Intonational variations at the end of interrogative sentences in Japanese dialects : From the “Corpus of Japanese Dialects”

National Institute for Japanese Language and LinguisticsNational Institute for Japanese Language and LinguisticsNational Institute for Japanese Language and LinguisticsLREC 2018 Special Speech Sessions "Speech Resources Collection in Real-World Situations"; Phoenix Seagaia Conference Center, Miyazaki; 2018-05-09In general, it is said that interrogative sentences have a final rising intonation (Kori 2003). However, this rule is not true of some Japanese dialects. Kibe (2010, 2011,2013) classify sentence-final tones of interrogatives in Japanese dialects into four types: Type A as a rising tone (Tōkyō dialect), Type B as a falling tone (Hirosaki dialect, Kagoshima dialect), Type C as a rising/falling tone (Hiroshima dialect), and Type D as a gradual rising tone (Fukuoka dialect). Since the data in Kibe (2010, 2011 and 3013) were extracted from an existing nation-wide dialect survey where an elicitation task was employed, it is not clear whether how much such intonation patterns appear in a spontaneous speech in each region. This article examines sentence-final tones of interrogatives extracted from a natural discourse stored in the “Corpus of Japanese Dialects” (COJADS), which is currently in preparation for release by the National Institute for Japanese Language and Linguistics (NINJAL). The results revealed that the four types are attestable even in a natural discourse, and furthermore, we identified a dialect such as Hirosaki dialect which distinguishes interrogatives from declaratives by the pitch range in the final falling tone

Factors related to depression among childcare worker;Cross-sectional study in Hokkaido, Japan

The goal of the present study was to investigate the factors related to depression among childcare workers. From November 2015 to August 2016, 358 nurseries (17.9%) answered a questionnaire. Adjusted for nursery work experience totaling more than five years, work place, cooperation in the work place, quality of sleep, hospital visiting, factors related to work of more than five years (OR=0.55, 95%CIs=(0.34, 0.91)), ability to consult troubles with boss (OR=0.36, 5%CIs=(0.18, 0.73)), to be able to take paid holidays (OR=0.49, 95%CIs=(0.27, 0.88)), having a spouse (OR=0.55, 95%CIs=(0.32, 0.94)) were considered to decrease the risk of depression. The Japanese government should prompt to improve the reatment of nurseries

Genetic Deletion of Vasohibin-2 Exacerbates Ischemia-Reperfusion-Induced Acute Kidney Injury

Acute kidney injury (AKI) has been increasingly recognized as a risk factor for transition to chronic kidney disease. Recent evidence suggests that endothelial damage in peritubular capillaries can accelerate the progression of renal injury. Vasohibin-2 (VASH2) is a novel proangiogenic factor that promotes tumor angiogenesis. However, the pathophysiological roles of VASH2 in kidney diseases remain unknown. In the present study, we examined the effects of VASH2 deficiency on the progression of ischemia-reperfusion (I/R) injury-induced AKI. I/R injury was induced by bilaterally clamping renal pedicles for 25 min in male wild-type (WT) andVash2homozygous knockout mice. Twenty-four hours later, I/R injury-induced renal dysfunction and tubular damage were more severe in VASH2-deficient mice than in WT mice, with more prominent neutrophil infiltration and peritubular capillary loss. After induction of I/R injury, VASH2 expression was markedly increased in injured renal tubules. These results suggest that VASH2 expression in renal tubular epithelial cells might be essential for alleviating I/R injury-induced AKI, probably through protecting peritubular capillaries and preventing inflammatory infiltration

Intracerebroventricular injection of adiponectin regulates locomotor activity in rats

Enhancing exercise motivation is the best way to prevent obesity and diabetes. In this study, we examined whether adiponectin affects locomotion activity in Wister and Spontaneously-Running Tokushima-Shikoku (SPORTS) rats using two types of behavioral assays : home cage and wheel running activity. SPORTS rats were established from an original line from Wister strain that had shown high level of wheel running activity in our laboratory. Injection of adiponectin into the lateral ventricle of Wister rats and SPORTS rats decreased home cage activity, but no change was observed in the food intake and oxygen consumption. This result indicates the possibility that adiponectin can reduce non-exercise activity thermogenesis (NEAT) and physical activity via the central nervous system. In contrast, injection of adiponectin did not change wheel running activity in SPORTS rats. We produced hypothalamus-destructed model rat using monosodium glutamate (MSG) to elucidate the regulation site of adiponectin. Injection of adiponectin into MSG-treated SPORTS rats did not change amount of home cage activity and food intake, suggesting that adiponectin action on home cage activity was in the hypothalamic area. These results suggest that adiponectin regulates locomotion activity through mediobasal hypothalamus

南極海インド洋区における粒状物質（全粒子、炭素、窒素）の鉛直フラックスの3年間に渡る変動

第6回極域科学シンポジウム分野横断セッション：[IB1] 海氷域における生物地球化学的研究11月17日（火）　統計数理研究所 セミナー室1（D305

Great apes’ understanding of biomechanics: eye-tracking experiments using three-dimensional computer-generated animations

Visual processing of the body movements of other animals is important for adaptive animal behaviors. It is widely known that animals can distinguish articulated animal movements even when they are just represented by points of light such that only information about biological motion is retained. However, the extent to which nonhuman great apes comprehend the underlying structural and physiological constraints affecting each moving body part, i.e., biomechanics, is still unclear. To address this, we examined the understanding of biomechanics in bonobos (Pan paniscus) and chimpanzees (Pan troglodytes), following a previous study on humans (Homo sapiens). Apes underwent eye tracking while viewing three-dimensional computer-generated (CG) animations of biomechanically possible or impossible elbow movements performed by a human, robot, or nonhuman ape. Overall, apes did not differentiate their gaze between possible and impossible movements of elbows. However, some apes looked at elbows for longer when viewing impossible vs. possible robot movements, which indicates that they may have had knowledge of biomechanics and that this knowledge could be extended to a novel agent. These mixed results make it difficult to draw a firm conclusion regarding the extent to which apes understand biomechanics. We discuss some methodological features that may be responsible for the results, as well as implications for future nonhuman animal studies involving the presentation of CG animations or measurement of gaze behaviors

Experimental verification of the detecting the internal horizontal crack of RC slab based on dynamical properties of a plate

To detect internal horizontal cracks in RC slabs of bridge structures, this paper proposes stimulating and measuring vibration of a plate consisting of concrete on the upper part of the internal horizontal crack of the RC slab. Giving enforced sweeping vibration from the RC surface and/or the asphalt pavement surface, both natural frequencies and mode shapes about the crack part are measured and compared with the corresponding theoretical ones. Their agreement implies applicability of the proposed method to detect the internal horizontal crack in RC slabs as one of the feasible non-destructive inspections in fields

Vasohibin-1 has α-tubulin detyrosinating activity in glomerular podocytes

Podocytes are highly specialized epithelial cells in glomeruli, with a complex morphology composed of a cell body, primary processes, and foot processes, which maintain barrier function in glomerular filtration. The microtubule-based cytoskeleton is necessary for podocyte morphology. Microtubule structure and function can be affected by post-translational modification of tubulin, including detyrosination. Recent studies have shown that vasohibin-1 (VASH1), an antiangiogenic factor, has tubulin carboxypeptidase activity that causes detyrosination of α-tubulin. We aimed to examine the role of VASH1 in regulating α-tubulin detyrosination in podocytes and the potential involvement of VASH1 deficiency in renal morphology. In normal mouse kidneys, detyrosinated α-tubulin was mainly identified in glomeruli, especially in podocytes; meanwhile, in cultured immortalized podocytes, α-tubulin detyrosination was promoted with cell differentiation. Notably, α-tubulin detyrosination in glomeruli was diminished in Vash1 homozygous knockout (Vash1−/−) mice, and knockdown of VASH1 in cultured podocytes prevented α-tubulin detyrosination. Although VASH1 deficiency-induced downregulation of detyrosination caused no remarkable glomerular lesions, urinary albuminuria excretion and glomerular volume were significantly higher in Vash1−/− mice than in wild-type mice. Furthermore, decreased glomerular nephrin expression and narrower slit diaphragms width were observed in Vash1−/− mice. Taken together, we demonstrated that α-tubulin detyrosination in podocytes was mainly regulated by VASH1 and that VASH1 deficiency-mediated decreases in α-tubulin detyrosination led to minor alterations in podocyte morphology and predisposition to albuminuria. VASH1 expression and α-tubulin detyrosination may be novel targets for maintaining glomerular filtration barrier integrity