Use shundingites in modern technologies

The ability to stand still in one place is important in a variety of activities of daily living. For persons with motion disorders, orthopaedic treatment, which changes geometric or biomechanical properties, can improve the individual'sposture and walking ability. Decisions on such treatment require insight in how posture and walking ability are aected, however, despite expectations based on experience, it is never a-priori known how a patient will react to a treatment. As this is very challenging to observe by the naked eye, engineering tools are increasingly employed to support clinical diagnostics and treatment planning. The development of predictive simulations allows for the evaluation of the eect of changed biomechanical parameters on the human biological system behavior and could become a valuable tool in future clinical decision making. In the first paper, we evaluated the use of the Zero Moment Point as a computationally inexpensive tool to obtain the ground reaction forces (GRFs) for normal human gait. The method was applied on ten healthy subjects walking in a motion analysis laboratory and predicted GRFs are evaluated against the simultaneously measured force plate data. Apart from the antero-posterior forces, GRFs are well-predicted and errors fall within the error ranges from other published methods. The computationally inexpensive method evaluated in this study can reasonably well predict the GRFs for normal human gait without using prior knowledge of common gait kinetics. The second manuscript addresses the complications in the creation and analysis of a posture prediction framework. The fmincon optimization function in MATLAB was used in conjunction with a musculoskeletal model in OpenSim. One clear local minimum was found in the form of a symmetric standing posture but perturbation analyses revealed the presence of many other postural congurations, each representing its own unique local minimum in the feasible parameter space. For human postural stance, this can translate to there being many different ways of standing without actually noticing a difference in the efforts required for these poses.This work was financially supported by the Swedish Scientic Council(Vetenskapsrådet) grant no. 2010-9401-79187-68, the ProMobilia handicapfoundation (ref. 13093), Sunnerdahls Handicap foundation (ansökan nr 11/14),and Norrbacka-Eugenia foundation (ansökan nr 218/15).</p

Photo-induced radical polarization and liquid-state dynamic nuclear polarization using fullerene nitroxide derivatives.

We report on radical polarization and optically-driven liquid DNP using nitroxide radicals functionalized by photoexcitable fullerene derivatives. Pulse laser excitation of the fullerene moiety leads to transient nitroxide radical polarization that is one order of magnitude larger than that at the Boltzmann equilibrium. The life time of the radical polarization increases with the size of the fullerene derivative and is correlated with the electronic spin-lattice relaxation time T1e. Overhauser NMR signal enhancements of toluene solvent protons were observed under steady-state illumination, which replaced microwave irradiation

Carbon - containing covering for anchoring breaking nematic microdevices

We demonstrate experimentally, that inresidual atmosphere of scanning electron microscope the nano-scale carbon-containing (hydrocarbon) films by snuff effect can be produced. The micropattern of carbon film including axial-symmetric ones is defined by the e-beam rasteryesBelgorod State Universit

Micropatterning in bistable cholesteric device with Bragg’s reflection

In this work, the method to form bistable patterning in a cholesteric cell with Bragg’s reflection in the visible spectral range is demonstratedyesBelgorod State Universit

Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection

Cells release diverse types of extracellular vesicles (EVs), which transfer complex signals to surrounding cells. Specific markers to distinguish different EVs (e.g. exosomes, ectosomes, enveloped viruses like HIV) are still lacking. We have developed a proteomic profiling approach for characterizing EV subtype composition and applied it to human Jurkat T cells. We generated an interactive database to define groups of proteins with similar profiles, suggesting release in similar EVs. Biochemical validation confirmed the presence of preferred partners of commonly used exosome markers in EVs: CD81/ADAM10/ITGB1, and CD63/syntenin. We then compared EVs from control and HIV-1-infected cells. HIV infection altered EV profiles of several cellular proteins, including MOV10 and SPN, which became incorporated into HIV virions, and SERINC3, which was re-routed to non-viral EVs in a Nef-dependent manner. Furthermore, we found that SERINC3 controls the surface composition of EVs. Our workflow provides an unbiased approach for identifying candidate markers and potential regulators of EV subtypes. It can be widely applied to in vitro experimental systems for investigating physiological or pathological modifications of EV release

BRST Algebra Quantum Double and Quantization of the Proper Time Cotangent Bundle

The quantum double for the quantized BRST superalgebra is studied. The corresponding R-matrix is explicitly constucted. The Hopf algebras of the double form an analytical variety with coordinates described by the canonical deformation parameters. This provides the possibility to construct the nontrivial quantization of the proper time supergroup cotangent bundle. The group-like classical limit for this quantization corresponds to the generic super Lie bialgebra of the double.Comment: 11 pages, LaTe

Long-term follow-up of brain-damaged children requiring feeding gastrostomy: Should an antireflux procedure always be performed?

Due to the frequent presence of latent gastroesophageal reflux (GER) in mentally impaired children, it is now standard to perform upper gastrointestinal contrast (UGI) and pH probe studies in all children referred for feeding gastrostomy, even if they are without clinical evidence for GER. For patients with documented GER, an antireflux operation performed in conjunction with gastrostomy is usually considered mandatory. Some authors have suggested that a "protective" antireflux operation be performed at the time of gastrostomy placement in all brain-damaged children, citing a high incidence of postoperative GER in this group of patients following gastrostomy, even with a negative preoperative evaluation for GER. To evaluate this theory, we prospectively studied, over the past 6 years, all mentally retarded children referred for feeding gastrostomy with UGI contrast and esophageal pH probe studies. In total, 148 children were studied; 105 had a positive evaluation for GER and underwent gastrostomy and antireflux surgery. Of the 43 children with a negative preoperative evaluation for GER, 37 are doing well following gastrostomy alone without clinical reflux at an average follow-up of 21 months. Six of the 43 (14%) developed symptomatic GER occurring at an average of 10 months following gastrostomy placement. Five of these children have been successfully treated with an antireflux operation and the sixth patient has been successfully man-aged nonoperatively. Given the significant morbidity and mortality that has been documented with antireflux operations in mentally retarded children, we conclude that a protective antireflux operation at the time of gastrostomy placement is not indicated because the data suggest that 86% of children with a negative preoperative evaluation for GER would undergo the operation needlessly.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/29436/1/0000517.pd