The role of the human papillomavirus (HPV) in cervical cancer : a review about HPV-induced carcinogenesis and its epidemiology, diagnosis, management and prevention

The human papillomavirus (HPV) was the first virus known to induce carcinogenesis and is associated with cancers of the uterine cervix, anogenital tumors and malignancies of the head and neck. This paper reviews the structure and basic genomic characteristics of the virus and outlines the clinical involvement of the main HPV serotypes, focusing on the carcinogenic role of HPV-16 and 18. The mecha¬nisms that occur in the development of cervical neoplasia due to the oncogenic proteins E6 and E7 which interfere with the regulation of the cell cycle through their interaction with p53 and retinoblastoma protein are described. Epidemiological factors, diagnostic tools and the management of the disease are also reviewed, along with the available vaccines to prevent the viral infection. Insights on current research on involvement of oxidative stress and micro-RNAs in cervical carcinogenesis are also explored as they may unlock new means of diagnosis and treatment in the future.peer-reviewe

Additional file 1: of An updated PREDICT breast cancer prognostication and treatment benefit prediction model with independent validation

The observed and predicted (PREDICT v1 and v2) events by individual data set and ER status for age at diagnosis (Table S1), tumour size (Table S2), nodes positive (Table S3) and tumour grade (Table S4). (XLSX 35 kb

Soft sets and soft modules

Bu tezde, öncelikle soft kümelerin yapısı ve özellikleri incelenmiş ve bunlarla ilgili sonuçlar özetlenerek verilmiştir. Bu kapsamda ilk olarak soft kümeler üzerinde tanımlanmış olan soft gruplar, soft halkalar ve soft modüllerden oluşan cebirsel yapılar ayrıntılı olarak ele alınmış daha sonrada soft alt modül ailesinin toplamı ve direkt toplamı detaylı olarak araştırılmıştır.In this thesis, the structure and properties of soft sets are investigated and the results related to these sets are summarized. In this context, we first discuss in detail algebraic structures consisting of soft groups, soft rings and soft modules which are defined on soft sets. Then the sum and direct sum of the collection of soft submodules are investigated in detail

Additional file 1: of An updated PREDICT breast cancer prognostication and treatment benefit prediction model with independent validation

The observed and predicted (PREDICT v1 and v2) events by individual data set and ER status for age at diagnosis (Table S1), tumour size (Table S2), nodes positive (Table S3) and tumour grade (Table S4). (XLSX 35 kb

Additional file 2: of Uva-ursi extract and ibuprofen as alternative treatments of adult female urinary tract infection (ATAFUTI): study protocol for a randomised controlled trial

Participant Information Sheet Main Trial. (PDF 218 kb

Additional file 1: of CONFIRM: a double-blind, placebo-controlled phase III clinical trial investigating the effect of nivolumab in patients with relapsed mesothelioma: study protocol for a randomised controlled trial

SPIRIT Checklist. (DOC 121 kb