Calpain 3 and CaMKIIβ signaling are required to induce HSP70 necessary for adaptive muscle growth after atrophy.

Mutations in CAPN3 cause autosomal recessive limb girdle muscular dystrophy 2A. Calpain 3 (CAPN3) is a calcium dependent protease residing in the myofibrillar, cytosolic and triad fractions of skeletal muscle. At the triad, it colocalizes with calcium calmodulin kinase IIβ (CaMKIIβ). CAPN3 knock out mice (C3KO) show reduced triad integrity and blunted CaMKIIβ signaling, which correlates with impaired transcriptional activation of myofibrillar and oxidative metabolism genes in response to running exercise. These data suggest a role for CAPN3 and CaMKIIβ in gene regulation that takes place during adaptation to endurance exercise. To assess whether CAPN3- CaMKIIβ signaling influences skeletal muscle remodeling in other contexts, we subjected C3KO and wild type mice to hindlimb unloading and reloading and assessed CaMKIIβ signaling and gene expression by RNA-sequencing. After induced atrophy followed by 4 days of reloading, both CaMKIIβ activation and expression of inflammatory and cellular stress genes were increased. C3KO muscles failed to activate CaMKIIβ signaling, did not activate the same pattern of gene expression and demonstrated impaired growth at 4 days of reloading. Moreover, C3KO muscles failed to activate inducible HSP70, which was previously shown to be indispensible for the inflammatory response needed to promote muscle recovery. Likewise, C3KO showed diminished immune cell infiltration and decreased expression of pro-myogenic genes. These data support a role for CaMKIIβ signaling in induction of HSP70 and promotion of the inflammatory response during muscle growth and remodeling that occurs after atrophy, suggesting that CaMKIIβ regulates remodeling in multiple contexts: endurance exercise and growth after atrophy

Texas is getting serious about stopping sex trafficking, but we need more resources

Institute on Domestic Violence and Sexual Assault (IDVSA

Relation between Brown Dwarfs and Exoplanets

One of the most debated subjects in Astronomy since the discovery of exoplanets is how can we distinguish the most massive of such objects from very-low mass stars like Brown Dwarfs (BDs)? We have been looking for evidences of a difference in physical characteristics that could be related to different formation processes. Using a new diagnostic diagram that compares the baryonic gravitational potential (BGP) with the distances from their host stars, we have classified a sample of 355 well-studied exoplanets according to their possible structures. We have then compared the exoplanets to a sample of 87 confirmed BDs, identifying a range in BGP that could be common to both objects. By analyzing the mass-radius relations (MRR) of the exoplanets and BDs in those different BGP ranges, we were able to distinguish different characteristic behaviors. By comparing with models in the literature, our results suggest that BDs and massive exoplanets might have similar structures dominated by liquid metallic hydrogen (LMH).Comment: Poster #149 from proceeding of The 19th Cambridge Workshop on Cool Stars, Stellar Systems, and the Sun; 06-10 June 2016, Uppsala, Swede

PERCEPTIONS OF SELF-DISCLOSURE IMPACTING THE SUPERVISORY RELATIONSHIP AND RECOGNIZING COUNTERTRANSFERENCE

Clinical supervision is an essential component in a social work student’s education and development in the field. Social work students should feel comfortable with their clinical supervisors in order to appropriately self-disclose during supervision and gain the ability to recognize countertransference when working with clients. The significance of this is that students should be aware of their feelings and learn how to process these reactions during supervision. A mixed methods approach was utilized, surveying and interviewing students and clinical supervisors affiliated with California State University, San Bernardino. A Pearson correlation coefficient was conducted to determine the relationship between the strength of the supervisory relationship and the ability of social work students to recognize countertransference. The findings of this study suggested that there are significant relationships between the supervisory relationship and perceptions of self-disclosure and countertransference. Based on the qualitative analyses, eight central themes emerged regarding supervision practices and the relationships between students and supervisors. The implications of this study should impact how clinical supervisors foster the development of strong relationships with student interns. This should allow students to gain skills to succeed and provide better services to clients

Campaña mercadeo social trastornos psicológicos en la adolescencia

This work is based on the general study of sexual disorders, mainly what they are talking about and what treatments are in each of these. Additionally we make an emphasis on one type of sexual disorders that are sexual dysfunctions. We focalize the research on disorders such as oversexed as pornography in adolescents. The access today to internet is so easy and how pornography increases in youth around the world, especially in children from 9 years old. Demonstrating the possible causes and consequences of this disorderEste trabajo, se basa en el estudio general de los Trastornos Sexuales principalmente habla de qué se tratan y cuáles son los tratamientos en cada uno de estos. Además, se realiza un énfasis en uno de los tipos de Trastornos Sexuales que son las Disfunciones sexuales. Focalizando la investigación en los Trastornos hipersexuales como es la pornografía en adolescentes. El acceso al internet que hoy en día se maneja y cómo la pornografía cada vez se incrementa a nivel mundial en los jóvenes en especial en los niños a partir de los 9 años de edad. Demostrando principalmente las posibles causas y consecuencias de este trastorno

Propuesta de ordenamiento ambiental territorial desde la perspectiva de cuencas hidrográficas, para el municipio de Dosquebradas (la ciudad - cuenca)

El ordenamiento territorial, es una disciplina relativamente joven, que surgió en los últimos treinta años del siglo XX, de allí tantas debilidades metodológicas y variedad de interpretaciones y acepciones sobre la misma. En Europa, el tema del ordenamiento, es guiado por la "Carta europea de ordenación del territorio" de 1983 (con versiones mejoradas más recientes), suscrita por todos los países de la comunidad europea, en la que definen el OT como "la expresión espacial de las políticas económica, social, cultural y ecológica de cualquier sociedad. Disciplina técnica, científica, administrativa y acción política concebida como práctica interdisciplinaria y global para lograr el desarrollo equilibrado de las regiones y la organización física del espacio". De allí entonces, cada país de Europa adopta este concepto como organismo rector de sus políticas internas. En Latinoamérica, las políticas de ordenación del territorio son más recientes, por lo cual no se encuentran aún muy consolidadas, además que siguen respondiendo a vacíos en la planificación y no a encontrar las causas generadoras de los conflictos territoriales presentados. Es entonces, la necesidad de los países latinoamericanos por sentar una posición frente al problema del medio ambiente y el desarrollo en la cumbre de Río en 1992, lo que los impulsa a posicionar su visión sobre el ordenamiento territorial, mediante un documento finalizado en 1990, titulado "Nuestra propia agenda sobre Desarrollo y Medio Ambiente". En dicho documento, se proponen unas líneas maestras para los países, orientadas por el concepto del ordenamiento territorial, como una estrategia para lograr el desarrollo sostenible basada en la "distribución geográfica de la población y sus actividades de acuerdo con la integridad y potencialidad de los recursos naturales que conforman el entorno físico-biótico, todo ello en la búsqueda de unas condiciones de vida mejores"

Building Institutional Support for Undocumented and DACA-eligible College Students in Michigan

In 2017, the state of Michigan operated, and continues to operate, in an unstipulated policy environment related to undocumented students. There is no higher education commission or policy coordinating body in Michigan nor has the state legislature passed any legislation related to undocumented students or students who are DACA-eligible. Under this unstipulated policy environment, postsecondary institutions have the discretion to establish their own admissions policies and practices, including tuition and financial aid guidelines for undocumented students. Some institutions have stated their public support of these students through what they identify as inclusive and supportive institutional practices via their websites. However, these polices have created a nebulous environment which has created additional barriers for undocumented and DACA-eligible students trying to access postsecondary education. The lack of clear and consistent financial aid and admission policies across the state has resulted in a convoluted environment for undocumented and DACA-eligible students in applying to institutions. In this paper, we highlight how a group of undergraduate and graduate University of Michigan student researchers, both documented and undocumented, developed an instrument to analyze institutional policies related to in-state resident tuition, admission, financial aid, as well as the availability of dedicated student support services for undocumented and DACA-eligible students in the state of Michigan during the Fall of 2017. The data for this project has been turned into a website with updated (as of 2020) and available at https://uleadnet.org/mi-undocu-map

Human Trafficking by the Numbers: The Initial Benchmark of Prevalence and Economic Impact for Texas

Prevalence HighlightsCurrently, there are approximately 79,000 minor and youth victims of sex trafficking in Texas.Currently, there are approximately 234,000 workers who are victims of labor trafficking in Texas.Currently, there arean estimated 313,000 victims of human trafficking in Texas.Cost HighlightsMinor and youth sex trafficking costs the state of Texas approximately $6.6 billion. Traffickers exploit approximately$600 million from victims of labor trafficking in Texas.BackgroundThough human trafficking is widespread in geographically large states with large urban centers like Texas, the true scope of this hidden crime is largely unconfirmed as data on human trafficking are difficult to ascertain. Existing data gathered in anti-trafficking efforts focus almost exclusively on identified victims, shedding light on only a fraction of the problem. The first phase of the Statewide Human Trafficking Mapping Project of Texas focused on providing empiricallygrounded data as a benchmark about the extent of human trafficking across the state. The following three primary research questions guided our data collection efforts, which included queries of existing databases, interviews, focus groups, and web-based surveys.1.What is the prevalence of human trafficking in Texas?2.What is the economic impact of human trafficking in Texas?3.What is our understanding of human trafficking in Texas?MethodsThe findings in this report were derived using a multi-methods approach to quantify the prevalence and economic impact of human trafficking in Texas. Higher-than-average risk industry and community segments were chosen for sex and labor markets. We defined community segments asgroups of people considered to be at higher-than-average risk of trafficking because of risk indicators found in trafficking cases (e.g. homelessness). More specifically, rather than attempting to establish prevalence of trafficking among the 27.4 million people living in Texas, for the purposes of demonstrating our methodology, establishing some benchmarks on human trafficking prevalence and economic impact estimates, and providing a concrete example of our planned activities moving forward, victimization rates were applied to a select few community segments that are at higher-than-average risk of trafficking.The methodology has addressed the critical industry and community segments to accurately estimate prevalencewhile reducing overlap between the chosen segments