Evaluation of the INECO Frontal Screening and the Frontal Assessment Battery in Peruvian patients with Alzheimer's disease and behavioral variant Frontotemporal dementia

Background: The physicians often confuse the early symptoms of Frontotemporal dementia (FTD) with Alzheimer dementia (AD), leading to misdiagnosis. There are some cognitive tests to discriminate between AD and behavioral variant FTD (bvFTD), and the INECO Frontal Screening (IFS) is a promising test for this purpose. Objective: To assess the performance of the IFS to differentiate patients with AD from patients with bvFTD, compared with the Frontal Assessment Battery (FAB). Methods: A prospective study with 117 patients of our cognitive unit (35 case-patients with AD, 34 case-patients with bvFTD, and 48 control subjects). They were submitted to the following successive phases of evaluation: 1) screening; 2) dementia diagnosis; and 3) dementia sub-type diagnosis. The IFS and FAB were blind and independently applied by one neurologist to all the participants to end of phase 1 (screening), before to the definitive diagnosis establishment. Results: bvFTD showed a lower performance than AD patients on the IFS total score (F(1, 66) = 70.10, p < 0.01) and FAB total score (F(1, 66) = 17.91, p < 0.01). The IFS and FAB showed a sensitivity of 94.12% (95%CI = 80.3–99.2) and 82.3% (95%CI = 65.4–93.2), and a specificity of 94.2% (95%CI = 80.8–99.3) and 48.5% (95%CI = 31.3, 66.1), respectively. The IFS showed significantly superior discriminatory accuracy than the FAB (AuCIFS = 0.98; AuCFAB = 0.73, p < 0.00001). Conclusion: The IFS is useful for discriminating between AD and bvFTD patients. The performance of the IFS to differentiate patients with AD from patients with bvFTD is greater than FAB.Fil: Custodio, Nilton. Instituto Peruano de Neurociencias; PerúFil: Herrera Perez, Eder. Instituto Peruano de Neurociencias; PerúFil: Lira, David. Instituto Peruano de Neurociencias; PerúFil: Roca, María. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Instituto de Neurología Cognitiva. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Fundación Favaloro. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt.; ArgentinaFil: Manes, Facundo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Instituto de Neurología Cognitiva. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Fundación Favaloro. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt.; Argentina. Australian Research Council; AustraliaFil: Báez Buitrago, Sandra Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Instituto de Neurología Cognitiva. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Fundación Favaloro. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt.; ArgentinaFil: Torralva, Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Instituto de Neurología Cognitiva. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt | Fundación Favaloro. Instituto de Neurociencia Cognitiva y Traslacional. Fundación Ineco Rosario Sede del Incyt.; Argentina. Australian Research Council; Australi

Analysis of errors in verbal fluency tasks in patients with chronic schizophrenia

Background and Objectives: Even if verbal fluency deficits have been described in Schizophrenia, error pattern in this test has not been analyzed in detail in the literature. The pattern analysis of such errors could contribute to the understanding of the factors that influence poor task performance in schizophrenia. In this study we analyzed the intrusion and perseveration errors in verbal fluency tasks in patients with chronic schizophrenia. Methods: 87 patients diagnosed with Chronic Schizophrenia and 87 healthy controls were included in this investigation and were assessed with four Phonological and Semantic Verbal Fluency tasks. Results The results of this study showed that at least half of schizophrenic patients produced perseverative errors on verbal fluency and about made intrusion errors. The severity of negative symptoms, the severity of Formal Thought Disorder and pharmacological variables were significant moderators to errors in Verbal Fluency performance. Conclusions Errors in Verbal Fluency can be explained by the interaction of different variables in patients with schizophrenia. Schizophrenia is a psychological pathology with great phenomenological complexity and its particularities can only be explained by the consideration of the multiple factors involved in its manifestation.Fil: Galaverna, Flavia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Bueno, Adrián Marcelo. Universidad Nacional de Córdoba. Facultad de Psicología; ArgentinaFil: Morra, Carlos A.. Prof. León S. Morra Sanitarium; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Roca, María. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Torralva, Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentin

Importance of electronic self-consistency in the TDDFT based treatment of nonadiabatic molecular dynamics

A mixed quantum-classical approach to simulate the coupled dynamics of electrons and nuclei in nanoscale molecular systems is presented. The method relies on a second order expansion of the Lagrangian in time-dependent density functional theory (TDDFT) around a suitable reference density. We show that the inclusion of the second order term renders the method a self-consistent scheme and improves the calculated optical spectra of molecules by a proper treatment of the coupled response. In the application to ion-fullerene collisions, the inclusion of self-consistency is found to be crucial for a correct description of the charge transfer between projectile and target. For a model of the photoreceptor in retinal proteins, nonadiabatic molecular dynamics simulations are performed and reveal problems of TDDFT in the prediction of intra-molecular charge transfer excitations.Comment: 9 pages, 8 figures. Minor changes in content wrt older versio

Biología trófica de los juveniles del género Liza (Pisces : Mugilidae) en la laguna costera del Mar Menor (SE Península Ibérica)

En el presente trabajo se presentan datos sobre la alimentación de juveniles de tres especies de mugílidos presentes en la laguna costera del Mar Menor: Liza saliens (Risso, 1810), L. aurata (Risso, 1810) y L. ramado (Risso, 1810). La dieta fue omnívora para las tres especies, consumiendo una gran variedad de presas, tanto de origen animal como vegetal. Se encontraron diferencias interespecíficas en la composición de la misma, así como diferencias intraespecíficas en función de la campaña de muestreo. Además, se observaron cambios en la dieta en función de la talla de los ejemplares, situación probablemente relacionada con cambios ontogénicos en la dieta de las especies estudiadas.In this work data is presented concerning the food and feeding habits of three species of mullet juveniles that are present in the Mar Menor coastal lagoon: Liza saliens (Risso, 1810), L. aurata (Risso, 1810) and L. ramado (Risso, 1810). Diet of of the three species was omnivorous; they fed on numerous prey items, both animal and vegetal preys. Interspecific differences on diet composition were found, as well as intraspecific differences from sampling periods. Moreover, size-related differences in their feeding habits were found, suggesting the existence of ontogenic changes in the diet of the studied species

The relationship between executive functions and fluid intelligence in schizophrenia

An enduring question is unity vs. separability of executive deficits resulting from impaired frontal lobe function. In previous studies, we have asked how executive deficits link to a conventional measure of fluid intelligence, obtained either by standard tests of novel problem-solving, or by averaging performance in a battery of novel tasks. For some classical executive tasks, such as the Wisconsin Card Sorting Test (WCST), Verbal Fluency, and Trail Making Test B (TMTB), frontal deficits are entirely explained by fluid intelligence. However, on a second set of executive tasks, including tests of multitasking and decision making, deficits exceed those predicted by fluid intelligence loss. In this paper we discuss how these results shed light on the diverse clinical phenomenology observed in frontal dysfunction, and present new data on a group of 15 schizophrenic patients and 14 controls. Subjects were assessed with a range of executive tests and with a general cognitive battery used to derive a measure of fluid intelligence. Group performance was compared and fluid intelligence was introduced as a covariate. In line with our previous results, significant patient-control differences in classical executive tests were removed when fluid intelligence was introduced as a covariate. However, for tests of multitasking and decision making, deficits remained. We relate our findings to those of previous factor analytic studies describing a single principal component, which accounts for much of the variance of schizophrenic patients' cognitive performance. We propose that this general factor reflects low fluid intelligence capacity, which accounts for much but not all cognitive impairment in this patient group. Partialling out the general effects of fluid intelligence, we propose, may clarify the role of additional, more specific cognitive impairments in conditions such as schizophrenia

Edad y crecimiento de Barbus graellsii Steindachner, 1866 y Chondrostoma miegii, Steindachner, 1866 (Pisces, Cyprinidae) en el río Cinca (cuenca hidrográfica del Ebro, NE España)

The age and growth of two endemic cyprinids from the lberian peninsula were studied for one year in a stretch of the Cinca River. There were caught by electrofishing 279 individuals of B. graellsii and 189 individuals of Ch. miegii. lmmature specimens of both species were not caught probably due to their migratory behaviour during the reproductive period. B. graellsii presented a maximum of 11 age classes in both sexes. Female Ch. miegii live for 8 years and males seven years. Growth was allometric in B. graellsii specimens whereas Ch. miegii showed isometric growth. Females were longer than males in both species. B. graellsii females showed higher growth rates than males whereas Ch. miegii showed similar growth rates between sexes. B. graellsii males showed a significant increase in condition before the reproductive period and a decrease in condition during this period, while females only showed a significant decrease in condition in July. Ch. miegii females presented dynamics of condition very similar to B. graellsii males. Key words: Age, Growth, Cyprinidae, Barbus graellsii, Chondrostoma miegii.The age and growth of two endemic cyprinids from the lberian peninsula were studied for one year in a stretch of the Cinca River. There were caught by electrofishing 279 individuals of B. graellsii and 189 individuals of Ch. miegii. lmmature specimens of both species were not caught probably due to their migratory behaviour during the reproductive period. B. graellsii presented a maximum of 11 age classes in both sexes. Female Ch. miegii live for 8 years and males seven years. Growth was allometric in B. graellsii specimens whereas Ch. miegii showed isometric growth. Females were longer than males in both species. B. graellsii females showed higher growth rates than males whereas Ch. miegii showed similar growth rates between sexes. B. graellsii males showed a significant increase in condition before the reproductive period and a decrease in condition during this period, while females only showed a significant decrease in condition in July. Ch. miegii females presented dynamics of condition very similar to B. graellsii males. Key words: Age, Growth, Cyprinidae, Barbus graellsii, Chondrostoma miegii.The age and growth of two endemic cyprinids from the lberian peninsula were studied for one year in a stretch of the Cinca River. There were caught by electrofishing 279 individuals of B. graellsii and 189 individuals of Ch. miegii. lmmature specimens of both species were not caught probably due to their migratory behaviour during the reproductive period. B. graellsii presented a maximum of 11 age classes in both sexes. Female Ch. miegii live for 8 years and males seven years. Growth was allometric in B. graellsii specimens whereas Ch. miegii showed isometric growth. Females were longer than males in both species. B. graellsii females showed higher growth rates than males whereas Ch. miegii showed similar growth rates between sexes. B. graellsii males showed a significant increase in condition before the reproductive period and a decrease in condition during this period, while females only showed a significant decrease in condition in July. Ch. miegii females presented dynamics of condition very similar to B. graellsii males. Key words: Age, Growth, Cyprinidae, Barbus graellsii, Chondrostoma miegii

Fish assemblages associated with Cymodocea nodosa and Caulerpa prolifera meadows in the shallow areas of the Mar Menor coastal lagoon

The present study investigates several biological parameters of the fish assemblages, mainly juvenile fishes and adults of small sized species, associated with the seagrass Cymodocea nodosa and the macroalga Caulerpa prolifera in the shallow littoral areas of the Mar Menor coastal lagoon. Results showed that C nodosa seagrass meadows have a much higher number of fish species and considerably greater fish abundance and biomass than Ca. prolifera meadows. Other community variables (diversity and evenness) did not show significant differences between both meadows.En el presente estudio se investigaron diversos parámetros biológicos de las comunidades de peces, principalmente peces juveniles y adultos de especies de talla pequeña, asociadas a las praderas de la fanerógama acuática Cymodocea nodosa y la macroalga Caulerpa prolifera en las zonas someras litorales de la laguna costera del Mar Menor. Los resultados mostraron que las praderas de C. nodosa presentaron un mayor numero de especies y una mayor abundancia y biomasa de peces que las praderas de Ca. prolifera. Otras variables de la comunidad (diversidad y equitatividad) no mostraron diferencias significativas entre ambos tipos de praderas

Edad, crecimiento y reproducción de Gobio gobio L. (Pisces, Cyprinidae) en un tramo regulado del río Segura (SE de España)

The age, growth and reproduction of Gobio gobio, were studied during a period of two years in a section of the Segura River regulated by the effect of a small upstream hydroelectric power station. A total of 254 specimens were caught monthly by electrofishing. The studied population showed a maximum of six age classes in females (0+–5+) and five in males (1+–5+). All females were mature at 2+ age class, whereas only 62.5% 2+ males showed mature gonads. During the studied period, both sexes showed maximum values of Gonadosomatic Index in May and spawn was different between the two studied periods. Compared with other populations, the studied population from a regulated locality is characterized by a non–seasonal body condition cycle and low captures of juvenile fish (0+, 1+) probably due to the effect of washing produced by drastic and unpredictable flow changes.La edad, crecimiento y reproducción de Gobio gobio, ha sido estudiada a lo largo de dos años en un tramo del río Segura regulado por una pequeña central hidroeléctrica. Mediante pesca eléctrica fueron capturados, mensualmente, un total de 254 ejemplares. Las hembras presentaron seis clases de edad (0+–5+) mientras que los machos presentaron cinco clases (1+–5+). Todas las hembras de clase de edad 2+ resultaron maduras mientras que los machos 2+ resultaron maduros en un 62,5% de los casos. Durante el periodo de estudio, ambos sexos presentaron los máximos valores del Índice Gonadosomático durante los meses de mayo aunque el desove resultó diferente entre los dos periodos estudiados. En comparación con otras poblaciones, la población estudiada en un tramo regulado del río se caracteriza por no presentar un ciclo estacional en la condición somática y bajas capturas de ejemplares juveniles (0+, 1+) debido, probablemente, al efecto de lavado provocado por los drásticos e impredecibles cambios en el caudal

The relationship between executive functions and fluid intelligence in euthymic Bipolar Disorder patients.

Distinct cognitive deficits have been described in Bipolar disorder (BD), including executive impairments, commonly attributed to frontal dysfunction. However, recent attention has been paid to the heterogeneity of cognitive functioning in this population, suggesting that the executive deficits observed in BD might be due to a loss in fluid intelligence (g). Following our previous line of investigation in multiple neurological and psychiatric conditions we aimed at determining the role of g in frontal deficits in BD. Euthymic BD patients (n = 51) and healthy controls (n = 37) were assessed with Wisconsin Card Sorting Test (WCST), Verbal Fluency, Trail Making Test B (TMTB), a multitasking test, and a theory of mind test. A general cognitive battery was used to derive a measure of g. As in other neuropsychiatric conditions, significant patient-control differences in WCST, Verbal Fluency and TMTB were removed when g was introduced as a covariate. Deficits remained significant in the multitasking test. We suggest that neuropsychological assessment in BD should include tests of general intelligence, together with one or more specific tasks that allow for the assessment of residual frontal deficits, putatively associated with anterior frontal functioning