Durability and Microstructure of Cement Composites Containing Qatar's Municipal Wastes

Qatar produces more than 2.5 million tons of municipal waste per year with an average waste generation rate of 1.8 kg/day/capita which is one of the highest rates in the world. The rapid growth of municipal solid waste has become one of the serious environmental problem that Qatar is facing with. Qatar's municipal waste is composed of organic and recyclables materials. Municipal solid waste incineration has been performed in Qatar since 2011. By incineration of wastes, not only the volume and weight of wastes are reduced but also energy is generated. Prior to incineration of municipal wastes, recyclables are separated from the waste and the remaining waste is incinerated at a minimum temperature of 850oC. Bottom ash and fly ash are produced as a result of incineration process. These by-products may contain heavy metals and pose a thread to the environment hence needs treatment and/or special disposal. Approximately 60 tonnes of fly ash is generated daily from municipal waste incineration in Qatar and this ash called as municipal solid waste incineration (MSWI) fly ash. This MSWI fly ash is stabilised with cement and then disposed into special landfill. However, cementitious property of MSWI fly ash due to similar mineralogical composition with cement and its finer particle size may favor its potential utilisation in cement based materials. As aforementioned before, 40% of municipal waste of Qatar is composed of recyclables of which 14% is plastic. The major portion of plastic wastes, about 90% of total, are composed of light density polyethylene (LDPE) and high density polyethylene (HDPE) wastes. Therefore, there is a huge potential for recycling of PE wastes in Qatar considering the shortage of raw materials i.e. natural aggregate for construction industry. The scarcity of available land for disposal of municipal wastes and limited natural resources of raw materials for construction industry has opened new research areas for proper disposal and recycling of municipal wastes. Therefore, in this research work, municipal solid waste incineration (MSWI) fly ash and municipal polymeric wastes were used as secondary raw materials for the preparation of cement based composites. MSWI fly ash was utilised as partial replacement of cement by 10% by weight. Polyetyhlene wastes in granular form were utilised as partial replacement of natural aggregate by 10% by volume. Portland cement, silica fume (10% by weight) and MSWI FA (10% by weight) at constant rates were used as binder in all cement-based composites. Three different cement based composites were fabricated by partial substition of natural aggregate with LDPE and HDPE wastes at 0 and 10% by volume. The mixture without PE waste substitution was called as the reference mixture, with LDPE waste was called as Mix 1 and with HDPE waste was called as Mix 2. Besides mechanical performance, durability of fabricated cement composites containing municipal wastes was investigated to determine if their utilisation has positive contribution or adverse impact. The durability properties were examined by performing drying shrinkage and expansion under sulfate exposure tests. Scanning electron microscopy coupled with EDX were used to determine the degradation products of sulfate exposure. In terms of mechanical strength, samples containing PE wastes showed lower strength at early ages due to weaker bonding between LDPE/HDPE and the cement matrix. At later ages, strength improvement was observed and comparable strength values for Mix 1 and Mix 2 were measured with respect to the reference. The effect of utilisation of municipal wastes on the dimensional stability of cement composites was evaluated by measuring the variation of length change at 4, 11, 18, 25, 126 and 168 days of air drying. This test showed that incorporation of PE wastes (Mix 1 and Mix 2) reduced the drying shrinkage and provided better dimensional stability compared to the reference. Sulfate attack is known as one of the most deleterious effects on cement based composites due to the formation of expansive degradation products. To investigate the sulfate resistance of fabricated composites, the length change at 1 week, 2 weeks, 3 weeks, 4 weeks, 8 weeks, 13 weeks, 15 weeks, 4 months and 6 months of sulfate exposure was measured. Both the reference and samples containing PE wastes did not show any visual deterioration except a white and soft layer formed on top of all samples. The length change indicated that composites containing PE wastes experienced reduction in expansion compared to the reference and hence considered as more durable for external sulfate attack. More voids and pores were present in PE incorporated samples, therefore sulfate degradation products probably filled these pores and resulted in lower expansion compared to the reference. There was no significant difference between the mechanical performance and durability of cement composites containing LDPE and HDPE. The microstructure and composition of sulfate degradation products were investigated by SEM-EDX. The decalcification of the C-S-H phase were detected in each sample. Gypsum, calcite and thaumasite were identified as the major deterioration related products, while ettringite was found at trace level. This laboratory study showed that MSWI fly ash and PE wastes can be utilised together to produce durable cement based materials with a lower carbon footprint.qscienc

Photonics and fracture toughness of heterogeneous composite materials

Fracture toughness measures the resistance of a material to fracture. This fundamental property is used in diverse engineering designs including mechanical, civil, materials, electronics and chemical engineering applications. In spite of the advancements made in the past 40 years, the evaluation of this remains challenging for extremely heterogeneous materials such as composite concretes. By taking advantage of the optical properties of a thin birefringent coating on the surface of opaque, notched composite concrete beams, here we sense the evolution of the maximum shear stress distribution on the beams under loading. The location of the maximum deviator stress is tracked ahead of the crack tip on the experimental concrete samples under the ultimate load, and hence the effective crack length is characterised. Using this, the fracture toughness of a number of heterogeneous composite beams is evaluated and the results compare favourably well with other conventional methods using combined experimental and numerical/analytical approaches. Finally a new model, correlating the optically measured shear stress concentration factor and flexural strength with the fracture toughness of concretes is proposed. The current photonics-based study could be vital in evaluating the fracture toughness of even opaque and complex heterogeneous materials more effectively in future

Comprehensive analysis via exome sequencing uncovers genetic etiology in autosomal recessive nonsyndromic deafness in a large multiethnic cohort

Purpose:Autosomal recessive nonsyndromic deafness (ARNSD) is characterized by a high degree of genetic heterogeneity, with reported mutations in 58 different genes. This study was designed to detect deafness-causing variants in a multiethnic cohort with ARNSD by using whole-exome sequencing (WES).Methods:After excluding mutations in the most common gene, GJB2, we performed WES in 160 multiplex families with ARNSD from Turkey, Iran, Mexico, Ecuador, and Puerto Rico to screen for mutations in all known ARNSD genes.Results:We detected ARNSD-causing variants in 90 (56) families, 54 of which had not been previously reported. Identified mutations were located in 31 known ARNSD genes. The most common genes with mutations were MYO15A (13), MYO7A (11), SLC26A4 (10), TMPRSS3 (9), TMC1 (8), ILDR1 (6), and CDH23 (4). Nine mutations were detected in multiple families with shared haplotypes, suggesting founder effects.Conclusion:We report on a large multiethnic cohort with ARNSD in which comprehensive analysis of all known ARNSD genes identifies causative DNA variants in 56 of the families. In the remaining families, WES allows us to search for causative variants in novel genes, thus improving our ability to explain the underlying etiology in more families.Genet Med 18 4, 364-371. © American College of Medical Genetics and Genomics

Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study

We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts. A total of 1141 respiratory physicians and 34 IPF experts participated. Participants evaluated 60 cases of interstitial lung disease (ILD) without interdisciplinary consultation. Diagnostic agreement was measured using the weighted kappa coefficient (\u3baw). Prognostic discrimination between IPF and other ILDs was used to validate diagnostic accuracy for first-choice diagnoses of IPF and were compared using the Cindex. A total of 404 physicians completed the study. Agreement for IPF diagnosis was higher among expert physicians (\u3baw=0.65, IQR 0.53-0.72, p20 years of experience (C-index=0.72, IQR 0.0-0.73, p=0.229) and non-university hospital physicians with more than 20 years of experience, attending weekly MDT meetings (C-index=0.72, IQR 0.70-0.72, p=0.052), did not differ significantly (p=0.229 and p=0.052 respectively) from the expert panel (C-index=0.74 IQR 0.72-0.75). Experienced respiratory physicians at university-based institutions diagnose IPF with similar prognostic accuracy to IPF experts. Regular MDT meeting attendance improves the prognostic accuracy of experienced non-university practitioners to levels achieved by IPF experts

Rivaroxaban Compared with Standard Anticoagulants for the Treatment of Acute Venous Thromboembolism in Children: a Randomised, Controlled, Phase 3 Trial

Background: Treatment of venous thromboembolism in children is based on data obtained in adults with little direct documentation of its efficacy and safety in children. The aim of our study was to compare the efficacy and safety of rivaroxaban versus standard anticoagulants in children with venous thromboembolism. Methods: In a multicentre, parallel-group, open-label, randomised study, children (aged 0–17 years) attending 107 paediatric hospitals in 28 countries with documented acute venous thromboembolism who had started heparinisation were assigned (2:1) to bodyweight-adjusted rivaroxaban (tablets or suspension) in a 20-mg equivalent dose or standard anticoagulants (heparin or switched to vitamin K antagonist). Randomisation was stratified by age and venous thromboembolism site. The main treatment period was 3 months (1 month in children <2 years of age with catheter-related venous thromboembolism). The primary efficacy outcome, symptomatic recurrent venous thromboembolism (assessed by intention-to-treat), and the principal safety outcome, major or clinically relevant non-major bleeding (assessed in participants who received ≥1 dose), were centrally assessed by investigators who were unaware of treatment assignment. Repeat imaging was obtained at the end of the main treatment period and compared with baseline imaging tests. This trial is registered with ClinicalTrials.gov, number NCT02234843 and has been completed. Findings: From Nov 14, 2014, to Sept 28, 2018, 500 (96%) of the 520 children screened for eligibility were enrolled. After a median follow-up of 91 days (IQR 87–95) in children who had a study treatment period of 3 months (n=463) and 31 days (IQR 29–35) in children who had a study treatment period of 1 month (n=37), symptomatic recurrent venous thromboembolism occurred in four (1%) of 335 children receiving rivaroxaban and five (3%) of 165 receiving standard anticoagulants (hazard ratio [HR] 0·40, 95% CI 0·11–1·41). Repeat imaging showed an improved effect of rivaroxaban on thrombotic burden as compared with standard anticoagulants (p=0·012). Major or clinically relevant non-major bleeding in participants who received ≥1 dose occurred in ten (3%) of 329 children (all non-major) receiving rivaroxaban and in three (2%) of 162 children (two major and one non-major) receiving standard anticoagulants (HR 1·58, 95% CI 0·51–6·27). Absolute and relative efficacy and safety estimates of rivaroxaban versus standard anticoagulation estimates were similar to those in rivaroxaban studies in adults. There were no treatment-related deaths. Interpretation: In children with acute venous thromboembolism, treatment with rivaroxaban resulted in a similarly low recurrence risk and reduced thrombotic burden without increased bleeding, as compared with standard anticoagulants. Funding: Bayer AG and Janssen Research & Development. © 2020 Elsevier Ltd

Mapping and linking supply- and demand-side measures in climate-smart agriculture. A review

Climate change and food security are two of humanity’s greatest challenges and are highly interlinked. On the one hand, climate change puts pressure on food security. On the other hand, farming significantly contributes to anthropogenic greenhouse gas emissions. This calls for climate-smart agriculture—agriculture that helps to mitigate and adapt to climate change. Climate-smart agriculture measures are diverse and include emission reductions, sink enhancements, and fossil fuel offsets for mitigation. Adaptation measures include technological advancements, adaptive farming practices, and financial management. Here, we review the potentials and trade-offs of climate-smart agricultural measures by producers and consumers. Our two main findings are as follows: (1) The benefits of measures are often site-dependent and differ according to agricultural practices (e.g., fertilizer use), environmental conditions (e.g., carbon sequestration potential), or the production and consumption of specific products (e.g., rice and meat). (2) Climate-smart agricultural measures on the supply side are likely to be insufficient or ineffective if not accompanied by changes in consumer behavior, as climate-smart agriculture will affect the supply of agricultural commodities and require changes on the demand side in response. Such linkages between demand and supply require simultaneous policy and market incentives. It, therefore, requires interdisciplinary cooperation to meet the twin challenge of climate change and food security. The link to consumer behavior is often neglected in research but regarded as an essential component of climate-smart agriculture. We argue for not solely focusing research and implementation on one-sided measures but designing good, site-specific combinations of both demand- and supply-side measures to use the potential of agriculture more effectively to mitigate and adapt to climate change