Decision Trees

The object of this paper is to inform those concerned with the administration of justice in Ethiopia – particularly, criminal justice – about a new and simple procedure which may assist in procuring uniform interpretation and application of laws and regulations. The problem of uniform interpretation and application is particularly severe where, as in Ethiopia, new laws must be interpreted and applied by persons who have not yet had the opportunity of formal legal education. For these persons the discovery of the relevant code articles and the understanding of their interrelationships and application must be very difficult indeed. One possible result of this unfortunate state of affairs is that the codes will not be fully, effectively, or consistently applied throughout the Empire. If, on the other hand, administrators try to avoid this problem by assigning the Empire\u27s comparatively few legally trained persons to such jobs as public prosecutor, woreda court judge, etc., then the result may be waste of legal resources. No one of these jobs is, in national perspective, of the very greatest importance; overall inefficiency of performance in them, on the other hand, can markedly reduce the quality of Ethiopian justice

Post-Disaster Assessment of the Performance of Hazard Mitigation Projects: The California SMART Approach

California\u27s SMART (State Mitigation Assessment Review Team) program for assessing natural hazard mitigation project performance after a disaster is a method of integrating multiple state agencies\u27 expertise into a working tool for assessing the value of public investments in risk reduction. The intent of the SMART program is to provide the California Emergency Management Agency with information about the performance of publicly financed mitigation projects so that it can better allocate future funding and improve the overall safety of California. A key aspect of the program is the mobilization of California State University faculty and staff from across the state after a disaster in order to conduct rapid performance assessments while field data is available. In order to test the SMART system, a pilot study was conducted using the Yountville Flood Barrier Wall Project performance during a 2005 flood on the Napa River. The case validated the idea that for a flood project, a rapid evaluation could be conducted using field observations that establish the height and extent of flooding and include the project\u27s original cost-benefit analysis. The data produced from this type of evaluation program will be valuable to state emergency management agencies trying to allocate program grants in the most efficient manner and to government agencies who want to make sure that federal dollars are being spent wisely

Understanding large-scale structure in the SSA22 protocluster region using cosmological simulations

We investigate the nature and evolution of large-scale structure within the SSA22 protocluster region at $z=3.09$ using cosmological simulations. A redshift histogram constructed from current spectroscopic observations of the SSA22 protocluster reveals two separate peaks at $z = 3.065$ (blue) and $z = 3.095$ (red). Based on these data, we report updated overdensity and mass calculations for the SSA22 protocluster. We find $\delta_{b,gal}=4.8 \pm 1.8$, $\delta_{r,gal}=9.5 \pm 2.0$ for the blue and red peaks, respectively, and $\delta_{t,gal}=7.6\pm 1.4$ for the entire region. These overdensities correspond to masses of $M_b = (0.76 \pm 0.17) \times 10^{15} h^{-1} M_{\odot}$, $M_r = (2.15 \pm 0.32) \times 10^{15} h^{-1} M_{\odot}$, and $M_t=(3.19 \pm 0.40) \times 10^{15} h^{-1} M_{\odot}$ for the red, blue, and total peaks, respectively. We use the Small MultiDark Planck (SMDPL) simulation to identify comparably massive $z\sim 3$ protoclusters, and uncover the underlying structure and ultimate fate of the SSA22 protocluster. For this analysis, we construct mock redshift histograms for each simulated $z\sim 3$ protocluster, quantitatively comparing them with the observed SSA22 data. We find that the observed double-peaked structure in the SSA22 redshift histogram corresponds not to a single coalescing cluster, but rather the proximity of a $\sim 10^{15}h^{-1} M_{\odot}$ protocluster and at least one $>10^{14} h^{-1} M_{\odot}$ cluster progenitor. Such associations in the SMDPL simulation are easily understood within the framework of hierarchical clustering of dark matter halos. We finally find that the opportunity to observe such a phenomenon is incredibly rare, with an occurrence rate of 7.4h^3 \mbox{ Gpc}^{-3}.Comment: 13 pages, 8 figures, Accepted to Ap

Differential effects of dietary whey, casein and soya on colonic DNA damage and large bowel SCFA in rats fed diets low and high in resistant starch

Feeding higher levels of dietary animal protein (as casein or red meat) increases colonic DNA damage and thins the colonic mucus barrier in rats. Feeding resistant starch (RS) reverses these changes and increases large bowel SCFA. The present study examined whether high dietary dairy (casein or whey) or plant (soya) proteins had similar adverse effects and whether dietary RS was protective. Adult male rats were fed diets containing 15 or 25 % casein, whey or soya protein with or without 48 % high amylose starch (as a source of RS) for 4 weeks. DNA damage was measured in isolated colonocytes using the comet assay. Higher dietary casein and soya (but not whey) increased colonocyte DNA damage. DNA damage was highest with soya when fed at 15 or 25 % protein without RS. Dietary RS attenuated protein-induced colonocyte DNA damage in all groups but it remained significantly higher in rats fed 25 % soya compared with those fed 15 % protein. Dietary protein level did not affect colonic mucus thickness overall but the barrier was thinner in rats fed high dietary casein. This effect was reversed by feeding RS. Caecal total SCFA and butyrate pools were higher in rats fed RS compared with digestible starch. Caecal and faecal SCFA were unrelated to genetic damage but correlated with mucus thickness. The present data confirm that higher dietary protein affected colonocyte DNA and colonic mucus thickness adversely but that proteins differ in their effects on these indices of colon health. The data show also that these changes were reversed by RS.Shusuke Toden, Anthony R. Bird, David L. Topping and Michael A. Conlo

Dietary Manipulation of Oncogenic MicroRNA Expression in Human Rectal Mucosa: A Randomized Trial

Author version made available in accordance with the publisher's policy.High red meat intake is associated with increased colorectal cancer (CRC) risk, while resistant starch is probably protective. Resistant starch fermentation produces butyrate, which can alter microRNA (miRNA) levels in CRC cells in vitro; effects of red meat and resistant starch on miRNA expression in vivo were unknown. This study examined whether a high red meat (HRM) diet altered miRNA expression in rectal mucosa tissue of healthy volunteers, and if supplementation with butyrylated resistant starch (HRM+HAMSB) modified this response. In a randomised cross-over design, twenty-three volunteers undertook four 4-week dietary interventions; an HRM diet (300 g/day lean red meat) and an HRM+HAMSB diet (HRM with 40 g/day butyrylated high amylose maize starch), preceded by an entry diet and separated by a washout. Faecal butyrate increased with the HRM+HAMSB diet. Levels of oncogenic mature miRNAs, including miR-17-92 cluster miRNAs and miR-21, increased in the rectal mucosa with the HRM diet, while the HRM+HAMSB diet restored miR-17-92 miRNAs, but not miR-21, to baseline levels. Elevated miR-17-92 and miR-21 in the HRM diet corresponded with increased cell proliferation, and a decrease in miR-17-92 target gene transcript levels, including CDKN1A. The oncogenic miR-17-92 cluster is differentially regulated by dietary factors that increase or decrease risk for CRC, and this may explain, at least in part, the respective risk profiles of high red meat and resistant starch. These findings support increased resistant starch consumption as a means of reducing risk associated with an HRM diet

Resistant Starches Protect against Colonic DNA Damage and Alter Microbiota and Gene Expression in Rats Fed a Western Diet123

Resistant starch (RS), fed as high amylose maize starch (HAMS) or butyrylated HAMS (HAMSB), opposes dietary protein-induced colonocyte DNA damage in rats. In this study, rats were fed Western-type diets moderate in fat (19%) and protein (20%) containing digestible starches [low amylose maize starch (LAMS) or low amylose whole wheat (LAW)] or RS [HAMS, HAMSB, or a whole high amylose wheat (HAW) generated by RNA interference] for 11 wk (n = 10/group). A control diet included 7% fat, 13% protein, and LAMS. Colonocyte DNA single-strand breaks (SSB) were significantly higher (by 70%) in rats fed the Western diet containing LAMS relative to controls. Dietary HAW, HAMS, and HAMSB opposed this effect while raising digesta levels of SCFA and lowering ammonia and phenol levels. SSB correlated inversely with total large bowel SCFA, including colonic butyrate concentration (R2 = 0.40; P = 0.009), and positively with colonic ammonia concentration (R2 = 0.40; P = 0.014). Analysis of gut microbiota populations using a phylogenetic microarray revealed profiles that fell into 3 distinct groups: control and LAMS; HAMS and HAMSB; and LAW and HAW. The expression of colonic genes associated with the maintenance of genomic integrity (notably Mdm2, Top1, Msh3, Ung, Rere, Cebpa, Gmnn, and Parg) was altered and varied with RS source. HAW is as effective as HAMS and HAMSB in opposing diet-induced colonic DNA damage in rats, but their effects on the large bowel microbiota and colonocyte gene expression differ, possibly due to the presence of other fiber components in HAW

The MOSDEF Survey: Untangling the Emission-line Properties of z ∼ 2.3 Star-forming Galaxies

We analyze the rest-optical emission-line spectra of z∼2.3 star-forming galaxies in the complete MOSFIRE Deep Evolution Field (MOSDEF) survey. In investigating the origin of the well-known offset between the sequences of high-redshift and local galaxies in the [O III]5008/Hβ vs. [N II]6585/Hα ("[N II] BPT") diagram, we define two populations of z∼2.3 MOSDEF galaxies. These include the "high" population that is offset towards higher [O III]5008/Hβ and/or [N II]6585/Hα with respect to the local SDSS sequence and the "low" population that overlaps the SDSS sequence. These two groups are also segregated within the [O III]5008/Hβ vs. [S II]6718,6733/Hα and the [O III]4960,5008/[O II]3727,3730 (O32) vs. ([O III]4960,5008+[O II]3727,3730)/Hβ (R23) diagram, which suggests qualitatively that star-forming regions in the more offset galaxies are characterized by harder ionizing spectra at fixed nebular oxygen abundance. We also investigate many galaxy properties of the split sample and find that the "high" sample is on average smaller in size and less massive, but has higher specific star-formation rate and star-formation-rate surface density values and is slightly younger compared to the "low" population. From Cloudy+BPASS photoionization models, we estimate that the "high" population has a lower stellar metallicity (i.e., harder ionizing spectrum) but slightly higher nebular metallicity and higher ionization parameter compared to the "low" population. While the "high" population is more α-enhanced (i.e., higher α/Fe) than the "low" population, both samples are significantly more α-enhanced compared to local star-forming galaxies with similar rest-optical line ratios. These differences must be accounted for in all high-redshift star-forming galaxies -- not only those "offset" from local excitation sequences

Re-evaluation of the mechanisms of dietary fibre and implications for macronutrient bioaccessibility, digestion and postprandial metabolism

The positive effects of dietary fibre on health are now widely recognised; however, our understanding of the mechanisms involved in producing such benefits remains unclear. There are even uncertainties about how dietary fibre in plant foods should be defined and analysed. This review attempts to clarify the confusion regarding the mechanisms of action of dietary fibre and deals with current knowledge on the wide variety of dietary fibre materials, comprising mainly of NSP that are not digested by enzymes of the gastrointestinal (GI) tract. These non-digestible materials range from intact cell walls of plant tissues to individual polysaccharide solutions often used in mechanistic studies. We discuss how the structure and properties of fibre are affected during food processing and how this can impact on nutrient digestibility. Dietary fibre can have multiple effects on GI function, including GI transit time and increased digesta viscosity, thereby affecting flow and mixing behaviour. Moreover, cell wall encapsulation influences macronutrient digestibility through limited access to digestive enzymes and/or substrate and product release. Moreover, encapsulation of starch can limit the extent of gelatinisation during hydrothermal processing of plant foods. Emphasis is placed on the effects of diverse forms of fibre on rates and extents of starch and lipid digestion, and how it is important that a better understanding of such interactions with respect to the physiology and biochemistry of digestion is needed. In conclusion, we point to areas of further investigation that are expected to contribute to realisation of the full potential of dietary fibre on health and well-being of humans