Complexity Management to design and produce customerspecific hydraulic controls for mobile applications

Complexity management is the key to success for mobile machinery where the variety of customers and applications requires individual solutions. This paper presents the way Bosch Rexroth supports each OEM with hydraulic controls – from specification and conception towards application and production. It gives examples how platforms and processes are optimized according to the customer needs. The demand for flexible, short-term deliveries is met by an agile production with the technologies of Industry 4.0

Informationsfusion für die kooperative Umfeldwahrnehmung vernetzter Fahrzeuge

Kooperative Fahrzeugentscheidungen erfordern eine gemeinsame, konsistente Wahrnehmung. Dazu werden Fusionsmethoden für kommunizierte Eigen- und Umfeldinformationen entwickelt und erprobt. Die Registrierung in gemeinsame Koordinaten erfolgt nach Lokalisierung durch fusionierte GPS- und Koppelnavigationsdaten. Die dezentrale Fusion kombiniert rekursive Multi-Objekt-Verfolgung und gitterbasierte Karte. So können negative Sensorevidenzen beschrieben und Inkonsistenzen plausibilisiert werden

Informationsfusion für die kooperative Umfeldwahrnehmung vernetzter Fahrzeuge

Kooperative Fahrzeugentscheidungen erfordern eine gemeinsame, konsistente Wahrnehmung. Dazu werden Fusionsmethoden für kommunizierte Eigen- und Umfeldinformationen entwickelt und erprobt. Die Registrierung in gemeinsame Koordinaten erfolgt nach Lokalisierung durch fusionierte GPS- und Koppelnavigationsdaten. Die dezentrale Fusion kombiniert rekursive Multi-Objekt-Verfolgung und gitterbasierte Karte. So können negative Sensorevidenzen beschrieben und Inkonsistenzen plausibilisiert werden

A Novel Signaling Network Essential for Regulating Pseudomonas aeruginosa Biofilm Development

The important human pathogen Pseudomonas aeruginosa has been linked to numerous biofilm-related chronic infections. Here, we demonstrate that biofilm formation following the transition to the surface attached lifestyle is regulated by three previously undescribed two-component systems: BfiSR (PA4196-4197) harboring an RpoD-like domain, an OmpR-like BfmSR (PA4101-4102), and MifSR (PA5511-5512) belonging to the family of NtrC-like transcriptional regulators. These two-component systems become sequentially phosphorylated during biofilm formation. Inactivation of bfiS, bfmR, and mifR arrested biofilm formation at the transition to the irreversible attachment, maturation-1 and -2 stages, respectively, as indicated by analyses of biofilm architecture, and protein and phosphoprotein patterns. Moreover, discontinuation of bfiS, bfmR, and mifR expression in established biofilms resulted in the collapse of biofilms to an earlier developmental stage, indicating a requirement for these regulatory systems for the development and maintenance of normal biofilm architecture. Interestingly, inactivation did not affect planktonic growth, motility, polysaccharide production, or initial attachment. Further, we demonstrate the interdependency of this two-component systems network with GacS (PA0928), which was found to play a dual role in biofilm formation. This work describes a novel signal transduction network regulating committed biofilm developmental steps following attachment, in which phosphorelays and two sigma factor-dependent response regulators appear to be key components of the regulatory machinery that coordinates gene expression during P. aeruginosa biofilm development in response to environmental cues

Informationsfusion für die kooperative Umfeldwahrnehmung vernetzter Fahrzeuge

Cooperative decisions of multiple vehicles need a collaborative perception. Therefore, fusion methods for ego and environmental information are developed and evaluated. Precondition for the registration of data in a common coordinates is the accurate localization. This is realized by a fusion approach with absolute data of GPS and relative data of a dead reckoning system. A decentral fusion procedure combines a recursive multi-target tracking of detections with a grid-based mapping. Thus, negative sensor evidences can be formulated and missing detections are recognized

Complexity Management to design and produce customerspecific hydraulic controls for mobile applications

Complexity management is the key to success for mobile machinery where the variety of customers and applications requires individual solutions. This paper presents the way Bosch Rexroth supports each OEM with hydraulic controls – from specification and conception towards application and production. It gives examples how platforms and processes are optimized according to the customer needs. The demand for flexible, short-term deliveries is met by an agile production with the technologies of Industry 4.0

Complexity Management to design and produce customerspecific hydraulic controls for mobile applications

Complexity management is the key to success for mobile machinery where the variety of customers and applications requires individual solutions. This paper presents the way Bosch Rexroth supports each OEM with hydraulic controls – from specification and conception towards application and production. It gives examples how platforms and processes are optimized according to the customer needs. The demand for flexible, short-term deliveries is met by an agile production with the technologies of Industry 4.0

Hantavirus-infection Confers Resistance to Cytotoxic Lymphocyte-Mediated Apoptosis

<div><p>Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardio-pulmonary syndrome (HCPS; also called hantavirus pulmonary syndrome (HPS)), both human diseases with high case-fatality rates. Endothelial cells are the main targets for hantaviruses. An intriguing observation in patients with HFRS and HCPS is that on one hand the virus infection leads to strong activation of CD8 T cells and NK cells, on the other hand no obvious destruction of infected endothelial cells is observed. Here, we provide an explanation for this dichotomy by showing that hantavirus-infected endothelial cells are protected from cytotoxic lymphocyte-mediated induction of apoptosis. When dissecting potential mechanisms behind this phenomenon, we discovered that the hantavirus nucleocapsid protein inhibits the enzymatic activity of both granzyme B and caspase 3. This provides a tentative explanation for the hantavirus-mediated block of cytotoxic granule-mediated apoptosis-induction, and hence the protection of infected cells from cytotoxic lymphocytes. These findings may explain why infected endothelial cells in hantavirus-infected patients are not destroyed by the strong cytotoxic lymphocyte response.</p> </div