Strong cosmic censorship in the BTZ black hole

Recently it has been shown that quantum fields can be regular on the inner, Cauchy horizon of a rotating BTZ black hole, which appears to indicate a failure of strong cosmic censorship. We argue that, instead, what these results imply is that the inner horizon remains non-singular when leading-order backreaction of the quantum fields is computed, but, after next-order backreaction is accounted for, it will become singular. Then, strong cosmic censorship will be enforced in the BTZ black hole. We support our claims using a four-dimensional holographic dual of the system, which connects the instability of the inner horizon of the BTZ black hole to that of Kerr-type black holes

Level of physical activity in patients with osteoporosis

Objectives: The aim of this research was to examine the degree and types of physical activity (heavy physical activity, medium heavy and light physical activity) in female patients with lower bone mineral density compared to healthy women. Materials and Methods: The cross-sectional study included 40 female patients (65,85±11,46 yrs) with lower bone mineral density (BMD) and 20 patients (56,25±6,6 yrs) with no existing abnormality of BMD levels. The research was conducted at the Medical Rehabilitation Clinic, Clinical Center of Vojvodina. Data were collected using the internationally endorsed questionnaire IPAQ. BMD was measured at lumbar spine (L1-4) and at proximal femur by Dual X-ray Absorptiometry technique (DXA). Osteoporosis was defined as BMD > -2.5 T score. Results: We found that subjects with a normal bone mineral density had the highest level of physical activity (MET = 3154.58), followed by subjects with osteopenia (MET = 2311.25). Patients suffering from osteoporosis who were physically active had the lowest value of MET (1972.95) (p˂0.01). Sub-analysis based on BMI categories showed 10% (2 patients) of those with osteopenia were underweight, compared to 40% (8 patients) in the group with osteoporosis. Conclusions: Patients with osteoporosis were more obese and less physically active, as compared to healthier females. Our findings support the fact that adapted physical activity seems to be important for the prevention and treatment of patients with osteoporosis

Exposure assessment to essential elements through the consumption of canned fish in Serbia

The aim of this study was to provide a quantitative exposure assessment to essential elements through the consumption of canned fish in Serbia. This objective was fulfilled by analyzing content of essential elements in canned fish and by using data from a food consumption survey. Consumption survey of canned fish was designed and performed to general principles and EFSA guidelines on data collection of national food consumption. The questionnaire was performed on 1,000 respondents during 2018. Determination of copper, zinc and iron levels were performed on 454 canned fish and seafood samples divided into four groups (canned tuna, canned sardines, canned other sea fish and canned seafood) during five consecutive years (2014–2018). This study showed significant association between sex, BMI and weight and consumption patterns. Obtained average weekly consumption of canned fish confirms our assumption that consumption of canned fish is significant in Serbia. Zinc and iron were found in all 454 samples (100%), and copper in 222 samples (48.9%). The average obtained concentration in all samples were 1.268 mg kg–1 for Cu, 5.661 mg kg–1 for Zn and 9.556 mg kg–1 for Fe. The highest concentration for all three minerals were found in canned sardines (Cu — 6.49 mg kg–1, Zn — 37.2 mg kg–1 and Fe — 21.8 mg kg–1). Obtained mean exposure to intake of copper, zinc and iron from canned fish was 1.2241 μg/kg bw/day, 5.4634 μg/kg bw/day and 9.2231 μg/kg bw/day, respectively. Exposure of Serbian population to zinc, copper, and iron through consumption of canned fish is less than recommended daily reference intakes and there is no risk of reaching toxic levels by consuming fish

Techno-functional, textural and sensorial properties of frankfurters as affected by the addition of bee pollen powder

The objective of this study was to determine whether the addition of different pollen powder concentrations (0.5; 1.0 and 1.5 g/100 g) had an influence on techno-functional, textural and sensorial traits of frankfurters. Examining the techno-functional characteristics of pollen, a conclusion was reached that the higher the concentration, the higher the emulsification and better techno-functional properties. Also, FTIR-ATR analysis has shown that specific pollen molecules provided good emulsifying properties of sausages. On the other hand, sensory analysis showed that sausages with the addition of 1.0% and 1.5% of pollen powder have a more pronounced floral odor. Warner-Bratzler shear force test has shown that the incorporation of pollen caused a more stable product throughout sixty days of storage than the control sample. It could be explained by the formation of more protein-protein interactions due to the addition of non-meat proteins in the formulation of frankfurters and obtaining a more stable product than the control one. All things considered, it can be concluded that pollen exhibits good techno-functional properties and could be utilized in the formulation of frankfurters with improved and steady techno-functional properties during two months of refrigerated storage

DOT-WINGED CRAKE PORZANA SPILOPTERA (RALLIDAE; DURNFORD, 1877) IN CHILE: NEW RECORDS AND A REVIEW OF THE STATUS OF PACIFIC POPULATIONS

We report new records of the Dot-winged Crake Porzana spiloptera in southern Chile, an almost unknown species distributed mainly in Argentina and recently discovered in Chile. The occasional capture of a juvenile of the species at Cruces River wetland (39°S), and the analysis of sound recordings obtained to explore the acoustic attributes of urban wetland soundscapes, made it possible to discuss the status of the Pacific populations of the species. The new records show that P. spiloptera has a resident status and suggest that the presence of the species in Chile went historically unnoticed, and that it has been confused with the Black Rail Laterallus jamaicensis. Comprehensive surveys and dedicated research that provide fundamental biological aspects such as the current distribution, population abundance, habitat requirements, and main threats for these secretive rails are urgently needed for their conservation

Self-adaptive prototype for seat adaption

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How do sous-vide treatment and herb spices addition improve sensory acceptance and antimicrobial attributes of organic oyster mushrooms (Pleurotus ostreatus)?

Sensory and physical properties of organic oyster mushrooms (Pleurotus ostreatus) prepared by the sous-vide culinary method (50–90°C, 10′) were investigated and compared with the cooking method (80°C, 30–60′) to analyze the effects of different temperature and time regimes. To promote organic oyster mushroom's nutritional benefits and improve its taste, oregano and thyme were added in different percentages, and mushrooms were exposed to sous-vide treatments at 60°C for 20′ and 30′. Sensory evaluation was focused on testing spices intensity, likeability, and recognizability with principal component analysis employed. While the likeability scores and color changes were higher for those with higher thyme content in the mixture, the antibacterial results showed the highest effect of oregano, proving certain positive effects and emphasizing the research's importance. As an added value of the research, the mixture concentrations of sous-vide vacuumed pouches containing spices and mushrooms, that is, sous-vide pure juice extracts were analyzed for the first time for antibacterial activity. The research highlights the sensory improvement of mushrooms using the convenient treatment and adding selected spices, altogether multiplying their health benefits by preserving beneficial compounds. Novelty impact statement: Sous-vide culinary method, as an innovative choice in the world of gastronomy, gives the possibility to adjust treatment conditions and enables control of changes associated with the physical properties of mushrooms. Concerning the importance of living a healthy lifestyle, the fact that this method provides the ability to preserve bioactive compounds in well-known healthy foods, such as mushrooms, widens the additional importance of its application. The research highlights the sensory improvement of mushrooms using convenient heat treatment and adding selected spices generally used in traditional and world-known cuisine and altogether multiply their health benefits by preserving beneficial compounds. © 2022 Wiley Periodicals LLC

AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice.

INTRODUCTION: Pathologic accumulation and activation of mast cells and eosinophils are implicated in allergic and inflammatory diseases. Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is an inhibitory receptor selectively expressed on mast cells, eosinophils and, at a lower extent, basophils. When engaged with an antibody, Siglec-8 can induce apoptosis of activated eosinophils and inhibit mast cell activation. AK002 is a humanized, non-fucosylated IgG1 anti-Siglec-8 antibody undergoing clinical investigation for treatment of allergic, inflammatory, and proliferative diseases. Here we examine the human tissue selectivity of AK002 and evaluate the in vitro, ex vivo, and in vivo activity of AK002 on eosinophils and mast cells. METHODS: The affinity of AK002 for Siglec-8 and CD16 was determined by biolayer interferometry. Ex vivo activity of AK002 on human eosinophils from blood and dissociated human tissue was tested in apoptosis and antibody-dependent cell-mediated cytotoxicity (ADCC) assays. The in vivo activity of a murine precursor of AK002 (mAK002) was tested in a passive systemic anaphylaxis (PSA) humanized mouse model. RESULTS: AK002 bound selectively to mast cells, eosinophils and, at a lower level, to basophils in human blood and tissue and not to other cell types examined. AK002 induced apoptosis of interleukin-5-activated blood eosinophils and demonstrated potent ADCC activity against blood eosinophils in the presence of natural killer cells. AK002 also significantly reduced eosinophils in dissociated human lung tissue. Furthermore, mAK002 prevented PSA in humanized mice through mast cell inhibition. CONCLUSION: AK002 selectively evokes potent apoptotic and ADCC activity against eosinophils and prevents systemic anaphylaxis through mast cell inhibition