observed B-band to the H-band, and VLT/MUSE integral field spectroscopy. We improve the structural parameters estimation we performed in a previous work (Tortorelli et al. 2018) by means of a newly developed Python package called morphofit (Tortorelli&Mercurio 2023). With its use on cluster ETGs, we find that the KR slopes smoothly increase with wavelength from the optical to the near-infrared bands in all three clusters, with the intercepts getting fainter at lower redshifts due to the passivisation of the ETGs population. The slope trend is consistent with previous findings at lower redshifts. The slope increase with wavelength implies that smaller size ETGs are more centrally concentrated than larger size ETGs in the near-infrared with respect to the optical regime. Since different bands probe different stellar populations in galaxies, the slope increase also implies that smaller ETGs have stronger internal gradients with respect to larger ETGs.Comment: Submitted to Astronomy and Astrophysics in the form of letter to the Editor, 5 pages, 1 figure, 1 tabl

Searching for galaxy-scale strong-lenses in galaxy clusters with deep networks -- I: methodology and network performance

Galaxy-scale strong lenses in galaxy clusters provide a unique tool to investigate their inner mass distribution and the sub-halo density profiles in the low-mass regime, which can be compared with the predictions from cosmological simulations. We search for galaxy-galaxy strong-lensing systems in HST multi-band imaging of galaxy cluster cores from the CLASH and HFF programs by exploring the classification capabilities of deep learning techniques. Convolutional neural networks are trained utilising highly-realistic simulations of galaxy-scale strong lenses injected into the HST cluster fields around cluster members. To this aim, we take advantage of extensive spectroscopic information on member galaxies in 16 clusters and the accurate knowledge of the deflection fields in half of these from high-precision strong lensing models. Using observationally-based distributions, we sample magnitudes, redshifts and sizes of the background galaxy population. By placing these sources within the secondary caustics associated with cluster galaxies, we build a sample of ~3000 galaxy-galaxy strong lenses which preserve the full complexity of real multi-colour data and produce a wide diversity of strong lensing configurations. We study two deep learning networks processing a large sample of image cutouts in three HST/ACS bands, and we quantify their classification performance using several standard metrics. We find that both networks achieve a very good trade-off between purity and completeness (85%-95%), as well as good stability with fluctuations within 2%-4%. We characterise the limited number of false negatives and false positives in terms of the physical properties of the background sources and cluster members. We also demonstrate the neural networks' high degree of generalisation by applying our method to HST observations of 12 clusters with previously known galaxy-scale lensing systems.Comment: 17 pages, 13 figures, to be published on A&

Evaluation of an Organic Waste Composting Device to Household Treatment

The performance of a plug-flow automated aerobic digester used with the compost of the Biodegradable Organic Waste (BOW) from a typical family at its generation rhythm was evaluated. During a 13 month assessment, 179.7 kg of BOW were treated and 106.7 kg of compost were obtained with a C:N ratio of 12 and an average concentration of N of about 2.72%. Additional tests enabled to assess the generation of stable and good quality compost according to the considered standards, suitable for using as organic fertilizer and other uses, such as biotreatments. The design, location and operational characteristics of the device have determined reduced leachate emissions, the absence of unpleasant odour generation and incidence of insects or other vectors, implying the viability of their use without affecting the user´s life quality. It could be an efficient alternative treatment for household BOW, from a technical, economic, energy, cultural and environmental point of view, easy to implement for users lacking in special training

High Temperature Corrosion Behavior of Iron Aluminide Alloys and Coatings

A multi-year effort has been focused on optimizing the long-term oxidation performance of ingot-processed (IP) and oxide-dispersion strengthened (ODS) Fe{sub 3}Al and iron aluminide-based coatings. Based on results from several composition iterations, a Hf-doped alloy (Fe-28Al-2Cr-0.05at.%Hf) has been developed with significantly better high temperature oxidation resistance than other iron aluminides. The scale adhesion is not significantly better; however, the {alpha}-Al{sub 2}O{sub 3} scale grows at a slower rate, approximately a factor of 10 less than undoped iron aluminide. The benefit of Hf is greatest at 1100-1200 C. Long-term oxidation resistance of commercially fabricated ODS Fe{sub 3}Al has been determined and compared to commercially available ODS FeCrAl. Scale spallation rates for ODS Fe{sub 3}Al are higher than for ODS FeCrAl. To complement studies of iron-aluminide weld-overlay coatings, carbon steel was coated with Fe-Al-Cr by thermal spraying. These specimens were then exposed in air at 900 and 1000 C and in air-1%SO{sub 2} at 800 C. Most likely due to an inadequate aluminum concentration in the coatings, continuous protective Al{sub 2}O{sub 3} could not be maintained and, consequently, the corrosion performance was significantly worse than what is normally observed for Fe{sub 3}Al