Sonic boom research

It is demonstrated that a supersonic airplane configuration weighing over half a million pounds while creating a maximum sonic boom of less than 1 p.s.f. can be designed. New experimental techniques are developed in the wind tunnel and experiments for the sonic boom measurements were carried out. Theoretical analyses were performed for the effects of sonic boom on structures and pollution problems associated with supersonic flights were investigated. Numerical programs were generated for the sonic boom propagations from the near field of an airplane in supersonic flight at high altitude to the ground, taking into account the nonlinear effects and the asymmetric effects due to lift and the spacewise distributions of lift and volume

Optimum shape of a blunt forebody in hypersonic flow

The optimum shape of a blunt forebody attached to a symmetric wedge or cone is determined. The length of the forebody, its semi-thickness or base radius, the nose radius and the radius of the fillet joining the forebody to the wedge or cone are specified. The optimum shape is composed of simple curves. Thus experimental models can be built readily to investigate the utilization of aerodynamic heating for boundary layer control. The optimum shape based on the modified Newtonian theory can also serve as the preliminary shape for the numerical solution of the optimum shape using the governing equations for a compressible inviscid or viscous flow

Sonic boom research

A computer program for CDC 6600 is developed for the nonlinear sonic boom analysis including the asymmetric effect of lift near the vertical plane of symmetry. The program is written in FORTRAN 4 language. This program carries out the numerical integration of the nonlinear governing equations from the input data at a finite distance from the airplane configuration at a flight altitude to yield the pressure signitude at ground. The required input data and the format for the output are described. A complete program listing and a sample calculation are given

Diffraction of a plane wave by a three-dimensional corner

By the superposition of the conical solution for the diffraction of a plane pulse by a three dimensional corner, the solution for a general incident plane wave is constructed. A numerical program is presented for the computation of the pressure distribution on the surface due to an incident plane wave of any wave form and at any incident angle. Numerical examples are presented to show the pressure signature at several points on the surface due to incident wave with a front shock wave, two shock waves in succession, or a compression wave with same peak pressure. The examples show that when the distance of a point on the surface from the edges or the vertex is comparable to the distance for the front pressure raise to reach the maximum, the peak pressure at that point can be much less than that given by a regular reflection, because the diffracted wave front arrives at that point prior to the arrival of the peak incident wave

Nonlinear periodic waves

Systematic perturbation procedures for the analysis of nonlinear problems are reviewed. The cases when the multiplicity of an eigenvalue is finite or infinite are treated for self-sustained and forced oscillations. The possibility of the formation of shock waves is discussed. Applications to acoustic problems are presented

Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the Avy obesity-associated gene.

There has been considerable debate as to whether obesity can act as an accelerator of type 1 diabetes (T1D). We assessed this possibility using transgenic mice (MIP-TF mice) whose ß-cells express enhanced green fluorescent protein (EGFP). Infecting these mice with EGFP-expressing murine herpes virus-68 (MHV68-EGFP) caused occasional transient elevation in their blood glucose, peri-insulitis, and Th1 responses to EGFP which did not spread to other ß-cell antigens. We hypothesized that obesity-related systemic inflammation and ß-cell stress could exacerbate the MHV68-EGFP-induced ß-cell autoreactivity. We crossed MIP-TF mice with Avy mice which develop obesity and provide models of metabolic disease alongside early stage T2D. Unlike their MIP-TF littermates, MHV68-EGFP-infected Avy/MIP-TF mice developed moderate intra-insulitis and transient hyperglycemia. MHV68-EGFP infection induced a more pronounced intra-insulitis in older, more obese, Avy/MIP-TF mice. Moreover, in MHV68-EGFP-infected Avy/MIP-TF mice, Th1 reactivity spread from EGFP to other ß-cell antigens. Thus, the spreading of autoreactivity among ß-cell antigens corresponded with the transition from peri-insulitis to intra-insulitis and occurred in obese Avy/MIP-TF mice but not lean MIP-TF mice. These observations are consistent with the notion that obesity-associated systemic inflammation and ß-cell stress lowers the threshold necessary for T cell autoreactivity to spread from EGFP to other ß-cell autoantigens

Evaluating the Vulnerability of Time-Sensitive Transportation Networks: A Hub Center Interdiction Problem

This work is licensed under a Creative Commons Attribution 4.0 International License.Time-sensitive transportation systems have received increasing research attention recently. Examples of time-sensitive networks include those of perishable goods, high-value commodity, and express delivery. Much research has been devoted to optimally locating key facilities such as transportation hubs to minimize transit time. However, there is a lack of research attention to the reliability and vulnerability of time-sensitive transportation networks. Such issues cannot be ignored as facilities can be lost due to reasons such as extreme weather, equipment malfunction, and even intentional attacks. This paper proposes a hub interdiction center (HIC) model for evaluating the vulnerability of time-sensitive hub-and-spoke networks under disruptions. The model identifies the set of hub facilities whose loss will lead to the greatest increase in the worst-case transit time. From a planning perspective, such hubs are critical facilities that should be protected or enhanced by preventive measures. An efficient integer linear programming (ILP) formulation of the new model is developed. Computational experiments on a widely used US air passenger dataset show that losing a small number of hub facilities can double the maximum transit time

Minimum Energy Path to Membrane Pore Formation and Rupture

We combine dynamic self-consistent field theory with the string method to calculate the minimum energy path to membrane pore formation and rupture. In the regime where nucleation can occur on experimentally relevant time scales, the structure of the critical nucleus is between a solvophilic stalk and a locally thinned membrane. Classical nucleation theory fails to capture these molecular details and significantly overestimates the free energy barrier. Our results suggest that thermally nucleated rupture may be an important factor for the low rupture strains observed in lipid membranes