The Lived Experience of Klinefelter Syndrome: A Narrative Review of the Literature

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Environmental Foundations: Studies of Climatical, Geological, Hydrological, and Phytological conditions in Hesban and Vicinity

This volume provides an introduction to the climate and landscape to which successive generations of Hesbanites have had to adapt. Includes 26 figures, 42 plates, and 9 tables.https://digitalcommons.andrews.edu/books/1065/thumbnail.jp

QuakeMigrate: a Modular, Open-Source Python Package for Automatic Earthquake Detection and Location

Detecting and locating microearthquakes from continuous waveform records is the fundamental step in microseismic processing. Dense local networks and arrays have introduced the possibility to detect large numbers of far weaker events, but when viewed on seismic records from individual stations their waveforms are often obscured by noise. Furthermore, areas of interest for microseismic monitoring often feature extremely high event rates, highlighting the limitations of traditional techniques based on phase picking and association. In order to maximise the new insights gained, we require fully automated techniques which can exploit modern recordings to produce highly complete earthquake catalogues containing few artefacts. QuakeMigrate is a new modular, open-source Python package providing a framework to efficiently, automatically and robustly detect and locate microseismicity. The user inputs continuous seismic data, a velocity model or pre-calculated look-up table and list of station locations. Instead of reducing the raw waveforms to discrete time picks, they are transformed (by amplitude, frequency and/or polarisation analysis) to continuous functions representing the probability of a particular phase arrival through time. These ‘onset functions’ from stations across the network are then migrated according to a travel-time look-up table and stacked to perform a grid-search for coherent sources of energy in the subsurface. This enables detection of earthquakes at close to or below the signal-to-noise ratio at individual stations, and implicitly associates phase arrivals even at very small inter-event times. We demonstrate the flexibility and power of this approach with examples of basal icequakes detected at the Rutford Ice Stream, Antarctica, dike- and caldera-collapse induced seismicity at Bárðarbunga central volcano, Iceland, and the aftershock sequence from a M5 earthquake at Mt. Kinabalu, northern Borneo. The modular nature of the workflow and wide range of automatic plotting options makes parameter choice straightforward, and robust event location uncertainty statistics facilitate filtering to produce a robust catalogue. QuakeMigrate also outputs phase picks and local magnitude estimates, with an architecture designed to promote further community-driven extension in future

Is arterial stiffening associated with adiposity, severity of obesity and other contemporary cardiometabolic markers in a community sample of adolescents with obesity in the UK?

BACKGROUND: Cardiovascular disease (CVD) prediction is problematic within groups of obese adolescents as measures such as adiposity and metabolic markers lack validation. Pulse wave velocity (PWV), a proxy for arterial stiffening, is a potential way to contemporaneously capture adolescents at greater risk of CVD. OBJECTIVES: To investigate associations between PWV and 1) adiposity and 2) other conventional metabolic factors in a community sample of (>95th centile body mass index (BMI)). DESIGN AND SETTING: Cross-sectional measurement and analysis in a hospital-based research centre drawn from a community sample of adolescents recruited to an obesity intervention at baseline. PATIENTS: 174 adolescents (12-19 years) with obesity (>95th centile BMI). 37% were male, while 66 (38%) were white, 53 (30%) black, 36 (21%) South Asian, 19 (11%) mixed/other. Participants with endocrine, genetic causes of obesity and chronic medical conditions (excluding asthma) were excluded. MEASURES: BMI z-score (zBMI), waist z-score, fat mass index (FMI: measured using bioimpedance), sagittal abdominal dimension (SAD), cardiometabolic blood tests and resting blood pressure (BP) were collected. Carotid-radial PWV was measured by a single operator. RESULTS: PWV was associated with age but not pubertal stage. PWV was positively associated with adiposity (zBMI: coefficient 0.44 (95% CI 0.08 to 0.79); FMI: coefficient 0.05 (95% CI 0.00 to 0.10); waist z-score: coefficient 0.27 (95% CI 0.00 to 0.53); SAD: coefficient 0.06 (95% CI: 0.00 to 0.12)). There was no association between PWV and BP, and few associations with cardiometabolic bloods. Associations between PWV and adiposity measures were robust to adjustment in multivariable models except for SAD. Participants with zBMI >2.5 SD and >3.5 SD had greater average PWV but overlap between groups was large. CONCLUSIONS: In our sample, increasing adiposity was positively associated with arterial stiffness, however partitioning by severity was not reliable. Lack of associations between BP, cardiometabolic bloods and arterial stiffness questions the reliability of these factors for predicting CVD risk in adolescents with obesity

Staying put in an era of climate change : the geographies, legalities, and public health implications of immobility

This study was supported by the ESRC Postdoctoral Fellowship (Grant number: ES/W005646/1), the NERC Discipline Hopping for Environmental Solutions (Grant number: G115565 EWAG/009), and the University of Exeter Law School Director of Research Discretionary Fund. All research at the Department of Psychiatry in the University of Cambridge is supported by the NIHR Cambridge Biomedical Research Centre (NIHR203312) and the NIHR Applied Research Collaboration East of England.In response to the proliferation of “climate migration” discourses, researchers are exploring how climate related hazards affect immobile populations. This paper contributes to the conceptualization of “environmental immobility.” Researchers from geography, public health, psychology, and law explore the climate change immobility nexus via three themes: (1) risk; (2) (mal)adaptation; and (3) resilience, protection, and vulnerability. The aim of this paper is to identify and discuss the key concepts and rationale for scholars and policymakers who consider both “voluntary” and “involuntary” immobility when researching and responding to the effects of climate change on human movement. The need is critical, as immobility is often underacknowledged as a desirable, pro-active, and practical response to environmental change, preventing large populations from being considered and included in policy, consultation, and support processes.Peer reviewe