Cavity Resonance Sensor with Disposable Analyte Container for Point of Care Testing

The use of phononic crystals and resonant structures as sensing platforms paves the way to the development of new biomedical technologies. An acoustic sensor with a resonant cavity and a disposable element was investigated in this paper. The sensor consists of seven layers with high acoustic impedance mismatch. The disposable element used was a glass spectrophotometry cuvette and, during the experimentation, it was filled with different liquid analytes showing characteristic transmission features that could be used as measures to differentiate and identify them. Experimental transmission curves were obtained using an electronic characterization system that uses a double sideband modulation technique to acquire valuable information about the structure being analyzed. Simulations using the 1-D transmission line method were performed to support the experimental realizations. The frequency of maximum transmission has been found to be strongly dependent on the speed of sound of the analyte under test

Fully-disposable multilayered phononic crystal liquid sensor with symmetry reduction and a resonant cavity

Phononic crystals are artificial structures with unique capabilities to control the transmission of acoustic waves. These novel periodic composite structures bring new possibilities for developing a fundamentally new sensor principle that combines features of both ultrasonic and resonant sensors. This paper reports the design, fabrication and evaluation of a phononic crystal sensor for biomedical applications, especially for its implementation in point of care testing technologies. The key feature of the sensor system is a fully-disposable multi-layered phononic crystal liquid sensor element with symmetry reduction and a resonant cavity. The phononic crystal structure consists of eleven layers with high acoustic impedance mismatch. A defect mode was utilized in order to generate a well-defined transmission peak inside the bandgap that can be used as a measure. The design of the structures has been optimized with simulations using a transmission line model. Experimental realizations were performed to evaluate the frequency response of the designed sensor using different liquid analytes. The frequency of the characteristic transmission peaks showed to be dependent on the properties of the analytes used in the experiments. Multi-layered phononic crystal sensors can be used in applications, like point of care testing, where the on-line measurement of small liquid samples is required

Acoustic spectrometer: Resonant sensing platform for measuring volumetric properties of liquid samples

A sensing platform for measuring volumetric properties of liquid samples using phononic crystals is presented in this paper. The proposed sensor concept is based on the transmission of elastic and acoustic waves through solids and liquids respectively to gather relevant information about the properties of the liquid under test. A major difference between this concept and the majority of current resonant sensors, like the well-known quartz crystal microbalance, is that the acoustic spectrometer proposed measures bulk properties and not interfacial properties of the liquid. The sensing platform uses a disposable analyte container to facilitate the measurement of hazardous substances and enable its use in biomedical applications. An electronic characterization system based on the acquisition of three mixed signals was developed to obtain the frequency response of the designed sensor. Finally, experimental and theoretical realizations were performed, using different analytes and showing characteristic transmission features that can be used as measures to determine the physical value speed of sound

Use of Transient Time Response as a Measure to Characterize Phononic Crystal Sensors

Phononic crystals are periodic composite structures with specific resonant features that are gaining popularity in the field as liquid sensors. The introduction of a structural defect in an otherwise periodic regular arrangement can generate a resonant mode, also called defect mode, inside the characteristic band gaps of phononic crystals. The morphology, as well as the frequency in which these defect modes appear, can give useful information on the composition and properties of an analyte. Currently, only gain and frequency measurements are performed using phononic crystal sensors. Other measurements like the transient response have been implemented in resonant sensors such as quartz microbalances showing great results and proving to be a great complimentary measure to the gain and frequency measurements. In the present paper, a study of the feasibility of using the transient response as a measure to acquire additional information about the analyte is presented. Theoretical studies using the transmission line model were realized to show the impact of variations in the concentration of an analyte, in this case, lithium carbonate solutions, in the transient time of the system. Experimental realizations were also performed showing that the proposed measurement scheme presents significant changes in the resulting data, indicating the potential use of this measure in phononic crystal sensors. This proposed measure could be implemented as a stand-alone measure or as a compliment to current sensing modalities

The Effect of Using Exoskeleton of Blue Crab (Callinectes sapidus) as a Dietary Calcium Source on the Egg Characteristics of Layer Hens (Gallus gallus domesticus)

The study focuses on the ability to use the exoskeleton of blue crab as alternative calcium and carotenoid supplement for layer hens and its effects on egg characteristics. Three groups of eighty layer hens each were fed a base feed formulation following the standards of the University of the Philippines Los Baños. The feeds were base feed as negative control (NG), a base feed with natural egg yolk colorants (capsorubin and lutein) as positive control (PG), and a base feed with 1% ground blue crab exoskeletons, as experimental (EG). The feeding lasted four weeks before egg collection. The eggs were weighed for their albumen, yolk, shell, and egg weight. The egg yolk color was determined using a DSM Fan and a digital Chroma meter, and the shell thickness using digital calipers. Statistical treatment was done through Kruskal Wallis test using SPSS software. Results showed that eggs of EG had significantly heavier shells with a mean of 5.93±0.11g, compared to 5.83±0.08g of the NG and 5.55±0.08g of the PG. Eggshell thickness was not significantly different among the three groups. Egg yolk color was significantly different in PG with a mean DSM gradient value of 11.96±0.11, compared to 5.92±0.14 of the NG and 6.48±0.20 of EG. Ground blue crab exoskeleton as a calcium supplement may increase the weight of the eggshells but may not intensify the egg yolk color

Evolución paleoambiental del Norte de España durante los últimos 2500 años a partir del estudio de biomarcadores de la Turbera de Roñanzas (Asturias)

Evolución paleoambiental del Norte de España durante los últimos 3000 años a partir del estudio de biomarcadores de la Turbera de Roñanzas (Asturias

Use of Transient Time Response as a Measure to Characterize Phononic Crystal Sensors

Phononic crystals are periodic composite structures with specific resonant features that are gaining strength in the field as liquid sensors. The introduction of a structural defect in an otherwise periodic regular arrangement can generate a resonant mode, also called defect mode, inside the characteristic band gaps of phononic crystals. The morphology, as well as the frequency in which these defect modes appear, can give useful information on the composition and properties of an analyte. Currently, only gain, and frequency measurements are performed using phononic crystal sensors. Other measurements like the transient response have been implemented in resonant sensors such as quartz microbalances showing great results and proving to be a great complimentary measure to the gain and frequency measurements. In the present paper, a study of the feasibility of using the transient response as a measure to acquire additional information about the analyte is presented. Theoretical studies using the transmission line model were realized to show the impact of variations in the concentration of an analyte, in this case, lithium carbonate solutions, in the transient time of the system. Experimental realizations were also performed showing that the proposed measurement scheme presents significant changes in the resulting data, indicating the potential use of this measure in phononic crystal sensors. This proposed measure could be implemented as a stand-alone measure or as a compliment to current sensing modalities

Experimental and statistical evaluation of a brain-computer interface (BCI) prototype.

En este trabajo se propone un estudio experimental y estadístico para comparar el prototipo de ICC con un sistema comercial (USBamp), estudiando si existen diferencias significativas entre los dos sistemas.In this paper, we propose an experimental and statistical design to compare the BCI prototype with a comercial device (USBamp), studyng if they show significant differences or not

Late subadult ontogeny and adult aging of the human thorax reveals divergent growth trajectories between sexes

Sexual dimorphism is an important feature of adult thorax morphology, but when and how sex-related differences in the ribcage arise during ontogeny is poorly known. Previous research proposed that sex-related size differences in the nasal region arise during puberty. Therefore, we explore whether ribcage sexual dimorphism also arises at that time and whether this sexual dimorphism is maintained until old age. We measured 526 (semi)landmarks on 80 CT-based human ribcage reconstructions, on individuals ranging from 7 to 65 year-old. The 3D coordinates were submitted to the Procrustes superimposition and analyzed. Our results show that the trajectories of thorax size and shape between sexes diverge at around 12 years of age, and continue slightly diverging until old age. The differential ontogenetic trends cause adult male ribcages to become deeper, shorter, and wider than female. Our results are consistent with the evidence from the cranial respiratory system, with the development of sexual dimorphism probably related to changes in body composition during puberty combined with changes in the reproductive system