Exophytic Giant Cell Glioblastoma in a Patient with Neurofibromatosis Type 1: Case Report

Giant cell glioblastoma multiforme (GCGBM) is an uncommon subtype within the spectrum of glioblastoma multiforme (GBM) tumors. Neurofibromatosis type 1 (NF1) has an increased risk of developing neoplasms that generally are of a benign nature. We report a rare case of an exophytic GCGBM in a 43-year-old woman with NF1. The tumor located in the right frontal region was removed totally and the patient underwent radiotherapy with 60 Gy and chemotherapy with temozolomide

Volume CXIV, Number 4, November 7, 1996

Objective: Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls. This study aimed to systematically investigate the key clinical features of TS in relationship to karyotype in a large pediatric Turkish patient population.Methods: Our retrospective study included 842 karyotype-proven TS patients aged 0-18 years who were evaluated in 35 different centers in Turkey in the years 2013-2014.Results: The most common karyotype was 45,X (50.7%), followed by 45,X/46,XX (10.8%), 46,X,i(Xq) (10.1%) and 45,X/46,X,i(Xq) (9.5%). Mean age at diagnosis was 10.2±4.4 years. The most common presenting complaints were short stature and delayed puberty. Among patients diagnosed before age one year, the ratio of karyotype 45,X was significantly higher than that of other karyotype groups. Cardiac defects (bicuspid aortic valve, coarctation of the aorta and aortic stenosis) were the most common congenital anomalies, occurring in 25% of the TS cases. This was followed by urinary system anomalies (horseshoe kidney, double collector duct system and renal rotation) detected in 16.3%. Hashimoto's thyroiditis was found in 11.1% of patients, gastrointestinal abnormalities in 8.9%, ear nose and throat problems in 22.6%, dermatologic problems in 21.8% and osteoporosis in 15.3%. Learning difficulties and/or psychosocial problems were encountered in 39.1%. Insulin resistance and impaired fasting glucose were detected in 3.4% and 2.2%, respectively. Dyslipidemia prevalence was 11.4%.Conclusion: This comprehensive study systematically evaluated the largest group of karyotype-proven TS girls to date. The karyotype distribution, congenital anomaly and comorbidity profile closely parallel that from other countries and support the need for close medical surveillance of these complex patients throughout their lifespa

Mediating effect of self-acceptance between values and offline/online identity expressions among college students

College-aged students face unique pressures to express a coherent identity to peers, particularly via social networking sites and other digital spaces. This study investigates how self-acceptance and values influence whether students express their identity authentically, i.e. "as they truly are", online and offline. Between November and December 2013, we surveyed 459 Turkish university students (78% female) between 18 and 38 years old (M= 21.6 years) about identity expression, self-acceptance, and values. Our pathway model hypothesized that self-acceptance mediates the effect of values upon online and offline identity expression. Results demonstrate that freedom as a value significantly influenced self-acceptance in our postsecondary student sample, and self-acceptance significantly influenced the tendency of participants to represent themselves authentically offline and online. Path analysis also yields that freedom, romantic values, human dignity, social, and career values have positive small indirect effects on authenticity in offline identity expression, whereas materialistic, spiritual, and intellectual values have small indirect negative effects. Similarly, freedom, romantic values, human dignity, social, and career values have positive small indirect effects on authenticity in online identity expression, whereas materialistic, spiritual, and intellectual values have small indirect negative effects. The study also found that sex, socioeconomic status (SES), and "wanting to be a teacher" did not have a significant effect on self-acceptance when age was controlled. Finally, the study found that "wanting to be a teacher" has a significant, but small effect on authenticity in offline and online identity expression. More research is needed that investigates the interaction between online/offline identity, self-acceptance, and values (especially freedom). (C) 2015 Elsevier Ltd. All rights reserved

Surgically Induced Corneal Astigmatism Following Intravitreal Ranibizumab Injection

WOS: 000424584400014PubMed ID: 26401170Purpose: To evaluate surgically induced astigmatism (SIA) after an intravitreal ranibizumab (IVR) injection. Methods: Fifty eight eyes of 58 patients who underwent IVR injection due to age-related macular degeneration (wet form) or macular edema were included in this study. Patients' pre-and postoperative detailed ophthalmologic examinations were done and topographic keratometric values (K1, K2) were noted. Pre- and postoperative measurements were compared. Results: The mean preoperative astigmatism of 0.87 Diopters (D) was found to be 0.95 D, 0.75 D, 0.82 D and 0.78 D on the 1st day, 3rd day, 1st week and 1st month, respectively. After injection, absolute change in astigmatism was found to be 0.08 D, 0.12 D, 0.05 D and 0.09 D on the 1st day, 3rd day, 1st week and 1st month, respectively. The absolute change in astigmatism seemed to be insignificant in terms of refractive analysis, however; when we performed a vectorial analysis, which takes into account changes in the axis of astigmatism, the mean value of induced astigmatism were found to be 0.33 +/- 0.22 D, 0.32 +/- 0.29 D, 0.41 +/- 0.37 D, 0.46 +/- 0.32 D on the 1st day, 3rd day, 1st week and on 1st month, respectively. Conclusion: Intravitreal injection is a minimally invasive ophthalmologic procedure, however; it may still cause statistically significant induced astigmatism when evaluated from a vectorial point of view

Imatinib mesylate decreases the cytotoxic effect of roscovitine on human glioblastoma cells in vitro and the role of midkine

The purpose of the present study was to overcome resistance to imatinib (IM) by combining it with roscovitine (ROSC) and to investigate whether or not midkine (MK) had an effect on this combination in the treatment of glioblastoma (GBL). Human T98 GBL cells were used to evaluate the effects of IM (10 μM), ROSC (200 μM) and their combination on the cell proliferation index, apoptotic index, the apoptotic protein and anti-apoptotic protein levels, and ultrastructure. All applications decreased the cell proliferation index and increased the apoptotic index, but ROSC was the most efficient drug and the second most efficient drug was IM. Notably, ROSC increased anti-apoptotic proteins levels (PDGFR-α, AQP-4, hTERT), COX-1 activity and ribosome numbers. The effects of ROSC on hTERT, MK, AQP-4 and MRP-1 levels and COX-1 activity were reported for the first time. ROSC induced the highest increase in caspase-3 levels. Autophagy was not involved in the activity of ROSC in GBL spheroids. The combination of IM with ROSC showed an antagonist effect in the treatment of human GBL cells. The combination group decreased certain anti-apoptotic protein levels (PDGFR-α, EGFR, p-gp, MRP-1 and MK), cAMP levels, COX-1 activity and apoptotic protein levels (caspase-3). However, it induced the highest increase in hTERT levels and COX-2 activity. Ribosome numbers were much lower than those in the ROSC group and no autophagic vacuole was observed. In conclusion, more investigations are required to identify the key regulatory components that are responsible for this antagonism; however, the determination of this combination therapy as a failure therapy may be precautionary for oncologists in the treatment of GBL patients and potentially may contribute to the efficacy of new therapeutic regimens

Finite element analysis of the stress distributions in peri-implant bone in modified and standard-threaded dental implants

The aim of this study was to examine the stress distributions with three different loads in two different geometric and threaded types of dental implants by finite element analysis. For this purpose, two different implant models, Nobel Replace and Nobel Active (Nobel Biocare, Zurich, Switzerland), which are currently used in clinical cases, were constructed by using ANSYS Workbench 12.1. The stress distributions on components of the implant system under three different static loadings were analysed for the two models. The maximum stress values that occurred in all components were observed in FIII (300 N). The maximum stress values occurred in FIII (300 N) when the Nobel Replace implant is used, whereas the lowest ones, in the case of FI (150 N) loading in the Nobel Active implant. In all models, the maximum tensions were observed to be in the neck region of the implants. Increasing the connection between the implant and the bone surface may allow more uniform distribution of the forces of the dental implant and may protect the bone around the implant. Thus, the implant could remain in the mouth for longer periods. Variable-thread tapered implants can increase the implant and bone contact

A rare case of quadrigeminal plate lipoma presenting with the sixth cranial nerve palsy

Intracranial lipomas are rare benign tumour that is slow growing, generally asymptomatic, most frequently located in the midline areas and are usually an incidental finding on imaging and therefore cases are not frequently reported. This study reports a case of a patient with quadrigeminal plate lipoma presenting with obstructive hydrocephalous and the 6th cranial nerve palsy that was successfully treated with ventriculo-peritoneal shunting without addressing the lesion

Representative PCR gel pictures of SIRT1 gene polymorphisms.

<p><b>A)</b> The genotype for rs7895833 SNP of <i>SIRT1</i> gene. <b>B)</b> The genotype for rs7069102 SNP of <i>SIRT1</i> gene. <b>C)</b> The genotype for rs2273773 SNP of <i>SIRT1</i> gene. The first lanes of each gel contain a 50 bp DNA ladder.</p

Distribution of rs7895833 A>G, rs7069102 C>G and rs2273773 C>T genotypes and alleles in study groups.

<p>n, number of individuals. Statistical evaluation by the Chi-square test. *p<0.05.</p><p>Distribution of rs7895833 A>G, rs7069102 C>G and rs2273773 C>T genotypes and alleles in study groups.</p