Initial condition for baryogenesis via neutrino oscillation

We consider a baryogenesis scenario via the oscillation of right-handed neutrinos with Majorana masses of the order of GeV, which are also responsible for neutrino masses by the seesaw mechanism. We study how the initial condition alters the prediction of the present baryon asymmetry by this mechanism. It is usually assumed that the abundance of right-handed neutrinos is zero after the reheating of the inflationary universe and they are produced in scattering processes by the renomalizable Yukawa interaction. However, the higher-dimensional operator with right-handed neutrinos may provide an additional production which is most effective at the reheating epoch. It is shown that such an initial abundance of right-handed neutrinos can significantly modify the prediction when the strong washout of the asymmetry is absent. This leads to the parameter space of the model for the successful baryogenesis being enlarged.Comment: 24 pages, 35 figures, v2; correspond to published versio

Energy redistribution and spatiotemporal evolution of correlations after a sudden quench of the Bose-Hubbard model

非局所相関の伝搬の観測とエネルギー保存則の検証に成功 --冷却原子を用いた量子多体ダイナミクスの量子シミュレーション--. 京都大学プレスリリース. 2020-10-09.An optical lattice quantum simulator is an ideal experimental platform to investigate nonequilibrium dynamics of a quantum many-body system, which is, in general, hard to simulate with classical computers. Here, we use our quantum simulator of the Bose-Hubbard model to study dynamics far from equilibrium after a quantum quench. We successfully confirm the energy conservation law in the one- and three-dimensional systems and extract the propagation velocity of the single-particle correlation in the one- and two-dimensional systems. We corroborate the validity of our quantum simulator through quantitative comparisons between the experiments and the exact numerical calculations in one dimension. In the computationally hard cases of two or three dimensions, by using the quantum-simulation results as references, we examine the performance of a numerical method, namely, the truncated Wigner approximation, revealing its usefulness and limitation. This work constitutes an exemplary case for the usage of analog quantum simulators

Energy redistribution and spatio-temporal evolution of correlations after a sudden quench of the Bose-Hubbard model

An optical-lattice quantum simulator is an ideal experimental platform to investigate non-equilibrium dynamics of a quantum many-body system, which is in general hard to simulate with classical computers. Here, we use our quantum simulator of the Bose-Hubbard model to study dynamics far from equilibrium after a quantum quench. We successfully confirm the energy conservation law in the one- and three-dimensional systems and extract the propagation velocity of the single-particle correlation in the one- and two-dimensional systems. We corroborate the validity of our quantum simulator through quantitative comparisons between the experiments and the exact numerical calculations in one dimension. In the computationally hard cases of two or three dimensions, by using the quantum-simulation results as references, we examine the performance of a numerical method, namely the truncated Wigner approximation, revealing its usefulness and limitation. This work constitutes an exemplary case for the usage of analog quantum simulators.Comment: 16 pages, 11 figures (the Supplementary Materials included

Glycoprotein Hyposialylation Gives Rise to a Nephrotic-Like Syndrome That Is Prevented by Sialic Acid Administration in GNE V572L Point-Mutant Mice

Mutations in the key enzyme of sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetyl-mannosamine kinase, result in distal myopathy with rimmed vacuoles (DMRV)/hereditary inclusion body myopathy (HIBM) in humans. Sialic acid is an acidic monosaccharide that modifies non-reducing terminal carbohydrate chains on glycoproteins and glycolipids, and it plays an important role in cellular adhesions and interactions. In this study, we generated mice with a V572L point mutation in the GNE kinase domain. Unexpectedly, these mutant mice had no apparent myopathies or motor dysfunctions. However, they had a short lifespan and exhibited renal impairment with massive albuminuria. Histological analysis showed enlarged glomeruli with mesangial matrix deposition, leading to glomerulosclerosis and abnormal podocyte foot process morphologies in the kidneys. Glycan analysis using several lectins revealed glomerular epithelial cell hyposialylation, particularly the hyposialylation of podocalyxin, which is one of important molecules for the glomerular filtration barrier. Administering Neu5Ac to the mutant mice from embryonic stages significantly suppressed the albuminuria and renal pathology, and partially recovered the glomerular glycoprotein sialylation. These findings suggest that the nephrotic-like syndrome observed in these mutant mice resulted from impaired glomerular filtration due to the hyposialylation of podocyte glycoproteins, including podocalyxin. Furthermore, it was possible to prevent the nephrotic-like disease in these mice by beginning Neu5Ac treatment during gestation

Two genetic variants of CD38 in subjects with autism spectrum disorder and controls

金沢大学医薬保健研究域医学系The neurobiological basis of autism spectrum disorder (ASD) remains poorly understood. Given the role of CD38 in social recognition through oxytocin (OT) release, we hypothesized that CD38 may play a role in the etiology of ASD. Here, we first examined the immunohistochemical expression of CD38 in the hypothalamus of post-mortem brains of non-ASD subjects and found that CD38 was colocalized with OT in secretory neurons. In studies of the association between CD38 and autism, we analyzed 10 single nucleotide polymorphisms (SNPs) and mutations of CD38 by re-sequencing DNAs mainly from a case-control study in Japan, and Caucasian cases mainly recruited to the Autism Genetic Resource Exchange (AGRE). The SNPs of CD38, rs6449197 (p 70; designated as high-functioning autism (HFA)) in the U.S. 104 AGRE family trios, but not with Japanese 188 HFA subjects. A mutation that caused tryptophan to replace arginine at amino acid residue 140 (R140W; (rs1800561, 4693C>T)) was found in 0.6-4.6% of the Japanese population and was associated with ASD in the smaller case-control study. The SNP was clustered in pedigrees in which the fathers and brothers of T-allele-carrier probands had ASD or ASD traits. In this cohort OT plasma levels were lower in subjects with the T allele than in those without. One proband with the T allele who was taking nasal OT spray showed relief of symptoms. The two variant CD38 poloymorphysms tested may be of interest with regard of the pathophysiology of ASD. © 2010 Elsevier Ireland Ltd and the Japan Neuroscience Society

Severe sepsis caused by Parvimonas micra identified using 16S ribosomal RNA gene sequencing following patient death

An 83-year-old man visited an orthopedic hospital for his lower back pain. A compression fracture was noted in his second lumbar vertebra. He had taken pain medication for approximately five weeks, but the pain had worsened and he was unable to walk by himself. He was transferred to our hospital and diagnosed with lumbar spondylodiscitis, an iliopsoas abscess, gas gangrene of his left lower limb, and left massive pleural effusion. He was admitted to the intensive care unit. We drained the abscess and pleural effusion, provided continuous hemodiafiltration under ventilator control, and administered intravenous antibiotics. However, he died from sepsis and multiple organ failure three days following admission. Several days after his death, gram-positive cocci were identified in blood culture, pus from the abscess, and pleural exudate; although the causative organism could not be identified. Two weeks subsequent to his death, 16S ribosomal RNA gene sequencing identified Parvimonas micra in specimens taken from his body. Keywords: Anaerobic infection, Gas gangrene, Iliopsoas abscess, Parvimonas micra, Spondylodisciti

Characteristics of Postural Muscle Activation Patterns Induced by Unexpected Surface Perturbations in Elite Ski Jumpers

[Purpose] This study investigated the characteristics of postural control following postural disturbance in elite athletes. [Subjects] Ten elite ski jumpers and ten control subjects participated in this study. [Methods] Subjects were required to maintain balance without stepping following unexpected horizontal surface perturbation in a forward or backward direction. [Results] A lower and reproducible peak magnitude of the center of mass velocity was shown in the athlete group compared to the control group. Cross-correlation analyses showed longer time lags at the moment of peak correlation coefficient between trunk flexor and extensor muscle activities, and shorter time lags and higher correlations between ankle flexor and extensor muscle activities were shown in the athlete group than in the control group. [Conclusion] The elite ski jumpers showed superior balance performance following surface perturbations, more reciprocal patterns in agonist-antagonist pairs of proximal postural muscles, and more co-contraction patterns in distal postural muscles during automatic postural responses than control individuals. This strategy may be useful in sports requiring effective balance recovery in environments with a dynamically changing surface, as well as in rehabilitation

Adaptation of postural control while standing on a narrow unfixed base of support

The purpose of this study was to investigate the adaptation with practice of postural control while standing on a rocker board. Thirteen healthy young adults participated. The participants were asked to stand in a sagittal plane on a rocker board with a semicircular base as steadily as possible for as long as they could. With practice, the duration of maintaining postural balance increased significantly and postural stability improved (P 0.05). This observation would be the consequence of a highly redundant human locomotor system. With practice, the central nervous system was able to shift the center of pressure position close to the accurate center of mass position