Quasi-periodic Variations in the Hard X-ray emission of a Large Arcade Flare

Quasi-periodic oscillations of the hard X-ray (HXR) emission of the large flare of 2 November 1991 have been investigated using HXR light curves and soft X-ray and HXR images recorded by the {\sl Yohkoh} X-ray telescopes. The results of the analysis of these observations are the following: i) The observations confirm that electrons are accelerated in oscillating magnetic traps which are contained within the cusp magnetic structure. ii) The amplitude of the HXR pulses increase due to the increase in the amplitude of the magnetic trap oscillations and the increase in the density within the traps caused by the chromospheric evaporation upflow. iii) The increase in the amplitude of the HXR pulses terminates when further increase in the density inside the traps inhibits the acceleration of electrons. iv) The model of oscillating magnetic traps is able to explain time variation of the electron precipitation, strong asymmetry in precipitation of accelerated electrons, and systematic differences in the precipitation of 15 and 25 keV electrons. v) We have obtained a direct observational evidence that strong HXR pulses are the result of the inflow of dense plasma coming from the chromospheric evaporation, into the acceleration volume.Comment: 18 pages, 12 figures, accepted by Solar Physic

Investigation of the X-ray Emission of the Large Arcade Flare of 2 March 1993

A large arcade flare of 2 March 1993 has been investigated using X-ray observations recorded by the {\sl Yohkoh} and GOES satellites and the {\sl Compton Gamma Ray Observatory}. We analyzed quasi-periodicity of the hard-X-ray (HXR) pulses in the flare impulsive phase and found close similarity between the quasi-periodic sequence of the pulses with that observed in another large arcade flare of 2 November 1991. This similarity helped to explain the strong HXR pulses which were recorded at the end of the impulsive phase, as due to an inflow of dense plasma (coming from the chromospheric evaporation) into the acceleration volume inside the cusp. In HXR images a high flaring loop was seen with a triangular cusp structure at the top, where the electrons were efficiently accelerated. The sequence of HXR images allowed us to investigate complicated changes in the precipitation of the accelerated electrons toward the flare footpoints. We have shown that all these impulsive-phase observations can be easily explained in terms of the model of electron acceleration in oscillating magnetic traps located within the cusp structure. Some soft-X-ray (SXR) images were available for the late decay phase. They show a long arcade of SXR loops. Important information about the evolution of the flare during the slow decay phase is contained in the time variation of the temperature, $T(t)$, and emission measure, EM$(t)$. This information is the following: i) weak heating occurs during the slow decay phase and it slowly decreases; ii) the decrease in the heating determines slow and smooth decrease in EM; iii) the coupling between the heating and the amount of the hot plasma makes the flare evolve along a sequence of quasi-steady states during the slow decay phase (QSS evolution).Comment: 21 pages, 12 figures, accepted for Solar Physic

Evaluation of diagnostic and therapeutic procedures in patients with acute pancreatitis

Introduction and purpose: Acute pancreatitis remains a clinically significant problem worldwide and in Poland, where its incidence is observed to be twice as high as in the global population.  The aim of this study is to describe the latest available guidelines for managing patients diagnosed with acute pancreatitis, including diagnostic methods, radiological approaches, as well as conservative and invasive therapeutic treatment. Materials and Methods: The literature available on PubMed, Scopus, Google Scholar databases, and guidelines from the Polish Society of Gastroenterology was reviewed using the words: „acute pancreatitis”, „pancreas", "AP treatment", and „acute pancreatitis management”. Description of the state of knowledge: Patients with suspicion of acute pancreatitis are mainly diagnosed based on their symptoms using the Revised Atlanta Classification comprising of clinical symptoms, elevated pancreatic enzymes level, and imaging test results. The recommended therapeutic management for patients with acute pancreatitis underlines the importance of conservative treatment before the implementation of invasive procedures, the choice of which should be based on the severity and form of the condition.  Summary: The existing recommendations regarding the diagnostic approach in acute pancreatitis emphasize the importance of correlating symptoms with radiological findings obtained through ultrasound, which is a quick and widely accessible diagnostic tool. In therapeutic management, conservative treatment remains significant with the early implementation of nutritional support, along with the appropriate method and timing of surgical intervention depending on the form of acute pancreatitis and the presence of infection

Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis.

Obesity is a well-known risk factor for colorectal cancer but precisely how it influences risks of malignancy remains unclear. During colon cancer development in humans or animals, attenuation of the colonic cell surface receptor guanylyl cyclase C (GUCY2C) that occurs due to loss of its paracrine hormone ligand guanylin contributes universally to malignant progression. In this study, we explored a link between obesity and GUCY2C silencing in colorectal cancer. Using genetically engineered mice on different diets, we found that diet-induced obesity caused a loss of guanylin expression in the colon with subsequent GUCY2C silencing, epithelial dysfunction, and tumorigenesis. Mechanistic investigations revealed that obesity reversibly silenced guanylin expression through calorie-dependent induction of endoplasmic reticulum stress and the unfolded protein response in intestinal epithelial cells. In transgenic mice, enforcing specific expression of guanylin in intestinal epithelial cells restored GUCY2C signaling, eliminating intestinal tumors associated with a high calorie diet. Our findings show how caloric suppression of the guanylin-GUCY2C signaling axis links obesity to negation of a universal tumor suppressor pathway in colorectal cancer, suggesting an opportunity to prevent colorectal cancer in obese patients through hormone replacement with the FDA-approved oral GUCY2C ligand linaclotide

NF-κB1 Inhibits TLR-Induced IFN-β Production in Macrophages Through TPL-2-dependent ERK Activation

available in PMC 2012 February 15.Although NF-κB1 p50/p105 has critical roles in immunity, the mechanism by which NF-κB1 regulates inflammatory responses is unclear. In this study, we analyzed the gene expression profile of LPS-stimulated Nfkb1−/− macrophages that lack both p50 and p105. Deficiency of p50/p105 selectively increased the expression of IFN-responsive genes, which correlated with increased IFN-β expression and STAT1 phosphorylation. IFN Ab-blocking experiments indicated that increased STAT1 phosphorylation and expression of IFN-responsive genes observed in the absence of p50/p105 depended upon autocrine IFN-β production. Markedly higher serum levels of IFN-β were observed in Nfkb1−/− mice than in wild-type mice following LPS injection, demonstrating that Nfkb1 inhibits IFN-β production under physiological conditions. TPL-2, a mitogen-activated protein kinase kinase kinase stabilized by association with the C-terminal ankyrin repeat domain of p105, negatively regulates LPS-induced IFN-β production by macrophages via activation of ERK MAPK. Retroviral expression of TPL-2 in Nfkb1−/− macrophages, which are deficient in endogenous TPL-2, reduced LPS-induced IFN-β secretion. Expression of the C-terminal ankyrin repeat domain of p105 in Nfkb1−/− macrophages, which rescued LPS activation of ERK, also inhibited IFN-β expression. These data indicate that p50/p105 negatively regulates LPS-induced IFN signaling in macrophages by stabilizing TPL-2, thereby facilitating activation of ERK.National Institutes of Health (U.S.) (NIH AI52267)National Institutes of Health (U.S.) (NIH CA108854)National Institutes of Health (U.S.) (NIH CA67529)Medical Research Council (Great Britain

ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells

Unresolved endoplasmic reticulum (ER) stress in the epithelium can provoke intestinal inflammation. Hypomorphic variants of ER stress response mediators, such as X-box–binding protein 1 (XBP1), confer genetic risk for inflammatory bowel disease. We report here that hypomorphic Xbp1 function instructs a multilayered regenerative response in the intestinal epithelium. This is characterized by intestinal stem cell (ISC) expansion as shown by an inositol-requiring enzyme 1α (Ire1α)–mediated increase in Lgr5+ and Olfm4+ ISCs and a Stat3-dependent increase in the proliferative output of transit-amplifying cells. These consequences of hypomorphic Xbp1 function are associated with an increased propensity to develop colitis-associated and spontaneous adenomatous polyposis coli (APC)–related tumors of the intestinal epithelium, which in the latter case is shown to be dependent on Ire1α. This study reveals an unexpected role for Xbp1 in suppressing tumor formation through restraint of a pathway that involves an Ire1α- and Stat3-mediated regenerative response of the epithelium as a consequence of ER stress. As such, Xbp1 in the intestinal epithelium not only regulates local inflammation but at the same time also determines the propensity of the epithelium to develop tumors

Exact solution of the geometrically frustrated spin-1/2 Ising-Heisenberg model on the triangulated Kagome (triangles-in-triangles) lattice

The geometric frustration of the spin-1/2 Ising-Heisenberg model on the triangulated Kagome (triangles-in-triangles) lattice is investigated within the framework of an exact analytical method based on the generalized star-triangle mapping transformation. Ground-state and finite-temperature phase diagrams are obtained along with other exact results for the partition function, Helmholtz free energy, internal energy, entropy, and specific heat, by establishing a precise mapping relationship to the corresponding spin-1/2 Ising model on the Kagome lattice. It is shown that the residual entropy of the disordered spin liquid phase is for the quantum Ising-Heisenberg model significantly lower than for its semi-classical Ising limit (S_0/N_T k_B = 0.2806 and 0.4752, respectively), which implies that quantum fluctuations partially lift a macroscopic degeneracy of the ground-state manifold in the frustrated regime. The investigated model system has an obvious relevance to a series of polymeric coordination compounds Cu_9X_2(cpa)_6 (X=F, Cl, Br and cpa=carboxypentonic acid) for which we made a theoretical prediction about the temperature dependence of zero-field specific heat.Comment: 13 pages, 7 figures, submitted to Phys. Rev.

We Do Not Like It: A Likert-Type Scale Survey on the Attitudes of a Young Population towards the Transhumanistic Theory of Education

Transhumanists assume that future education may be purely based on technological stimulation. The question is: Do potential clients of education “like” such vision? In order to check this, we asked over one thousand two hundred young Poles to evaluate their identification with the transhumanistic theory of education. The results are quite surprising: its show that they disagree with the assumptions of this theory, while they rather agree with the postulates of more traditional (and no technology-based) concepts of education