165 research outputs found
Exile Vol. XXII No. 1
PROSE
Dust by Katie Tight 4-13
The Masculine Cure by Elizabeth Thomas 14-19
The Rats Still Sleep At Night by Wolfgang Borchert (translated from the German by Eric Fridman) 20-22
Largo for a Pelican by Morgan Wills 23-25
Role by Anne Tomfohrde 26-29
Goody Two-Shoes Meets the Cincinnati Kid by Kim McMullen 30-38
In the Final Analysis (Psychological or Otherwise): A Review of Carl Jung\u27s Theory of Art by Issa Christian Halabi 39-42
POETRY
Here by Fayad Jamis (translated from the Spanish by Joseph R. deArmas) 44
No. 236 by Dawn Patnode 45
No. 237 by Dawn Patnode 46
In my Room by Ulf Miehe 47
Saturday Night Lament by Woodrow Jones 48-49
Basho\u27s Hut by Lenore Mayhew 50
From a Train: Ireland by Kim McMullen 51
Suggested by One Hundred Years Of Solitude by Martin Cloran 52
(to L. Martynov) by Yevgeny Yevtushenko 53
At Sea by Paul Bennett 54
Words In A Line by Lawrence Weber 55
a leave-taking by Debra Allbery 56
untitled by Alison Orleans 57
As The Water Whittles in Colour by Lawrence Weber 58-59
Falconsong or Falcon Song by The Man from Kurenben (translated from the German by John Kessler) 60
POUND
Introduction 62
Response from Hugh Kenner 63
Response from Mary de Rachewiltz 64
The Cantos: The Vision of Ezra Pound by William McNaughton 65-78
CONTRIBUORS 79-80
Cover sketch by Lisa Rope
Pound Photograph Courtesy of Bill McNaughto
Exile Vol. XXIII no. 1
PROSE
The White Butterfly by Dalton Trevisan (translated from the Portugese by Alexis Levitin) 5-6
Natural Selection by Anne Tomfohrde 7-14
Stuck a Feather in His Cap... (for Boo) by Tim Cockey 15-18
An Act of Violence by William McNaughton 19-22
Shall We Now Praise Famous Men? by Lawrence Weber 23-24
POETRY
Wake by Dawn Patnode 26
Pebble by Lenore Mayhew 27
Bien: yo respeto... by José Mártí 28
Yes: I respect by José Mártí (translated from the Spanish by Joan Straub) 29
untitled by Mary Schloss 30
Nursing Home by Tim Cockey 31
Maia by Betsy Sloan 32
untitled by Loranna Franz 33
Momento Num Cafe by Manuel Banderia 34
Moment in a Café by Manuel Banderia (translated from the Portoguese by Alexis Levitin) 35
Pleiades by Dawn Patnode 36-37
untitled by Sharon Singleton 39
Travel by Libby Thomas 40
untitled by José Pretlow 41
Melancolía by Rubén Darío 42
Melancholy by Rubén Darío (translated from the Spanish by Joan Straub) 43
Lake Shore Drive by Alison Orleans 44
Repudiation by Tona Dickerson 45
Auvers 1889 by Dawn Patnode 47
Retreat by Deb Allbery 48
An Illusion Of Dancing Figures by Lawrence Weber 50-58
Cloud by Lenore Mayhew 59
ESSAYS
Climbing \u27earth\u27s undying monument\u27 by Richard H. Soaper, Jr. 61-71
A Program for the American Land by Lindy Davies 72-77
Kerouac and His Critics (For Amy) by John Kralik 80-82
Cover photograph from a late nineteenth century glass negative found in an Ohio antique shop and used with the permission of its owner
Association analysis identifies ZNF750 regulatory variants in psoriasis
<p>Abstract</p> <p>Background</p> <p>Mutations in the <it>ZNF750 </it>promoter and coding regions have been previously associated with Mendelian forms of psoriasis and psoriasiform dermatitis. <it>ZNF750 </it>encodes a putative zinc finger transcription factor that is highly expressed in keratinocytes and represents a candidate psoriasis gene.</p> <p>Methods</p> <p>We examined whether <it>ZNF750 </it>variants were associated with psoriasis in a large case-control population. We sequenced the promoter and exon regions of <it>ZNF750 </it>in 716 Caucasian psoriasis cases and 397 Caucasian controls.</p> <p>Results</p> <p>We identified a total of 47 variants, including 38 rare variants of which 35 were novel. Association testing identified two <it>ZNF750 </it>haplotypes associated with psoriasis (p < 0.05). We also identified an excess of rare promoter and 5'untranslated region (UTR) variants in psoriasis cases compared to controls (p = 0.041), whereas there was no significant difference in the number of rare coding and rare 3' UTR variants. Using a promoter functional assay in stimulated human primary keratinocytes, we showed that four <it>ZNF750 </it>promoter and 5' UTR variants displayed a 35-55% reduction of <it>ZNF750 </it>promoter activity, consistent with the promoter activity reduction seen in a Mendelian psoriasis family with a <it>ZNF750 </it>promoter variant. However, the rare promoter and 5' UTR variants identified in this study did not strictly segregate with the psoriasis phenotype within families.</p> <p>Conclusions</p> <p>Two haplotypes of <it>ZNF750 </it>and rare 5' regulatory variants of <it>ZNF750 </it>were found to be associated with psoriasis. These rare 5' regulatory variants, though not causal, might serve as a genetic modifier of psoriasis.</p
Psoriasis Patients Are Enriched for Genetic Variants That Protect against HIV-1 Disease
An important paradigm in evolutionary genetics is that of a delicate balance between genetic variants that favorably boost host control of infection but which may unfavorably increase susceptibility to autoimmune disease. Here, we investigated whether patients with psoriasis, a common immune-mediated disease of the skin, are enriched for genetic variants that limit the ability of HIV-1 virus to replicate after infection. We analyzed the HLA class I and class II alleles of 1,727 Caucasian psoriasis cases and 3,581 controls and found that psoriasis patients are significantly more likely than controls to have gene variants that are protective against HIV-1 disease. This includes several HLA class I alleles associated with HIV-1 control; amino acid residues at HLA-B positions 67, 70, and 97 that mediate HIV-1 peptide binding; and the deletion polymorphism rs67384697 associated with high surface expression of HLA-C. We also found that the compound genotype KIR3DS1 plus HLA-B Bw4-80I, which respectively encode a natural killer cell activating receptor and its putative ligand, significantly increased psoriasis susceptibility. This compound genotype has also been associated with delay of progression to AIDS. Together, our results suggest that genetic variants that contribute to anti-viral immunity may predispose to the development of psoriasis
Students' Beliefs about the Ethics of Teaching
Color poster with text.There is literature on professors' beliefs about the ethics of teaching, but little about students' beliefs. Seminal research by Keith-Spiegel et al. (1993) and two later studies by Kuther (2003) and Morgan and Korschgen (2001) form the core of a sparse and asystematic literature by psychologists. Because of the lack of coherence in the studies available, growing focus on moral and ethical theory (Haidt, 2007), and 20 years between student cohorts, the purpose of this study was to replicate aspects of Keith-Speigel et al.'s study.University of Wisconsin--Eau Claire Office of Research and Sponsored Programs
Theological aesthetics and missionary intervention in non-Christian cultures, with reference to Polynesian History
Guest lecture
Conversion and culture change: narrating failures and impacts of early English-Speaking Christian Missionaries in Polynesia
Tourist guidebooks to Hawaii frequently lament that “the missionaries” swathed carefree Hawaiians in mu’umu’us, banned surfing and the hula, and in the process, drained the joy out of Polynesian life, while conceding the benefits of literacy introduced by missionaries. Emphasizing Hawaii, Tahiti, and Tonga 1797-1830, this paper tests these assertions of cultural intervention. While literary scholarship has targeted missionary successes celebrated in the published accounts of missionary legends John Williams and William Ellis, around whom a veritable hagiography developed in the wake of Polynesian mass conversions to Christianity, this paper hones in on the decades of missionary failures in Polynesia which preceded spectacular episodes of iconoclasm. With an examination of visual and textual narration of missionary impact, comparing published and unpublished sources, this paper argues that early missionaries did try to change culture in Polynesia – and failed; the civilizing intent of the mission backfired until after extensive patient conversations kindled a situation receptive to the textual logos of evangelism rapidly expedited by the establishment of the printing press. In the South Seas, initially material possessions impeded the work of evangelism, and later cultural impacts of missionaries in architecture, agriculture, fashion, manufacturing, medicine, and other domains included a large measure of indigenous agency, which initially operated as outright rejection. By attending to the details of early failures, monotonous archival descriptions of the mechanics of evangelism frequently bypassed in favor of more salacious content, and the dynamism of culture change through additional vectors, this paper reconfigures missionary impact on culture during the years surrounding Polynesian mass conversions to Christianity
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