7,573 research outputs found
Pressure and Motion of Dry Sand -- Translation of Hagen's Paper from 1852
In a remarkable paper from 1852, Gotthilf Heinrich Ludwig Hagen measured and
explained two fundamental aspects of granular matter: The first effect is the
saturation of pressure with depth in a static granular system confined by silo
walls -- generally known as the Janssen effect. The second part of his paper
describes the dynamics observed during the flow out of the container -- today
often called the Beverloo law -- and forms the foundation of the hourglass
theory. The following is a translation of the original German paper from 1852.Comment: 4 pages, accepted for publication in Granular Matter, original
article (German) can be found under http://www.phy.duke.edu/~msperl/Janssen
Association of the IL-10 gene family locus on chromosome 1 with juvenile idiopathic arthritis (JIA)
The cytokine IL-10 and its family members have been implicated in autoimmune diseases and we have previously reported that genetic variants in IL-10 were associated with a rare group of diseases called juvenile idiopathic arthritis (JIA). The aim of this study was to fine map genetic variants within the IL-10 cytokine family cluster on chromosome 1 using linkage disequilibrium (LD)-tagging single nucleotide polymorphisms (tSNPs) approach with imputation and conditional analysis to test for disease associations
Non-ancient solution of the Ricci flow
For any complete noncompact Khler manifold with nonnegative and
bounded holomorphic bisectional curvature,we provide the necessary and
sufficient condition for non-ancient solution to the Ricci flow in this paper.Comment: seven pages, latex fil
Existence of maximal hypersurfaces in some spherically symmetric spacetimes
We prove that the maximal development of any spherically symmetric spacetime
with collisionless matter (obeying the Vlasov equation) or a massless scalar
field (obeying the massless wave equation) and possessing a constant mean
curvature Cauchy surface also contains a maximal Cauchy
surface. Combining this with previous results establishes that the spacetime
can be foliated by constant mean curvature Cauchy surfaces with the mean
curvature taking on all real values, thereby showing that these spacetimes
satisfy the closed-universe recollapse conjecture. A key element of the proof,
of interest in itself, is a bound for the volume of any Cauchy surface
in any spacetime satisfying the timelike convergence condition in terms of the
volume and mean curvature of a fixed Cauchy surface and the maximal
distance between and . In particular, this shows that any
globally hyperbolic spacetime having a finite lifetime and obeying the
timelike-convergence condition cannot attain an arbitrarily large spatial
volume.Comment: 8 pages, REVTeX 3.
Gravitational wave detection using pulsars: status of the Parkes Pulsar Timing Array project
The first direct detection of gravitational waves may be made through
observations of pulsars. The principal aim of pulsar timing array projects
being carried out worldwide is to detect ultra-low frequency gravitational
waves (f ~ 10^-9 to 10^-8 Hz). Such waves are expected to be caused by
coalescing supermassive binary black holes in the cores of merged galaxies. It
is also possible that a detectable signal could have been produced in the
inflationary era or by cosmic strings. In this paper we review the current
status of the Parkes Pulsar Timing Array project (the only such project in the
Southern hemisphere) and compare the pulsar timing technique with other forms
of gravitational-wave detection such as ground- and space-based interferometer
systems.Comment: Accepted for publication in PAS
A Low-Mass Planet with a Possible Sub-Stellar-Mass Host in Microlensing Event MOA-2007-BLG-192
We report the detection of an extrasolar planet of mass ratio q ~ 2 x 10^(-4)
in microlensing event MOA-2007-BLG-192. The best fit microlensing model shows
both the microlensing parallax and finite source effects, and these can be
combined to obtain the lens masses of M = 0.060 (+0.028 -0.021) M_sun for the
primary and m = 3.3 (+4.9 -1.6) M_earth for the planet. However, the
observational coverage of the planetary deviation is sparse and incomplete, and
the radius of the source was estimated without the benefit of a source star
color measurement. As a result, the 2-sigma limits on the mass ratio and finite
source measurements are weak. Nevertheless, the microlensing parallax signal
clearly favors a sub-stellar mass planetary host, and the measurement of finite
source effects in the light curve supports this conclusion. Adaptive optics
images taken with the Very Large Telescope (VLT) NACO instrument are consistent
with a lens star that is either a brown dwarf or a star at the bottom of the
main sequence. Follow-up VLT and/or Hubble Space Telescope (HST) observations
will either confirm that the primary is a brown dwarf or detect the low-mass
lens star and enable a precise determination of its mass. In either case, the
lens star, MOA-2007-BLG-192L, is the lowest mass primary known to have a
companion with a planetary mass ratio, and the planet, MOA-2007-BLG-192Lb, is
probably the lowest mass exoplanet found to date, aside from the lowest mass
pulsar planet.Comment: Accepted for publication in the Astrophysical Journal. Scheduled for
the Sept. 1, 2008 issu
Effects of cognac on coronary flow reserve and plasma antioxidant status in healthy young men
<p>Abstract</p> <p>Background</p> <p>The cardioprotective effects of certain alcoholic beverages are partly related to their polyphenol content, which may improve the vasodilatory reactivity of arteries. Effect of cognac on coronary circulation, however, remains unknown. The purpose of this randomized controlled cross-over study was to determine whether moderate doses of cognac improve coronary reactivity as assessed with cold pressor testing (CPT) and coronary flow reserve (CFR) measument.</p> <p>Methods</p> <p>Study group consisted of 23 subjects. Coronary flow velocity and epicardial diameter was assessed using transthoracic echocardiography at rest, during CPT and adenosine infusion-derived CFR measurements before drinking, after a moderate (1.2 ± 0.1 dl) and an escalating high dose (total amount 2.4 ± 0.3 dl) of cognac. To explore the bioavailability of antioxidants, the antioxidant contents of cognac was measured and the absorption from the digestive tract was verified by plasma antioxidant capacity determination.</p> <p>Results</p> <p>Serum alcohol levels increased to 1.2 ± 0.2‰ and plasma antioxidant capacity from 301 ± 43.9 μmol/l to 320 ± 25.0 μmol/l by 7.6 ± 11.8%, (p = 0.01) after high doses of cognac. There was no significant change in flow velocity during CPT after cognac ingestion compared to control day. CFR was 4.4 ± 0.8, 4.1 ± 0.9 (p = NS), and 4.5 ± 1.2 (p = NS) before drinking and after moderate and high doses on cognac day, and 4.5 ± 1.4, and 4.0 ± 1.2 (p = NS) on control day.</p> <p>Conclusion</p> <p>Cognac increased plasma antioxidant capacity, but it had no effect on coronary circulation in healthy young men.</p> <p>Trial Registration</p> <p>NCT00330213</p
Human H7N9 virus induces a more pronounced pro-inflammatory cytokine but an attenuated interferon response in human bronchial epithelial cells when compared with an epidemiologically-linked chicken H7N9 virus
Association between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer
Wild-type p53 competitively binds to the promoter region of COX-2 in vitro and inhibits its transcription. We examined the association between p53 mutation and COX-2 expression in gastric cancer. COX-2 over-expression was seen in 19 (48.7%) cases. These tumours had more lymph-node metastasis (P = 0.048) and tended to have a poorer survival (P = 0.07). Missense mutations of p53 were detected in 20 (51.3%) patients and had a significantly stronger COX-2 expression than tumours without p53 mutation (P = 0.016). Our results suggest a link between p53 mutation and COX-2 overexpression in gastric cancer. © 2001 Cancer Research Campaign http://www.bjcancer.co
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