Patches for Repairing Ceramics and Ceramic-Matrix Composites

Patches consisting mostly of ceramic fabrics impregnated with partially cured polymers and ceramic particles are being developed as means of repairing ceramics and ceramic-matrix composites (CMCs) that must withstand temperatures above the melting points of refractory metal alloys. These patches were conceived for use by space-suited, space-walking astronauts in repairing damaged space-shuttle leading edges: as such, these patches could be applied in the field, in relatively simple procedures, and with minimal requirements for specialized tools. These design characteristics also make the patches useful for repairing ceramics and CMCs in terrestrial settings. In a typical patch as supplied to an astronaut or repair technician, the polymer would be in a tacky condition, denoted as an A stage, produced by partial polymerization of a monomeric liquid. The patch would be pressed against the ceramic or CMC object to be repaired, relying on the tackiness for temporary adhesion. The patch would then be bonded to the workpiece and cured by using a portable device to heat the polymer to a curing temperature above ambient temperature but well below the maximum operating temperature to which the workpiece is expected to be exposed. The patch would subsequently become pyrolized to a ceramic/glass condition upon initial exposure to the high operating temperature. In the original space-shuttle application, this exposure would be Earth-atmosphere-reentry heating to about 3,000 F (about 1,600 C). Patch formulations for space-shuttle applications include SiC and ZrO2 fabrics, a commercial SiC-based pre-ceramic polymer, and suitable proportions of both SiC and ZrO2 particles having sizes of the order of 1 m. These formulations have been tailored for the space-shuttle leading-edge material, atmospheric composition, and reentry temperature profile so as to enable repairs to survive re-entry heating with expected margin. Other formulations could be tailored for specific terrestrial applications

Ceramic Paste for Patching High-Temperature Insulation

A ceramic paste that can be applied relatively easily, either by itself or in combination with one or more layer(s) of high-temperature ceramic fabrics, such as silicon carbide or zirconia, has been invented as a means of patching cracks or holes in the reinforced carbon-carbon forward surfaces of a space shuttle in orbit before returning to Earth. The paste or the paste/fabric combination could also be used to repair rocket-motor combustion chambers, and could be used on Earth to patch similar high-temperature structures. The specified chemical composition of the paste admits of a number of variations, and the exact proportions of its constituents are proprietary. In general, the paste consists of (1) silicon carbide, possibly with addition of (2) hafnium carbide, zirconium carbide, zirconium boride, silicon tetraboride, silicon hexaboride, or other metal carbides or oxides blended with (3) a silazane-based polymer. Because the paste is viscous and sticky at normal terrestrial and outer-space ambient temperatures, high-temperature ceramic fabrics such as silicon carbide or zirconia fabric impregnated with the paste (or the paste alone) sticks to the damaged surface to which it is applied. Once the patch has been applied, it is smoothed to minimize edge steps as required [forward-facing edge steps must be < or equal to 0.030 in. (< or equal to 0.76 mm) in the original intended space-shuttle application]. The patch is then heated to a curing temperature thereby converting it from a flexible material to a hard, tough material. The curing temperature is 375 to 450 F (approx.190 to 230 C). In torch tests and arc-jet tests, the cured paste was found to be capable of withstanding a temperature of 3,500 F (approx. 1,900 C) for 15 minutes. As such, the material appears to satisfy the requirement, in the original space-shuttle application, to withstand re-entry temperatures of approx.3,000 F (approx. 1,600 C)

Dignity and Narrative Medicine

Critiques of the dehumanising aspects of contemporary medical practice have generated increasing interest in the ways in which health care can foster a holistic sense of wellbeing. We examine the relationship between two areas of this humanistic endeavour: narrative and dignity. This paper makes two simple arguments that are intuitive but have not yet been explored in detail: that narrative competence of carers is required for maintaining or recreating dignity, and that dignity promotion in health care practice is primarily narrative in form. The multiple meanings that dignity has in a person’s life are what give the concept power and can only be captured by narrative. This has implications for health care practice where narrative work will be increasingly required to support patient dignity in under-resourced and over-subscribed health care system

Including Condition into Ecological Maps Changes Everything—A Study of Ecological Condition in the Conterminous United States

In 2021, the Biden administration signed an executive order to protect 30% of American lands by 2030. Accomplishing this ambitious goal in the U.S. requires understanding the relative contribution of public and private lands toward supporting biodiversity. New approaches are needed because existing approaches focus on quantity of habitat without incorporating quality. To fill this need, we developed a 30 m resolution national habitat condition index (HCI) that integrates quality and quantity measures of habitat. We hypothesized that including an evaluation of the quality of habitat at landscape scales, both in conservation-focused preserves and working lands would provide a better assessment of the value of geographies for conservation. We divided the conterminous U.S. by major land cover type and into natural and cultivated lands and then spatially mapped multiple anthropogenic stressors, proximity to aquatic habitat, and vegetation departure from expected natural disturbance regimes. Each map layer was then scored for site impact and distance decay and combined into a final national index. Field observations providing scored relative ecological conditions were used for HCI calibration and validation at both CONUS and regional scales. Finally, we evaluate lands by management (conservation versus working lands) and ownership (public versus private) testing the value of these lands for conservation. While we found regional differences across CONUS, functional habitat was largely independent of protection status: working lands provide clear habitat and other values. These results are relevant for guiding strategies to achieve the U.S. 30 by 30 goals. Where similar data exist in other countries, analogous modeling could be used to meet their national conservation commitments

Including Condition into Ecological Maps Changes Everything—A Study of Ecological Condition in the Conterminous United States

In 2021, the Biden administration signed an executive order to protect 30% of American lands by 2030. Accomplishing this ambitious goal in the U.S. requires understanding the relative contribution of public and private lands toward supporting biodiversity. New approaches are needed because existing approaches focus on quantity of habitat without incorporating quality. To fill this need, we developed a 30 m resolution national habitat condition index (HCI) that integrates quality and quantity measures of habitat. We hypothesized that including an evaluation of the quality of habitat at landscape scales, both in conservation-focused preserves and working lands would provide a better assessment of the value of geographies for conservation. We divided the conterminous U.S. by major land cover type and into natural and cultivated lands and then spatially mapped multiple anthropogenic stressors, proximity to aquatic habitat, and vegetation departure from expected natural disturbance regimes. Each map layer was then scored for site impact and distance decay and combined into a final national index. Field observations providing scored relative ecological conditions were used for HCI calibration and validation at both CONUS and regional scales. Finally, we evaluate lands by management (conservation versus working lands) and ownership (public versus private) testing the value of these lands for conservation. While we found regional differences across CONUS, functional habitat was largely independent of protection status: working lands provide clear habitat and other values. These results are relevant for guiding strategies to achieve the U.S. 30 by 30 goals. Where similar data exist in other countries, analogous modeling could be used to meet their national conservation commitments

Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia.

: To investigate serum neurofilament light chain (NfL) concentrations in frontotemporal dementia (FTD) and to see whether they are associated with the severity of disease. : Serum samples were collected from 74 participants (34 with behavioral variant FTD [bvFTD], 3 with FTD and motor neuron disease and 37 with primary progressive aphasia [PPA]) and 28 healthy controls. Twenty-four of the FTD participants carried a pathogenic mutation in C9orf72 (9), microtubule-associated protein tau (MAPT; 11), or progranulin (GRN; 4). Serum NfL concentrations were determined with the NF-Light kit transferred onto the single-molecule array platform and compared between FTD and healthy controls and between the FTD clinical and genetic subtypes. We also assessed the relationship between NfL concentrations and measures of cognition and brain volume. : Serum NfL concentrations were higher in patients with FTD overall (mean 77.9 pg/mL [SD 51.3 pg/mL]) than controls (19.6 pg/mL [SD 8.2 pg/mL]; p &lt; 0.001). Concentrations were also significantly higher in bvFTD (57.8 pg/mL [SD 33.1 pg/mL]) and both the semantic and nonfluent variants of PPA (95.9 and 82.5 pg/mL [SD 33.0 and 33.8 pg/mL], respectively) compared with controls and in semantic variant PPA compared with logopenic variant PPA. Concentrations were significantly higher than controls in both the C9orf72 and MAPT subgroups (79.2 and 40.5 pg/mL [SD 48.2 and 20.9 pg/mL], respectively) with a trend to a higher level in the GRN subgroup (138.5 pg/mL [SD 103.3 pg/mL). However, there was variability within all groups. Serum concentrations correlated particularly with frontal lobe atrophy rate (r = 0.53, p = 0.003). : Increased serum NfL concentrations are seen in FTD but show wide variability within each clinical and genetic group. Higher concentrations may reflect the intensity of the disease in FTD and are associated with more rapid atrophy of the frontal lobes.<br/