3 research outputs found
Analysis of characteristics related to interstitial lung disease or pulmonary hypertension in patients with dermatomyositis
Abstract Introduction Dermatomyositis (DM) is often associated with interstitial lung disease (ILD) or pulmonary hypertension (PH). The aim of this study was to investigate the clinical characteristics of DM patients with ILD or PH. Methods This study retrospectively analysed the clinical characteristics of 372 patients with DM, including cytokines, lymphocyte subsets, immunoglobulin and complement. The DM patients were divided into different groups according to whether complicated with ILD, PH or antiâmelanoma differentiationâassociated gene 5 antibodies (MDA5). A qualitative and quantitative data analysis was performed. Results IgG, IgA and IgM in the DMâassociated ILD (ILDâDM) were higher than that of the DM nonâcomplicating ILD (NonâILDâDM) (p =â0.022, 0.002 and 0.029, respectively). Meanwhile, ILâ6 (p =â0.008) and ILâ10 (p =â0.001) were increased in the DMâassociated PH (PHâDM) than in the DM nonâcomplicating PH (NonâPHâDM), while ILâ17 (p =â0.004), double positive (DP) cell ratio and B lymphocyte ratio were reduced in the PHâDM. Moreover, the incidence of ILD and levels of C4 were higher in the DM with MDA5 (MDA5+ DM) than that of the DM without MDA5. Conclusion ILDâDM has higher IgG, IgA and IgM than that of NonâILDâDM. PHâDM has higher ILâ6, ILâ10 and lower ILâ17, DP cell ratio and B lymphocyte ratio than that of NonâPHâDM