123 research outputs found
Victimización y perpetración de violencia en las relaciones de pareja en la adolescencia: un análisis en función del género.
Programa de prevención de la violencia de género en adolescentes del CPEIPS Mayex
The purpose of this program is to promote critical attitudes towards situations of gender
inequality, raising awareness of the magnitude of this social problem and improving the
climate of coexistence in the school. The same is destined to students of 1st and 2nd cycle
of Secondary School of Early Childhood Education, Primary and Secondary (hereafter
referred to as CPEIPS) Mayex, located in the municipality of La Laguna. It will be
developed in three phases; Phase of communication and commitment, phase of
sensitization and evaluation phase, being the phase of sensitization where will be carried
out the 8 sessions distributed in a school year.
The following is a tour of the conceptions of gender violence, its types and the
adolescent's view on it. As well as the legal framework in coeducation that protects the
equal rights of men and women.
The program has an active and participatory methodology, where reflection and practice
play a fundamental role throughout.La finalidad de este programa es promover actitudes críticas frente a situaciones de
desigualdad de género, concienciando al alumnado en cuanto a la magnitud de este
problema social y mejorando así el clima de convivencia en el centro escolar. El mismo
está destinado a alumnos y alumnas de 1ºy 2º ciclo de Secundaria del Colegio Privado de
Educación Infantil, Primaria y Secundaria (en adelante CPEIPS) Mayex, situado en el
municipio de La Laguna. Se desarrollará en tres fases; fase de comunicación y
compromiso, fase de sensibilización y fase de evaluación, siendo la fase de
sensibilización donde se llevarán a cabo las 8 sesiones repartidas en un año escolar.
A continuación se presenta un recorrido por las concepciones de violencia de género, sus
tipos y la visión del adolescente sobre la misma. Así como el marco legal en la
coeducación que ampara lo derechos en igualdad de hombres y mujeres.
El programa tiene una metodología activa y participativa, donde la reflexión y la práctica
juegan un papel fundamental a lo largo del mismo
A step towards the validation of bacteria biotic indices using DNA metabarcoding for benthic monitoring
Environmental genomics is a promising field for monitoring biodiversity in a timely fashion. Efforts have increasingly been dedicated to the use of bacteria DNA derived data to develop biotic indices for benthic monitoring. However, a substantial debate exists about whether bacteria‐derived data using DNA metabarcoding should follow, for example, a taxonomy‐based or a taxonomy‐free approach to marine bioassessments. Here, we showcase the value of DNA‐based monitoring using the impact of fish farming as an example of anthropogenic disturbances in coastal areas and compare the performance of taxonomy‐based and taxonomy‐free approaches in detecting environmental alterations. We analysed samples collected near to the farm cages and along distance gradients from two aquaculture installations, and at control sites, to evaluate the effect of this activity on bacterial assemblages. Using the putative response of bacterial taxa to stress we calculated the taxonomy‐based biotic index microgAMBI. The distribution of individual amplicon sequence variants (ASVs), as a function of a gradient in sediment acid volatile sulphides, was then used to derive a taxonomy‐free bacterial biotic index specific for this data set using a de novo approach based on quantile regression splines. Our results show that microgAMBI revealed a organically enriched environment along the gradient. However, the de novo biotic index outperformed microgAMBI by providing a higher discriminatory power in detecting changes in abiotic factors directly related to fish production, whilst allowing the identification of new ASVs bioindicators. The de novo strategy applied here represents a robust method to define new bioindicators in regions or habitats where no previous information about the response of bacteria to environmental stressors exists.This work was partially funded by the project CGL2015-70136-R from the Spanish Ministry of Economy and Competitiveness (MINECO) and the EU ERDF funding program. E.A. and S.C. are supported by funding from a collaboration between KAUST and Saudi Aramco within the framework of the Saudi Aramco –KAUST Center for Marine Environmental Observations. K.T.-G. is supported by Ministerio de Ciencia, Innnovación y Universidades through the Juan de la Cierva Incorporación program (IJCI-2017-34174)
Neuroimagen en epilepsia
El objetivo de este estudio es describir las alteraciones interictales de perfusión en RM por técnica de arterial spin labelled (ASL) y difusión, en pacientes con epilepsia focal y analizar su posible valor lateralizador/localizador del foco epileptógeno. Se trata de un estudio transversal de 53 pacientes adultos con epilepsia focal diagnosticados por semiología, RM y EEG. En todos ellos se realizó una RM de 3 TESLA con protocolo de epilepsia, que incluía secuencias de ASL. Las imágenes fueron sometidas a un análisis visual por un neurorradiólogo, clasificándolas en alteraciones de perfusión hemisféricas o focales. La muestra tenía un 51% de hombres y una edad media de 42.9 años (±16.5). El 60% tenían epilepsias sintomáticas. El 64% eran fármacorresistentes. Las etiologías más frecuentes fueron vascular (15%), malformaciones del desarrollo cortical (15%) y tumoral (13%). Un 45% se clasificaron como epilepsia temporal, 32% frontal y 13% temporal posterior, 8% occipital y 2% parietal. El 45% presentaban crisis parciales complejas, entre las que la semiología automotora era la más frecuente (36%). El ASL mostró, en un 74% de los pacientes, alteraciones de la perfusión interhemisféricas, observándose un valor lateralizador de éstas, especialmente cuando se observa hiperperfusión en la localización del foco y cuando se trata de epilepsia sintomática. Se observaron alteraciones focales en ASL que a pesar de encontrarse en un bajo porcentaje podrían tener valor localizador del área epileptógena
Improving Cognitive Visual-Motor Abilities in Individuals with Down Syndrome
Down syndrome causes a reduction in cognitive abilities, with visual-motor skills being
particularly affected. In this work, we have focused on this skill in order to stimulate better learning.
The proposal relies on stimulating the cognitive visual-motor skills of individuals with Down
Syndrome (DS) using exercises with a gestural interaction platform based on the KINECT sensor
named TANGO:H, the goal being to improve them. To validate the proposal, an experimental
single-case study method was designed using two groups: a control group and an experimental
one, with similar cognitive ages. Didactic exercises were provided to the experimental group using
visual cognitive stimulation. These exercises were created on the TANGO:H Designer, a platform that
was designed for gestural interaction using the KINECT sensor. As a result, TANGO:H allows for
visual-motor cognitive stimulation through the movement of hands, arms, feet and head. The “Illinois
Test of Psycholinguistic Abilities (ITPA)” was applied to both groups as a pre-test and post-test in its
four reference sections: visual comprehension, visual-motor sequential memory, visual association,
and visual integration. Two checks were made, one using the longitudinal comparison of the
pre-test/post-test of the experimental group, and another that relied on comparing the difference of the
means of the pre-test/post-test. We also used an observational methodology for the working sessions
from the experimental group. Although the statistical results do not show significant differences
between the two groups, the results of the observations exhibited an improvement in visual-motor
cognitive skills
Gut epithelial barrier markers in patients with obstructive sleep apnea
Background: obstructive sleep apnea (OSA) is now being recognized as an additional contributing factor to the pathogenesis of obesity-related comorbidities. At the same time, there is now increasing evidence to suggest that intestinal wall permeability plays a role in the development of metabolic syndrome. In the present study, circulating zonulin and fatty acid binding protein (I-FABP) were measured in association with metabolic, hepatic, and inflammatory parameters. Results: compared with controls, plasma I-FABP levels were significantly higher in patients with OSA (571 pg/mL [IQR 290-950] vs 396 pg/mL [IQR 234-559], p = 0.04). Zonulin levels were similar between groups. Significant relationships were observed between zonulin levels and waist circumference (p < 0.05), glucose (p < 0.05), and insulin (p < 0.05). In addition, in the OSA group, zonulin levels correlated negatively with the mean nocturnal oxygenation saturation (p < 0.05) and positively with total cholesterol (p < 0.05), alanine aminotransferase (ALT) (p < 0.005), aminotransferase (AST) (p < 0.01), gamma glutamyltransferase (GGT) (p < 0.005), and high-sensitivity C-reactive protein (hs-CRP) (p < 0.05). Multivariate analysis showed that associations between zonulin and ALT, AST, and hs-CRP were attenuated, but not eliminated, after adjustment for other variables. Conclusions: the results of this study suggest that OSA is a risk factor for intestinal damage, regardless of metabolic profile, and that intestinal permeability might be a possible contributor to nonalcoholic fatty liver disease in patients with OSA
Bone marrow characterization in COPD: a multi-level network analysis
BACKGROUND: Bone marrow (BM) produces hematopoietic and progenitor cells that contribute to distant organ inflammation and repair. Chronic obstructive pulmonary disease (COPD) is characterized by defective lung repair. Yet, BM composition has not been previously characterized in COPD patients. METHODS: In this prospective and controlled study, BM was obtained by sternum fine-needle aspiration in 35 COPD patients and 25 healthy controls (10 smokers and 15 never-smokers). BM cell count and immunophenotype were determined by microscopy and flow cytometry, respectively. Circulating inflammatory (C-reactive protein, IL-6, IL-8) and repair markers (HGF, IGF, TGF-β, VEGF) were quantified by ELISA. Results were integrated by multi-level network correlation analysis. RESULTS: We found that: (1) there were no major significant pair wise differences between COPD patients and controls in the BM structural characteristics; (2) multi-level network analysis including patients and controls identifies a relation between immunity, repair and lung function not previously described, that remains in the COPD network but is absent in controls; and (3) this novel network identifies eosinophils as a potential mediator relating immunity and repair, particularly in patients with emphysema. CONCLUSIONS: Overall, these results suggest that BM is activated in COPD with impaired repair capacity in patients with more emphysema and/or higher circulating eosinophils
Impact of Blood Eosinophil Variability in Asthma:A Real-Life Population Study
RATIONALE: Blood eosinophil count predicts response to inhaled corticosteroids and specific biologic therapies in selected asthma patients. Despite this important role, fundamental aspects of eosinophil behavior in asthma have not been studied. Objectives To investigate the behavior of blood eosinophils in a population comparing their distribution with the general population and studying their intra-individual variability over time in relation to hospital episodes (emergency department visits and hospitalizations) in clinical practice. METHODS: The distribution and variability of 35,703 eosinophil determinations in 10,059 stable asthma patients were investigated in the Majorca Real-Life Investigation in COPD and Asthma cohort (MAJORICA). Eosinophil distribution in the asthma population was compared with a control sample from the general population of 8,557 individuals. Eosinophil variability and hospital episodes were analyzed using correlations, ROC curves and multiple regression analysis. We defined the Eosinophil Variability Index (EVI) as (Eosmax-Eosmin/Eosmax) x 100%. The findings of the asthma population were re-tested in an external well-characterized asthma cohort. RESULTS: The eosinophil count values and variability were higher in the asthma population than in the general population (p-value<0.001). Variability data showed a better association with hospital episodes than the counting values. An EVI≥50% was more strongly associated with hospital episodes than any of the absolute counting values. These results were validated in the external cohort. CONCLUSION: The eosinophil variability in asthma patients better identifies the risk of any hospital episode than the absolute counting values currently used to target specific treatments
Clinical course impacts early kinetics,magnitude, and amplitude of SARS-CoV-2 neutralizing antibodies beyond 1 year after infection
To understand the determinants of long-term immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the concurrent impact of vaccination and emerging variants, we follow a prospective cohort of 332 patients with coronavirus disease 2019 (COVID-19) over more than a year after symptom onset. We evaluate plasma-neutralizing activity using HIV-based pseudoviruses expressing the spike of different SARS-CoV-2 variants and analyze them longitudinally using mixed-effects models. Long-term neutralizing activity is stable beyond 1 year after infection in mild/asymptomatic and hospitalized participants. However, longitudinal models suggest that hospitalized individuals generate both short- and long-lived memory B cells, while the responses of non-hospitalized individuals are dominated by long-lived B cells. In both groups, vaccination boosts responses to natural infection. Long-term (>300 days from infection) responses in unvaccinated participants show a reduced efficacy against beta, but not alpha nor delta, variants. Multivariate analysis identifies the severity of primary infection as an independent determinant of higher magnitude and lower relative cross-neutralization activity of long-term neutralizing responses.info:eu-repo/semantics/publishedVersio
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