The Effect of Anesthetic Drugs During Craniotomy on Patient Outcomes

Glioblastoma remains an aggressive, highly malignant brain cancer with poor prognosis despite treatment options including surgery, radiotherapy, and chemotherapy. The objective of this retrospective chart review study was to evaluate if there is a correlation between the type and dose of anesthetic drugs administered during craniotomy surgery for glioblastoma and the time to first postoperative tumor progression and mortality. Based on preliminary data in mice, it was hypothesized that the use of propofol during surgery is associated with slower tumor progression and lower mortality, when compared with other anesthetic drugs. In the observed time frame, 133 patients were diagnosed with glioblastoma and underwent a total of 161 craniotomy surgeries (23 awake, 138 asleep) at Henry Ford Hospital. Propofol was utilized in 97.5% of these surgeries. Other anesthetics such as isoflurane (53.4%), dexmedetomidine (37.7%), sevoflurane (31.0%), desflurane (14.3%), and nitrous oxide (4.9%) were used less frequently. Data analysis regarding time to progression and mortality after use of each anesthetic remains in progress. This study will guide the administration of anesthetic drugs during surgery to treat glioblastoma, with potential to improve the poor prognosis for these patients

Free-living Neoparamoeba perurans depth distribution is mostly uniform in salmon cages, but reshaped by stratification and potentially extreme fish crowding

Understanding the spatio-temporal positioning of hosts and their parasites in free-living states is useful in devising methods to diminish parasite encounters in animal production systems. We explored the potential for depth-based control methods of the amoebic gill disease (AGD) agent, Neoparamoeba perurans, in salmon mariculture systems by conducting: (1) depth-stratified N. perurans water sampling surveys in 2 years, and (2) a mensurative experiment comparing depth distributions of N. perurans and salmon hosts in commercial salmon sea-cages. From water sampling mostly at marine salinities, N. perurans abundance (quantitative PCR-derived cells l-1) varied among years, but overall, neither depth, time since freshwater bathing, temperature and salinity were predictors of N. perurans abundance. However, at 1 survey time, depth patterns in N. perurans abundance appeared during strong vertical salinity gradients following rainfall (at 1 site, salinity ranged between 14 and 35 g l-1), with greater numbers of cells below a less saline surface layer. This suggested that salinity mediates N. perurans depth distribution during intermittent halocline development. Fish depth distribution monitoring revealed intense fish crowding, with local swimming densities up to 5 times stocking densities, typically at the surface at night. Simultaneously collected daytime water samples during low levels of fish crowding, with stock scattered amongst upper and lower cage sections, revealed no relationship between N. perurans and fish depth distributions. If intense fish crowding in narrow depth bands leads to high concentrations of N. perurans in cage environments and increased AGD risk, behavioural manipulations that vertically spread fish could be a successful AGD mitigation strategy.publishedVersio

Chandra X-ray spectroscopy of the focused wind in the Cygnus X-1 system III. Dipping in the low/hard state

We present an analysis of three Chandra High Energy Transmission Gratings observations of the black hole binary Cyg X-1/HDE 226868 at different orbital phases. The stellar wind that is powering the accretion in this system is characterized by temperature and density inhomogeneities including structures, or "clumps", of colder, more dense material embedded in the photoionized gas. As these clumps pass our line of sight, absorption dips appear in the light curve. We characterize the properties of the clumps through spectral changes during various dip stages. Comparing the silicon and sulfur absorption line regions (1.6-2.7 keV $\equiv$ 7.7-4.6 {\AA}) in four levels of varying column depth reveals the presence of lower ionization stages, i.e., colder or denser material, in the deeper dip phases. The Doppler velocities of the lines are roughly consistent within each observation, varying with the respective orbital phase. This is consistent with the picture of a structure that consists of differently ionized material, in which shells of material facing the black hole shield the inner and back shells from the ionizing radiation. The variation of the Doppler velocities compared to a toy model of the stellar wind, however, does not allow us to pin down an exact location of the clump region in the system. This result, as well as the asymmetric shape of the observed lines, point at a picture of a complex wind structure.Comment: 19 pages, 15 figures, accepted for publication in A&

The rising tide of criticality in social entrepreneurship and social innovation

In this article, we trace a rising tide of criticality to highlight three waves in a sea of social entrepreneurship/social innovation (SE/SI) research. Our aim is to draw attention to counter, alternative and critical perspectives in the field and how ‘dangerous’ their co-option by right wing narratives is. We review what we believe to be three waves in the development of a critical research agenda undertaken by a cohort of academics who, in their loyalty to the field, have sought to unpick the underlying assumptions in the practice of, and academic reflection on, social innovation. We set out the early instrumentalist critique, in which the success and social utility of SE/SI is questioned. We secondly highlight a post-structuralist shift, in which hidden and unheard voices and perspectives are welcomed and celebrated. The third wave, for us, constitutes a dangerous threat to the SE/SI project, threatening to undermine and co-opt the first two waves, as has happened in other related fields of intellectual endeavour. We position this paper to not only engage with scholars who challenge the normative assumptions behind social innovation research, but also to draw attention to the entry of right-wing politics in post-modernist critical theory. It is not that everything in this third wave is bad, but that everything becomes unexpectedly dangerous, especially if we uncritically adopt reflexivity, naturalization and performativity as politically and morally neutral positions. Contra to Foucault, in adopting a critical realist stance, we begin to propose that ‘the social’, posed as an inherently ‘good’ thing, is an ontological reality that is knowable, albeit given that our knowledge of what is ‘good’ is nonetheless limited and partial. In the first Skoll World Forum (2004) some activists put up posters in the toilets of Said Business School warning delegates, ‘beware social entrepreneurship: a wolf in sheep’s clothes!’ (Nicholls & Young, 2008, p. 272). We conclude our paper warning that SE/SI is not the only wolf to be concerned about

Editorial Presentation: Critical perspectives in social innovation, social enterprise and/or the social solidarity economy

This Thematic Issue seeks to explore critical perspectives of an international nature on social innovation (SI), social enterprise (SE) and/or social solidarity economy (SSE). The aim is to examine the grand narrative, explore the ontological assumptions of the field, challenge the normative and present alternatives that draw attention to political economy, critical theory and critical management studies

Avoiding Pitfalls in Comparison of Activity and Selectivity of Solid Catalysts for Electrochemical HMF Oxidation

Electrocatalytic oxidation of 5-hydroxymethylfurfural (HMF) offers a renewable approach to produce the value-added platform chemical 2,5-furandicarboxylic acid (FDCA). The key for the economic viability of this approach is to develop active and selective electrocatalysts. Nevertheless, a reliable catalyst evaluation protocol is still missing, leading to elusive conclusions on criteria for a high-performing catalyst. Herein, we demonstrate that besides the catalyst identity, secondary parameters such as materials of conductive substrates for the working electrode, concentration of the supporting electrolyte, and electrolyzer configurations have profound impact on the catalyst performance and thus need to be optimized before assessing the true activity of a catalyst. Moreover, we highlight the importance of those secondary parameters in suppressing side reactions, which has long been overlooked. The protocol is validated by evaluating the performance of free-standing Cu-foam, and CuCoO modified with NaPO2H2 and Ni, which were immobilized on boron-doped diamond (BDD) electrodes. Recommended practices and figure of merits in carefully evaluating the catalyst performance are proposed. © 2021 The Authors. Published by The Chemical Society of Japan & Wiley-VCH Gmb